{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T16:25:44Z","timestamp":1782923144647,"version":"3.54.5"},"reference-count":6,"publisher":"The Endocrine Society","issue":"9","license":[{"start":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:00:00Z","timestamp":1560297600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Adrenocortical carcinoma (ACC) is a rare malignancy that usually is detected as a result of symptoms of hormone excess or mass effect. We describe a rare presentation of ACC with primary aldosterone production leading to profound hypokalemia and cardiac arrest. The patient was previously asymptomatic with low-grade, untreated hypertension and no documented electrolyte abnormalities. She had sudden cardiac arrest, and potassium levels were undetectable. After successful resuscitation, imaging showed a 6-cm left adrenal mass highly suspicious for malignancy. Biochemical workup revealed aldosterone excess as well as cortisol excess, despite the absence of Cushingoid symptoms. Histopathological examination after surgical resection demonstrated high-grade ACC. This case illustrates that the workup of cardiac arrest as a result of electrolyte abnormalities should include evaluation for adrenal pathology.<\/jats:p>","DOI":"10.1210\/js.2019-00092","type":"journal-article","created":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T09:10:30Z","timestamp":1560330630000},"page":"1678-1681","source":"Crossref","is-referenced-by-count":5,"title":["Aldosterone-Secreting Adrenocortical Carcinoma Presenting With Cardiac Arrest"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9550-7394","authenticated-orcid":false,"given":"Nicole K","family":"Zern","sequence":"first","affiliation":[{"name":"Division of General Surgery, Department of Surgery, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5025-2001","authenticated-orcid":false,"given":"Keith D","family":"Eaton","sequence":"additional","affiliation":[{"name":"Division of Medical Oncology, Department of Medicine, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3965-9254","authenticated-orcid":false,"given":"Mara Y","family":"Roth","sequence":"additional","affiliation":[{"name":"Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2019,6,12]]},"reference":[{"issue":"1","key":"2019081711250899200_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0022-5347(05)64023-2","article-title":"Adrenocortical carcinoma: diagnosis, evaluation and treatment","volume":"169","author":"Ng","year":"2003","journal-title":"J Urol"},{"issue":"3","key":"2019081711250899200_bib2","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/s12022-014-9307-x","article-title":"Aldosterone-secreting adrenal cortical carcinoma. A case report and review of the literature","volume":"25","author":"Griffin","year":"2014","journal-title":"Endocr Pathol"},{"issue":"4","key":"2019081711250899200_bib3","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1159\/000282795","article-title":"Isolated clinical syndrome of primary aldosteronism in a patient with adrenocortical carcinoma. Case report and review of the literature","volume":"55","author":"Weing\u00e4rtner","year":"1995","journal-title":"Urol Int"},{"key":"2019081711250899200_bib4","unstructured":"National Comprehensive Cancer Network. NCCN Guidelines: Neuroendocrine and Adrenal Tumors. Available at: www.nccn.org\/professionals\/physician_gls\/default.aspx. Accessed 21 December 2018."},{"issue":"6","key":"2019081711250899200_bib5","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/0002-9343(55)90163-7","article-title":"Adrenal cortical carcinoma producing solely mineralocorticoid effect","volume":"19","author":"Foye","year":"1955","journal-title":"Am J Med"},{"issue":"3","key":"2019081711250899200_bib6","first-page":"347","article-title":"Ventricular fibrillation: an extreme presentation of primary hyperaldosteronism","volume":"15","author":"Abdo","year":"1999","journal-title":"Can J Cardiol"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/js.2019-00092\/28790956\/js.2019-00092.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jes\/article-pdf\/3\/9\/1678\/29183720\/js.2019-00092.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,17]],"date-time":"2019-08-17T11:25:24Z","timestamp":1566041124000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/3\/9\/1678\/5513494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,12]]},"references-count":6,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9,1]]}},"URL":"https:\/\/doi.org\/10.1210\/js.2019-00092","relation":{},"ISSN":["2472-1972"],"issn-type":[{"value":"2472-1972","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,9]]},"published":{"date-parts":[[2019,6,12]]}}}