{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:50:54Z","timestamp":1788187854094,"version":"build-2803163510"},"reference-count":25,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T00:00:00Z","timestamp":1505779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>The effects of maternal inorganic iodine therapy on infant thyroid function are not well known.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study investigated the effects on infant thyroid function of maternal inorganic iodine therapy when administered to lactating mothers with Graves disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting<\/jats:title>\n                  <jats:p>This study was a prospective case series performed at the Tajiri Thyroid Clinic, Kumamoto, Japan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>Subjects were 26 infants of lactating mothers with Graves disease treated with potassium iodide (KI) for postpartum thyrotoxicosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measures<\/jats:title>\n                  <jats:p>Infant blood levels of thyroid-stimulating hormone (TSH) and free thyroxine were measured using the dried filter-paper method. Iodine concentrations in breast milk and infant urine were measured on the same day. Subclinical hypothyroidism was defined as a blood TSH level of \u226510 or \u22655 \u03bcIU\/mL in &amp;lt;6-month-old and 6- to 12-month-old infants, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median age of the infants was 3 months (range, 0 to 10 months). The median KI dose was 50 mg\/d (range, 10 to 100 mg\/d). High median iodine concentrations were detected in breast milk (15,050 \u03bcg\/L; range, 831 to 72,000 \u03bcg\/L) and infant urine (15,650 \u03bcg\/L; range, 157 to 250,000 \u03bcg\/L). Twenty-five of 26 infants had normal thyroid function. Although one infant had subclinical hypothyroidism (blood TSH, 12.3 \u03bcIU\/mL), the TSH level normalized to 2.3 \u03bcIU\/mL at 2 months after KI discontinuation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In Japan, where iodine intake is sufficient, administration of inorganic iodine to lactating mothers with Graves disease did not affect thyroid function in most infants despite high levels of exposure to iodine via breast milk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/js.2017-00297","type":"journal-article","created":{"date-parts":[[2017,9,19]],"date-time":"2017-09-19T18:05:25Z","timestamp":1505844325000},"page":"1293-1300","source":"Crossref","is-referenced-by-count":11,"title":["Effects of Inorganic Iodine Therapy Administered to Lactating Mothers With Graves Disease on Infant Thyroid Function"],"prefix":"10.1210","volume":"1","author":[{"given":"Katsuhiko","family":"Hamada","sequence":"first","affiliation":[{"name":"Tajiri Thyroid Clinic, Kumamoto 862-0950, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Mizokami","sequence":"additional","affiliation":[{"name":"Tajiri Thyroid Clinic, Kumamoto 862-0950, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsushi","family":"Maruta","sequence":"additional","affiliation":[{"name":"Tajiri Thyroid Clinic, Kumamoto 862-0950, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiichiro","family":"Higashi","sequence":"additional","affiliation":[{"name":"Tajiri Thyroid Clinic, Kumamoto 862-0950, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Konishi","sequence":"additional","affiliation":[{"name":"Division of Newborn Screening, Tokyo Health Service Association, Tokyo 162-8460, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Momotani","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Tokyo Health Service Association, Tokyo 162-8402, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Tajiri","sequence":"additional","affiliation":[{"name":"Tajiri Thyroid Clinic, Kumamoto 862-0950, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2017,9,19]]},"reference":[{"key":"2020071619521357300_B1","first-page":"492","volume-title":"Werner and Ingbar\u2019s The Thyroid","author":"Cooper","year":"2013","edition":"10th ed."},{"issue":"10","key":"2020071619521357300_B2","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1089\/thy.2016.0229","article-title":"2016 American thyroid association guidelines for diagnosis and management of hyperthyroidism and other causes of 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