{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:30:07Z","timestamp":1778538607465,"version":"3.51.4"},"reference-count":40,"publisher":"The Endocrine Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10,1]]},"DOI":"10.1210\/me.2012-1357","type":"journal-article","created":{"date-parts":[[2013,7,27]],"date-time":"2013-07-27T07:00:16Z","timestamp":1374908416000},"page":"1593-1602","source":"Crossref","is-referenced-by-count":33,"title":["miR-449a Contributes to Glucocorticoid-Induced CRF-R1 Downregulation in the Pituitary During Stress"],"prefix":"10.1210","volume":"27","author":[{"given":"Takahiro","family":"Nemoto","sequence":"first","affiliation":[{"name":"Department of Physiology, Nippon Medical School, Tokyo, 113-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asuka","family":"Mano","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nippon Medical School, Tokyo, 113-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamotsu","family":"Shibasaki","sequence":"additional","affiliation":[{"name":"Department of Physiology, Nippon Medical School, Tokyo, 113-8602, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2019041122550351800_B1","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.1073\/pnas.80.22.6982","article-title":"Glucocorticoids regulate proopiomelanocortin gene expression in vivo at the levels of transcription and secretion","volume":"80","author":"Birnberg","year":"1983","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2019041122550351800_B2","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1159\/000124846","article-title":"Dexamethasone inhibits corticotropin-releasing factor gene expression in the rat paraventricular nucleus","volume":"46","author":"Kov\u00e1cs","year":"1987","journal-title":"Neuroendocrinology"},{"key":"2019041122550351800_B3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1046\/j.1365-2826.1998.00212.x","article-title":"Interaction between glucocorticoids and corticotropin releasing hormone (CRH) in the regulation of the pituitary CRH receptor in vivo in the rat","volume":"10","author":"Ochedalski","year":"1998","journal-title":"J Neuroendocrinol"},{"key":"2019041122550351800_B4","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1210\/endo-119-5-2129","article-title":"Cytochemical studies of corticotropin-releasing factor (CRF) receptors in anterior lobe corticotropes: binding, glucocorticoid regulation, and endocytosis of [biotinyl-Ser1]CRF","volume":"119","author":"Childs","year":"1986","journal-title":"Endocrinology"},{"key":"2019041122550351800_B5","doi-asserted-by":"crossref","first-page":"2376","DOI":"10.1210\/endo-119-5-2376","article-title":"Identification of corticotropin-releasing factor (CRF) target cells and effects of dexamethasone on binding in anterior pituitary using a fluorescent analog of CRF","volume":"119","author":"Schwartz","year":"1986","journal-title":"Endocrinology"},{"key":"2019041122550351800_B6","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1210\/endo-120-4-1527","article-title":"Differential regulation of brain and pituitary corticotropin-releasing factor receptors by corticosterone","volume":"120","author":"Hauger","year":"1987","journal-title":"Endocrinology"},{"key":"2019041122550351800_B7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0196-9781(96)00014-9","article-title":"Modulation of CRF-R1 mRNA in rat anterior pituitary by dexamethasone: correlation with POMC mRNA","volume":"17","author":"Zhou","year":"1996","journal-title":"Peptides"},{"key":"2019041122550351800_B8","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1124\/mol.51.5.794","article-title":"Glucocorticoid regulation of corticotropin-releasing factor1 receptor expression in pituitary-derived AtT-20 cells","volume":"51","author":"Iredale","year":"1997","journal-title":"Mol Pharmacol"},{"key":"2019041122550351800_B9","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1046\/j.1365-2826.1997.00626.x","article-title":"Regulation of pituitary corticotropin releasing hormone (CRH) receptor mRNA and CRH binding during adrenalectomy: role of glucocorticoids and hypothalamic factors","volume":"9","author":"Rabadan-Diehl","year":"1997","journal-title":"J Neuroendocrinol"},{"key":"2019041122550351800_B10","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.cell.2009.01.035","article-title":"Origins and mechanisms of miRNAs and siRNAs","volume":"136","author":"Carthew","year":"2009","journal-title":"Cell"},{"key":"2019041122550351800_B11","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1038\/nm1008-1041","article-title":"The perfect storm of tiny RNAs","volume":"14","author":"Ruvkun","year":"2008","journal-title":"Nat