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On the other hand, B-2 cells are the principal mediators of the adaptive humoral immune response and represent an important pharmacological target for various conditions including rheumatoid arthritis, lupus erythematosus, and lymphomas. Using the resources of the Nuclear Receptor Signaling Atlas program, we used quantitative real-time PCR to assess the complement of the 49 murine nuclear receptor superfamily expressed in quiescent and toll-like receptor (TLR)-stimulated peritoneal B-1 and B-2 cells. We report the expression of 24 nuclear receptors in basal B-1 cells and 25 nuclear receptors in basal B-2 cells, with, in some cases, dramatic changes in response to TLR 4 or TLR 2\/1 stimulation. Comparative nuclear receptor profiling between B-1 and peritoneal B-2 cells reveals a highly concordant expression pattern, albeit at quantitatively dissimilar levels. We also found that splenic B cells express 23 nuclear receptors. This catalog of nuclear receptor expression in B-1 and B-2 cells provides data to be used to better understand the specific roles of nuclear receptors in B cell function, chronic inflammation, and autoimmune disease.<\/jats:p>","DOI":"10.1210\/me.2010-0384","type":"journal-article","created":{"date-parts":[[2011,1,28]],"date-time":"2011-01-28T04:10:42Z","timestamp":1296187842000},"page":"529-545","source":"Crossref","is-referenced-by-count":14,"title":["Research Resource: Comparative Nuclear Receptor Atlas: Basal and Activated Peritoneal B-1 and B-2 Cells"],"prefix":"10.1210","volume":"25","author":[{"given":"Cody J.","family":"Diehl","sequence":"first","affiliation":[{"name":"Departments of Medicine (C.J.D., M.-Y.C., C.K.G., J.L.W.)University of California, San Diego, La Jolla, California 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant D.","family":"Barish","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute (G.D.B., M.D., R.M.E.), Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Downes","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute (G.D.B., M.D., R.M.E.), Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Yun","family":"Chou","sequence":"additional","affiliation":[{"name":"Departments of Medicine (C.J.D., M.-Y.C., C.K.G., J.L.W.)University of California, San Diego, La Jolla, California 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"Heinz","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Medicine (S.H., C.K.G.), University of California, San Diego, La Jolla, California 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher K.","family":"Glass","sequence":"additional","affiliation":[{"name":"Departments of Medicine (C.J.D., M.-Y.C., C.K.G., J.L.W.)University of California, San Diego, La Jolla, California 92093;"},{"name":"Cellular and Molecular Medicine (S.H., C.K.G.), University of California, San Diego, La Jolla, California 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald M.","family":"Evans","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute (G.D.B., M.D., R.M.E.), Gene Expression Laboratory, The Salk Institute for Biological Studies, La Jolla, California 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Witztum","sequence":"additional","affiliation":[{"name":"Departments of Medicine (C.J.D., M.-Y.C., C.K.G., J.L.W.)University of California, San Diego, La Jolla, California 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071615002687000_B1","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1600-065X.2000.imr017515.x","article-title":"B-cell subsets and the mature preimmune repertoire. 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