{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T12:55:21Z","timestamp":1772801721539,"version":"3.50.1"},"reference-count":52,"publisher":"The Endocrine Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1999,5,1]]},"DOI":"10.1210\/mend.13.5.0282","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:30:35Z","timestamp":1389202235000},"page":"659-669","source":"Crossref","is-referenced-by-count":5,"title":["Inducible Binding of Cyclic Adenosine 3\u2032,5\u2032-Monophosphate (cAMP)-Responsive Element Binding Protein (CREB) to a cAMP-Responsive Promoter in Vivo"],"prefix":"10.1210","volume":"13","author":[{"given":"Stefan","family":"Wo\u0308lfl","sequence":"first","affiliation":[{"name":"Hans-Kno\u0308ll-Institut fu\u0308r Naturstoff-Forschung (S.W.) 07745 Jena, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilo","family":"Martinez","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (C.M., J.A.M.) Children\u2019s Hospital Harvard Medical School Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph A.","family":"Majzoub","sequence":"additional","affiliation":[{"name":"Division of Endocrinology (C.M., J.A.M.) Children\u2019s Hospital Harvard Medical School Boston, Massachusetts 02115"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"80","reference":[{"key":"2019041123401194300_R1","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/0092-8674(89)90013-5","article-title":"Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133.","volume":"59","author":"Gonzalez","year":"1989","journal-title":"Cell"},{"key":"2019041123401194300_R2","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1128\/MCB.13.8.4852","article-title":"Coupling of hormonal stimulation and transcription via the cyclic AMP-responsive factor CREB is rate limited by nuclear entry of protein kinase A.","volume":"13","author":"Hagiwara","year":"1993","journal-title":"Mol Cell Biol"},{"key":"2019041123401194300_R3","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1126\/science.1646483","article-title":"CREB: a Ca(2+)-regulated transcription factor phosphorylated by calmodulin-dependent kinases.","volume":"252","author":"Sheng","year":"1991","journal-title":"Science"},{"key":"2019041123401194300_R4","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/32448","article-title":"Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons.","volume":"392","author":"Deisseroth","year":"1998","journal-title":"Nature"},{"key":"2019041123401194300_R5","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1146\/annurev.biochem.66.1.807","article-title":"Transcriptional regulation by cyclic AMP.","volume":"66","author":"Montminy","year":"1997","journal-title":"Annu Rev Biochem"},{"key":"2019041123401194300_R6","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/365855a0","article-title":"Phosphorylated CREB binds specifically to the nuclear protein CBP.","volume":"365","author":"Chrivia","year":"1993","journal-title":"Nature"},{"key":"2019041123401194300_R7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/370223a0","article-title":"Nuclear protein CBP is a coactivator for the transcription factor CREB.","volume":"370","author":"Kwok","year":"1994","journal-title":"Nature"},{"key":"2019041123401194300_R8","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1073\/pnas.91.4.1210","article-title":"The cAMP-regulated transcription factor CREB interacts with a component of the TFIID complex.","volume":"91","author":"Ferreri","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123401194300_R9","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/334494a0","article-title":"Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.","volume":"334","author":"Yamamoto","year":"1988","journal-title":"Nature"},{"key":"2019041123401194300_R10","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/328175a0","article-title":"Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene.","volume":"328","author":"Montminy","year":"1987","journal-title":"Nature"},{"key":"2019041123401194300_R11","doi-asserted-by":"crossref","first-page":"13716","DOI":"10.1074\/jbc.271.23.13716","article-title":"Analysis of the structural properties of cAMP-responsive element-binding protein (CREB) and phosphorylated CREB.","volume":"271","author":"Richards","year":"1996","journal-title":"J Biol Chem"},{"key":"2019041123401194300_R12","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1002\/j.1460-2075.1992.tb05412.x","article-title":"Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription.","volume":"11","author":"Nichols","year":"1992","journal-title":"EMBO