{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:51:47Z","timestamp":1783633907118,"version":"3.55.0"},"reference-count":40,"publisher":"The Endocrine Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"DOI":"10.1210\/me.2005-0129","type":"journal-article","created":{"date-parts":[[2005,7,15]],"date-time":"2005-07-15T00:14:18Z","timestamp":1121386458000},"page":"3060-3072","source":"Crossref","is-referenced-by-count":13,"title":["DARPP-32 (Dopamine and 3\u2032,5\u2032-Cyclic Adenosine Monophosphate-Regulated Neuronal Phosphoprotein) Is Essential for the Maintenance of Thyroid Differentiation"],"prefix":"10.1210","volume":"19","author":[{"given":"Custodia","family":"Garci\u0301a-Jime\u0301nez","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones Biome\u0301dicas \u201cAlberto Sols\u201d (C.G.-J., M.A.Z., P.S.), Consejo Superior de Investigaciones Cientificas, 28029 Madrid, Spain"},{"name":"Universidad Rey Juan Carlos (C.G.-J.), Facultad Ciencias de la Salud, 28922 Alcorco\u0301n, Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Zaballos","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biome\u0301dicas \u201cAlberto Sols\u201d (C.G.-J., M.A.Z., P.S.), Consejo Superior de Investigaciones Cientificas, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Santisteban","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones Biome\u0301dicas \u201cAlberto Sols\u201d (C.G.-J., M.A.Z., P.S.), Consejo Superior de Investigaciones Cientificas, 28029 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041200425980600_R1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0079-6603(00)66033-6","article-title":"A unique combination of transcription factors controls differentiation of thyroid cells.","volume":"66","author":"Damante","year":"2001","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"2019041200425980600_R2","doi-asserted-by":"crossref","first-page":"23334","DOI":"10.1074\/jbc.272.37.23334","article-title":"Transcriptional control of the forkhead thyroid transcription factor TTF-2 by thyrotropin, insulin, and insulin-like growth factor I.","volume":"272","author":"Ortiz","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041200425980600_R3","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/edrv.22.5.0444","article-title":"Regulation of thyroid cell proliferation by TSH and other factors: a critical evaluation of in vitro models.","volume":"22","author":"Kimura","year":"2001","journal-title":"Endocr Rev"},{"key":"2019041200425980600_R4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1749-6632.2002.tb04330.x","article-title":"The role of cyclic AMP and its effect on protein kinase A in the mitogenic action of thyrotropin on the thyroid cell.","volume":"968","author":"Dremier","year":"2002","journal-title":"Ann NY Acad Sci"},{"key":"2019041200425980600_R5","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/S1359-6446(02)02503-5","article-title":"Do all paths lead to DARPP-32?","volume":"7","author":"Foubister","year":"2002","journal-title":"Drug Discov Today"},{"key":"2019041200425980600_R6","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/S0165-0173(99)00047-8","article-title":"The DARPP-32 knockout mouse.","volume":"31","author":"Fienberg","year":"2000","journal-title":"Brain Res Brain Res Rev"},{"key":"2019041200425980600_R7","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1210\/jc.2003-030542","article-title":"Expression of the apical iodide transporter in human thyroid tissues: a comparison study with other iodide transporters.","volume":"89","author":"Lacroix","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041200425980600_R8","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0014-5793(95)00359-H","article-title":"DARPP-32 (dopamine and cAMP-regulated phosphoprotein, Mr 32,000) is a membrane protein in the bovine parathyroid.","volume":"364","author":"Matovcik","year":"1995","journal-title":"FEBS Lett"},{"key":"2019041200425980600_R9","doi-asserted-by":"crossref","first-page":"5793","DOI":"10.1128\/MCB.12.12.5793","article-title":"Multiple mechanisms of interference between transformation and differentiation in thyroid cells.","volume":"12","author":"Francis-Lang","year":"1992","journal-title":"Mol Cell Biol"},{"key":"2019041200425980600_R10","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1002\/(SICI)1097-0142(19981115)83:10<2185::AID-CNCR18>3.0.CO;2-4","article-title":"Genetic and epigenetic alterations of the cyclin-dependent kinase inhibitors p15INK4b and p16INK4a in human thyroid carcinoma cell lines and primary thyroid carcinomas.","volume":"83","author":"Elisei","year":"1998","journal-title":"Cancer"},{"key":"2019041200425980600_R11","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0167-4781(97)00127-9","article-title":"Transfection of TTF-1 gene induces thyroglobulin gene expression in