{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:42:20Z","timestamp":1780562540557,"version":"3.54.1"},"reference-count":56,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,11,1]]},"DOI":"10.1210\/me.2014-1375","type":"journal-article","created":{"date-parts":[[2015,9,17]],"date-time":"2015-09-17T17:00:45Z","timestamp":1442509245000},"page":"1594-1607","source":"Crossref","is-referenced-by-count":36,"title":["Exploiting Expression of Hippo Effector, Yap, for Expansion of Functional Islet Mass"],"prefix":"10.1210","volume":"29","author":[{"given":"Nicholas M.","family":"George","sequence":"first","affiliation":[{"name":"Holland Regenerative Medicine Program (N.M.G., B.P.B., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha, Nebraska 68198"},{"name":"Department of Surgery (N.M.G., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha 68198, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian P.","family":"Boerner","sequence":"additional","affiliation":[{"name":"Holland Regenerative Medicine Program (N.M.G., B.P.B., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha, Nebraska 68198"},{"name":"Department of Internal Medicine (B.P.B.), University of Nebraska Medical Center, Omaha, Nebraska 68198"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shakeel U. R.","family":"Mir","sequence":"additional","affiliation":[{"name":"Holland Regenerative Medicine Program (N.M.G., B.P.B., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha, Nebraska 68198"},{"name":"Department of Surgery (N.M.G., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha 68198, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zachary","family":"Guinn","sequence":"additional","affiliation":[{"name":"Holland Regenerative Medicine Program (N.M.G., B.P.B., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha, Nebraska 68198"},{"name":"Department of Surgery (N.M.G., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha 68198, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora E.","family":"Sarvetnick","sequence":"additional","affiliation":[{"name":"Holland Regenerative Medicine Program (N.M.G., B.P.B., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha, Nebraska 68198"},{"name":"Department of Surgery (N.M.G., S.U.R.M., Z.G., N.E.S.), University of Nebraska Medical Center, Omaha 68198, Nebraska"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"issue":"9911","key":"2019041122002964000_B1","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0140-6736(13)60591-7","article-title":"Type 1 diabetes","volume":"383","author":"Atkinson","year":"2014","journal-title":"Lancet"},{"issue":"12","key":"2019041122002964000_B2","doi-asserted-by":"crossref","first-page":"2472","DOI":"10.1242\/dev.093187","article-title":"How to make a functional \u03b2-cell","volume":"140","author":"Pagliuca","year":"2013","journal-title":"Development"},{"issue":"4","key":"2019041122002964000_B3","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1056\/NEJM200007273430401","article-title":"Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen","volume":"343","author":"Shapiro","year":"2000","journal-title":"N Engl J Med"},{"issue":"9","key":"2019041122002964000_B4","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.2337\/db12-0018","article-title":"Human \u03b2-cell proliferation and intracellular signaling: driving in the dark without a road map","volume":"61","author":"Kulkarni","year":"2012","journal-title":"Diabetes"},{"issue":"3","key":"2019041122002964000_B5","doi-asserted-by":"crossref","first-page":"819","DOI":"10.2337\/db13-1146","article-title":"Human \u03b2-cell proliferation and intracellular signaling part 2: still driving in the dark without a road map","volume":"63","author":"Bernal-Mizrachi","year":"2014","journal-title":"Diabetes"},{"issue":"8","key":"2019041122002964000_B6","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1101\/gad.1536007","article-title":"Hippo signaling in organ size control","volume":"21","author":"Pan","year":"2007","journal-title":"Genes Dev"},{"issue":"8","key":"2019041122002964000_B7","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/ncb2303","article-title":"The Hippo pathway in organ size control, tissue regeneration and stem cell self-renewal","volume":"13","author":"Zhao","year":"2011","journal-title":"Nat Cell Biol"},{"issue":"14","key":"2019041122002964000_B8","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1101\/gad.1664408","article-title":"TEAD mediates YAP-dependent gene induction and growth control","volume":"22","author":"Zhao","year":"2008","journal-title":"Genes Dev"},{"issue":"24","key":"2019041122002964000_B9","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1128\/MCB.01034-12","article-title":"Hippo signaling regulates pancreas development through inactivation of Yap","volume":"32","author":"George","year":"2012","journal-title":"Mol Cell