{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T18:40:53Z","timestamp":1789497653601,"version":"build-2803163510"},"reference-count":70,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T00:00:00Z","timestamp":1531180800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Polycystic ovary syndrome (PCOS), the most common endocrine disorder in women of reproductive age, is characterized by androgen excess and ovarian dysfunction and presents with increased cardiometabolic risk factors such as obesity, insulin resistance, and elevated blood pressure (BP). We previously reported that administration of dihydrotestosterone (DHT) to female rats elicits cardiometabolic derangements similar to those found in women with PCOS. In this study, we tested the hypothesis that the DHT-mediated cardiometabolic derangements observed in PCOS are long lasting despite DHT withdrawal. Four-week-old female Sprague Dawley rats were treated with DHT (7.5 mg\/90 days) or placebo for 6 months. DHT was discontinued (ex-DHT), and rats were followed for 6 additional months. After 6 months of DHT withdrawal, food intake, body weight, fat and lean mass, fasting plasma insulin, leptin, and adiponectin were elevated in ex-DHT rats. BP remained significantly elevated, and enalapril, an angiotensin-converting enzyme (ACE) inhibitor, normalized BP in ex-DHT rats. Expression of components of the intrarenal renin-angiotensin system was increased in ex-DHT rats. The cardiometabolic features found in ex-DHT rats were associated with lower plasma androgen levels but increased expression of renal and adipose tissue androgen receptors. In summary, androgen-induced cardiometabolic effects persisted after DHT withdrawal in a PCOS experimental model. Activation of intrarenal renin-angiotensin system plays a major role in the androgen-mediated increase in BP in ex-DHT. Upregulation of the renal and adipose tissue androgen receptor may explain the long-lasting effects of androgens. In clinical scenarios characterized by hyperandrogenemia in women, prompt normalization of androgen levels may be necessary to prevent their long-lasting cardiometabolic effects.<\/jats:p>","DOI":"10.1210\/js.2018-00131","type":"journal-article","created":{"date-parts":[[2018,7,10]],"date-time":"2018-07-10T14:02:22Z","timestamp":1531231342000},"page":"949-964","source":"Crossref","is-referenced-by-count":24,"title":["Long-Lasting Androgen-Induced Cardiometabolic Effects in Polycystic Ovary Syndrome"],"prefix":"10.1210","volume":"2","author":[{"given":"Edgar D","family":"Torres Fernandez","sequence":"first","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Mississippi Center for Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Women\u2019s Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Cardio Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen V","family":"Adams","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Syed","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo O","family":"Maranon","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Mississippi Center for Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Women\u2019s Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Cardio Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damian G","family":"Romero","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Mississippi Center for Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Women\u2019s Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Cardio Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Licy L","family":"Yanes Cardozo","sequence":"additional","affiliation":[{"name":"Department of Cell and Molecular Biology, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Mississippi Center for Excellence in Perinatal Research, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Women\u2019s Health Research Center, University of Mississippi Medical Center, Jackson, Mississippi"},{"name":"Cardio Renal Research Center, University of Mississippi Medical Center, Jackson, Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,7,10]]},"reference":[{"issue":"12","key":"2020071621350416800_B1","doi-asserted-by":"crossref","first-page":"2841","DOI":"10.1093\/humrep\/dew218","article-title":"The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis","volume":"31","author":"Bozdag","year":"2016","journal-title":"Hum Reprod"},{"issue":"9","key":"2020071621350416800_B2","first-page":"3078","article-title":"Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study","volume":"83","author":"Knochenhauer","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621350416800_B3","doi-asserted-by":"crossref","first-page":"16057","DOI":"10.1038\/nrdp.2016.57","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"1","key":"2020071621350416800_B4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1056\/NEJMcp1514916","article-title":"Polycystic ovary syndrome","volume":"375","author":"McCartney","year":"2016","journal-title":"N Engl J Med"},{"issue":"5","key":"2020071621350416800_B5","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrendo.2018.24","article-title":"Polycystic ovary syndrome: definition, aetiology, diagnosis and