{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:05:21Z","timestamp":1791846321010,"version":"4.3.4"},"reference-count":111,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The life-threatening, emotional, and economic burdens of premature birth have been greatly alleviated by antenatal glucocorticoid (GC) treatment. Antenatal GCs accelerate tissue development reducing respiratory distress syndrome and intraventricular hemorrhage in premature infants. However, they can also alter developmental processes in the brain and trigger adverse behavioral and metabolic outcomes later in life. This review summarizes animal model and clinical studies that examined the impact of antenatal GCs on the developing brain. In addition, we describe studies that assess glucocorticoid receptor (GR) action in neural stem\/progenitor cells (NSPCs) in vivo and in vitro. We highlight recent work from our group on two GR pathways that impact NSPC proliferation, ie, a nongenomic GR pathway that regulates gap junction intercellular communication between coupled NSPCs through site-specific phosphorylation of connexin 43 and a genomic pathway driven by differential promoter recruitment of a specific GR phosphoisoform.<\/jats:p>","DOI":"10.1210\/me.2015-1042","type":"journal-article","created":{"date-parts":[[2015,3,12]],"date-time":"2015-03-12T12:56:21Z","timestamp":1426164981000},"page":"658-666","source":"Crossref","is-referenced-by-count":26,"title":["Minireview: The Impact of Antenatal Therapeutic Synthetic Glucocorticoids on the Developing Fetal Brain"],"prefix":"10.1210","volume":"29","author":[{"given":"Melanie E.","family":"Peffer","sequence":"first","affiliation":[{"name":"Program in Integrative Molecular Biology (M.E.P., D.B.D.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260"},{"name":"Department of Pharmacology and Chemical Biology (M.E.P., J.Y.Z., L.U., D.B.D.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janie Y.","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology (M.E.P., J.Y.Z., L.U., D.B.D.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leah","family":"Umfrey","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology (M.E.P., J.Y.Z., L.U., D.B.D.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony C.","family":"Rudine","sequence":"additional","affiliation":[{"name":"Newborn Medicine Program (A.C.R.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. Paula","family":"Monaghan","sequence":"additional","affiliation":[{"name":"Children's Hospital of Pittsburgh, and Department of Neurobiology (A.P.M.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald B.","family":"DeFranco","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Chemical Biology (M.E.P., J.Y.Z., L.U., D.B.D.), University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15260"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2020071614184363200_B1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1079\/PNS19980017","article-title":"Glucocorticoids and the preparation for life after birth: are there long-term consequences of the life insurance?","volume":"57","author":"Fowden","year":"1998","journal-title":"Proc Nutr Soc"},{"key":"2020071614184363200_B2","first-page":"281","article-title":"The effects of hypophysectomy, thyroidectomy, and postoperative infusion of cortisol or adrenocorticotrophin on the structure of the ovine fetal lung","volume":"5","author":"Crone","year":"1983","journal-title":"J Dev Physiol"},{"key":"2020071614184363200_B3","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1203\/00006450-198709000-00019","article-title":"Elastin and collagen in the fetal sheep lung. 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