{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T22:09:32Z","timestamp":1787782172385,"version":"build-2784847793"},"reference-count":46,"publisher":"The Endocrine Society","issue":"1","license":[{"start":{"date-parts":[[2018,11,24]],"date-time":"2018-11-24T00:00:00Z","timestamp":1543017600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG019695"],"award-info":[{"award-number":["R01 AG019695"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 DK073148"],"award-info":[{"award-number":["R01 DK073148"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG029362"],"award-info":[{"award-number":["R01 AG029362"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG031763"],"award-info":[{"award-number":["R01 AG031763"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30 DK050456"],"award-info":[{"award-number":["P30 DK050456"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR000135"],"award-info":[{"award-number":["UL1 TR000135"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000161","name":"National Institute of Standards and Technology","doi-asserted-by":"publisher","award":["60NANB10D005Z"],"award-info":[{"award-number":["60NANB10D005Z"]}],"id":[{"id":"10.13039\/100000161","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,1,1]]},"DOI":"10.1210\/js.2018-00317","type":"journal-article","created":{"date-parts":[[2018,11,23]],"date-time":"2018-11-23T19:02:54Z","timestamp":1542999774000},"page":"235-249","source":"Crossref","is-referenced-by-count":5,"title":["Feedback on LH in Testosterone-Clamped Men Depends on the Mode of Testosterone Administration and Body Composition"],"prefix":"10.1210","volume":"3","author":[{"given":"Ferdinand","family":"Roelfsema","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Section Endocrinology and Metabolism, Leiden University Medical Center, Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J","family":"Yang","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter Y","family":"Liu","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota"},{"name":"Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at University of California Los Angeles, Harbor-University of California Los Angeles Medical Center, and Los Angeles Biomedical Research Institute, Los Angeles, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul Y","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Primary Care Internal Medicine, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6477-7092","authenticated-orcid":false,"given":"Johannes D","family":"Veldhuis","sequence":"additional","affiliation":[{"name":"Endocrine Research Unit, Mayo School of Graduate Medical Education, Center for Translational Science Activities, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2018,11,23]]},"reference":[{"key":"2019041122153361400_B1","first-page":"285","volume-title":"Yen & Jaffe's Reproductive Endocrinology: Physiology, Pathophysiology, and Clinical Management: Eighth Edition","author":"Liu","year":"2018"},{"issue":"47","key":"2019041122153361400_B2","doi-asserted-by":"crossref","first-page":"E10216","DOI":"10.1073\/pnas.1713897114","article-title":"Definition of the hypothalamic GnRH pulse generator in mice","volume":"114","author":"Clarkson","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"2019041122153361400_B3","first-page":"3040","article-title":"Specific linkages among luteinizing hormone, follicle-stimulating hormone, and testosterone release in the peripheral blood and human spermatic vein: evidence for both positive (feed-forward) and negative (feedback) within-axis regulation","volume":"82","author":"Foresta","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019041122153361400_B4","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1210\/jcem-73-3-609","article-title":"Sex steroid control of gonadotropin secretion in the human male. I. Effects of testosterone administration in normal and gonadotropin-releasing hormone-deficient men","volume":"73","author":"Finkelstein","year":"1991","journal-title":"J Clin Endocrinol Metab"},{"issue":"2 Pt 2","key":"2019041122153361400_B5","first-page":"R464","article-title":"Neuroendocrine mechanisms by which selective Leydig cell castration unleashes increased pulsatile LH release","volume":"272","author":"Veldhuis","year":"1997","journal-title":"Am J Physiol"},{"issue":"1","key":"2019041122153361400_B6","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/jcem-64-1-68","article-title":"Influence of age on pulsatile luteinizing hormone release and responsiveness of the gonadotrophs to sex hormone feedback in men","volume":"64","author":"Deslypere","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"issue":"11","key":"2019041122153361400_B7","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/0026-0495(84)90237-3","article-title":"The gonadotropin-suppressive activity of androgen is increased in elderly men","volume":"33","author":"Winters","year":"1984","journal-title":"Metabolism"},{"issue":"7","key":"2019041122153361400_B8","first-page":"2062","article-title":"Disparate serum free testosterone concentrations and degrees of hypothalamo-pituitary-LH suppression are achieved by continuous versus pulsatile intravenous androgen replacement in men: a clinical experimental model of ketoconazole-induced reversible hypoandrogenemia with controlled testosterone add-back","volume":"82","author":"Zwart","year":"1997","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"2019041122153361400_B9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/j.1939-4640.1999.tb02488.x","article-title":"Recent