J"},{"key":"2019041123401194300_R13","doi-asserted-by":"crossref","first-page":"3795","DOI":"10.1021\/bi970982t","article-title":"Phosphorylation of the cAMP response element binding protein CREB by cAMP-dependent protein kinase A and glycogen synthase kinase-3 alters DNA-binding affinity, conformation, and increases net charge.","volume":"37","author":"Bullock","year":"1998","journal-title":"Biochemistry"},{"key":"2019041123401194300_R14","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1038\/364821a0","article-title":"Protein-kinase-A-dependent activator in transcription factor CREB reveals new role for CREM repressors.","volume":"364","author":"Brindle","year":"1993","journal-title":"Nature"},{"key":"2019041123401194300_R15","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1128\/MCB.16.2.694","article-title":"Phosphorylation of CREB at Ser-133 induces complex formation with CREB-binding protein via a direct mechanism.","volume":"16","author":"Parker","year":"1996","journal-title":"Mol Cell Biol"},{"key":"2019041123401194300_R16","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1101\/gad.4.8.1437","article-title":"In vivo monitoring of a cAMP-stimulated DNA-binding activity.","volume":"4","author":"Weih","year":"1990","journal-title":"Genes Dev"},{"key":"2019041123401194300_R17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/0092-8674(91)90432-X","article-title":"The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase.","volume":"66","author":"Boshart","year":"1991","journal-title":"Cell"},{"key":"2019041123401194300_R18","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.1016\/S0021-9258(17)37333-7","article-title":"Recombinant cyclic AMP response element binding protein (CREB) phosphorylated on Ser-133 is transcriptionally active upon its introduction into fibroblast nuclei.","volume":"269","author":"Alberts","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041123401194300_R19","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1073\/pnas.55.4.805","article-title":"RNA synthesis and histone acetylation during the course of gene activation in lymphocytes.","volume":"55","author":"Pogo","year":"1966","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123401194300_R20","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/373427a0","article-title":"Corticotropin-releasing hormone deficiency reveals major fetal but not adult glucocorticoid need.","volume":"373","author":"Muglia","year":"1995","journal-title":"Nature"},{"key":"2019041123401194300_R21","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1210\/mend-2-12-1311","article-title":"Identification of a cyclic adenosine monophosphate-responsive element in the rat corticotropin-releasing hormone gene.","volume":"2","author":"Seasholtz","year":"1988","journal-title":"Mol Endocrinol"},{"key":"2019041123401194300_R22","doi-asserted-by":"crossref","first-page":"14784","DOI":"10.1016\/S0021-9258(17)36693-0","article-title":"The cAMP-responsive element in the corticotropin-releasing hormone gene mediates transcriptional regulation by depolarization.","volume":"269","author":"Guardiola-Diaz","year":"1994","journal-title":"J Biol Chem"},{"key":"2019041123401194300_R23","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/0303-7207(90)90156-3","article-title":"Regulated expression of the human corticotropin releasing hormone gene by cyclic AMP.","volume":"70","author":"Adler","year":"1990","journal-title":"Mol Cell Endocrinol"},{"key":"2019041123401194300_R24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0303-7207(93)90100-X","article-title":"Transcriptional regulation of human corticotropin releasing factor gene expression by cyclic adenosine 3\u2032,5\u2032-monophosphate: differential effects at proximal and distal promoter elements.","volume":"96","author":"Dorin","year":"1993","journal-title":"Mol Cell Endocrinol"},{"key":"2019041123401194300_R25","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1210\/endo-127-3-1412","article-title":"Glucocorticoid repression of 3\u2032,5\u2032-cyclic-adenosine monophosphate-dependent human corticotropin-releasing-hormone gene promoter activity in a transfected mouse anterior pituitary cell line.","volume":"127","author":"Van","year":"1990","journal-title":"Endocrinology"},{"key":"2019041123401194300_R26","first-page":"30","article-title":"Second