Biol"},{"issue":"7","key":"2019041122002964000_B10","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1053\/j.gastro.2013.02.037","article-title":"Hippo signaling regulates differentiation and maintenance in the exocrine pancreas","volume":"144","author":"Gao","year":"2013","journal-title":"Gastroenterology"},{"issue":"10","key":"2019041122002964000_B11","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","article-title":"Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors","volume":"129","author":"Gu","year":"2002","journal-title":"Development"},{"issue":"21","key":"2019041122002964000_B12","doi-asserted-by":"crossref","first-page":"3567","DOI":"10.1242\/dev.039214","article-title":"Pancreatic neurogenin 3-expressing cells are unipotent islet precursors","volume":"136","author":"Desgraz","year":"2009","journal-title":"Development"},{"issue":"1","key":"2019041122002964000_B13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1073\/pnas.1004842108","article-title":"Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a","volume":"108","author":"Miyatsuka","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2019041122002964000_B14","first-page":"671","article-title":"Murine pancreatic ductal adenocarcinoma produced by in vitro transduction of polyoma middle T oncogene into the islets of Langerhans","volume":"145","author":"Yoshida","year":"1994","journal-title":"Am J Pathol"},{"issue":"1","key":"2019041122002964000_B15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0002-9440(10)65567-8","article-title":"Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma","volume":"153","author":"Liu","year":"1998","journal-title":"Am J Pathol"},{"issue":"11","key":"2019041122002964000_B16","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.1210\/en.2013-1197","article-title":"TGF-\u03b2 superfamily member nodal stimulates human \u03b2-cell proliferation while maintaining cellular viability","volume":"154","author":"Boerner","year":"2013","journal-title":"Endocrinology"},{"issue":"4","key":"2019041122002964000_B17","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1073\/pnas.0911427107","article-title":"Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver","volume":"107","author":"Lu","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2019041122002964000_B18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1074\/jbc.274.1.305","article-title":"Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic \u03b2 cell-specific gene knock-outs using Cre recombinase","volume":"274","author":"Postic","year":"1999","journal-title":"J Biol Chem"},{"issue":"3","key":"2019041122002964000_B19","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.cell.2005.06.007","article-title":"The Hippo signaling pathway coordinately regulates cell proliferation and apoptosis by inactivating Yorkie, the Drosophila homolog of YAP","volume":"122","author":"Huang","year":"2005","journal-title":"Cell"},{"issue":"6","key":"2019041122002964000_B20","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1016\/j.cell.2007.07.019","article-title":"Elucidation of a universal size-control mechanism in Drosophila and mammals","volume":"130","author":"Dong","year":"2007","journal-title":"Cell"},{"issue":"21","key":"2019041122002964000_B21","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1101\/gad.1602907","article-title":"Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control","volume":"21","author":"Zhao","year":"2007","journal-title":"Genes Dev"},{"issue":"4","key":"2019041122002964000_B22","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1073\/pnas.97.4.1607","article-title":"Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas","volume":"97","author":"Gradwohl","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"issue":"36","key":"2019041122002964000_B23","doi-asserted-by":"crossref","first-page":"13245","DOI":"10.1073\/pnas.0405301101","article-title":"Proendocrine genes coordinate the pancreatic islet differentiation program in vitro","volume":"101","author":"Gasa","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"issue":"10","key":"2019041122002964000_B24","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1210\/me.2011-1074","article-title":"cMyc is a principal upstream driver of \u03b2-cell proliferation in rat insulinoma cell lines and is an effective mediator of human \u03b2-cell replication","volume":"25","author":"Karslioglu","year":"2011","journal-title":"Mol Endocrinol"},{"issue":"1","key":"2019041122002964000_B25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2337\/diabetes.53.1.149","article-title":"Induction of \u03b2-cell proliferation and retinoblastoma protein phosphorylation in rat and human islets using adenovirus-mediated transfer of cyclin-dependent kinase-4 and cyclin D1","volume":"53","author":"Cozar-Castellano","year":"2004","journal-title":"Diabetes"},{"issue":"8","key":"2019041122002964000_B26","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.2337\/db09-1776","article-title":"Induction of human \u03b2-cell proliferation and engraftment using a single G1\/S regulatory molecule, cdk6","volume":"59","author":"Fiaschi-Taesch","year":"2010","journal-title":"Diabetes"},{"issue":"9","key":"2019041122002964000_B27","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1210\/me.2012-1019","article-title":"Overexpression of hepatocyte nuclear factor-4\u03b1 initiates cell cycle entry, but is not sufficient to promote \u03b2-cell expansion in human islets","volume":"26","author":"Rieck","year":"2012","journal-title":"Mol Endocrinol"},{"issue":"12","key":"2019041122002964000_B28","doi-asserted-by":"crossref","first-page":"5284","DOI":"10.1210\/en.2009-0671","article-title":"Forkhead box O1\/pancreatic and duodenal homeobox 1 intracellular translocation is regulated by c-Jun N-terminal kinase and involved in prostaglandin E2-induced pancreatic \u03b2-cell dysfunction","volume":"150","author":"Meng","year":"2009","journal-title":"Endocrinology"},{"issue":"37","key":"2019041122002964000_B29","doi-asserted-by":"crossref","first-page":"32413","DOI":"10.1074\/jbc.M506000200","article-title":"Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans","volume":"280","author":"Hagman","year":"2005","journal-title":"J Biol Chem"},{"issue":"8","key":"2019041122002964000_B30","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1172\/JCI65390","article-title":"Inactivation of specific \u03b2 cell transcription factors in type 2 diabetes","volume":"123","author":"Guo","year":"2013","journal-title":"J Clin Invest"},{"issue":"12","key":"2019041122002964000_B31","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/ncb2615","article-title":"YAP mediates crosstalk between the Hippo and PI(3)K\u2013TOR pathways by suppressing PTEN via miR-29","volume":"14","author":"Tumaneng","year":"2012","journal-title":"Nat Cell Biol"},{"issue":"2","key":"2019041122002964000_B32","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s00125-013-3085-8","article-title":"Adult-onset deletion of Pten increases islet mass and \u03b2 cell proliferation in mice","volume":"57","author":"Yang","year":"2014","journal-title":"Diabetologia"},{"issue":"4","key":"2019041122002964000_B33","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1073\/pnas.0911409107","article-title":"Mammalian Mst1 and Mst2 kinases play essential roles in organ size control and tumor suppression","volume":"107","author":"Song","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"issue":"6","key":"2019041122002964000_B34","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.cell.2014.03.060","article-title":"Hippo pathway activity influences liver cell fate","volume":"157","author":"Yimlamai","year":"2014","journal-title":"Cell"},{"issue":"1","key":"2019041122002964000_B35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ydbio.2011.10.017","article-title":"Negative regulation of Yap during neuronal differentiation","volume":"361","author":"Zhang","year":"2012","journal-title":"Dev Biol"},{"issue":"2","key":"2019041122002964000_B36","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1242\/dev.041673","article-title":"Rfx6 is an Ngn3-dependent winged helix transcription factor required for pancreatic islet cell development","volume":"137","author":"Soyer","year":"2010","journal-title":"Development"},{"issue":"6","key":"2019041122002964000_B37","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1073\/pnas.0609217104","article-title":"SOX9 is required for maintenance of the pancreatic progenitor cell pool","volume":"104","author":"Seymour","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"2019041122002964000_B38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ydbio.2011.11.010","article-title":"Ongoing Notch signaling maintains phenotypic fidelity in the adult exocrine pancreas","volume":"362","author":"Kopinke","year":"2012","journal-title":"Dev Biol"},{"issue":"6","key":"2019041122002964000_B39","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ceb.2007.10.004","article-title":"Mechanisms controlling cell cycle exit upon terminal differentiation","volume":"19","author":"Buttitta","year":"2007","journal-title":"Curr Opin Cell Biol"},{"issue":"1","key":"2019041122002964000_B40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.2337\/db13-0384","article-title":"Pak3 promotes cell cycle exit and differentiation of \u03b2-cells in the embryonic pancreas and is necessary to maintain glucose homeostasis in adult mice","volume":"63","author":"Piccand","year":"2014","journal-title":"Diabetes"},{"issue":"3","key":"2019041122002964000_B41","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1093\/carcin\/bgq254","article-title":"YAP is a candidate oncogene for esophageal squamous cell carcinoma","volume":"32","author":"Muramatsu","year":"2011","journal-title":"Carcinogenesis"},{"issue":"2","key":"2019041122002964000_B42","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/emboj.2011.402","article-title":"An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence","volume":"31","author":"Vigneron","year":"2012","journal-title":"EMBO