{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:03:23Z","timestamp":1791216203399,"version":"4.1.0"},"reference-count":50,"publisher":"The Endocrine Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"DOI":"10.1210\/me.2006-0529","type":"journal-article","created":{"date-parts":[[2007,10,12]],"date-time":"2007-10-12T00:33:59Z","timestamp":1192149239000},"page":"415-429","source":"Crossref","is-referenced-by-count":39,"title":["Female Infertility and Disrupted Angiogenesis Are Actions of Specific Follistatin Isoforms"],"prefix":"10.1210","volume":"22","author":[{"given":"Shyr-Yeu","family":"Lin","sequence":"first","affiliation":[{"name":"Monash Institute of Medical Research (S.-Y.L., R.G.C., A.E.O\u2019C., J.E.G., J.R.M., D.M.deK.), Victoria 3168, Australia"},{"name":"Stem Cell Lab (S.-Y.L.), Department of Medical Research, Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei 10449, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca G.","family":"Craythorn","sequence":"additional","affiliation":[{"name":"Monash Institute of Medical Research (S.-Y.L., R.G.C., A.E.O\u2019C., J.E.G., J.R.M., D.M.deK.), Victoria 3168, Australia"},{"name":"Department of Obstetrics and Gynaecology (R.G.C., J.E.G.), Monash University, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne E.","family":"O\u2019Connor","sequence":"additional","affiliation":[{"name":"Monash Institute of Medical Research (S.-Y.L., R.G.C., A.E.O\u2019C., J.E.G., J.R.M., D.M.deK.), Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin M.","family":"Matzuk","sequence":"additional","affiliation":[{"name":"Departments of Pathology, Molecular and Cellular Biology, and Molecular and Human Genetics (M.M.M.), Baylor College of Medicine, Houston, Texas 77030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane E.","family":"Girling","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology (R.G.C., J.E.G.), Monash University, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Morrison","sequence":"additional","affiliation":[{"name":"Monash Institute of Medical Research (S.-Y.L., R.G.C., A.E.O\u2019C., J.E.G., J.R.M., D.M.deK.), Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"de Kretser","sequence":"additional","affiliation":[{"name":"Monash Institute of Medical Research (S.-Y.L., R.G.C., A.E.O\u2019C., J.E.G., J.R.M., D.M.deK.), Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041122400244300_R1","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/0006-291X(87)90430-X","article-title":"The isolation of polypeptides with FSH suppressing activity from bovine follicular fluid which are structurally different to inhibin.","volume":"149","author":"Robertson","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041122400244300_R2","doi-asserted-by":"crossref","first-page":"8282","DOI":"10.1073\/pnas.84.23.8282","article-title":"Isolation and partial characterization of follistatin: a single-chain Mr 35,000 monomeric protein that inhibits the release of follicle-stimulating hormone.","volume":"84","author":"Ueno","year":"1987","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122400244300_R3","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1210\/en.2002-0203","article-title":"Differential binding and neutralization of activins A and B by follistatin and follistatin like-3 (FSTL-3\/FSRP\/FLRG).","volume":"144","author":"Schneyer","year":"2003","journal-title":"Endocrinology"},{"key":"2019041122400244300_R4","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1126\/science.2106159","article-title":"Activin-binding protein from rat ovary is follistatin.","volume":"247","author":"Nakamura","year":"1990","journal-title":"Science"},{"key":"2019041122400244300_R5","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1210\/er.2002-0003","article-title":"Genetic analysis of the mammalian transforming growth factor-\u03b2 superfamily.","volume":"23","author":"Chang","year":"2002","journal-title":"Endocr Rev"},{"key":"2019041122400244300_R6","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1177\/153537020222700905","article-title":"Activins, inhibins, and follistatins: from endocrinology to signaling. A paradigm for the new millennium.","volume":"227","author":"Welt","year":"2002","journal-title":"Exp Biol Med (Maywood)"},{"key":"2019041122400244300_R7","doi-asserted-by":"crossref","first-page":"9306","DOI":"10.1073\/pnas.151270098","article-title":"Regulation of myostatin activity and muscle