insights into neuroendocrine mechanisms of aging of the human male hypothalamic-pituitary-gonadal axis","volume":"20","author":"Veldhuis","year":"1999","journal-title":"J Androl"},{"issue":"4","key":"2019041122153361400_B10","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1172\/JCI112673","article-title":"Testosterone and estradiol are co-secreted episodically by the human testis","volume":"78","author":"Winters","year":"1986","journal-title":"J Clin Invest"},{"issue":"5 Pt 1","key":"2019041122153361400_B11","first-page":"E652","article-title":"Pituitary and gonadal responsiveness is enhanced during GnRH-induced puberty","volume":"254","author":"Spratt","year":"1988","journal-title":"Am J Physiol"},{"issue":"7","key":"2019041122153361400_B12","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1210\/er.2008-0005","article-title":"Motivations and methods for analyzing pulsatile hormone secretion","volume":"29","author":"Veldhuis","year":"2008","journal-title":"Endocr Rev"},{"key":"2019041122153361400_B13"},{"key":"2019041122153361400_B14"},{"key":"2019041122153361400_B15"},{"key":"2019041122153361400_B16"},{"key":"2019041122153361400_B17","first-page":"E1108","article-title":"Abdominal adiposity rather than age and sex predicts the mass and patterned regularity of growth hormone secretion in mid-life healthy adults","volume":"272","author":"Vahl","year":"1997","journal-title":"Am J Physiol"},{"issue":"6","key":"2019041122153361400_B18","doi-asserted-by":"crossref","first-page":"R1755","DOI":"10.1152\/ajpregu.2001.280.6.R1755","article-title":"Hypothesis testing of the aging male gonadal axis via a biomathematical construct","volume":"280","author":"Keenan","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"2019041122153361400_B19","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1073\/pnas.051624198","article-title":"A feedback-controlled ensemble model of the stress-responsive hypothalamo-pituitary-adrenal axis","volume":"98","author":"Keenan","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2019041122153361400_B20","doi-asserted-by":"crossref","first-page":"R721","DOI":"10.1152\/ajpregu.2001.280.3.R721","article-title":"Secretory process regularity monitors neuroendocrine feedback and feedforward signaling strength in humans","volume":"280","author":"Veldhuis","year":"2001","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"10","key":"2019041122153361400_B21","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1172\/JCI107454","article-title":"Episodic luteinizing hormone secretion in man. Pulse analysis, clinical interpretation, physiologic mechanisms","volume":"52","author":"Santen","year":"1973","journal-title":"J Clin Invest"},{"issue":"3","key":"2019041122153361400_B22","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1530\/JOE-16-0568","article-title":"Effect of androgen on Kiss1 expression and luteinizing hormone release in female rats","volume":"233","author":"Iwata","year":"2017","journal-title":"J Endocrinol"},{"issue":"1","key":"2019041122153361400_B23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/j.1939-4640.1994.tb01674.x","article-title":"The direct pituitary effect of testosterone to inhibit gonadotropin secretion in men is partially mediated by aromatization to estradiol","volume":"15","author":"Bagatell","year":"1994","journal-title":"J Androl"},{"issue":"3","key":"2019041122153361400_B24","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1210\/jc.2007-2156","article-title":"Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men","volume":"93","author":"Pitteloud","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"8","key":"2019041122153361400_B25","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1210\/endo.140.8.6942","article-title":"Regulation of lutenizing hormone secretion and subunit messenger ribonucleic acid expression by gonadal steroids in perifused pituitary cells from male monkeys and rats","volume":"140","author":"Kawakami","year":"1999","journal-title":"Endocrinology"},{"issue":"6","key":"2019041122153361400_B26","first-page":"2600","article-title":"Aromatization mediates testosterone\u2019s short-term feedback restraint of 24-hour endogenously driven and acute exogenous GnRH-stimulated LH and FSH secretion in young men","volume":"86","author":"Schnorr","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"1-6","key":"2019041122153361400_B27","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0022-4731(88)90128-8","article-title":"Aromatase inhibition by the antifungal ketoconazole","volume":"30","author":"Wouters","year":"1988","journal-title":"J Steroid Biochem"},{"issue":"2","key":"2019041122153361400_B28","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/0960-0760(91)90128-R","article-title":"Effect of ketoconazole on human ovarian C17,20-desmolase and aromatase","volume":"38","author":"Weber","year":"1991","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"4","key":"2019041122153361400_B29","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1530\/EJE-09-1085","article-title":"Kinetics of removal of intravenous testosterone pulses in normal men","volume":"162","author":"Veldhuis","year":"2010","journal-title":"Eur J Endocrinol"},{"issue":"3\u20134","key":"2019041122153361400_B30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1159\/000438904","article-title":"Growth-hormone dynamics in healthy adults are related to age and gender, and strongly dependent on body mass