undifferentiated FRT cells.","volume":"1354","author":"Mascia","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"2019041200425980600_R12","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1210\/endo.139.6.6076","article-title":"Ha-ras interference with thyroid cell differentiation is associated with a down-regulation of thyroid transcription factor-1 phosphorylation.","volume":"139","author":"Velasco","year":"1998","journal-title":"Endocrinology"},{"key":"2019041200425980600_R13","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1042\/bj3480351","article-title":"Phosphatidylinositol 3-kinase, protein kinase B and ribosomal S6 kinases in the stimulation of thyroid epithelial cell proliferation by cAMP and growth factors in the presence of insulin.","volume":"348","author":"Coulonval","year":"2000","journal-title":"Biochem J"},{"key":"2019041200425980600_R14","doi-asserted-by":"crossref","first-page":"21960","DOI":"10.1074\/jbc.M300805200","article-title":"Regulation of the phosphatidylinositol 3-kinase, Akt\/protein kinase B, FRAP\/mammalian target of rapamycin, and ribosomal S6 kinase 1 signaling pathways by thyroid-stimulating hormone (TSH) and stimulating type TSH receptor antibodies in the thyroid gland.","volume":"278","author":"Suh","year":"2003","journal-title":"J Biol Chem"},{"key":"2019041200425980600_R15","first-page":"209","article-title":"New signaling pathways for hormones and cyclic adenosine 3\u2032,5\u2032-monophosphate action in endocrine cells.","volume":"15","author":"Richards","year":"2001","journal-title":"Mol Endocrinol"},{"key":"2019041200425980600_R16","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1042\/bj3510095","article-title":"Specificity and mechanism of action of some commonly used protein kinase inhibitors.","volume":"351","author":"Davies","year":"2000","journal-title":"Biochem J"},{"key":"2019041200425980600_R17","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/sj.onc.1203393","article-title":"Ras signaling through PI3K confers hormone-independent proliferation that is compatible with differentiation.","volume":"19","author":"Cass","year":"2000","journal-title":"Oncogene"},{"key":"2019041200425980600_R18","doi-asserted-by":"crossref","first-page":"3188","DOI":"10.1073\/pnas.052712699","article-title":"DARPP-32 mediates serotonergic neurotransmission in the forebrain.","volume":"99","author":"Svenningsson","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041200425980600_R19","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1016\/S0021-9258(18)61309-2","article-title":"Thyroglobulin gene expression is regulated by insulin and insulin-like growth factor I, as well as thyrotropin, in FRTL-5 thyroid cells.","volume":"262","author":"Santisteban","year":"1987","journal-title":"J Biol Chem"},{"key":"2019041200425980600_R20","doi-asserted-by":"crossref","first-page":"5568","DOI":"10.1073\/pnas.94.11.5568","article-title":"Characterization of the thyroid Na+\/I\u2212 symporter with an anti-COOH terminus antibody.","volume":"94","author":"Levy","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041200425980600_R21","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1210\/endo.138.6.5189","article-title":"Regulation by thyroid-stimulating hormone of sodium\/iodide symporter gene expression and protein levels in FRTL-5 cells.","volume":"138","author":"Kogai","year":"1997","journal-title":"Endocrinology"},{"key":"2019041200425980600_R22","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1677\/joe.0.1720163","article-title":"Hormonal control of the transcription factor Pax8 and its role in the regulation of thyroglobulin gene expression in thyroid cells.","volume":"172","author":"Mascia","year":"2002","journal-title":"J Endocrinol"},{"key":"2019041200425980600_R23","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1530\/eje.0.1430161","article-title":"Thyrotropin dependent proliferation of in vitro rat thyroid cell systems.","volume":"143","author":"Medina","year":"2000","journal-title":"Eur J Endocrinol"},{"key":"2019041200425980600_R24","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1210\/me.2004-0172","article-title":"Dose-dependent inhibition of thyroid differentiation by RAS oncogenes.","volume":"19","author":"De Vita","year":"2005","journal-title":"Mol Endocrinol"},{"key":"2019041200425980600_R25","first-page":"4061","article-title":"Gastric cancers overexpress DARPP-32 and a novel isoform, t-DARPP.","volume":"62","author":"El-Rifai","year":"2002","journal-title":"Cancer Res"},{"key":"2019041200425980600_R26","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/cncr.11654","article-title":"Overexpression of the 32-kilodalton dopamine and cyclic adenosine 3\u2032,5\u2032-monophosphate-regulated phosphoprotein in common