{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:24:29Z","timestamp":1790702669107,"version":"4.1.0"},"reference-count":65,"publisher":"The Endocrine Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,1,1]]},"DOI":"10.1210\/me.2002-0223","type":"journal-article","created":{"date-parts":[[2003,1,2]],"date-time":"2003-01-02T20:24:19Z","timestamp":1041539059000},"page":"11-26","source":"Crossref","is-referenced-by-count":26,"title":["A Central Role for Ets-2 in the Transcriptional Regulation and Cyclic Adenosine 5\u2032-Monophosphate Responsiveness of the Human Chorionic Gonadotropin-\u03b2 Subunit Gene"],"prefix":"10.1210","volume":"17","author":[{"given":"Debjani","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Animal Sciences (D.G., T.E., R.M.R.), University of Missouri, Columbia, Missouri 65211"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Ezashi","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences (D.G., T.E., R.M.R.), University of Missouri, Columbia, Missouri 65211"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael C.","family":"Ostrowski","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics (M.C.O.), Ohio State University, Columbus, Ohio 43210"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Michael","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences (D.G., T.E., R.M.R.), University of Missouri, Columbia, Missouri 65211"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041123251475200_R1","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1146\/annurev.bi.50.070181.002341","article-title":"Glycoprotein hormones: structure and function.","volume":"50","author":"Pierce","year":"1981","journal-title":"Annu Rev Biochem"},{"key":"2019041123251475200_R2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/307037a0","article-title":"Evolution of the genes for the \u03b2 subunits of human chorionic gonadotropin and luteinizing hormone.","volume":"307","author":"Talmadge","year":"1984","journal-title":"Nature"},{"key":"2019041123251475200_R3","first-page":"203","article-title":"Regulation of chorionic gonadotropin gene expression.","volume":"14","author":"Jameson","year":"1993","journal-title":"Endocr Rev"},{"key":"2019041123251475200_R4","doi-asserted-by":"crossref","first-page":"5907","DOI":"10.1016\/S0021-9258(17)38469-7","article-title":"A map of the hCG\u03b2-LH\u03b2 gene cluster.","volume":"261","author":"Policastro","year":"1986","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R5","doi-asserted-by":"crossref","first-page":"3179","DOI":"10.1016\/S0021-9258(19)50712-8","article-title":"Identification of the transcriptionally active genes of the chorionic gonadotropin \u03b2 gene cluster in vivo.","volume":"267","author":"Bo","year":"1992","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1210\/jcem-64-2-319","article-title":"Gonadotropin and thyrotropin \u03b1- and \u03b2-subunit gene expression in normal and neoplastic tissues characterized using specific messenger ribonucleic acid hybridization probes.","volume":"64","author":"Jameson","year":"1987","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041123251475200_R7","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1074\/jbc.271.28.16683","article-title":"Silencing of the gene for the \u03b2 subunit of human chorionic gonadotropin by the embryonic transcription factor Oct-3\/4.","volume":"271","author":"Liu","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R8","first-page":"1651","article-title":"Silencing of the gene for the \u03b1-subunit of human chorionic gonadotropin by embryonic transcription factor Oct-3\/4.","volume":"11","author":"Liu","year":"1997","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R9","doi-asserted-by":"crossref","first-page":"7322","DOI":"10.1016\/S0021-9258(18)68645-4","article-title":"Identification of a promoter region in the CG\u03b2 gene cluster.","volume":"263","author":"Otani","year":"1988","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R10","first-page":"1579","article-title":"Coordinate control of the \u03b1- and \u03b2-subunit genes of human chorionic gonadotropin by trophoblast specific element binding protein.","volume":"7","author":"Steger","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1210\/mend-5-5-693","article-title":"Novel cyclic adenosine 3\u2032, 5\u2032 monophosphate response element in the human chorionic gonadotropin \u03b2-subunit gene.","volume":"5","author":"Albanese","year":"1991","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R12","doi-asserted-by":"crossref","first-page":"31090","DOI":"10.1016\/S0021-9258(18)47394-2","article-title":"c-Jun represses transcription of the human chorionic gonadotropin \u03b1 and \u03b2 genes through distinct types of CREs.","volume":"269","author":"Pestell","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R13","first-page":"1963","article-title":"AP-2 (activating protein 2) and Sp1 (selective promoter factor 1) regulatory elements play distinct roles in the control of basal activity and cyclic adenosine 3\u2032, 5\u2032 monophosphate responsiveness of the human chorionic gonadotropin \u03b2 promoter.","volume":"13","author":"Johnson","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R14","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1210\/mend.13.3.0243","article-title":"Identification of a placental specific enhancer in the rat placental