growth.","volume":"98","author":"Lee","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041122400244300_R8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1530\/rep.1.00090","article-title":"Bone morphogenetic protein (BMP) ligands and receptors in bovine ovarian follicle cells: actions of BMP-4, -6 and -7 on granulosa cells and differential modulation of Smad-1 phosphorylation by follistatin.","volume":"127","author":"Glister","year":"2004","journal-title":"Reproduction"},{"key":"2019041122400244300_R9","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0006-291X(88)80097-4","article-title":"Porcine follistatin gene structure supports two forms of mature follistatin produced by alternative splicing.","volume":"152","author":"Shimasaki","year":"1988","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041122400244300_R10","doi-asserted-by":"crossref","first-page":"15579","DOI":"10.1016\/S0021-9258(18)82296-7","article-title":"Molecular heterogeneity of follistatin, an activin-binding protein. Higher affinity of the carboxyl-terminal truncated forms for heparan sulfate proteoglycans on the ovarian granulosa cell.","volume":"268","author":"Sugino","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041122400244300_R11","doi-asserted-by":"crossref","first-page":"13835","DOI":"10.1074\/jbc.272.21.13835","article-title":"A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparan sulfate.","volume":"272","author":"Hashimoto","year":"1997","journal-title":"J Biol Chem"},{"key":"2019041122400244300_R12","doi-asserted-by":"crossref","first-page":"5067","DOI":"10.1210\/jc.2004-0162","article-title":"Differential distribution of follistatin isoforms: application of a new FS315-specific immunoassay.","volume":"89","author":"Schneyer","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122400244300_R13","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/374360a0","article-title":"Multiple defects and perinatal death in mice deficient in follistatin.","volume":"374","author":"Matzuk","year":"1995","journal-title":"Nature"},{"key":"2019041122400244300_R14","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1210\/me.2003-0301","article-title":"Granulosa cell-specific inactivation of follistatin causes female fertility defects.","volume":"18","author":"Jorgez","year":"2004","journal-title":"Mol Endocrinol"},{"key":"2019041122400244300_R15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/dbio.2001.0399","article-title":"Activins as regulators of branching morphogenesis.","volume":"238","author":"Ball","year":"2001","journal-title":"Dev Biol"},{"key":"2019041122400244300_R16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1006\/dbio.2001.0364","article-title":"Regulation of prostate branching morphogenesis by activin A and follistatin.","volume":"237","author":"Cancilla","year":"2001","journal-title":"Dev Biol"},{"key":"2019041122400244300_R17","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1095\/biolreprod.103.016337","article-title":"Ovarian regulation of endometrial gland morphogenesis and activin-follistatin system in the neonatal ovine uterus.","volume":"69","author":"Carpenter","year":"2003","journal-title":"Biol Reprod"},{"key":"2019041122400244300_R18","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1365-2222.2006.02523.x","article-title":"Follistatin is a candidate endogenous negative regulator of activin A in experimental allergic asthma.","volume":"36","author":"Hardy","year":"2006","journal-title":"Clin Exp Allergy"},{"key":"2019041122400244300_R19","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/0016-5085(95)90212-0","article-title":"A single intraportal administration of follistatin accelerates liver regeneration in partially hepatectomized rats.","volume":"108","author":"Kogure","year":"1995","journal-title":"Gastroenterology"},{"key":"2019041122400244300_R20","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/S0168-8278(98)80126-8","article-title":"Immediate onset of DNA synthesis in remnant rat liver after 90% hepatectomy by an administration of follistatin.","volume":"29","author":"Kogure","year":"1998","journal-title":"J Hepatol"},{"key":"2019041122400244300_R21","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1053\/he.2000.6100","article-title":"The role of activin and transforming growth factor-\u03b2 in the regulation of organ mass in the rat