{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T05:54:47Z","timestamp":1791352487016,"version":"4.3.1"},"reference-count":30,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,1]]},"DOI":"10.1210\/me.2003-0281","type":"journal-article","created":{"date-parts":[[2003,9,23]],"date-time":"2003-09-23T01:33:15Z","timestamp":1064280795000},"page":"2386-2392","source":"Crossref","is-referenced-by-count":340,"title":["A Crucial Role for the Vitamin D Receptor in Experimental Inflammatory Bowel Diseases"],"prefix":"10.1210","volume":"17","author":[{"given":"Monica","family":"Froicu","sequence":"first","affiliation":[{"name":"Department of Nutrition (M.F., V.W., M.T.C.), University Park, Pennsylvania 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronika","family":"Weaver","sequence":"additional","affiliation":[{"name":"Department of Nutrition (M.F., V.W., M.T.C.), University Park, Pennsylvania 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Wynn","sequence":"additional","affiliation":[{"name":"Immunopathogenesis Section (T.A.W.), National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Ann","family":"McDowell","sequence":"additional","affiliation":[{"name":"Department of Biology (M.A.M., J.E.W.), Notre Dame University, South Bend, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Ellen","family":"Welsh","sequence":"additional","affiliation":[{"name":"Department of Biology (M.A.M., J.E.W.), Notre Dame University, South Bend, Indiana 46556"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margherita T.","family":"Cantorna","sequence":"additional","affiliation":[{"name":"Department of Nutrition (M.F., V.W., M.T.C.), University Park, Pennsylvania 16802"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041123522585500_R1","doi-asserted-by":"crossref","first-page":"7861","DOI":"10.1073\/pnas.93.15.7861","article-title":"1, 25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.","volume":"93","author":"Cantorna","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123522585500_R2","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1093\/jn\/130.11.2648","article-title":"1, 25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease.","volume":"130","author":"Cantorna","year":"2000","journal-title":"J Nutr"},{"key":"2019041123522585500_R3","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1097\/00007890-199810150-00002","article-title":"Prolongation of allograft survival by 1, 25-dihydroxyvitamin D3.","volume":"66","author":"Hullett","year":"1998","journal-title":"Transplantation"},{"key":"2019041123522585500_R4","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1097\/00007890-199810150-00003","article-title":"1, 25-Dihydroxyvitamin D3 prolongs graft survival without compromising host resistance to infection or bone mineral density.","volume":"66","author":"Cantorna","year":"1998","journal-title":"Transplantation"},{"key":"2019041123522585500_R5","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1210\/jcem-57-6-1308","article-title":"Specific high-affinity receptors for 1, 25-dihydroxyvitamin D3 in human peripheral blood mononuclear cells: presence in monocytes and induction in T lymphocytes following activation.","volume":"57","author":"Bhalla","year":"1983","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041123522585500_R6","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1126\/science.6310748","article-title":"1, 25-Dihydroxyvitamin D3 receptors in human leukocytes.","volume":"221","author":"Provvedini","year":"1983","journal-title":"Science"},{"key":"2019041123522585500_R7","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/jcb.240490106","article-title":"Immunomodulatory role of 1, 25-dihydroxyvitamin D3.","volume":"49","author":"Lemire","year":"1992","journal-title":"J Cell Biochem"},{"key":"2019041123522585500_R8","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1002\/jcb.10580","article-title":"The targets of vitamin D depend on the differentiation and activation status of the CD4 positive T cells.","volume":"89","author":"Mahon","year":"2003","journal-title":"J Cell Biochem"},{"key":"2019041123522585500_R9","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/jcb.10340","article-title":"Tolerogenic dendritic cells induced by vitamin D receptor ligands enhance regulatory T cells inhibiting allograft rejection and autoimmune diseases.","volume":"88","author":"Adorini","year":"2003","journal-title":"J Cell Biochem"},{"key":"2019041123522585500_R10","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.2337\/diabetes.51.5.1367","article-title":"A 1\u03b1, 25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice.","volume":"51","author":"Gregori","year":"2002","journal-title":"Diabetes"},{"key":"2019041123522585500_R11","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/jcb.10335","article-title":"Effects of 1\u03b1, 25(OH)2D3 and its analogs on dendritic cell function.","volume":"88","author":"Griffin","year":"2003","journal-title":"J Cell Biochem"},{"key":"2019041123522585500_R12","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S0003-9861(02)00580-5","article-title":"The vitamin D receptor is necessary for 1\u03b1, 25-dihydroxyvitamin D(3) to suppress experimental autoimmune encephalomyelitis in mice.","volume":"408","author":"Meehan","year":"2002","journal-title":"Arch Biochem Biophys"},{"key":"2019041123522585500_R13","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1006\/abbi.1993.1260","article-title":"Vitamin D deficiency suppresses cell-mediated immunity in vivo.","volume":"303","author":"Yang","year":"1993","journal-title":"Arch Biochem