{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:36:49Z","timestamp":1790768209447,"version":"4.1.0"},"reference-count":41,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Steroid receptor coactivator-1 (SRC-1) is a transcription cofactor that enhances the hormone-dependent action mediated by the thyroid hormone (TH) receptor (TR) as well as other nuclear receptors. However, it is not known whether the SRC-1-mediated activation of TH-regulated gene transcription is TR isoform specific in the pituitary. We generated mice that were deficient in TR\u03b1 and SRC-1 (TR\u03b10\/0SRC-1\u2212\/\u2212), as well in TR\u03b2 and SRC-1 (TR\u03b2\u2212\/\u2212SRC-1\u2212\/\u2212), and thyroid function tests and effects of TH deprivation and TH treatment were compared with wild-type mice or mice with deletion of either TRs or SRC-1 alone. We have shown that 1) TR\u03b2\u2212\/\u2212SRC-1\u2212\/\u2212 mice demonstrate more severe TH resistance than either the SRC-1\u2212\/\u2212 or TR\u03b2\u2212\/\u2212 mice; the additive effect indicates that SRC-1 has an independent role in TH action over that of TR\u03b2; 2) SRC-1 facilitates TR\u03b2 and TR\u03b1-mediated down-regulation of TSH, as TR\u03b10\/0SRC-1\u2212\/\u2212 mice demonstrate TH resistance rather than hypersensitivity as seen in TR\u03b10\/0mice; and 3) a compensatory increase in SRC-1 expression is associated with the TH hypersensitivity seen in TR\u03b1-deficient animals. We conclude that SRC-1 action in the pituitary mediates TH action via specific TR subtypes.<\/jats:p>","DOI":"10.1210\/me.2002-0174","type":"journal-article","created":{"date-parts":[[2003,4,25]],"date-time":"2003-04-25T22:18:59Z","timestamp":1051309139000},"page":"882-894","source":"Crossref","is-referenced-by-count":24,"title":["Thyroid Hormone Receptor-Specific Interactions with Steroid Receptor Coactivator-1 in the Pituitary"],"prefix":"10.1210","volume":"17","author":[{"given":"Peter M.","family":"Sadow","sequence":"first","affiliation":[{"name":"Departments of Medicine (P.M.S., E.K., R.E.W.), Chicago, Illinois 60637"},{"name":"Pathology (P.M.S.), The University of Chicago, Chicago, Illinois 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene","family":"Koo","sequence":"additional","affiliation":[{"name":"Departments of Medicine (P.M.S., E.K., R.E.W.), Chicago, Illinois 60637"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Chassande","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Moleculaire et Cellulaire de l\u2019Ecole Normale Supe\u0301rieure de Lyon (O.C., K.G., J.S.), Lyon 69364, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Gauthier","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Moleculaire et Cellulaire de l\u2019Ecole Normale Supe\u0301rieure de Lyon (O.C., K.G., J.S.), Lyon 69364, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Samarut","sequence":"additional","affiliation":[{"name":"Laboratoire de Biologie Moleculaire et Cellulaire de l\u2019Ecole Normale Supe\u0301rieure de Lyon (O.C., K.G., J.S.), Lyon 69364, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianming","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology (J.X., B.W.O\u2019M.), Baylor College of Medicine, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert W.","family":"O\u2019Malley","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology (J.X., B.W.O\u2019M.), Baylor College of Medicine, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisao","family":"Seo","sequence":"additional","affiliation":[{"name":"Research Institute of Environmental Medicine (H.S., Y.M.), Nagoya University, Nagoya 464-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiharu","family":"Murata","sequence":"additional","affiliation":[{"name":"Research Institute of Environmental Medicine (H.S., Y.M.), Nagoya University, Nagoya 464-8601, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy E.","family":"Weiss","sequence":"additional","affiliation":[{"name":"Departments of 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