{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T06:11:36Z","timestamp":1791353496836,"version":"4.3.1"},"reference-count":86,"publisher":"The Endocrine Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations in the transcription factors PIT1 (pituitary transcription factor 1) and PROP1 (prophet of Pit1) lead to pituitary hormone deficiency and hypopituitarism in mice and humans. To determine the basis for this, we performed histological analysis of Pit1- and Prop1-deficient dwarf mouse pituitaries throughout fetal and postnatal development. Pit1-deficient mice first exhibit pituitary hypoplasia after birth, primarily caused by reduced cell proliferation, although there is some apoptosis. To determine whether altered development of the vascular system contributes to hypopituitarism, we examined vascularization from embryonic d 14.5 and throughout development. No obvious differences in vascularization are evident in developing Pit1-deficient pituitaries. In contrast, the Prop1-deficient mouse pituitaries are poorly vascularized and dysmorphic, with a striking elevation in apoptosis. At postnatal d 11, apoptosis-independent caspase-3 activation occurs in thyrotropes and somatotropes of normal but not mutant pituitaries. This suggests that Prop1 and\/or Pit1 may be necessary for caspase-3 expression. These studies provide further insight as to the mechanisms of Prop1 and Pit1 action in mice.<\/jats:p>","DOI":"10.1210\/me.2005-0409","type":"journal-article","created":{"date-parts":[[2006,3,24]],"date-time":"2006-03-24T01:45:07Z","timestamp":1143164707000},"page":"1378-1390","source":"Crossref","is-referenced-by-count":86,"title":["Cell Proliferation and Vascularization in Mouse Models of Pituitary Hormone Deficiency"],"prefix":"10.1210","volume":"20","author":[{"given":"Robert D.","family":"Ward","sequence":"first","affiliation":[{"name":"Graduate Program in Cellular and Molecular Biology (R.D.W., S.A.C.), University of Michigan, Ann Arbor, Michigan 48109-0618"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon M.","family":"Stone","sequence":"additional","affiliation":[{"name":"Graduate Program in Cellular and Molecular Biology (R.D.W., S.A.C.), University of Michigan, Ann Arbor, Michigan 48109-0618"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori T.","family":"Raetzman","sequence":"additional","affiliation":[{"name":"Department of Human Genetics (B.M.S., L.T.R., S.A.C.), University of Michigan, Ann Arbor, Michigan 48109-0618"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally A.","family":"Camper","sequence":"additional","affiliation":[{"name":"Graduate Program in Cellular and Molecular Biology (R.D.W., S.A.C.), University of Michigan, Ann Arbor, Michigan 48109-0618"},{"name":"Department of Human Genetics (B.M.S., L.T.R., S.A.C.), University of Michigan, Ann Arbor, Michigan 48109-0618"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071614032080600_R1","first-page":"3346","article-title":"The PROP1 2-base pair deletion is a common cause of combined pituitary hormone deficiency.","volume":"83","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614032080600_R2","first-page":"942","article-title":"Longitudinal hormonal and pituitary imaging changes in two females with combined pituitary hormone deficiency due to deletion of A301,G302 in the PROP1 gene.","volume":"84","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614032080600_R3","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/ng0298-147","article-title":"Mutations in PROP1 cause familial combined pituitary hormone deficiency.","volume":"18","year":"1998","journal-title":"Nat Genet"},{"key":"2020071614032080600_R4","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.257.5073.1118","article-title":"Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia.","volume":"257","year":"1992","journal-title":"Science"},{"key":"2020071614032080600_R5","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1126\/science.257.5073.1115","article-title":"A mutation in the POU-homeodomain of Pit-1 responsible for combined pituitary hormone deficiency.","volume":"257","year":"1992","journal-title":"Science"},{"key":"2020071614032080600_R6","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1210\/jc.2002-020818","article-title":"Sporadic heterozygous frameshift mutation of HESX1 causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese patient.","volume":"88","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614032080600_R7","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/76041","article-title":"Mutations in LHX3 result in a new syndrome revealed by combined pituitary hormone deficiency.","volume":"25","year":"2000","journal-title":"Nat Genet"},{"key":"2020071614032080600_R8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1086\/323764","article-title":"Syndromic short stature in patients with a germline mutation in the LIM homeobox LHX4.","volume":"69","year":"2001","journal-title":"Am J Hum Genet"},{"key":"2020071614032080600_R9","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0889-8529(05)70339-X","article-title":"Role of Pit-1 in the gene expression of growth hormone, prolactin, and thyrotropin.","volume":"25","year":"1996","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2020071614032080600_R10","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.1210\/jcem.85.12.7013","article-title":"Adrenocorticotropin