adenocarcinomas.","volume":"98","author":"Beckler","year":"2003","journal-title":"Cancer"},{"key":"2019041200425980600_R27","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1046\/j.1471-4159.2001.00651.x","article-title":"Role of phosphatidylinositide 3-kinase in brain-derived neurotrophic factor-induced DARPP-32 expression in medium size spiny neurons in vitro.","volume":"79","author":"Stroppolo","year":"2001","journal-title":"J Neurochem"},{"key":"2019041200425980600_R28","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/bbrc.1997.7268","article-title":"Cloning and expression of a brain-derived TSH receptor.","volume":"238","author":"Bockmann","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041200425980600_R29","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S0024-3205(99)00030-2","article-title":"Thyroid stimulating hormone-receptor overexpression in brain of patients with Down syndrome and Alzheimer\u2019s disease.","volume":"64","author":"Labudova","year":"1999","journal-title":"Life Sci"},{"key":"2019041200425980600_R30","doi-asserted-by":"crossref","first-page":"4294","DOI":"10.1158\/1078-0432.CCR-04-0074","article-title":"The Na+\/I\u2212 symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid.","volume":"10","author":"Wapnir","year":"2004","journal-title":"Clin Cancer Res"},{"key":"2019041200425980600_R31","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1158\/1078-0432.CCR-04-1636","article-title":"In vivo radioiodide imaging and treatment of breast cancer xenografts after MUC1-driven expression of the sodium iodide symporter.","volume":"11","author":"Dwyer","year":"2005","journal-title":"Clin Cancer Res"},{"key":"2019041200425980600_R32","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/ng0598-87","article-title":"Follicular cells of the thyroid gland require Pax8 gene function.","volume":"19","author":"Mansouri","year":"1998","journal-title":"Nat Genet"},{"key":"2019041200425980600_R33","doi-asserted-by":"crossref","first-page":"29698","DOI":"10.1074\/jbc.272.47.29698","article-title":"The regulation of glycogen synthase by protein phosphatase 1 in 3T3\u2013L1 adipocytes. Evidence for a potential role for DARPP-32 in insulin action.","volume":"272","author":"Brady","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041200425980600_R34","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1530\/acta.0.114S242","article-title":"The FRTL-5 thyroid cell strain as a model for studies on thyroid cell growth.","volume":"281","author":"Ambesi-Impiombato","year":"1987","journal-title":"Acta Endocrinol Suppl (Copenh)"},{"key":"2019041200425980600_R35","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.1128\/MCB.7.9.3365","article-title":"One- and two-step transformations of rat thyroid epithelial cells by retroviral oncogenes.","volume":"7","author":"Fusco","year":"1987","journal-title":"Mol Cell Biol"},{"key":"2019041200425980600_R36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1530\/eje.0.1400094","article-title":"Insulin and TSH promote growth in size of PC Cl3 rat thyroid cells, possibly via a pathway different from DNA synthesis: comparison with FRTL-5 cells.","volume":"140","author":"Kimura","year":"1999","journal-title":"Eur J Endocrinol"},{"key":"2019041200425980600_R37","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction.","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"2019041200425980600_R38","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1093\/nar\/11.5.1475","article-title":"Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei.","volume":"11","author":"Dignam","year":"1983","journal-title":"Nucleic Acids Res"},{"key":"2019041200425980600_R39","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1210\/mend.16.2.0774","article-title":"PI3K is involved in the IGF-I inhibition of TSH-induced sodium\/iodide symporter gene expression.","volume":"16","author":"Garcia","year":"2002","journal-title":"Mol Endocrinol"},{"key":"2019041200425980600_R40","doi-asserted-by":"crossref","first-page":"3631","DOI":"10.1002\/j.1460-2075.1990.tb07574.x","article-title":"Thyroid nuclear factor 1 (TTF-1) contains a homeodomain and displays a novel DNA binding specificity.","volume":"9","author":"Guazzi","year":"1990","journal-title":"EMBO J"}],"container-title":["Molecular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mend\/article-pdf\/19\/12\/3060\/10717929\/mend3060.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T16:12:28Z","timestamp":1626192748000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mend\/article\/19\/12\/3060\/2738055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12,1]]},"references-count":40,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1210\/me.2005-0129","relation":{},"ISSN":["0888-8809","1944-9917"],"issn-type":[{"value":"0888-8809","type":"print"},{"value":"1944-9917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12,1]]}}}