liver.","volume":"31","author":"Kogure","year":"2000","journal-title":"Hepatology"},{"key":"2019041122400244300_R22","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1002\/dvdy.20042","article-title":"Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis.","volume":"230","author":"Yao","year":"2004","journal-title":"Dev Dyn"},{"key":"2019041122400244300_R23","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1111\/j.1365-2567.2004.01876.x","article-title":"Semen activates the female immune response during early pregnancy in mice.","volume":"112","author":"Johansson","year":"2004","journal-title":"Immunology"},{"key":"2019041122400244300_R24","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.4049\/jimmunol.148.6.1699","article-title":"Activation and distribution of inflammatory cells in the mouse uterus during the preimplantation period.","volume":"148","author":"McMaster","year":"1992","journal-title":"J Immunol"},{"key":"2019041122400244300_R25","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1530\/jrf.0.1070265","article-title":"Role of high molecular weight seminal vesicle proteins in eliciting the uterine inflammatory response to semen in mice.","volume":"107","author":"Robertson","year":"1996","journal-title":"J Reprod Fertil"},{"key":"2019041122400244300_R26","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1677\/joe.0.1820069","article-title":"Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe.","volume":"182","author":"Jones","year":"2004","journal-title":"J Endocrinol"},{"key":"2019041122400244300_R27","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1071-55760300045-5","article-title":"Endometrial expression and secretion of activin A, but not follistatin, increase in the secretory phase of the menstrual cycle.","volume":"10","author":"Florio","year":"2003","journal-title":"J Soc Gynecol Investig"},{"key":"2019041122400244300_R28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/molehr\/8.4.363","article-title":"Expression of activin receptors, follistatin and betaglycan by human endometrial stromal cells; consistent with a role for activins during decidualization.","volume":"8","author":"Jones","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"2019041122400244300_R29","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1677\/joe.0.1260417","article-title":"Influence of oestrogen and progesterone on macrophage distribution in the mouse uterus.","volume":"126","author":"De","year":"1990","journal-title":"J Endocrinol"},{"key":"2019041122400244300_R30","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1095\/biolreprod60.5.1158","article-title":"Progesterone via its receptor antagonizes the pro-inflammatory activity of estrogen in the mouse uterus.","volume":"60","author":"Tibbetts","year":"1999","journal-title":"Biol Reprod"},{"key":"2019041122400244300_R31","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1101\/gad.9.18.2266","article-title":"Mice lacking progesterone receptor exhibit pleiotropic reproductive abnormalities.","volume":"9","author":"Lydon","year":"1995","journal-title":"Genes Dev"},{"key":"2019041122400244300_R32"},{"key":"2019041122400244300_R33","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.mce.2006.03.041","article-title":"Stimulatory effects of lipopolysaccharide on endothelial cell activin and follistatin.","volume":"253","author":"Wilson","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"2019041122400244300_R34","first-page":"267","article-title":"The activin-binding protein follistatin regulates autocrine endothelial cell activity and induces angiogenesis.","volume":"76","author":"Kozian","year":"1997","journal-title":"Lab Invest"},{"key":"2019041122400244300_R35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0303-7207(02)00053-9","article-title":"Recruitment and development of the follicle; the roles of the transforming growth factor-\u03b2 superfamily.","volume":"191","author":"Findlay","year":"2002","journal-title":"Mol Cell Endocrinol"},{"key":"2019041122400244300_R36","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1677\/joe.0.1710385","article-title":"The activin binding proteins follistatin and follistatin-related protein are differentially regulated in vitro and during cutaneous wound repair.","volume":"171","author":"Wankell","year":"2001","journal-title":"J Endocrinol"},{"key":"2019041122400244300_R37","doi-asserted-by":"crossref","first-page":"4206","DOI":"10.1210\/jcem.86.9.7798","article-title":"Dynamics of inhibin subunit