deficiency in combined pituitary hormone deficiency patients homozygous for a novel PROP1 deletion.","volume":"85","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614032080600_R11","first-page":"1645","article-title":"\u201cHot spot\u201d in the PROP1 gene responsible for combined pituitary hormone deficiency.","volume":"84","year":"1999","journal-title":"J Clin Endocrinol 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Metab"},{"key":"2020071614032080600_R15","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1093\/hmg\/ddh311","article-title":"Pituitary hypoplasia and respiratory distress syndrome in Prop1 knockout mice.","volume":"13","year":"2004","journal-title":"Hum Mol Genet"},{"key":"2020071614032080600_R16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/384327a0","article-title":"Pituitary lineage determination by the Prophet of Pit-1 homeodomain factor defective in Ames dwarfism.","volume":"384","year":"1996","journal-title":"Nature"},{"key":"2020071614032080600_R17","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1210\/me.2004-0341","article-title":"Role of PROP1 in pituitary gland growth.","volume":"19","year":"2005","journal-title":"Mol Endocrinol"},{"key":"2020071614032080600_R18","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1210\/endo.132.6.8504754","article-title":"Gonadotropin secretion, synthesis, and gene expression in human growth hormone transgenic mice and in Ames dwarf mice.","volume":"132","year":"1993","journal-title":"Endocrinology"},{"key":"2020071614032080600_R19","first-page":"1570","article-title":"The Ames dwarf gene, df, is required early in pituitary ontogeny for the extinction of Rpx transcription and initiation of lineage-specific cell proliferation.","volume":"10","year":"1996","journal-title":"Mol Endocrinol"},{"key":"2020071614032080600_R20","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/0888-7543(90)90050-5","article-title":"The Pit-1 transcription factor gene is a candidate for the Snell dwarf mutation.","volume":"8","year":"1990","journal-title":"Genomics"},{"key":"2020071614032080600_R21","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1038\/347528a0","article-title":"Dwarf locus mutants lacking three pituitary cell types result from mutations in the POU-domain gene. Pit-1.","volume":"347","year":"1990","journal-title":"Nature"},{"key":"2020071614032080600_R22","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1038\/360765a0","article-title":"Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth.","volume":"360","year":"1992","journal-title":"Nature"},{"key":"2020071614032080600_R23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1043-2760(99)00189-7","article-title":"Genealogy of the anterior pituitary gland: tracing a family tree.","volume":"10","year":"1999","journal-title":"Trends Endocrinol Metab"},{"key":"2020071614032080600_R24","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0168-9525(98)01476-0","article-title":"How many homeobox genes does it take to make a pituitary gland?","volume":"14","year":"1998","journal-title":"Trends 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studies.","volume":"97","year":"2005","journal-title":"J Natl Cancer Inst"},{"key":"2020071614032080600_R29"},{"key":"2020071614032080600_R30","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/S0195-668X(02)00635-8","article-title":"Angiogenesis: basic pathophysiology and implications for disease.","volume":"24","year":"2003","journal-title":"Eur Heart J"},{"key":"2020071614032080600_R31","first-page":"229","article-title":"Origin of the adenohypophyseal vessels in the rat.","volume":"154","year":"1987","journal-title":"J Anat"},{"key":"2020071614032080600_R32","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1210\/endo-122-4-1622","article-title":"Correlation of spatial differences in concentrations of prolactin and growth hormone cells with vascular pattern in the female mouse adenohypophysis.","volume":"122","year":"1988","journal-title":"Endocrinology"},{"key":"2020071614032080600_R33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/(SICI)1097-0177(199805)212:1<157::AID-AJA14>3.0.CO;2-4","article-title":"Three-dimensional analysis of the developing pituitary gland in the mouse.","volume":"212","year":"1998","journal-title":"Dev Dyn"},{"key":"2020071614032080600_R34"},{"key":"2020071614032080600_R35","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1126\/science.1064344","article-title":"Induction of pancreatic differentiation by signals from blood vessels.","volume":"294","year":"2001","journal-title":"Science"},{"key":"2020071614032080600_R36","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0925-4773(02)00332-5","article-title":"Role of endothelial cells in early pancreas and liver development.","volume":"120","year":"2003","journal-title":"Mech 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GHF1 in pituitary cell proliferation.","volume":"253","year":"1991","journal-title":"Science"},{"key":"2020071614032080600_R41","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1046\/j.1365-2559.2002.01343.x","article-title":"Ki67 protein: the immaculate