index","volume":"103","author":"Roelfsema","year":"2016","journal-title":"Neuroendocrinology"},{"issue":"1","key":"2019041122153361400_B31","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mce.2008.09.005","article-title":"The aging male hypothalamic-pituitary-gonadal axis: pulsatility and feedback","volume":"299","author":"Veldhuis","year":"2009","journal-title":"Mol Cell Endocrinol"},{"issue":"5","key":"2019041122153361400_B32","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/0002-9343(74)90850-X","article-title":"Declining testicular function with age. Hormonal and clinical correlates","volume":"57","author":"Stearns","year":"1974","journal-title":"Am J Med"},{"issue":"2","key":"2019041122153361400_B33","doi-asserted-by":"crossref","first-page":"192","DOI":"10.4103\/1008-682X.122336","article-title":"Late-onset hypogonadism: current concepts and controversies of pathogenesis, diagnosis and treatment","volume":"16","author":"Huhtaniemi","year":"2014","journal-title":"Asian J Androl"},{"issue":"1","key":"2019041122153361400_B34","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1210\/jcem-57-1-71","article-title":"Hormonal changes and sexual function in aging men","volume":"57","author":"Davidson","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019041122153361400_B35","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/humupd\/dmp047","article-title":"The impact of body mass index on semen parameters and reproductive hormones in human males: a systematic review with meta-analysis","volume":"16","author":"MacDonald","year":"2010","journal-title":"Hum Reprod Update"},{"issue":"4","key":"2019041122153361400_B36","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1023\/A:1015238102830","article-title":"Lifestyle and nutritional determinants of bioavailable androgens and related hormones in British men","volume":"13","author":"Allen","year":"2002","journal-title":"Cancer Causes Control"},{"issue":"3","key":"2019041122153361400_B37","first-page":"997","article-title":"Secretion of testosterone and its delta4 precursor steroids into spermatic vein blood in men with varicocele-associated infertility","volume":"84","author":"Winters","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"2019041122153361400_B38","first-page":"1140","article-title":"Attenuated luteinizing hormone (LH) pulse amplitude but normal LH pulse frequency, and its relation to plasma androgens in hypogonadism of obese men","volume":"76","author":"Vermeulen","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2019041122153361400_B39","first-page":"997","article-title":"Pathogenesis of the decreased androgen levels in obese men","volume":"79","author":"Giagulli","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2019041122153361400_B40","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/S0026-0495(03)00186-0","article-title":"Reversal of the hypogonadotropic hypogonadism of obese men by administration of the aromatase inhibitor testolactone","volume":"52","author":"Zumoff","year":"2003","journal-title":"Metabolism"},{"issue":"6","key":"2019041122153361400_B41","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1210\/jcem.86.6.7536","article-title":"Growth hormone (GH) secretion in patients with an inactivating defect of the GH-releasing hormone (GHRH) receptor is pulsatile: evidence for a role for non-GHRH inputs into the generation of GH pulses","volume":"86","author":"Roelfsema","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"issue":"17","key":"2019041122153361400_B42","doi-asserted-by":"crossref","first-page":"E4091","DOI":"10.1073\/pnas.1714239115","article-title":"Ultradian rhythmicity of plasma cortisol is necessary for normal emotional and cognitive responses in man","volume":"115","author":"Kalafatakis","year":"2018","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2019041122153361400_B43","first-page":"96","article-title":"Divergent effects of short term glucocorticoid excess on the gonadotropic and somatotropic axes in normal men","volume":"74","author":"Veldhuis","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"2019041122153361400_B44","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1055\/s-0034-1374589","article-title":"Male and female hypogonadism are highly prevalent in South Africans with Addison\u2019s disease","volume":"46","author":"Ross","year":"2014","journal-title":"Horm Metab Res"},{"issue":"9","key":"2019041122153361400_B45","doi-asserted-by":"crossref","first-page":"4354","DOI":"10.1210\/jc.2010-0445","article-title":"Sexuality and fertility in women with Addison\u2019s disease","volume":"95","author":"Erichsen","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"2019041122153361400_B46","first-page":"736","article-title":"Pulsatile luteinizing hormone secretion in patients with Addison\u2019s disease. Impact of glucocorticoid substitution","volume":"83","author":"Hangaard","year":"1998","journal-title":"J Clin Endocrinol Metab"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jes\/article-pdf\/3\/1\/235\/27386752\/js.2018-00317.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T18:29:01Z","timestamp":1720808941000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/3\/1\/235\/5198611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,23]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,11,23]]},"published-print":{"date-parts":[[2019,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/js.2018-00317","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,1]]},"published":{"date-parts":[[2018,11,23]]}}}