treatment","volume":"14","author":"Escobar-Morreale","year":"2018","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"2020071621350416800_B6","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1210\/jc.2009-2724","article-title":"Assessment of cardiovascular risk and prevention of cardiovascular disease in women with the polycystic ovary syndrome: a consensus statement by the Androgen Excess and Polycystic Ovary Syndrome (AE-PCOS) Society","volume":"95","author":"Wild","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2020071621350416800_B7","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1111\/aogs.12706","article-title":"Polycystic ovary syndrome: cardiovascular risk factors according to specific phenotypes","volume":"94","author":"Aziz","year":"2015","journal-title":"Acta Obstet Gynecol Scand"},{"issue":"4","key":"2020071621350416800_B8","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1210\/jc.2005-2430","article-title":"Epidemiology and adverse cardiovascular risk profile of diagnosed polycystic ovary syndrome","volume":"91","author":"Lo","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2020071621350416800_B9","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1093\/humrep\/16.3.556","article-title":"Prevalence of diabetes mellitus, hypertension and cardiac complaints in a follow-up study of a Dutch PCOS population","volume":"16","author":"Elting","year":"2001","journal-title":"Hum Reprod"},{"issue":"1","key":"2020071621350416800_B10","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1055\/s-2007-992923","article-title":"Cardiovascular disease risk factors in polycystic ovary syndrome","volume":"26","author":"Dokras","year":"2008","journal-title":"Semin Reprod Med"},{"issue":"11","key":"2020071621350416800_B11","doi-asserted-by":"crossref","first-page":"4237","DOI":"10.1210\/jc.2006-0178","article-title":"Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline","volume":"91","author":"Azziz","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071621350416800_B12","first-page":"377","volume-title":"Polycystic Ovary Syndrome","author":"Zawadski","year":"1992"},{"key":"2020071621350416800_B13","doi-asserted-by":"crossref","unstructured":"Rotterdam ESHRE\/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril. 2004;81(1):19\u201325.","DOI":"10.1016\/j.fertnstert.2003.10.004"},{"issue":"2","key":"2020071621350416800_B14","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1093\/humrep\/dep399","article-title":"The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria","volume":"25","author":"March","year":"2010","journal-title":"Hum Reprod"},{"key":"2020071621350416800_B15","unstructured":"National Institutes of Health. Evidence-Based Methodology Workshop on Polycystic Ovary Syndrome. 3\u20135 December 2012; Bethesda, MD."},{"issue":"5","key":"2020071621350416800_B16","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1016\/j.fertnstert.2014.08.001","article-title":"Cardiovascular and metabolic profiles amongst different polycystic ovary syndrome phenotypes: who is really at risk","volume":"102","author":"Daan","year":"2014","journal-title":"Fertil Steril"},{"issue":"2","key":"2020071621350416800_B17","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1210\/jc.2007-1756","article-title":"A more atherogenic serum lipoprotein profile is present in women with polycystic ovary syndrome: a case-control study","volume":"93","author":"Valkenburg","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2020071621350416800_B18","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/09513590802585597","article-title":"Prevalence and predictors of abnormal glucose metabolism in Mediterranean women with polycystic ovary syndrome","volume":"25","author":"Espin\u00f3s-G\u00f3mez","year":"2009","journal-title":"Gynecol Endocrinol"},{"issue":"6","key":"2020071621350416800_B19","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1161\/HYPERTENSIONAHA.106.083972","article-title":"Relationship between androgen levels and blood pressure in young women with polycystic ovary syndrome","volume":"49","author":"Chen","year":"2007","journal-title":"Hypertension"},{"issue":"6","key":"2020071621350416800_B20","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1093\/aje\/kwh250","article-title":"Glucose and insulin components of the metabolic syndrome are associated with hyperandrogenism in postmenopausal women: the atherosclerosis risk in communities study","volume":"160","author":"Golden","year":"2004","journal-title":"Am J Epidemiol"},{"issue":"5","key":"2020071621350416800_B21","first-page":"357","article-title":"Cardiometabolic features of polycystic ovary syndrome: role of androgens","volume":"32","author":"Yanes Cardozo","year":"2017","journal-title":"Physiology (Bethesda)"},{"issue":"2","key":"2020071621350416800_B22","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jash.2008.11.003","article-title":"Collecting duct renin: a major player in angiotensin II-dependent hypertension","volume":"3","author":"Prieto-Carrasquero","year":"2009","journal-title":"J Am Soc Hypertens"},{"issue":"2","key":"2020071621350416800_B23","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1161\/hy0202.103821","article-title":"Regulation