Med"},{"key":"2019041122550351800_B12","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.cell.2010.11.018","article-title":"Modifications of small RNAs and their associated proteins","volume":"143","author":"Kim","year":"2010","journal-title":"Cell"},{"key":"2019041122550351800_B13","doi-asserted-by":"crossref","first-page":"E567","DOI":"10.1152\/ajpendo.00163.2010","article-title":"Role of urocortin 2 secreted by the pituitary in the stress-induced suppression of luteinizing hormone secretion in rats","volume":"299","author":"Nemoto","year":"2010","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2019041122550351800_B14","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0304-3940(98)00719-8","article-title":"Non-peptidic corticotropin-releasing hormone receptor type 1 antagonist reverses restraint stress-induced shortening of sodium pentobarbital-induced sleeping time of rats: evidence that an increase in arousal induced by stress is mediated through CRH receptor type 1","volume":"255","author":"Arai","year":"1998","journal-title":"Neurosci Lett"},{"key":"2019041122550351800_B15","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1677\/joe.1.07023","article-title":"Regulation of the expression and secretion of urocortin 2 in rat pituitary","volume":"192","author":"Nemoto","year":"2007","journal-title":"J Endocrinol"},{"key":"2019041122550351800_B16","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nprot.2006.236","article-title":"Quantification of mRNA using real-time RT-PCR","volume":"1","author":"Nolan","year":"2006","journal-title":"Nat Protoc"},{"key":"2019041122550351800_B17","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1210\/jcem-59-2-263","article-title":"Distribution of growth hormone-releasing hormone-like immunoreactivity in human tissue extracts","volume":"59","author":"Shibasaki","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"2019041122550351800_B18","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1242\/dev.046045","article-title":"The RNA-binding protein bicaudal C regulates polycystin 2 in the kidney by antagonizing miR-17 activity","volume":"137","author":"Tran","year":"2010","journal-title":"Development"},{"key":"2019041122550351800_B19","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.2337\/diabetes.48.9.1741","article-title":"Corticotropin-releasing factor modulation of Ca2+ influx in rat pancreatic \u03b2-cells","volume":"48","author":"Kanno","year":"1999","journal-title":"Diabetes"},{"key":"2019041122550351800_B20","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1677\/joe.1.06927","article-title":"Expression of molecular equivalent of hypothalamic-pituitary-adrenal axis in adult retinal pigment epithelium","volume":"193","author":"Zmijewski","year":"2007","journal-title":"J Endocrinol"},{"key":"2019041122550351800_B21","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1369\/jhc.2010.956789","article-title":"Expression of IGFBP7 mRNA in corticotrophs in the anterior pituitary of adrenalectomized rats","volume":"58","author":"Nakakura","year":"2010","journal-title":"J Histochem Cytochem"},{"key":"2019041122550351800_B22","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.neuroscience.2004.06.023","article-title":"Corticotropin-releasing factor receptor type 1 and 2 mRNA expression in the rat anterior pituitary is modulated by intermittent hypoxia, cold and restraint","volume":"128","author":"Wang","year":"2004","journal-title":"Neuroscience"},{"key":"2019041122550351800_B23","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1210\/endo-116-4-1653","article-title":"Regulation of corticotropin-releasing factor (CRF) receptors in the rat pituitary gland: effects of adrenalectomy on CRF receptors and corticotroph responses","volume":"116","author":"Wynn","year":"1985","journal-title":"Endocrinology"},{"key":"2019041122550351800_B24","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1038\/sj.emboj.7600385","article-title":"MicroRNA genes are transcribed by RNA polymerase II","volume":"23","author":"Lee","year":"2004","journal-title":"EMBO J"},{"key":"2019041122550351800_B25","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/nsmb1167","article-title":"RNA polymerase III transcribes human microRNAs","volume":"13","author":"Borchert","year":"2006","journal-title":"Nat Struct Mol Biol"},{"key":"2019041122550351800_B26","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.tig.2007.09.001","article-title":"The expanding RNA polymerase III transcriptome","volume":"23","author":"Dieci","year":"2007","journal-title":"Trends