lactogen II gene that contains binding sites for members of the Ets and AP1 (activator protein1) families of transcription factors.","volume":"13","author":"Sun","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R15","doi-asserted-by":"crossref","first-page":"7882","DOI":"10.1073\/pnas.95.14.7882","article-title":"Control of interferon \u03b9 gene expression by Ets2.","volume":"95","author":"Ezashi","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123251475200_R16","first-page":"1084","article-title":"Stimulation of the P-450 side chain cleavage enzyme (CYP11A1) promoter through ras- and Ets-2-signaling pathways.","volume":"10","author":"Pestell","year":"1996","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R17","doi-asserted-by":"crossref","first-page":"4032","DOI":"10.1210\/endo.140.9.6954","article-title":"Transcriptional activation of the decidual\/trophoblast prolactin related protein gene.","volume":"140","author":"Orwig","year":"1999","journal-title":"Endocrinol"},{"key":"2019041123251475200_R18","first-page":"2297","article-title":"Erg, an Ets-family member, differentially regulates human collagenase1 (MMP1) and stromelysin1 (MMP3) gene expression by physically interacting with the Fos\/jun complex.","volume":"13","author":"Buttice","year":"1996","journal-title":"Oncogene"},{"key":"2019041123251475200_R19","doi-asserted-by":"crossref","first-page":"17342","DOI":"10.1074\/jbc.274.24.17342","article-title":"P300\/cAMP-responsive element binding protein interactions with Ets-1 and Ets-2 in the transcriptional activation of the human stromelysin promoter.","volume":"274","author":"Jayaraman","year":"1999","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1002\/(SICI)1097-0215(19980703)77:1<128::AID-IJC20>3.0.CO;2-9","article-title":"The Ets-1 and Ets-2 transcription factors activate the promoters for invasion-associated urokinase and collagenase genes in response to epidermal growth factor.","volume":"77","author":"Watabe","year":"1998","journal-title":"Int J Cancer"},{"key":"2019041123251475200_R21","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1101\/gad.12.9.1315","article-title":"Defective trophoblast function in mice with a targeted mutation of Ets-2.","volume":"12","author":"Yamamoto","year":"1998","journal-title":"Genes Dev"},{"key":"2019041123251475200_R22","first-page":"615","article-title":"The Ets-family of proteins: weak modulators of gene expression in quest for transcriptional partners.","volume":"5","author":"Crepieux","year":"1994","journal-title":"Crit Rev Oncogene"},{"key":"2019041123251475200_R23","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1101\/gad.4.9.1451","article-title":"The Ets-domain: a new DNA-binding motif that recognizes a purin-rich core DNA sequence.","volume":"4","author":"Karim","year":"1990","journal-title":"Genes Dev"},{"key":"2019041123251475200_R24","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S1357-2725(97)00086-1","article-title":"The Ets-domain transcription factor family.","volume":"29","author":"Sharrocks","year":"1997","journal-title":"Int J Biochem Cell Biol"},{"key":"2019041123251475200_R25","first-page":"179","article-title":"Transactivation through Ets and AP-1 transcription sites determines the expression of the tumor-suppressing gene Maspin.","volume":"8","author":"Zhang","year":"1997","journal-title":"Cell Growth Differ"},{"key":"2019041123251475200_R26","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1074\/jbc.271.2.774","article-title":"Synergistic transcriptional activation of the tissue inhibitor of Metalloproteinases-1 promoter via functional interaction of AP-1 and Ets-1 transcription factors.","volume":"271","author":"Logan","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R27","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/mend.11.8.9958","article-title":"Fibroblast growth factor activates the human interstitial collagenase promoter via the bipartite Ets-AP1 element.","volume":"11","author":"Newberry","year":"1997","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R28","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1074\/jbc.275.5.3100","article-title":"The Pit-1 homeodomain and \u03b2-domain interact with Ets-1 and modulate synergistic activation of the rat prolactin promoter.","volume":"275","author":"Bradford","year":"2000","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R29","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1128\/MCB.16.2.538","article-title":"Ras mediated phosphorylation of a conserved threonine residue enhances the transactivation activity of cEts1 and cEts2.","volume":"16","author":"Yang","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2019041123251475200_R30","doi-asserted-by":"crossref","first-page":"5148","DOI":"10.1128\/MCB.18.9.5148","article-title":"Persistent activation of Mitogen-activated protein kinase p42 and p44 and ets-2 phosphorylation in response to colony stimulating factor 1\/c-fms signaling.","volume":"18","author":"Fowles","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041123251475200_R31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/0092-8674(94)90580-0","article-title":"The activities of two Ets-related transcription factors required for Drosophila eye development are modulated by Ras\/MAP kinase pathway.","volume":"78","author":"O\u2019Neill","year":"1994","journal-title":"Cell"},{"key":"2019041123251475200_R32","first-page":"1","article-title":"Specificity