of intrarenal angiotensin II in hypertension","volume":"39","author":"Navar","year":"2002","journal-title":"Hypertension"},{"issue":"5","key":"2020071621350416800_B24","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0015-0282(16)57537-2","article-title":"Serum total renin is elevated in women with polycystic ovarian syndrome","volume":"63","author":"Jaatinen","year":"1995","journal-title":"Fertil Steril"},{"issue":"6","key":"2020071621350416800_B25","doi-asserted-by":"crossref","first-page":"864","DOI":"10.3325\/cmj.2007.6.864","article-title":"Decreased androgen levels and improved menstrual pattern after angiotensin II receptor antagonist telmisartan treatment in four hypertensive patients with polycystic ovary syndrome: case series","volume":"48","author":"Jensterle","year":"2007","journal-title":"Croat Med J"},{"issue":"4","key":"2020071621350416800_B26","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2265.2007.02764.x","article-title":"Metabolic characteristics of women with polycystic ovaries and oligo-amenorrhoea but normal androgen levels: implications for the management of polycystic ovary syndrome","volume":"66","author":"Barber","year":"2007","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"2","key":"2020071621350416800_B27","first-page":"604","article-title":"Delayed diagnosis and a lack of information associated with dissatisfaction in women with polycystic ovary syndrome","volume":"102","author":"Gibson-Helm","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2020071621350416800_B28","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1517\/14728222.2015.1101067","article-title":"Targets to treat metabolic syndrome in polycystic ovary syndrome","volume":"19","author":"Mahalingaiah","year":"2015","journal-title":"Expert Opin Ther Targets"},{"issue":"2","key":"2020071621350416800_B29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.genm.2010.11.013","article-title":"Cardiovascular-renal and metabolic characterization of a rat model of polycystic ovary syndrome","volume":"8","author":"Yanes","year":"2011","journal-title":"Gend Med"},{"issue":"7","key":"2020071621350416800_B30","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1210\/en.2015-1617","article-title":"Cardiometabolic effects of chronic hyperandrogenemia in a new model of postmenopausal polycystic ovary syndrome","volume":"157","author":"Dalmasso","year":"2016","journal-title":"Endocrinology"},{"issue":"4","key":"2020071621350416800_B31","doi-asserted-by":"crossref","first-page":"F771","DOI":"10.1152\/ajprenal.90389.2008","article-title":"Testosterone-dependent hypertension and upregulation of intrarenal angiotensinogen in Dahl salt-sensitive rats","volume":"296","author":"Yanes","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"issue":"6","key":"2020071621350416800_B32","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1210\/en.2016-1707","article-title":"Role and regulation of microRNAs in aldosterone-mediated cardiac injury and dysfunction in male rats","volume":"158","author":"Ball","year":"2017","journal-title":"Endocrinology"},{"issue":"2","key":"2020071621350416800_B33","doi-asserted-by":"crossref","first-page":"R383","DOI":"10.1152\/ajpregu.00510.2005","article-title":"Sexual dimorphism in the renin-angiotensin system in aging spontaneously hypertensive rats","volume":"291","author":"Yanes","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"4","key":"2020071621350416800_B34","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"issue":"6","key":"2020071621350416800_B35","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"issue":"3 Pt 2","key":"2020071621350416800_B36","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1161\/01.HYP.0000046924.94886.EF","article-title":"Characterization of an animal model of postmenopausal hypertension in spontaneously hypertensive rats","volume":"41","author":"Fortepiani","year":"2003","journal-title":"Hypertension"},{"issue":"9623","key":"2020071621350416800_B37","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/S0140-6736(08)60655-8","article-title":"Global burden of blood-pressure-related disease, 2001","volume":"371","author":"Lawes","year":"2008","journal-title":"Lancet"},{"issue":"9349","key":"2020071621350416800_B38","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0140-6736(02)11911-8","article-title":"Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies","volume":"360","author":"Lewington","year":"2002","journal-title":"Lancet"},{"issue":"1","key":"2020071621350416800_B39","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/oxfordjournals.humrep.a019028","article-title":"Elevated ambulatory day-time blood pressure in women with polycystic ovary syndrome: a sign of a pre-hypertensive state","volume":"11","author":"Holte","year":"1996","journal-title":"Hum Reprod"},{"issue":"5","key":"2020071621350416800_B40","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1046\/j.1365-2265.2000.01000.x","article-title":"Cardiovascular disease in women with polycystic ovary syndrome at long-term follow-up: a retrospective cohort