messenger regulation of mRNA for corticotropin-releasing factor.","volume":"172","author":"Majzoub","year":"1993","journal-title":"Ciba Found Symp"},{"key":"2019041123401194300_R27","first-page":"1931","article-title":"Identification and characterization of a 3\u2032,5\u2032-cyclic adenosine monophosphate-responsive element in the human corticotropin-releasing hormone gene promoter.","volume":"6","author":"Spengler","year":"1992","journal-title":"Mol Endocrinol"},{"key":"2019041123401194300_R28","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1073\/pnas.93.8.3664","article-title":"Transcription of the human corticotropin-releasing hormone gene in NPLC cells is correlated with Z-DNA formation.","volume":"93","author":"Wolfl","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123401194300_R29","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1210\/mend.12.8.0150","article-title":"Characterization of a human-specific regulator of placental corticotropin-releasing hormone.","volume":"12","author":"Scatena","year":"1998","journal-title":"Mol Endocrinol"},{"key":"2019041123401194300_R30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1523\/JNEUROSCI.16-01-00262.1996","article-title":"Sequence of stress-induced alterations in indices of synaptic and transcriptional activation in parvocellular neurosecretory neurons.","volume":"16","author":"Kovacs","year":"1996","journal-title":"J Neurosci"},{"key":"2019041123401194300_R31","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/0014-5793(81)80952-0","article-title":"Isolation and structural organization of the human corticotropin-beta-lipotropin precursor gene.","volume":"135","author":"Takahashi","year":"1981","journal-title":"FEBS Lett"},{"key":"2019041123401194300_R32","doi-asserted-by":"crossref","first-page":"18466","DOI":"10.1016\/S0021-9258(19)81381-9","article-title":"Structural determinants for transcriptional activation by cAMP-responsive DNA elements.","volume":"263","author":"Deutsch","year":"1988","journal-title":"J Biol Chem"},{"key":"2019041123401194300_R33","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1128\/MCB.8.1.25","article-title":"Expression and biosynthetic variation of the epidermal growth factor receptor in human hepatocellular carcinoma-derived cell lines.","volume":"8","author":"Carlin","year":"1988","journal-title":"Mol Cell Biol"},{"key":"2019041123401194300_R34","doi-asserted-by":"crossref","first-page":"4653","DOI":"10.1002\/j.1460-2075.1992.tb05567.x","article-title":"Transcription of human c-myc in permeabilized nuclei is associated with formation of Z-DNA in three discrete regions of the gene.","volume":"11","author":"Wittig","year":"1992","journal-title":"EMBO J"},{"key":"2019041123401194300_R35","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0092-8674(95)90512-X","article-title":"Histone H3 and H4 N-termini interact with SIR3 and SIR4 proteins: a molecular model for the formation of heterochromatin in yeast.","volume":"80","author":"Hecht","year":"1995","journal-title":"Cell"},{"key":"2019041123401194300_R36","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1101\/gad.12.5.627","article-title":"Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo.","volume":"12","author":"Kuo","year":"1998","journal-title":"Genes Dev"},{"key":"2019041123401194300_R37","doi-asserted-by":"crossref","first-page":"5121","DOI":"10.1128\/MCB.18.9.5121","article-title":"Targeted recruitment of the Sin3-Rpd3 histone deacetylase complex generates a highly localized domain of repressed chromatin in vivo.","volume":"18","author":"Kadosh","year":"1998","journal-title":"Mol Cell Biol"},{"key":"2019041123401194300_R38","doi-asserted-by":"crossref","first-page":"6419","DOI":"10.1093\/nar\/17.15.6419","article-title":"Rapid detection of octamer binding proteins with \u2019mini-extracts\u2019, prepared from a small number of cells.","volume":"17","author":"Schreiber","year":"1989","journal-title":"Nucleic Acids Res"},{"key":"2019041123401194300_R39","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1210\/mend-5-10-1418","article-title":"Developmental stage-specific expression of cyclic adenosine 3\u2032,5\u2032-monophosphate response element-binding protein CREB during spermatogenesis involves alternative exon splicing [published erratum appears in Mol Endocrinol 1993 Nov;7(11):1501].","volume":"5","author":"Waeber","year":"1991","journal-title":"Mol