Genet"},{"key":"2019041122550351800_B27","doi-asserted-by":"crossref","first-page":"8777","DOI":"10.1073\/pnas.91.19.8777","article-title":"Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary","volume":"91","author":"Potter","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2019041122550351800_B28","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1210\/endo.135.5.7956950","article-title":"Localization of corticotropin-releasing hormone (CRH) receptor mRNA in adult rat brain by in situ hybridization histochemistry","volume":"135","author":"Wong","year":"1994","journal-title":"Endocrinology"},{"key":"2019041122550351800_B29","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.1111\/j.1742-4658.2012.08741.x","article-title":"MicroRNA-133b inhibits the growth of non-small-cell lung cancer by targeting the epidermal growth factor receptor","volume":"279","author":"Liu","year":"2012","journal-title":"FEBS J"},{"key":"2019041122550351800_B30","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.3892\/ol.2011.372","article-title":"Elevated microRNA-126 is associated with high vascular endothelial growth factor receptor 2 expression levels and high microvessel density in colorectal cancer","volume":"2","author":"Hansen","year":"2011","journal-title":"Oncol Lett"},{"key":"2019041122550351800_B31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1186\/1471-2164-13-306","article-title":"Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens","volume":"13","author":"Lin","year":"2012","journal-title":"BMC Genomics"},{"key":"2019041122550351800_B32","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/1476-4598-11-44","article-title":"Silencing of a large micro-RNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor","volume":"11","author":"Zehavi","year":"2012","journal-title":"Mol Cancer"},{"key":"2019041122550351800_B33","doi-asserted-by":"crossref","first-page":"349","DOI":"10.18632\/oncotarget.167","article-title":"miR-449a causes Rb-dependent cell cycle arrest and senescence in prostate cancer cells","volume":"1","author":"Noonan","year":"2010","journal-title":"Oncotarget"},{"key":"2019041122550351800_B34","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.canlet.2012.01.027","article-title":"MicroRNA-449a acts as a tumor suppressor in human bladder cancer through the regulation of pocket proteins","volume":"320","author":"Chen","year":"2012","journal-title":"Cancer Lett"},{"key":"2019041122550351800_B35","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.lungcan.2011.10.012","article-title":"Combining microRNA-449a\/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer","volume":"76","author":"Jeon","year":"2012","journal-title":"Lung Cancer"},{"key":"2019041122550351800_B36","doi-asserted-by":"crossref","first-page":"e363","DOI":"10.1371\/journal.pbio.0020363","article-title":"Human MicroRNA targets","volume":"2","author":"John","year":"2004","journal-title":"PLoS Biol"},{"key":"2019041122550351800_B37","doi-asserted-by":"crossref","first-page":"e3694","DOI":"10.1371\/journal.pone.0003694","article-title":"Detection of microRNA expression in human peripheral blood microvesicles","volume":"3","author":"Hunter","year":"2008","journal-title":"PLoS One"},{"key":"2019041122550351800_B38","doi-asserted-by":"crossref","first-page":"7223","DOI":"10.1093\/nar\/gkr254","article-title":"Characterization of extracellular circulating microRNA","volume":"39","author":"Turchinovich","year":"2011","journal-title":"Nucleic Acids Res"},{"key":"2019041122550351800_B39","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/1471-2164-11-249","article-title":"Small RNA expression and strain specificity in the rat","volume":"11","author":"Linsen","year":"2010","journal-title":"BMC Genomics"},{"key":"2019041122550351800_B40","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1161\/CIRCRESAHA.111.253286","article-title":"Exosomes from human CD34+ stem cells mediate their proangiogenic paracrine activity","volume":"109","author":"Sahoo","year":"2011","journal-title":"Circ Res"}],"container-title":["Molecular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mend\/article-pdf\/27\/10\/1593\/8938525\/mend1593.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T20:03:47Z","timestamp":1563566627000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mend\/article\/27\/10\/1593\/2615035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,1]]},"references-count":40,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2013,10,1]]}},"URL":"https:\/\/doi.org\/10.1210\/me.2012-1357","relation":{},"ISSN":["0888-8809","1944-9917"],"issn-type":[{"value":"0888-8809","type":"print"},{"value":"1944-9917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,10,1]]}}}