{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T09:09:19Z","timestamp":1791104959650,"version":"4.1.0"},"reference-count":63,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Gene inactivation studies have shown that members of the Gata family of transcription factors are critical for endoderm development throughout evolution. We show here that Gata-4 and\/or Gata-6 are not only expressed in the adult exocrine pancreas but also in glucagonoma and insulinoma cell lines, whereas Gata-5 is restricted to the exocrine pancreas. During pancreas development, Gata-4 is expressed already at embryonic d 10.5 and colocalizes with early glucagon+ cells at embryonic d 12.5. Gata-4 was able to transactivate the glucagon gene both in heterologous BHK-21 (nonislet Syrian baby hamster kidney) and in glucagon-producing InR1G9 cells. Using gel-mobility shift assays, we identified a complex formed with nuclear extracts from InR1G9 cells on the G5 control element (\u2212140 to \u2212169) of the glucagon gene promoter as Gata-4. Mutation of the GATA binding site on G5 abrogated the transcriptional activation mediated by Gata-4 and reduced basal glucagon gene promoter activity in glucagon-producing cells by 55%. Furthermore, Gata-4 acted more than additively with Forkhead box A (hepatic nuclear factor-3) to trans-activate the glucagon gene promoter. We conclude that, besides its role in endoderm differentiation, Gata-4 might be implicated in the regulation of glucagon gene expression in the fetal pancreas and that Gata activity itself may be modulated by interactions with different cofactors.<\/jats:p>","DOI":"10.1210\/me.2004-0051","type":"journal-article","created":{"date-parts":[[2004,11,12]],"date-time":"2004-11-12T01:14:13Z","timestamp":1100222053000},"page":"759-770","source":"Crossref","is-referenced-by-count":36,"title":["The Zinc Finger-Containing Transcription Factor Gata-4 Is Expressed in the Developing Endocrine Pancreas and Activates Glucagon Gene Expression"],"prefix":"10.1210","volume":"19","author":[{"given":"Beate","family":"Ritz-Laser","sequence":"first","affiliation":[{"name":"Diabetes Unit, University Hospital Geneva, 1211 Gene\u0300ve 14, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline","family":"Mamin","sequence":"additional","affiliation":[{"name":"Diabetes Unit, University Hospital Geneva, 1211 Gene\u0300ve 14, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Brun","sequence":"additional","affiliation":[{"name":"Diabetes Unit, University Hospital Geneva, 1211 Gene\u0300ve 14, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Avril","sequence":"additional","affiliation":[{"name":"Diabetes Unit, University Hospital Geneva, 1211 Gene\u0300ve 14, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vale\u0301rie M.","family":"Schwitzgebel","sequence":"additional","affiliation":[{"name":"Diabetes Unit, University Hospital Geneva, 1211 Gene\u0300ve 14, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Philippe","sequence":"additional","affiliation":[{"name":"Diabetes Unit, University Hospital Geneva, 1211 Gene\u0300ve 14, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071613594531900_R1","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/S0959-437X(02)00319-2","article-title":"The GATA family (vertebrates and invertebrates).","volume":"12","author":"Patient","year":"2002","journal-title":"Curr Opin Genet Dev"},{"key":"2020071613594531900_R2","doi-asserted-by":"crossref","first-page":"4023","DOI":"10.1242\/dev.122.12.4023","article-title":"A molecular aspect of hematopoiesis and endoderm development common to vertebrates and Drosophila.","volume":"122","author":"Rehorn","year":"1996","journal-title":"Development"},{"key":"2020071613594531900_R3","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1101\/gad.11.21.2883","article-title":"End-1 encodes an apparent GATA factor that specifies the endoderm precursor in Caenorhabditis elegans embryos.","volume":"11","author":"Zhu","year":"1997","journal-title":"Genes Dev"},{"key":"2020071613594531900_R4","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1101\/gad.12.24.3809","article-title":"Reprogramming of early embryonic blastomeres into endodermal progenitors by a Caenorhabditis elegans GATA factor.","volume":"12","author":"Zhu","year":"1998","journal-title":"Genes Dev"},{"key":"2020071613594531900_R5","first-page":"286","article-title":"The GATA-factor elt-2 is essential for formation of the Caenorhabditis elegans intestine.","volume":"198","author":"Fukushige","year":"1998","journal-title":"Dev Biol"},{"key":"2020071613594531900_R6","doi-asserted-by":"crossref","first-page":"2983","DOI":"10.1101\/gad.13.22.2983","article-title":"Gata5 is required for the development of the heart and endoderm in zebrafish.","volume":"13","author":"Reiter","year":"1999","journal-title":"Genes Dev"},{"key":"2020071613594531900_R7","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1242\/dev.127.20.4345","article-title":"A role for GATA5 in Xenopus endoderm specification.","volume":"127","author":"Weber","year":"2000","journal-title":"Development"},{"key":"2020071613594531900_R8","doi-asserted-by":"crossref","first-page":"38949","DOI":"10.1074\/jbc.R000029200","article-title":"The zinc finger-containing transcription factors GATA-4, -5, and -6. 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