and follistatin mRNA during development of normal and polycystic ovary syndrome follicles.","volume":"86","author":"Fujiwara","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122400244300_R38","first-page":"4596","article-title":"The N-myc oncogene in human neuroblastoma cells: down-regulation of an angiogenesis inhibitor identified as activin A.","volume":"60","author":"Breit","year":"2000","journal-title":"Cancer Res"},{"key":"2019041122400244300_R39","doi-asserted-by":"crossref","first-page":"5686","DOI":"10.1158\/0008-5472.CAN-05-3821","article-title":"Dissociation of angiogenesis and tumorigenesis in follistatin- and activin-expressing tumors.","volume":"66","author":"Krneta","year":"2006","journal-title":"Cancer Res"},{"key":"2019041122400244300_R40","doi-asserted-by":"crossref","first-page":"23066","DOI":"10.1016\/S0021-9258(19)49426-X","article-title":"Inhibition of vascular endothelial cell growth by activin-A.","volume":"268","author":"McCarthy","year":"1993","journal-title":"J Biol Chem"},{"key":"2019041122400244300_R41","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1158\/0008-5472.CAN-04-2828","article-title":"Activin A suppresses neuroblastoma xenograft tumor growth via antimitotic and antiangiogenic mechanisms.","volume":"65","author":"Panopoulou","year":"2005","journal-title":"Cancer Res"},{"key":"2019041122400244300_R42","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/sj.onc.1208087","article-title":"High activin A-expression in human neuroblastoma: suppression of malignant potential and correlation with favourable clinical outcome.","volume":"24","author":"Schramm","year":"2005","journal-title":"Oncogene"},{"key":"2019041122400244300_R43","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1016\/S0002-9440(10)63216-6","article-title":"Activin A in the regulation of corneal neovascularization and vascular endothelial growth factor expression.","volume":"164","author":"Poulaki","year":"2004","journal-title":"Am J Pathol"},{"key":"2019041122400244300_R44","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1210\/en.2004-0213","article-title":"Crucial role of activin a in tubulogenesis of endothelial cells induced by vascular endothelial growth factor.","volume":"145","author":"Maeshima","year":"2004","journal-title":"Endocrinology"},{"key":"2019041122400244300_R45","first-page":"311","article-title":"Activin A as a critical mediator of capillary formation: interaction with the fibroblast growth factor action.","volume":"54","author":"Hayashi","year":"2007","journal-title":"J Endocrinol"},{"key":"2019041122400244300_R46"},{"key":"2019041122400244300_R47","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1007\/s003359900551","article-title":"Behavioral and functional analysis of mouse phenotype: SHIRPA, a proposed protocol for comprehensive phenotype assessment.","volume":"8","author":"Rogers","year":"1997","journal-title":"Mamm Genome"},{"key":"2019041122400244300_R48","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1590\/S1519-69842002000400008","article-title":"Determination of the estrous cycle phases of rats: some helpful considerations.","volume":"62","author":"Marcondes","year":"2002","journal-title":"Braz J Biol"},{"key":"2019041122400244300_R49","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1095\/biolreprod.101.001446","article-title":"Identification of a novel testis-specific member of the phosphatidylethanolamine binding protein family, pebp-2.","volume":"67","author":"Hickox","year":"2002","journal-title":"Biol Reprod"},{"key":"2019041122400244300_R50","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1530\/jrf.0.1120233","article-title":"Localization of follistatin in the rat testis.","volume":"112","author":"Meinhardt","year":"1998","journal-title":"J Reprod Fertil"}],"container-title":["Molecular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mend\/article-pdf\/22\/2\/415\/10720661\/mend0415.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,18]],"date-time":"2024-02-18T13:15:40Z","timestamp":1708262140000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mend\/article\/22\/2\/415\/2661082"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2,1]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1210\/me.2006-0529","relation":{},"ISSN":["0888-8809","1944-9917"],"issn-type":[{"value":"0888-8809","type":"print"},{"value":"1944-9917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,2,1]]}}}