study","volume":"52","author":"Wild","year":"2000","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"5","key":"2020071621350416800_B41","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1093\/humrep\/deg218","article-title":"Cardiovascular risk factors in young Czech females with polycystic ovary syndrome","volume":"18","author":"Vrb\u00edkov\u00e1","year":"2003","journal-title":"Hum Reprod"},{"issue":"1","key":"2020071621350416800_B42","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1111\/cen.12986","article-title":"Influence of race\/ethnicity on cardiovascular risk factors in polycystic ovary syndrome, the Dallas Heart Study","volume":"85","author":"Chang","year":"2016","journal-title":"Clin Endocrinol (Oxf)"},{"issue":"9","key":"2020071621350416800_B43","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1210\/jc.2012-1690","article-title":"Evaluation of adverse outcome in young women with polycystic ovary syndrome versus matched, reference controls: a retrospective, observational study","volume":"97","author":"Morgan","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2020071621350416800_B44","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.fertnstert.2016.12.017","article-title":"Normo- and hyperandrogenic women with polycystic ovary syndrome exhibit an adverse metabolic profile through life","volume":"107","author":"Pinola","year":"2017","journal-title":"Fertil Steril"},{"issue":"6","key":"2020071621350416800_B45","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1093\/biolre\/iox043","article-title":"Hyperandrogenemia reduces endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric artery of female rats","volume":"96","author":"Mishra","year":"2017","journal-title":"Biol Reprod"},{"issue":"5","key":"2020071621350416800_B46","doi-asserted-by":"crossref","first-page":"e0126119","DOI":"10.1371\/journal.pone.0126119","article-title":"Liraglutide improves hypertension and metabolic perturbation in a rat model of polycystic ovarian syndrome","volume":"10","author":"Hoang","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"2020071621350416800_B47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1055\/s-2007-1024972","article-title":"Deleterious effects of anabolic steroids on serum lipoproteins, blood pressure, and liver function in amateur body builders","volume":"9","author":"Lenders","year":"1988","journal-title":"Int J Sports Med"},{"key":"2020071621350416800_B48","first-page":"S35","article-title":"Pressure-volume regulation in hypertension","volume":"55","author":"Hall","year":"1996","journal-title":"Kidney Int Suppl"},{"issue":"1","key":"2020071621350416800_B49","first-page":"1","article-title":"Renin inhibitors: specific modulators of the renin-angiotensin system","volume":"39","author":"Luther","year":"1989","journal-title":"Arzneimittelforschung"},{"issue":"1 Pt 2","key":"2020071621350416800_B50","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1161\/01.HYP.35.1.480","article-title":"Gender differences in development of hypertension in spontaneously hypertensive rats: role of the renin-angiotensin system","volume":"35","author":"Reckelhoff","year":"2000","journal-title":"Hypertension"},{"issue":"6","key":"2020071621350416800_B51","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1002\/tera.1420500606","article-title":"Teratogen update: angiotensin-converting enzyme inhibitors","volume":"50","author":"Barr","year":"1994","journal-title":"Teratology"},{"issue":"1","key":"2020071621350416800_B52","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.earlhumdev.2005.11.001","article-title":"Fetopathy associated with exposure to angiotensin converting enzyme inhibitors and angiotensin receptor antagonists","volume":"82","author":"Quan","year":"2006","journal-title":"Early Hum Dev"},{"issue":"2","key":"2020071621350416800_B53","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.ejogrb.2005.03.010","article-title":"Obesity and extreme obesity, manifest by ages 20-24 years, continuing through 32-41 years in women, should alert physicians to the diagnostic likelihood of polycystic ovary syndrome as a reversible underlying endocrinopathy","volume":"122","author":"Glueck","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2020071621350416800_B54","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.ejogrb.2013.11.011","article-title":"Hypertension in women with polycystic ovary syndrome: prevalence and associated cardiovascular risk factors","volume":"173","author":"Shi","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"11","key":"2020071621350416800_B55","doi-asserted-by":"crossref","first-page":"4071","DOI":"10.1210\/en.2015-1159","article-title":"Hyperandrogenism and insulin resistance, not changes in body weight, mediate the development of endothelial dysfunction in a female rat model of polycystic ovary syndrome (PCOS)","volume":"156","author":"Hurliman","year":"2015","journal-title":"Endocrinology"},{"issue":"1","key":"2020071621350416800_B56","doi-asserted-by":"crossref","first-page":"146","DOI":"10.4103\/1008-682X.122346","article-title":"Metabolic effects of testosterone replacement therapy on hypogonadal men with type 2 diabetes mellitus: a systematic review