{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T19:57:36Z","timestamp":1777319856268,"version":"3.51.4"},"reference-count":41,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Mutations and polymorphisms in PPARG have been linked to adiposity and partial lipodystrophy in humans. However, how disturbances in PPARG lead to depot-specific effects on adipose tissue, as shown by the characteristic aberrant fat distribution in patients, remains unclear. By manipulating the 3\u2032-untranslated region of the Pparg gene, we have generated mice with peroxisome proliferator-activated receptor \u03b3 (PPAR\u03b3) gene expression ranging from 25% to 100% normal. Basal levels of PPAR\u03b3 transcripts between 50% and approximately 100% had no significant effect on body weight, fat mass, and insulin sensitivity. In contrast, mice with 25% normal PPAR\u03b3 expression exhibited reduced body weight and total fat mass, insulin resistance, and dyslipidemia. Interestingly, fat mass was selectively reduced in perigonadal depot without significant changes in inguinal and other depots. Expression of adipogenic factor CCAAT enhancer binding protein-\u03b1 and some other metabolic genes containing peroxisome proliferator response element were reduced in a perigonadal depot-specific fashion. This was further associated with depot-specific reduction in the expression of adipokines, increased expression of TNF\u03b1, and increased ectopic lipid deposition in muscles. Together, these results underscore the differential sensitivity of the individual fat depots on PPAR\u03b3 availability as an underlying mechanism of partial lipodystrophy.<\/jats:p>","DOI":"10.1210\/me.2009-0073","type":"journal-article","created":{"date-parts":[[2009,9,12]],"date-time":"2009-09-12T01:53:07Z","timestamp":1252720387000},"page":"1787-1798","source":"Crossref","is-referenced-by-count":25,"title":["Decreased PPAR\u03b3 Expression Compromises Perigonadal-Specific Fat Deposition and Insulin Sensitivity"],"prefix":"10.1210","volume":"23","author":[{"given":"Yau-Sheng","family":"Tsai","sequence":"first","affiliation":[{"name":"Institute of Clinical Medicine (Y.-S.T., M.-J.J.), Tainan 701, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Jane","family":"Tsai","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Department of Medical Laboratory Science and Biotechnology (P.-J.T.), Tainan 701, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man-Jin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Institute of Clinical Medicine (Y.-S.T., M.-J.J.), Tainan 701, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting-Yu","family":"Chou","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine (T.-Y.C.), College of Medicine, National Cheng Kung University, Tainan 701, Taiwan, Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Avani","family":"Pendse","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine (A.P., H.-S.K., N.M.), University of North Carolina, Chapel Hill, North Carolina 27599"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung-Suk","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine (A.P., H.-S.K., N.M.), 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