deception?","volume":"40","year":"2002","journal-title":"Histopathology"},{"key":"2020071614032080600_R42","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.4049\/jimmunol.133.4.1710","article-title":"Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.","volume":"133","year":"1984","journal-title":"J Immunol"},{"key":"2020071614032080600_R43","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1432-0436.1973.tb00137.x","article-title":"Incorportaiton of thymidine and its analogue, bromodeoxyuridine, into embryos and maternal tissues of the mouse.","volume":"1","year":"1973","journal-title":"Differentiation"},{"key":"2020071614032080600_R44","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/BF01190834","article-title":"Bromodeoxyuridine immunohistochemical determination of the lengths of the cell cycle and the DNA-synthetic phase for an anatomically defined population.","volume":"18","year":"1989","journal-title":"J Neurocytol"},{"key":"2020071614032080600_R45","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1172\/JCI200419383","article-title":"Soluble VEGF isoforms are essential for establishing epiphyseal vascularization and regulating chondrocyte development and survival.","volume":"113","year":"2004","journal-title":"J Clin Invest"},{"key":"2020071614032080600_R46","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1242\/dev.01053","article-title":"VEGFA is necessary for chondrocyte survival during bone development.","volume":"131","year":"2004","journal-title":"Development"},{"key":"2020071614032080600_R47","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2220\/biomedres.10.275","article-title":"Cell proliferation in the anterior pituitary of mice during growth.","volume":"10","year":"1989","journal-title":"Biomed Res"},{"key":"2020071614032080600_R48","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/s004290100161","article-title":"Proliferation and differentiation of thyrotrophs in the pars distalis of the rat pituitary gland during the fetal and postnatal period.","volume":"203","year":"2001","journal-title":"Anat Embryol (Berl)"},{"key":"2020071614032080600_R49","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s429-001-8003-x","article-title":"Proliferation and differentiation of pituitary somatotrophs and mammotrophs during late fetal and postnatal periods.","volume":"204","year":"2001","journal-title":"Anat Embryol (Berl)"},{"key":"2020071614032080600_R50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1196\/annals.1294.001","article-title":"The \u201cnormal\u201d endocrine cell of the gut: changing concepts and new evidences.","volume":"1014","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"2020071614032080600_R51"},{"key":"2020071614032080600_R52","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/364208a0","article-title":"Molecular basis of the little mouse phenotype and implications for cell type-specific growth.","volume":"364","year":"1993","journal-title":"Nature"},{"key":"2020071614032080600_R53","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1210\/me.2004-0192","article-title":"A novel mouse model of hypogonadotrophic hypogonadism: N-ethyl-N-nitrosourea-induced gonadotropin-releasing hormone receptor gene mutation.","volume":"19","year":"2005","journal-title":"Mol Endocrinol"},{"key":"2020071614032080600_R54","first-page":"151","article-title":"Molecular mechanisms for pituitary thyrotroph cell growth.","volume":"27","year":"2004","journal-title":"J Endocrinol Invest"},{"key":"2020071614032080600_R55","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bone.2005.04.020","article-title":"Ghrelin stimulates proliferation and differentiation and inhibits apoptosis in osteoblastic MC3T3\u2013E1 cells.","volume":"37","year":"2005","journal-title":"Bone"},{"key":"2020071614032080600_R56","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1210\/en.2004-0119","article-title":"A mouse with targeted ablation of the growth hormone-releasing hormone gene: a new model of isolated growth hormone deficiency.","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"2020071614032080600_R57","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1172\/JCI14036","article-title":"Targeted expression of a human pituitary tumor-derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis.","volume":"109","year":"2002","journal-title":"J Clin Invest"},{"key":"2020071614032080600_R58","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1006\/bbrc.2000.3721","article-title":"FGF10 acts as a major ligand for FGF receptor 2 IIIb in mouse multi-organ development.","volume":"277","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"2020071614032080600_R59","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1172\/JCI118388","article-title":"Heparin-binding secretory transforming gene (hst) facilitates rat lactotrope cell tumorigenesis and induces prolactin gene transcription.","volume":"97","year":"1996","journal-title":"J Clin Invest"},{"key":"2020071614032080600_R60","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1242\/dev.125.6.1005","article-title":"Integrated FGF and BMP signaling controls the progression of progenitor cell differentiation and the emergence of pattern in the embryonic anterior pituitary.","volume":"125","year":"1998","journal-title":"Development"},{"key":"2020071614032080600_R61","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1101\/gad.12.11.1691","article-title":"Multistep