and meta-analysis of randomized controlled trials","volume":"16","author":"Cai","year":"2014","journal-title":"Asian J Androl"},{"issue":"3","key":"2020071621350416800_B57","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/MED.0b013e32833919cf","article-title":"Testosterone and type 2 diabetes","volume":"17","author":"Grossmann","year":"2010","journal-title":"Curr Opin Endocrinol Diabetes Obes"},{"issue":"2-3","key":"2020071621350416800_B58","first-page":"82","article-title":"Influence of adiposity on leptin, LH and androgen levels in lean, overweight and obese PCOS patients","volume":"52","author":"LaZovic","year":"2007","journal-title":"Int J Fertil Womens Med"},{"issue":"7","key":"2020071621350416800_B59","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1210\/en.2011-2111","article-title":"Androgen effects on adipose tissue architecture and function in nonhuman primates","volume":"153","author":"Varlamov","year":"2012","journal-title":"Endocrinology"},{"issue":"1","key":"2020071621350416800_B60","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13098-015-0040-5","article-title":"The association between hyperandrogenemia and the metabolic syndrome in morbidly obese women","volume":"7","author":"Valderhaug","year":"2015","journal-title":"Diabetol Metab Syndr"},{"issue":"2","key":"2020071621350416800_B61","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1677\/joe.1.05762","article-title":"Androgen generation in adipose tissue in women with simple obesity: a site-specific role for 17beta-hydroxysteroid dehydrogenase type 5","volume":"183","author":"Quinkler","year":"2004","journal-title":"J Endocrinol"},{"key":"2020071621350416800_B62","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/S0140-6736(15)60331-2","article-title":"Effect of insulin on AKR1C3 expression in female adipose tissue: in-vivo and in-vitro study of adipose androgen generation in polycystic ovary syndrome","volume":"385","author":"O\u2019Reilly","year":"2015","journal-title":"Lancet"},{"issue":"2","key":"2020071621350416800_B63","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s00424-005-1410-x","article-title":"Expression of androgen receptor and androgen regulation of NDRG2 in the rat renal collecting duct","volume":"451","author":"Boulkroun","year":"2005","journal-title":"Pflugers Arch"},{"issue":"4","key":"2020071621350416800_B64","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1161\/01.HYP.0000184362.61744.c1","article-title":"Androgen receptor-mediated regulation of the alpha-subunit of the epithelial sodium channel in human kidney","volume":"46","author":"Quinkler","year":"2005","journal-title":"Hypertension"},{"issue":"12","key":"2020071621350416800_B65","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.7150\/ijbs.13109","article-title":"Regulation of androgen receptor expression alters AMPK phosphorylation in the endometrium: in vivo and in vitro studies in women with polycystic ovary syndrome","volume":"11","author":"Li","year":"2015","journal-title":"Int J Biol Sci"},{"issue":"2","key":"2020071621350416800_B66","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1210\/jc.2003-031122","article-title":"Androgen excess in women: experience with over 1000 consecutive patients","volume":"89","author":"Azziz","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2020071621350416800_B67","first-page":"671","article-title":"Drug treatments for polycystic ovary syndrome","volume":"79","author":"Radosh","year":"2009","journal-title":"Am Fam Physician"},{"issue":"4","key":"2020071621350416800_B68","doi-asserted-by":"crossref","first-page":"256","DOI":"10.7326\/M17-0577","article-title":"Cardiovascular disease among transgender adults receiving hormone therapy: a narrative review","volume":"167","author":"Streed","year":"2017","journal-title":"Ann Intern Med"},{"issue":"5","key":"2020071621350416800_B69","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1111\/andr.12382","article-title":"Effects of testosterone therapy on BMI, blood pressure, and laboratory profile of transgender men: a systematic review","volume":"5","author":"Velho","year":"2017","journal-title":"Andrology"},{"issue":"3","key":"2020071621350416800_B70","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S1440-2440(03)80024-5","article-title":"Blood pressure and rate pressure product response in males using high-dose anabolic androgenic steroids (AAS)","volume":"6","author":"Grace","year":"2003","journal-title":"J Sci Med Sport"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jes\/article-pdf\/2\/8\/949\/25249269\/js.2018-00131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jes\/article-pdf\/2\/8\/949\/25249269\/js.2018-00131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,7]],"date-time":"2024-07-07T22:26:10Z","timestamp":1720391170000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/2\/8\/949\/5051324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,10]]},"references-count":70,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2018,8,1]]}},"URL":"https:\/\/doi.org\/10.1210\/js.2018-00131","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,8]]},"published":{"date-parts":[[2018,7,10]]}}}