J"},{"issue":"12","key":"2019041122002964000_B43","doi-asserted-by":"crossref","first-page":"3615","DOI":"10.1158\/0008-5472.CAN-12-3793","article-title":"YAP\/TEAD-mediated transcription controls cellular senescence","volume":"73","author":"Xie","year":"2013","journal-title":"Cancer Res"},{"issue":"7","key":"2019041122002964000_B44","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.2337\/db14-1412","article-title":"The basic helix-loop-helix transcription factor NEUROG3 is required for development of the human endocrine pancreas","volume":"64","author":"McGrath","year":"2015","journal-title":"Diabetes"},{"issue":"17","key":"2019041122002964000_B45","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1056\/NEJMc063247","article-title":"Mutant neurogenin-3 in congenital malabsorptive diarrhea","volume":"356","author":"Jensen","year":"2007","journal-title":"N Engl J Med"},{"issue":"11","key":"2019041122002964000_B46","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s00125-014-3349-y","article-title":"Neurogenin 3 is important but not essential for pancreatic islet development in humans","volume":"57","author":"Rubio-Cabezas","year":"2014","journal-title":"Diabetologia"},{"issue":"3","key":"2019041122002964000_B47","doi-asserted-by":"crossref","first-page":"e954436","DOI":"10.4161\/19382014.2014.954436","article-title":"The window period of NEUROGENIN3 during human gestation","volume":"6","author":"Salisbury","year":"2014","journal-title":"Islets"},{"issue":"13","key":"2019041122002964000_B48","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.4161\/cc.20545","article-title":"Differential regulation of embryonic and adult \u03b2 cell replication","volume":"11","author":"Gunasekaran","year":"2012","journal-title":"Cell Cycle"},{"issue":"37","key":"2019041122002964000_B49","doi-asserted-by":"crossref","first-page":"15242","DOI":"10.1073\/pnas.1100072108","article-title":"Connective tissue growth factor acts within both endothelial cells and \u03b2 cells to promote proliferation of developing \u03b2 cells","volume":"108","author":"Guney","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"2019041122002964000_B50","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.2337\/db14-1195","article-title":"Connective tissue growth factor modulates adult \u03b2-cell maturity and proliferation to promote \u03b2-cell regeneration in mice","volume":"64","author":"Riley","year":"2015","journal-title":"Diabetes"},{"issue":"20","key":"2019041122002964000_B51","doi-asserted-by":"crossref","first-page":"13355","DOI":"10.1074\/jbc.M900843200","article-title":"TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition","volume":"284","author":"Zhang","year":"2009","journal-title":"J Biol Chem"},{"issue":"7369","key":"2019041122002964000_B52","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nature10502","article-title":"PDGF signalling controls age-dependent proliferation in pancreatic \u03b2-cells","volume":"478","author":"Chen","year":"2011","journal-title":"Nature"},{"issue":"43","key":"2019041122002964000_B53","doi-asserted-by":"crossref","first-page":"17474","DOI":"10.1073\/pnas.1312830110","article-title":"Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment","volume":"110","author":"Kawamura","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"34","key":"2019041122002964000_B54","doi-asserted-by":"crossref","first-page":"13839","DOI":"10.1073\/pnas.1313192110","article-title":"Hippo pathway effector Yap promotes cardiac regeneration","volume":"110","author":"Xin","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"2019041122002964000_B55","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1161\/CIRCRESAHA.115.303632","article-title":"Cardiac-specific YAP activation improves cardiac function and survival in an experimental murine MI model","volume":"115","author":"Lin","year":"2014","journal-title":"Circ Res"},{"key":"2019041122002964000_B56","first-page":"1153","article-title":"Intracellular delivery of cell-penetrating peptide-transcriptional factor fusion protein and its role in selective osteogenesis","volume":"9","author":"Suh","year":"2014","journal-title":"Int J Nanomedicine"}],"container-title":["Molecular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mend\/article-pdf\/29\/11\/1594\/8909482\/mend1594.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,21]],"date-time":"2022-05-21T23:51:52Z","timestamp":1653177112000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mend\/article\/29\/11\/1594\/2556375"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,1]]},"references-count":56,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/me.2014-1375","relation":{},"ISSN":["0888-8809","1944-9917"],"issn-type":[{"value":"0888-8809","type":"print"},{"value":"1944-9917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,1]]}}}