signaling requirements for pituitary organogenesis in vivo.","volume":"12","year":"1998","journal-title":"Genes Dev"},{"key":"2020071614032080600_R62","doi-asserted-by":"crossref","first-page":"21653","DOI":"10.1074\/jbc.M002129200","article-title":"Differentiation of lactotrope precursor GHFT cells in response to fibroblast growth factor-2.","volume":"275","year":"2000","journal-title":"J Biol Chem"},{"key":"2020071614032080600_R63","first-page":"2537","article-title":"Expression of the pituitary transcription factor Ptx-1, but not that of the trans-activating factor prop-1, is reduced in human corticotroph adenomas and is associated with decreased \u03b1-subunit secretion.","volume":"85","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614032080600_R64","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0303-7207(00)00318-X","article-title":"Biochemical and genetic characterization of the porcine Prophet of Pit-1 pituitary transcription factor.","volume":"168","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"2020071614032080600_R65"},{"key":"2020071614032080600_R66","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1385\/ENDO:18:1:67","article-title":"Transcript abundance in mouse pituitaries with altered growth hormone expression quantified by reverse transcriptase polymerase chain reaction implicates transcription factor Zn-16 in gene regulation in vivo.","volume":"18","year":"2002","journal-title":"Endocrine"},{"key":"2020071614032080600_R67","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1210\/jcem.84.7.5974","article-title":"Prop-1 gene expression in human pituitary tumors.","volume":"84","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614032080600_R68","first-page":"1414","article-title":"Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans.","volume":"84","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"2020071614032080600_R69"},{"key":"2020071614032080600_R70","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/hmg\/10.11.1141","article-title":"Persistent Prop1 expression delays gonadotrope differentiation and enhances pituitary tumor susceptibility.","volume":"10","year":"2001","journal-title":"Hum Mol Genet"},{"key":"2020071614032080600_R71","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1242\/dev.122.1.151","article-title":"Anterior pituitary cells defective in the cell-autonomous factor, df, undergo cell lineage specification but not expansion.","volume":"122","year":"1996","journal-title":"Development"},{"key":"2020071614032080600_R72","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ydbio.2003.09.033","article-title":"Developmental regulation of Notch signaling genes in the embryonic pituitary: Prop1 deficiency affects Notch2 expression.","volume":"265","year":"2004","journal-title":"Dev Biol"},{"key":"2020071614032080600_R73","doi-asserted-by":"crossref","first-page":"6589","DOI":"10.1242\/dev.00898","article-title":"The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo.","volume":"130","year":"2003","journal-title":"Development"},{"key":"2020071614032080600_R74","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1046\/j.1523-1747.2003.12636.x","article-title":"Tumor necrosis factor related apoptosis inducing ligand triggers apoptosis in dividing but not in differentiating human epidermal keratinocytes.","volume":"121","year":"2003","journal-title":"J Invest Dermatol"},{"key":"2020071614032080600_R75","doi-asserted-by":"crossref","first-page":"30983","DOI":"10.1074\/jbc.M400692200","article-title":"Differentiation-dependent sensitivity to apoptogenic factors in PC12 cells.","volume":"279","year":"2004","journal-title":"J Biol Chem"},{"key":"2020071614032080600_R76","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.yexcr.2003.12.029","article-title":"Caspase activation independent of cell death is required for proper cell dispersal and correct morphology in PC12 cells.","volume":"295","year":"2004","journal-title":"Exp Cell Res"},{"key":"2020071614032080600_R77","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1084\/jem.190.12.1891","article-title":"Caspase activation is required for T cell proliferation.","volume":"190","year":"1999","journal-title":"J Exp Med"},{"key":"2020071614032080600_R78","doi-asserted-by":"crossref","first-page":"11025","DOI":"10.1073\/pnas.162172899","article-title":"Caspase 3 activity is required for skeletal muscle differentiation.","volume":"99","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"2020071614032080600_R79","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1084\/jem.193.2.247","article-title":"Caspase activation is required for terminal erythroid differentiation.","volume":"193","year":"2001","journal-title":"J Exp Med"},{"key":"2020071614032080600_R80","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1002\/cne.1121","article-title":"Expression of active caspase-3 in mitotic and postmitotic cells of the rat forebrain.","volume":"433","year":"2001","journal-title":"J Comp Neurol"},{"key":"2020071614032080600_R81","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1016\/S1357-2725(02)00069-9","article-title":"Calpain: a role in cell transformation and 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