Endocrinol"},{"key":"2019041123401194300_R40","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1210\/endo.136.8.7628390","article-title":"Expression of the gene encoding transcription factor cyclic adenosine 3\u2032,5\u2032-monophosphate (cAMP) response element-binding protein (CREB): regulation by follicle-stimulating hormone-induced cAMP signaling in primary rat Sertoli cells.","volume":"136","author":"Walker","year":"1995","journal-title":"Endocrinology"},{"key":"2019041123401194300_R41","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0167-4781(97)00015-8","article-title":"Identification of processes that influence negative supercoiling in the human c-myc gene.","volume":"1352","author":"Wolfl","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"2019041123401194300_R42","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/384641a0","article-title":"The CBP co-activator is a histone acetyltransferase.","volume":"384","author":"Bannister","year":"1996","journal-title":"Nature"},{"key":"2019041123401194300_R43","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/382319a0","article-title":"A p300\/CBP-associated factor that competes with the adenoviral oncoprotein E1A.","volume":"382","author":"Yang","year":"1996","journal-title":"Nature"},{"key":"2019041123401194300_R44","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0092-8674(00)80521-8","article-title":"Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain.","volume":"90","author":"Gu","year":"1997","journal-title":"Cell"},{"key":"2019041123401194300_R45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/j.1460-2075.1990.tb08099.x","article-title":"Both the basic region and the \u2019leucine zipper\u2019 domain of the cyclic AMP response element binding (CREB) protein are essential for transcriptional activation.","volume":"9","author":"Dwarki","year":"1990","journal-title":"EMBO J"},{"key":"2019041123401194300_R46","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/350622a0","article-title":"Somatotroph hypoplasia and dwarfism in transgenic mice expressing a non-phosphorylatable CREB mutant.","volume":"350","author":"Struthers","year":"1991","journal-title":"Nature"},{"key":"2019041123401194300_R47","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1089\/dna.1988.7.47","article-title":"A high-efficiency HeLa cell nuclear transcription extract.","volume":"7","author":"Shapiro","year":"1988","journal-title":"DNA"},{"key":"2019041123401194300_R48","first-page":"454","article-title":"Luciferase reporter gene vectors for analysis of promoters and enhancers.","volume":"6","author":"Nordeen","year":"1988","journal-title":"Biotechniques"},{"key":"2019041123401194300_R49","doi-asserted-by":"crossref","first-page":"5266","DOI":"10.1210\/endo.138.12.5639","article-title":"Positive and negative regulation of the rat vasopressin gene promoter.","volume":"138","author":"Iwasaki","year":"1997","journal-title":"Endocrinology"},{"key":"2019041123401194300_R50","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1002\/j.1460-2075.1985.tb03718.x","article-title":"A general method for preparing chromatin containing intact DNA.","volume":"4","author":"Jackson","year":"1985","journal-title":"EMBO J"},{"key":"2019041123401194300_R51","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0022-2836(75)80083-0","article-title":"Detection of specific sequences among DNA fragments separated by gel electrophoresis.","volume":"98","author":"Southern","year":"1975","journal-title":"J Mol Biol"},{"key":"2019041123401194300_R52","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.1016\/S0021-9258(18)60643-X","article-title":"Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line.","volume":"263","author":"Adler","year":"1988","journal-title":"J Biol Chem"}],"container-title":["Molecular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mend\/article-pdf\/13\/5\/659\/8945573\/mend0659.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:26:40Z","timestamp":1647908800000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mend\/article\/13\/5\/659\/2741583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,5,1]]},"references-count":52,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1999,5,1]]}},"URL":"https:\/\/doi.org\/10.1210\/mend.13.5.0282","relation":{},"ISSN":["0888-8809","1944-9917"],"issn-type":[{"value":"0888-8809","type":"print"},{"value":"1944-9917","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,5,1]]}}}