within the ets family of transcriotion factors. Advances in cancer research.","volume":"75","author":"Graves","year":"1998","journal-title":"San Diego: Academic Press;"},{"key":"2019041123251475200_R33","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0303-7207(00)00269-0","article-title":"Role of Ets-2 in cyclic AMP regulation of the human chorionic gonadotropin \u03b2 promoter.","volume":"165","author":"Johnson","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"2019041123251475200_R34","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1073\/pnas.90.16.7588","article-title":"The Ets1 transcription factor is widely expressed during murine embryo development and is associated with mesodermal cells involved in morphogenetic processes such as organ formation.","volume":"90","author":"Kola","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123251475200_R35","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1128\/MCB.17.5.2401","article-title":"Rapid phosphorylation of Ets2 accompanies mitogen activated protein kinase activation and the induction of heparin-binding epidermal growth factor gene expression by oncogenic Raf-1.","volume":"17","author":"McCarthy","year":"1997","journal-title":"Mol Cell Biol"},{"key":"2019041123251475200_R36","doi-asserted-by":"crossref","first-page":"27489","DOI":"10.1074\/jbc.270.46.27489","article-title":"PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo.","volume":"270","author":"Alessi","year":"1995","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R37","doi-asserted-by":"crossref","first-page":"7686","DOI":"10.1073\/pnas.92.17.7686","article-title":"A synthetic inhibitor of the mitogen-activated protein kinase cascade.","volume":"92","author":"Dudley","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123251475200_R38","doi-asserted-by":"crossref","first-page":"18623","DOI":"10.1074\/jbc.273.29.18623","article-title":"Identification of a novel inhibitor of mitogen-activated protein kinase kinase.","volume":"273","author":"Favata","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R39","doi-asserted-by":"crossref","first-page":"32111","DOI":"10.1074\/jbc.273.48.32111","article-title":"Specific inhibitors of p38 mitogen-activated protein kinase block 3T3-L1 adipogenesis.","volume":"273","author":"Engelman","year":"1998","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R40","doi-asserted-by":"crossref","first-page":"40968","DOI":"10.1074\/jbc.M010890200","article-title":"High intensity ERK signal mediates hepatocytes growth factor induced proliferation inhibition of the human hepatocellular carcinoma cell line HepG2.","volume":"276","author":"Tsukada","year":"2001","journal-title":"J Biol Chem"},{"key":"2019041123251475200_R41","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1095\/biolreprod65.2.358","article-title":"Involvement of MEK-mitogen activated protein kinase pathway in follicle-stimulating hormone-induced but not spontaneous meiotic resumption of mouse oocytes.","volume":"65","author":"Su","year":"2001","journal-title":"Biol Reprod"},{"key":"2019041123251475200_R42","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1093\/nar\/28.4.1036","article-title":"AP-2 family members regulate basal and cAMP-induced expression of human chorionic gonadotropin.","volume":"28","author":"LiCalsi","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2019041123251475200_R43","first-page":"43","article-title":"Structure, expression and evolution of the genes for the human glycoprotein hormones.","volume":"40","author":"Fiddes","year":"1984","journal-title":"Recent Prog Horm Res"},{"key":"2019041123251475200_R44","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1210\/edrv-11-1-105","article-title":"In vitro systems for the study of human placental endocrine function.","volume":"11","author":"Ringler","year":"1990","journal-title":"Endocr Rev"},{"key":"2019041123251475200_R45","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1002\/j.1460-2075.1991.tb08053.x","article-title":"The cEts oncoprotein activates the stromelysin promoter through the same elements as several non nuclear oncoproteins.","volume":"10","author":"Wasylyk","year":"1991","journal-title":"EMBO J"},{"key":"2019041123251475200_R46","first-page":"2913","article-title":"Oncogenic Ras can induce transcriptional activation through a variety of promoter elements, including tandem c-Ets-2 binding sites.","volume":"9","author":"Galang","year":"1994","journal-title":"Oncogene"},{"key":"2019041123251475200_R47","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1002\/j.1460-2075.1990.tb07394.x","article-title":"The collagenase gene promoter contains a TPA and oncogene-responsive unit encompassing the PEA3 and AP-1 binding sites.","volume":"9","author":"Gutman","year":"1990","journal-title":"EMBO J"},{"key":"2019041123251475200_R48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1385\/ENDO:12:1:47","article-title":"Mitogen activated protein kinase activates human placental lactogen-B enhancer by an NF-IL6-dependent pathway.","volume":"12","author":"Brar","year":"2000","journal-title":"Endocrine"},{"key":"2019041123251475200_R49","doi-asserted-by":"crossref","first-page":"3331","DOI":"10.1128\/MCB.20.10.3331-3344.2000","article-title":"Role of the cyclic AMP response element binding complex and activation of mitogen-activated protein kinases in synergistic activation of the glycoprotein hormone \u03b1 subunit gene by epidermal growth factor and forscolin.","volume":"20","author":"Roberson","year":"2000","journal-title":"Mol Cell Biol"},{"key":"2019041123251475200_R50","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1046\/j.1432-1327.2000.01140.x","article-title":"A protein kinase C-independent pathway leading to c-Jun dependent expression of 100-kDa Ras GTPase-activating protein in JEG-3 human choriocarcinoma cells.","volume":"267","author":"Ye","year":"2000","journal-title":"Eur J Biochem"},{"key":"2019041123251475200_R51","first-page":"623","article-title":"Roles of Ras genes on biological properties of human choriocarcinoma cells.","volume":"70","author":"Watari","year":"1995","journal-title":"Hokkaido Igaku Zasshi"},{"key":"2019041123251475200_R52","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1046\/j.1432-1327.1998.2530545.x","article-title":"Mitogen-activated protein kinase is involved in epidermal-growth-factor-regulated protein phosphorylation in nuclear membranes isolated from JEG-3 human choriocarcinoma cells.","volume":"253","author":"Bian","year":"1998","journal-title":"Eur J Biochem"},{"key":"2019041123251475200_R53","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1067\/mob.2000.104225","article-title":"Keratinocyte growth factor in the promotion of human chorionic gonadotropin production in human choriocarcinoma cells.","volume":"182","author":"Taniguchi","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"2019041123251475200_R54","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1006\/excr.1994.1232","article-title":"Demonstration of functional cytokine-placental interaction: CSF-1 and GM-CSF stimulate human cytotrophoblast differentiation and peptide hormone secretion.","volume":"214","author":"Garcia-Lloret","year":"1994","journal-title":"Exp Cell Res"},{"key":"2019041123251475200_R55","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1128\/MCB.8.12.5100","article-title":"Isolation and characterization of the human chorionic gonadotropin \u03b2 subunit (CG\u03b2) gene cluster: regulation of a transcriptionally active CG\u03b2 gene by cyclic AMP.","volume":"8","author":"Jameson","year":"1988","journal-title":"Mol Cell Biol"},{"key":"2019041123251475200_R56","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1210\/mend-5-4-582","article-title":"Bromo-adenosine stimulates choriogonadotropin production in JAr and cytotrophoblast cells: evidence for effects on two stages of differentiation.","volume":"5","author":"Sibley","year":"1991","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R57","first-page":"614","article-title":"Analysis of the role of the mitogen-activated protein kinase in mediating cyclic-adenosine 3\u2032, 5\u2032-monophosphate effects on prolactin promoter activity.","volume":"15","author":"Kievit","year":"2001","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R58","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1128\/MCB.21.23.7883-7891.2001","article-title":"Repression of Ets-2 induced transactivation of the \u03c4 interferon promoter by Oct-4.","volume":"21","author":"Ezashi","year":"2001","journal-title":"Mol Cell Biol"},{"key":"2019041123251475200_R59","first-page":"181","article-title":"Trophoblast-specific transcription from the mouse placental lactogen-1 gene promoter.","volume":"7","author":"Shida","year":"1993","journal-title":"Mol Endocrinol"},{"key":"2019041123251475200_R60","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0092-8674(90)90589-7","article-title":"Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation.","volume":"60","author":"Tanaka","year":"1990","journal-title":"Cell"},{"key":"2019041123251475200_R61","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/310469a0","article-title":"Malignant transformation of early passage rodent cells by a single mutated human oncogene.","volume":"310","author":"Spandidos","year":"1984","journal-title":"Nature"},{"key":"2019041123251475200_R62","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MCB.10.1.1","article-title":"Ras oncogene activation of a VL30 transcriptional element is linked to transformation.","volume":"10","author":"Owen","year":"1990","journal-title":"Mol Cell Biol"},{"key":"2019041123251475200_R63","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1016\/S0076-6879(80)65059-9","article-title":"Sequencing end-labeled DNA with base-specific chemical cleavages.","volume":"65","author":"Maxam","year":"1980","journal-title":"Methods Enzymol"},{"key":"2019041123251475200_R64","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal Biochem"},{"key":"2019041123251475200_R65","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Res"}],"container-title":["Molecular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mend\/article-pdf\/17\/1\/11\/8962686\/mend0011.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,30]],"date-time":"2021-05-30T19:19:14Z","timestamp":1622402354000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mend\/article\/17\/1\/11\/2741656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1,1]]}},"URL":"https:\/\/doi.org\/10.1210\/me.2002-0223","relation":{},"ISSN":["0888-8809","1944-9917"],"issn-type":[{"value":"0888-8809","type":"print"},{"value":"1944-9917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1,1]]}}}