{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:37:47Z","timestamp":1759333067370,"version":"3.37.3"},"reference-count":10,"publisher":"The Endocrine Society","issue":"7","license":[{"start":{"date-parts":[[2019,6,5]],"date-time":"2019-06-05T00:00:00Z","timestamp":1559692800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Dumping syndrome-associated hypoglycemia is caused by an exaggerated hyperinsulinemic response to glucose absorption in the small intestine. Diazoxide acts on the ATP-sensitive potassium channels and prevents insulin secretion and, thus, should be beneficial for the treatment of hypoglycemia secondary to dumping syndrome. We report on the efficacy of diazoxide in a pediatric patient with dumping syndrome. A 6-year-old girl born at 32 weeks\u2019 gestation age with resultant short gut syndrome and liver failure, who had undergone liver, small bowel, and pancreas transplantation at 1 year of age, developed late dumping-like symptoms with postprandial hypoglycemia, headaches, tremors, and irritability. She experienced relief of symptoms with oral intake. An oral glucose tolerance test showed a fasting and 2-hour blood glucose of 3.9 and 2.8 mmol\/L, respectively. A gastric emptying study confirmed the diagnosis of dumping. A diet with 2 g of fiber and cornstarch and antimotility medications failed to improve the dumping symptoms. Diazoxide was started orally at a dose of 3 mg\/kg\/d and was increased to 5 mg\/kg\/d, divided every 8 hours, after 1 month, with improvement of postprandial blood glucose values (3.6 to 5.0 mmol\/L). No hypertrichosis, fluid retention, respiratory concerns, or other side effects were noted. Several duodenal dilations were performed, with resultant improvement of gastric emptying. She was eventually weaned from diazoxide, and no further episodes of substantial hypoglycemia occurred. In conclusion, diazoxide was efficacious and safe for the treatment of hypoglycemia secondary to dumping syndrome in children. It could be of particular use as a bridging therapy for children awaiting more definitive surgical interventions.<\/jats:p>","DOI":"10.1210\/js.2019-00120","type":"journal-article","created":{"date-parts":[[2019,6,13]],"date-time":"2019-06-13T09:59:49Z","timestamp":1560419989000},"page":"1357-1360","source":"Crossref","is-referenced-by-count":5,"title":["Diazoxide for the Treatment of Hypoglycemia Resulting From Dumping Syndrome in a Child"],"prefix":"10.1210","volume":"3","author":[{"given":"Juan D","family":"Mejia-Otero","sequence":"first","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen K","family":"Grishman","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5926-7784","authenticated-orcid":false,"given":"Nivedita","family":"Patni","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","published-online":{"date-parts":[[2019,6,5]]},"reference":[{"issue":"9","key":"2019070309425775000_bib1","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1093\/qjmed\/hcr234","article-title":"Diazoxide for the treatment of hypoglycaemic dumping syndrome","volume":"106","author":"Thondam","year":"2013","journal-title":"QJM"},{"issue":"1","key":"2019070309425775000_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.orcp.2015.07.003","article-title":"Recognition and management of hyperinsulinemic hypoglycemia after bariatric surgery","volume":"10","author":"Malik","year":"2016","journal-title":"Obes Res Clin Pract"},{"issue":"5-6","key":"2019070309425775000_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/s003830000525","article-title":"Dumping syndrome: a common problem following Nissen fundoplication in young children","volume":"17","author":"Bufler","year":"2001","journal-title":"Pediatr Surg Int"},{"issue":"2","key":"2019070309425775000_bib4","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1159\/000442155","article-title":"Postprandial hypoglycemia in children after gastric surgery: clinical characterization and pathophysiology","volume":"85","author":"Calabria","year":"2016","journal-title":"Horm Res Paediatr"},{"issue":"12","key":"2019070309425775000_bib5","doi-asserted-by":"crossref","first-page":"4563","DOI":"10.1210\/jc.2007-2260","article-title":"Incretin hypersecretion in post-gastric bypass hypoglycemia\u2014primary problem or red herring","volume":"92","author":"Vella","year":"2007","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"2019070309425775000_bib6","doi-asserted-by":"crossref","first-page":"2308","DOI":"10.2337\/db11-0203","article-title":"Gastric bypass surgery enhances glucagon-like peptide 1-stimulated postprandial insulin secretion in humans","volume":"60","author":"Salehi","year":"2011","journal-title":"Diabetes"},{"issue":"8","key":"2019070309425775000_bib7","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1210\/jc.2018-00528","article-title":"Hypoglycemia after gastric bypass surgery: current concepts and controversies","volume":"103","author":"Salehi","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"issue":"4","key":"2019070309425775000_bib8","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.cgh.2008.11.025","article-title":"Efficacy of the long-acting repeatable formulation of the somatostatin analogue octreotide in postoperative dumping","volume":"7","author":"Arts","year":"2009","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"2019070309425775000_bib9","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1530\/EJE-11-1065","article-title":"Prolonged successful therapy for hyperinsulinaemic hypoglycaemia after gastric bypass: the pathophysiological role of GLP1 and its response to a somatostatin analogue","volume":"166","author":"Myint","year":"2012","journal-title":"Eur J Endocrinol"},{"issue":"6","key":"2019070309425775000_bib10","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1542\/peds.80.6.937","article-title":"Hypoglycemia pathogenesis in children with dumping syndrome","volume":"80","author":"Rivkees","year":"1987","journal-title":"Pediatrics"}],"container-title":["Journal of the Endocrine Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jes\/advance-article-pdf\/doi\/10.1210\/js.2019-00120\/28760534\/js.2019-00120.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jes\/article-pdf\/3\/7\/1357\/28900665\/js.2019-00120.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T17:44:03Z","timestamp":1663695843000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jes\/article\/3\/7\/1357\/5510494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,5]]},"references-count":10,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2019,6,5]]},"published-print":{"date-parts":[[2019,7,1]]}},"URL":"https:\/\/doi.org\/10.1210\/js.2019-00120","relation":{},"ISSN":["2472-1972"],"issn-type":[{"type":"electronic","value":"2472-1972"}],"subject":[],"published-other":{"date-parts":[[2019,7]]},"published":{"date-parts":[[2019,6,5]]}}}