{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:00:40Z","timestamp":1790290840361,"version":"4.1.0"},"reference-count":44,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1997,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Pituitary-specific transcription of the evolutionarily related rat (r) GH and PRL genes involves synergistic interactions between Pit-1 and other promoter-binding factors including nuclear receptors. We show that Pit-1\/thyroid hormone receptor (TR) and Pit-1\/estrogen receptor (ER) synergistic activation of the rGH and rPRL promoters are globally similar. Both synergies depend upon the same activation functions in Pit-1 and also require activation function-2 conserved in TR and ER. The activation function-2 binding protein, RIP140, previously thought to be a nuclear receptor coactivator, strongly inhibits both Pit-1\/TR and Pit-1\/ER synergy. RIP140 inhibition is profoundly influenced, in a promoter-specific fashion, by a synergism-selective function in Pit-1: deletion of Pit-1 amino acids 72\u2013100 switches RIP140 to an activator of Pit-1\/ER and Pit-1\/TR synergy at the rPRL promoter but not at the rGH promoter. Pit-1 amino acids 101\u2013125 are required for RIP140 inhibition or activation again only at the rPRL promoter. Therefore, functions within one factor can determine the activity of a coactivator binding to its synergistic partner. This promoter context-specific synergistic interplay between transcription factors and coactivators is likely an essential determinant of cell-specific transcriptional regulation.<\/jats:p>","DOI":"10.1210\/mend.11.9.9978","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:30:06Z","timestamp":1389202206000},"page":"1332-1341","source":"Crossref","is-referenced-by-count":33,"title":["Activities in Pit-1 Determine Whether Receptor Interacting Protein 140 Activates or Inhibits Pit-1\/Nuclear Receptor Transcriptional Synergy"],"prefix":"10.1210","volume":"11","author":[{"given":"F. Max","family":"Chuang","sequence":"first","affiliation":[{"name":"Metabolic Research Unit University of California, San Francisco, California 94143-0540"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L.","family":"West","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit University of California, San Francisco, California 94143-0540"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John D.","family":"Baxter","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit University of California, San Francisco, California 94143-0540"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"Schaufele","sequence":"additional","affiliation":[{"name":"Metabolic Research Unit University of California, San Francisco, California 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