{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:17:16Z","timestamp":1791328636239,"version":"4.3.1"},"reference-count":57,"publisher":"The Endocrine Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3,1]]},"DOI":"10.1210\/mend.16.3.0794","type":"journal-article","created":{"date-parts":[[2014,1,8]],"date-time":"2014-01-08T17:31:05Z","timestamp":1389202265000},"page":"497-505","source":"Crossref","is-referenced-by-count":86,"title":["A Nonclassical Estrogen Membrane Receptor Triggers Rapid Differential Actions in the Endocrine Pancreas"],"prefix":"10.1210","volume":"16","author":[{"given":"Ana B.","family":"Ropero","sequence":"first","affiliation":[{"name":"Institute of Bioengineering, Miguel Herna\u0301ndez University, Campus of San Juan, Alicante 03550, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernat","family":"Soria","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Miguel Herna\u0301ndez University, Campus of San Juan, Alicante 03550, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Nadal","sequence":"additional","affiliation":[{"name":"Institute of Bioengineering, Miguel Herna\u0301ndez University, Campus of San Juan, Alicante 03550, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","reference":[{"key":"2019041123063646900_R1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0006-291X(87)80122-5","article-title":"The actions of arginine and glucose on glucagon secretion are mediated by opposite effects on cytoplasmic Ca2+.","volume":"147","author":"Johansson","year":"1987","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041123063646900_R2","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1152\/physrev.1987.67.4.1185","article-title":"Ca2+, cAMP, and phospholipid-derived messengers in coupling mechanisms of insulin secretion.","volume":"67","author":"Prentki","year":"1987","journal-title":"Physiol Rev"},{"key":"2019041123063646900_R3","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0079-6107(89)90013-8","article-title":"Electrophysiology of the pancreatic \u03b2-cell.","volume":"54","author":"Ashcroft","year":"1989","journal-title":"Prog Biophys Mol Biol"},{"key":"2019041123063646900_R4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1113\/jphysiol.1992.sp019295","article-title":"The relationship between glucose-induced K+ATP channel closure and the rise in [Ca2+]i in single mouse pancreatic \u03b2-cells.","volume":"455","author":"Valdeolmillos","year":"1992","journal-title":"J Physiol (Lond)"},{"key":"2019041123063646900_R5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/BF00550880","article-title":"Widespread synchronous [Ca2+]i oscillations due to bursting electrical activity in single pancreatic islets.","volume":"418","author":"Santos","year":"1991","journal-title":"Pflugers Arch"},{"key":"2019041123063646900_R6","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.2337\/diab.42.8.1210","article-title":"Fluorescence digital image analysis of glucose-induced [Ca2+]i oscillations in mouse pancreatic islets of Langerhans.","volume":"42","author":"Valdeolmillos","year":"1993","journal-title":"Diabetes"},{"key":"2019041123063646900_R7","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1469-7793.1999.0085z.x","article-title":"Homologous and heterologous asynchronicity between identified \u03b1-, \u03b2- and \u03b4-cells within intact islets of Langerhans in the mouse.","volume":"517","author":"Nadal","year":"1999","journal-title":"J Physiol (Lond)"},{"key":"2019041123063646900_R8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/978-1-4684-5314-0_40","article-title":"Pulsatile insulin release and electrical activity from single ob\/ob mouse islets of Langerhans.","volume":"211","author":"Rosario","year":"1986","journal-title":"Adv Exp Med Biol"},{"key":"2019041123063646900_R9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1677\/jme.0.0150177","article-title":"Secretagogue-induced [Ca2+]i changes in single rat pancreatic islets and correlation with simultaneously measured insulin release.","volume":"15","author":"Martin","year":"1995","journal-title":"J Mol Endocrinol"},{"key":"2019041123063646900_R10","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/j.1469-7793.1998.135bz.x","article-title":"Control of pulsatile 5-HT\/insulin secretion from single mouse pancreatic islets by intracellular calcium dynamics.","volume":"510","author":"Barbosa","year":"1998","journal-title":"J Physiol (Lond)"},{"key":"2019041123063646900_R11","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000179510","article-title":"Glucagon and insulin secretion by dispersed islet cells: possible paracrine relationships.","volume":"16","author":"Dunbar","year":"1982","journal-title":"Horm Res"},{"key":"2019041123063646900_R12","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1097\/00006676-198808000-00019","article-title":"Characterization and control of pulsatile secretion of insulin and glucagon.","volume":"3","author":"Opara","year":"1988","journal-title":"Pancreas"},{"key":"2019041123063646900_R13","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1085\/jgp.91.2.223","article-title":"Voltage-activated currents in guinea pig pancreatic \u03b1 2 cells. Evidence for Ca2+-dependent action potentials.","volume":"91","author":"Rorsman","year":"1988","journal-title":"J Gen Physiol"},{"key":"2019041123063646900_R14","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/j.1469-7793.2000.00509.x","article-title":"Regulation of glucagon release in mouse-cells by KATP channels and inactivation of TTX-sensitive Na+ channels.","volume":"528","author":"Gopel","year":"2000","journal-title":"J Physiol"},{"key":"2019041123063646900_R15","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0167-4889(95)00173-5","article-title":"Suppression of Ca2+ oscillations in glucagon-producing \u03b12-cells by insulin\/glucose and amino acids.","volume":"1310","author":"Berts","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"2019041123063646900_R16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1085\/jgp.110.3.217","article-title":"Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels.","volume":"110","author":"Gromada","year":"1997","journal-title":"J Gen Physiol"},{"key":"2019041123063646900_R17","first-page":"795","article-title":"Preliminary report: effects of female sex hormones on insulin secretion by the perfused rat pancreas.","volume":"72","author":"SutterDub","year":"1976","journal-title":"J Physiol (Paris)"},{"key":"2019041123063646900_R18","first-page":"452","article-title":"Short term and direct influence of oestradiol on glucagon secretion stimulated by arginine.","volume":"14","author":"Faure","year":"1988","journal-title":"Diabet Metab"},{"key":"2019041123063646900_R19","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1096\/fasebj.12.13.1341","article-title":"Rapid insulinotropic effect of 17\u03b2-estradiol via a plasma membrane receptor.","volume":"12","author":"Nadal","year":"1998","journal-title":"FASEB J"},{"key":"2019041123063646900_R20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1469-7793.1999.00397.x","article-title":"Non-genomic actions of 17\u03b2-oestradiol in mouse pancreatic \u03b2-cells are mediated by a cGMP-dependent protein kinase.","volume":"521","author":"Ropero","year":"1999","journal-title":"J Physiol (Lond)"},{"key":"2019041123063646900_R21","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/S1043-2760(99)00190-3","article-title":"Estrogen modulation of G-protein-coupled receptors.","volume":"10","author":"Kelly","year":"1999","journal-title":"Trends Endocrinol Metab"},{"key":"2019041123063646900_R22","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/S1043-2760(01)00377-0","article-title":"Rapid actions of plasma membrane estrogen receptors.","volume":"12","author":"Kelly","year":"2001","journal-title":"Trends Endocrinol Metab"},{"key":"2019041123063646900_R23","first-page":"251","article-title":"The estrogen trinity: membrane, cytosolic and nuclear effects.","volume":"16","author":"Nadal","year":"2001","journal-title":"News Physiol Sci"},{"key":"2019041123063646900_R24","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1146\/annurev.physiol.59.1.365","article-title":"Specific, nongenomic actions of steroid hormones.","volume":"59","author":"Wehling","year":"1997","journal-title":"Annu Rev Physiol"},{"key":"2019041123063646900_R25","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0031-6997(24)01468-6","article-title":"Multiple actions of steroid hormones\u2014a focus on rapid, nongenomic effects.","volume":"52","author":"Falkenstein","year":"2000","journal-title":"Pharmacol Rev"},{"key":"2019041123063646900_R26","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1111\/j.1469-445X.1999.01903.x","article-title":"Membrane oestrogen receptors on rat pituitary tumour cells: immuno-identification and responses to oestradiol and xenoestrogens.","volume":"84","author":"Watson","year":"1999","journal-title":"Exp Physiol"},{"key":"2019041123063646900_R27","first-page":"307","article-title":"Cell membrane and nuclear estrogen receptors (ERs) originate from a single transcript: studies of ER\u03b1 and ER\u03b2 expressed in Chinese hamster ovary