Biophys"},{"key":"2019041123522585500_R14","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0092-8674(93)80068-P","article-title":"Interleukin-10-deficient mice develop chronic enterocolitis.","volume":"75","author":"Kuhn","year":"1993","journal-title":"Cell"},{"key":"2019041123522585500_R15","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0960-9822(00)00060-9","article-title":"Gastrointestinal inflammation. Inflammatory bowel disease in knockout mice.","volume":"4","author":"MacDonald","year":"1994","journal-title":"Curr Biol"},{"key":"2019041123522585500_R16","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/(SICI)1521-4141(199801)28:01<379::AID-IMMU379>3.0.CO;2-X","article-title":"Increased intracellular Th1 cytokines in scid mice with inflammatory bowel disease.","volume":"28","author":"Bregenholt","year":"1998","journal-title":"Eur J Immunol"},{"key":"2019041123522585500_R17","doi-asserted-by":"crossref","first-page":"3464","DOI":"10.4049\/jimmunol.158.7.3464","article-title":"Analysis of intestinal lymphocytes in mouse colitis mediated by transfer of CD4+, CD45RBhigh T cells to SCID recipients.","volume":"158","author":"Aranda","year":"1997","journal-title":"J Immunol"},{"key":"2019041123522585500_R18","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/intimm\/5.11.1461","article-title":"Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice.","volume":"5","author":"Powrie","year":"1993","journal-title":"Int Immunol"},{"key":"2019041123522585500_R19","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1084\/jem.178.1.237","article-title":"CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells.","volume":"178","author":"Morrissey","year":"1993","journal-title":"J Exp Med"},{"key":"2019041123522585500_R20","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/39614","article-title":"A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis.","volume":"389","author":"Groux","year":"1997","journal-title":"Nature"},{"key":"2019041123522585500_R21","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1084\/jem.184.1.241","article-title":"T helper cell 1-type CD4+ T cells, but not B cells, mediate colitis in interleukin 10-deficient mice.","volume":"184","author":"Davidson","year":"1996","journal-title":"J Exp Med"},{"key":"2019041123522585500_R22","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1128\/MCB.15.10.5789","article-title":"Transcriptional repression of the interleukin-2 gene by vitamin D3: direct inhibition of NFATp\/AP-1 complex formation by a nuclear hormone receptor.","volume":"15","author":"Alroy","year":"1995","journal-title":"Mol Cell Biol"},{"key":"2019041123522585500_R23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1600-065X.1985.tb01155.x","article-title":"The functional and histological basis for graft-versus-host-induced immunosuppression.","volume":"88","author":"Lapp","year":"1985","journal-title":"Immunol Rev"},{"key":"2019041123522585500_R24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1126\/science.273.5271.70","article-title":"The aging immune system: primer and prospectus.","volume":"273","author":"Miller","year":"1996","journal-title":"Science"},{"key":"2019041123522585500_R25","first-page":"5840","article-title":"Induction of granulocytic hyperplasia, thymic atrophy, and hypercalcemia by a selected subpopulation of a murine mammary adenocarcinoma.","volume":"45","author":"Thomas","year":"1985","journal-title":"Cancer Res"},{"key":"2019041123522585500_R26","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.3109\/00365529709028155","article-title":"Inflammatory bowel disease and osteoporosis.","volume":"32","author":"Andreassen","year":"1997","journal-title":"Scand J Gastroenterol"},{"key":"2019041123522585500_R27","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1080\/003655298750026804","article-title":"Regulators of calcium homeostasis and bone mineral density in patients with Crohn\u2019s disease.","volume":"33","author":"Andreassen","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"2019041123522585500_R28","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.1210\/endo.140.11.7110","article-title":"Rescue of the skeletal phenotype of vitamin D receptor-ablated mice in the setting of normal mineral ion homeostasis: formal histomorphometric and biomechanical analyses.","volume":"140","author":"Amling","year":"1999","journal-title":"Endocrinology"},{"key":"2019041123522585500_R29","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1093\/jn\/129.11.1966","article-title":"Dietary calcium is a major factor in 1, 25-dihydroxycholecalciferol suppression of experimental autoimmune encephalomyelitis in mice.","volume":"129","author":"Cantorna","year":"1999","journal-title":"J Nutr"},{"key":"2019041123522585500_R30","doi-asserted-by":"crossref","first-page":"6406","DOI":"10.4049\/jimmunol.164.12.6406","article-title":"IL-10 and the dangers of immune polarization: excessive type 1 and type 2 cytokine responses induce distinct forms of lethal immunopathology in murine schistosomiasis.","volume":"164","author":"Hoffmann","year":"2000","journal-title":"J Immunol"}],"container-title":["Molecular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mend\/article-pdf\/17\/12\/2386\/10715941\/mend2386.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T00:06:38Z","timestamp":1682553998000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mend\/article\/17\/12\/2386\/2747374"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12,1]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/me.2003-0281","relation":{},"ISSN":["0888-8809","1944-9917"],"issn-type":[{"value":"0888-8809","type":"print"},{"value":"1944-9917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,12,1]]}}}