{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T14:55:41Z","timestamp":1789052141057,"version":"build-2803163510"},"reference-count":39,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T00:00:00Z","timestamp":1564963200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Office of Research and Development of the Department of Veterans Affairs","award":["1 IK CX 001043-01A2"],"award-info":[{"award-number":["1 IK CX 001043-01A2"]}]},{"name":"Office of Research and Development of the Department of Veterans Affairs","award":["IK2-CX001266-01"],"award-info":[{"award-number":["IK2-CX001266-01"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["K24-DK091419"],"award-info":[{"award-number":["K24-DK091419"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["R01-DK078106"],"award-info":[{"award-number":["R01-DK078106"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["K23-DK102903"],"award-info":[{"award-number":["K23-DK102903"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK119498"],"award-info":[{"award-number":["DK119498"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DA034009"],"award-info":[{"award-number":["DA034009"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK114978"],"award-info":[{"award-number":["DK114978"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH-National Center for Research Resources and National Center for Advancing Translational Sciences","award":["UL1 TR001414"],"award-info":[{"award-number":["UL1 TR001414"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Previous studies have shown that the endocannabinoid system plays a major role in energy metabolism through the actions of its main mediators, 2-arachidonoyl-sn-glycerol (2-AG) and anandamide (AEA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We examined serum levels of major endocannabinoid mediators and their association with clinical parameters in patients with end-stage renal disease (ESRD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design and Setting<\/jats:title>\n                  <jats:p>Serum concentrations of 2-AG and AEA were measured in patients on maintenance hemodialysis (MHD) and controls, and correlations with various clinical and laboratory indices were examined. 2-AG was also measured in age and sex-matched healthy subjects for comparison of levels in patients undergoing MHD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main Outcome Measure<\/jats:title>\n                  <jats:p>Serum 2-AG.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Serum 2-AG levels were significantly elevated in patients with ESRD compared with healthy controls. Higher levels of 2-AG were found in patients on MHD compared to healthy subjects, and similar findings were seen in a second set of subjects in independent analyses. Among 96 patients on MHD, 2-AG levels correlated significantly and positively with serum triglycerides (\u03c1 = 0.43; P &lt; 0.0001), body mass index (\u03c1 = 0.40; P &lt; 0.0001), and body anthropometric measures and negatively with serum high-density lipoprotein cholesterol (\u03c1 = \u22120.33; P = 0.001) following adjustment for demographic and clinical variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In patients on MHD, levels of serum 2-AG, a major endocannabinoid mediator, were increased. In addition, increasing serum 2-AG levels correlated with increased serum triglycerides and markers of body mass. Future studies will need to evaluate the potential mechanisms responsible for these findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/js.2019-00242","type":"journal-article","created":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T14:48:14Z","timestamp":1565189294000},"page":"1869-1880","source":"Crossref","is-referenced-by-count":13,"title":["Serum Endocannabinoid Levels in Patients With End-Stage Renal Disease"],"prefix":"10.1210","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7752-3622","authenticated-orcid":false,"given":"Hamid","family":"Moradi","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, University of California Irvine School of Medicine, Irvine, California"},{"name":"Tibor Rubin Veterans Affairs Medical Center, Long Beach, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Nephrology and 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