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CRF-induced cAMP was amplified 15-fold by arginine-vasopressin (AVP) or phorbol-dibutyrate ester. In the presence of inhibitors of cyclic nucleotide phosphodiesterases and phorbol-dibutyrate ester, the depletion of Ca2+ stores had no further effect on CRF-induced cAMP accumulation. Adenohypophysial expression of mRNAs for the Ca2+-inhibited adenylyl cyclases (ACs) VI and IX, and the protein kinase C-stimulated ACs II and VII was demonstrated. ACIX was detected in corticotropes by immunocytochemistry, whereas ACII and ACVI were not present. The data show negative feedback regulation of CRF-induced cAMP levels by Ca2+ derived from ryanodine receptor-operated intracellular stores. Stimulation of protein kinase C by AVP enhances Ca2+-independent cAMP synthesis, thus changing the characteristics of intracellular Ca2+ feedback. It is proposed that the modulation of intracellular Ca2+ feedback in corticotropes by AVP is an important element of physiological control.<\/jats:p>","DOI":"10.1210\/me.2002-0369","type":"journal-article","created":{"date-parts":[[2003,3,27]],"date-time":"2003-03-27T01:44:36Z","timestamp":1048729476000},"page":"692-703","source":"Crossref","is-referenced-by-count":31,"title":["Short-Term Plasticity of Cyclic Adenosine 3\u2032,5\u2032-Monophosphate Signaling in Anterior Pituitary Corticotrope Cells: The Role of Adenylyl Cyclase Isotypes"],"prefix":"10.1210","volume":"17","author":[{"given":"Ferenc A.","family":"Antoni","sequence":"first","affiliation":[{"name":"Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.","family":"Sosunov","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Hauns\u00f8","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice M.","family":"Paterson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2020071614252817300_R1","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1006\/frne.1993.1004","article-title":"Vasopressinergic control of anterior pituitary adrenocorticotropin secretion comes of age.","volume":"14","author":"Antoni","year":"1993","journal-title":"Front Neuroendocrinol"},{"key":"2020071614252817300_R2","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2826.1992.tb00200.x","article-title":"Stress, feedback and facilitation on the hypothalamo-pituitary-adrenal axis.","volume":"4","author":"Dallman","year":"1992","journal-title":"J Neuroendocrinol"},{"key":"2020071614252817300_R3","first-page":"55","article-title":"How do glucocorticoids influence stress responses? 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