cells.","volume":"13","author":"Razandi","year":"1999","journal-title":"Mol Endocrinol"},{"key":"2019041123063646900_R28","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1210\/endo.140.2.6500","article-title":"Rapid action of 17\u03b2-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors.","volume":"140","author":"Gu","year":"1999","journal-title":"Endocrinology"},{"key":"2019041123063646900_R29","doi-asserted-by":"crossref","first-page":"12786","DOI":"10.1073\/pnas.94.24.12786","article-title":"Estrogenic responses in estrogen receptor-\u03b1 deficient mice reveal a distinct estrogen signaling pathway.","volume":"94","author":"Das","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123063646900_R30","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/0470870818.ch6","article-title":"Novel sites and mechanisms of oestrogen action in the brain.","author":"Toran-Allerand","year":"2000","journal-title":"Neuronal and cognitive effects of oestrogens."},{"key":"2019041123063646900_R31","doi-asserted-by":"crossref","first-page":"11603","DOI":"10.1073\/pnas.97.21.11603","article-title":"Nongenomic actions of estrogens and xenoestrogens by binding at a plasma membrane receptor unrelated to estrogen receptor \u03b1 and estrogen receptor \u03b2.","volume":"97","author":"Nadal","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123063646900_R32","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1210\/endo.142.4.8094","article-title":"Estradiol signaling via sequestrable surface receptors.","volume":"142","author":"Benten","year":"2001","journal-title":"Endocrinology"},{"key":"2019041123063646900_R33","first-page":"661","article-title":"Imaging intracellular calcium in living tissue by laser-scanning confocal microscopy","author":"Nadal","year":"2000"},{"key":"2019041123063646900_R34","doi-asserted-by":"crossref","first-page":"2390","DOI":"10.2337\/diabetes.48.12.2390","article-title":"Different effects of tolbutamide and diazoxide in \u03b1, \u03b2-, and \u03b4-cells within intact islets of Langerhans.","volume":"48","author":"Quesada","year":"1999","journal-title":"Diabetes"},{"key":"2019041123063646900_R35","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1113\/jphysiol.1982.sp014268","article-title":"Noradrenaline receptors on the rat basilar artery.","volume":"328","author":"Hirst","year":"1982","journal-title":"J Physiol (Lond)"},{"key":"2019041123063646900_R36","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1210\/endo-84-1-41","article-title":"Effects of pregnancy and chorionic growth hormone upon insulin secretion.","volume":"84","author":"Malaisse","year":"1969","journal-title":"Endocrinology"},{"key":"2019041123063646900_R37","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1172\/JCI106593","article-title":"Relative effects of pregnancy, estradiol, and progesterone on plasma insulin and pancreatic islet insulin secretion.","volume":"50","author":"Costrini","year":"1971","journal-title":"J Clin Invest"},{"key":"2019041123063646900_R38","first-page":"47","article-title":"Effects of pregnancy and progesterone and\/or oestradiol on the insulin secretion and pancreatic insulin content in the perfused rat pancreas.","volume":"5","author":"Sutter-Dub","year":"1979","journal-title":"Diabete Metab"},{"issue":"Suppl 2","key":"2019041123063646900_R39","first-page":"35","article-title":"Hormone replacement therapy and the cardiovascular system","volume":"47","author":"Stevenson","year":"1994","journal-title":"Nonlipid effects. Drugs"},{"key":"2019041123063646900_R40","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s001250050758","article-title":"Short-term oestrogen replacement therapy improves insulin resistance, lipids and fibrinolysis in postmenopausal women with NIDDM.","volume":"40","author":"Brussaard","year":"1997","journal-title":"Diabetologia"},{"key":"2019041123063646900_R41","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1096\/fasebj.9.5.7896011","article-title":"Membrane estrogen receptors identified by multiple antibody labeling and impeded-ligand binding.","volume":"9","author":"Pappas","year":"1995","journal-title":"FASEB J"},{"key":"2019041123063646900_R42","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1006\/bbrc.1999.1348","article-title":"Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor \u03b1 localized in caveolae.","volume":"263","author":"Kim","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"2019041123063646900_R43","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1161\/01.RES.87.8.677","article-title":"Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells.","volume":"87","author":"Haynes","year":"2000","journal-title":"Circ Res"},{"key":"2019041123063646900_R44","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1073\/pnas.97.11.5930","article-title":"Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling.","volume":"97","author":"Russell","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"2019041123063646900_R45","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1172\/JCI5347","article-title":"Estrogen receptor \u03b1 mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen.","volume":"103","author":"Chen","year":"1999","journal-title":"J Clin Invest"},{"key":"2019041123063646900_R46","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0165-6147(00)01846-0","article-title":"The plasma membrane estrogen receptor: nuclear or unclear?","volume":"22","author":"Nadal","year":"2001","journal-title":"Trends Pharmacol Sci"},{"key":"2019041123063646900_R47","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1210\/mend.14.10.0532","article-title":"Estrogen-induced activation of Erk-1 and Erk-2 requires the G protein-coupled receptor homolog, GPR30, and occurs via trans-activation of the epidermal growth factor receptor through release of HB-EGF.","volume":"14","author":"Filardo","year":"2000","journal-title":"Mol Endocrinol"},{"key":"2019041123063646900_R48","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1111\/j.1469-7793.2001.0047m.x","article-title":"17\u03b2-Oestradiol acutely regulates Cl\u2212 secretion in rat distal colonic epithelium.","volume":"530","author":"Condliffe","year":"2001","journal-title":"J Physiol"},{"key":"2019041123063646900_R49","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/(SICI)1097-4547(20000101)59:1<107::AID-JNR13>3.0.CO;2-W","article-title":"Estrogenic stimulation of neurite growth in midbrain dopaminergic neurons depends on cAMP\/protein kinase A signalling.","volume":"59","author":"Beyer","year":"2000","journal-title":"J Neurosci Res"},{"key":"2019041123063646900_R50","doi-asserted-by":"crossref","first-page":"4030","DOI":"10.1210\/endo.138.9.5489","article-title":"Rapid membrane effects of steroids in neuroblastoma cells: effects of estrogen on mitogen activated protein kinase signalling cascade and c-fos immediate early gene transcription.","volume":"138","author":"Watters","year":"1997","journal-title":"Endocrinology"},{"key":"2019041123063646900_R51","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0014-2999(00)00425-8","article-title":"Putative membrane-bound estrogen receptors possibly stimulate mitogen-activated protein kinase in the rat hippocampus.","volume":"400","author":"Kuroki","year":"2000","journal-title":"Eur J Pharmacol"},{"key":"2019041123063646900_R52","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/283767a0","article-title":"Evidence for two populations of excitatory receptors for noradrenaline on arteriolar smooth muscle.","volume":"283","author":"Hirst","year":"1980","journal-title":"Nature"},{"key":"2019041123063646900_R53","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1113\/jphysiol.1988.sp017318","article-title":"Noradrenaline modulation of calcium channels in single smooth muscle cells from rabbit ear artery.","volume":"404","author":"Benham","year":"1988","journal-title":"J Physiol (Lond)"},{"key":"2019041123063646900_R54","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1113\/jphysiol.1996.sp021390","article-title":"Noradrenaline modulates transmitter release by enhancing the Ca2+ sensitivity of exocytosis in the chick ciliary presynaptic terminal.","volume":"493","author":"Yawo","year":"1996","journal-title":"J Physiol (Lond)"},{"key":"2019041123063646900_R55","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1523\/JNEUROSCI.19-13-05293.1999","article-title":"Involvement of cGMP-dependent protein kinase in adrenergic potentiation of transmitter release from the calyx-type presynaptic terminal.","volume":"19","author":"Yawo","year":"1999","journal-title":"J Neurosci"},{"key":"2019041123063646900_R56","first-page":"E769","article-title":"Metabolic regulation of intracellular calcium concentration in mouse pancreatic islets of Langerhans","volume":"267","author":"Nadal","year":"1994","journal-title":"Am J Physiol"},{"key":"2019041123063646900_R57","first-page":"807","article-title":"Laser scanning microscopy in enzyme histochemistry. Visualization of cerium-based and DAB-based primary reaction products of phosphatases, oxidases and peroxidases by reflectance and transmission laser scanning microscopy.","volume":"44","author":"Halbhuber","year":"1998","journal-title":"Cell Mol Biol (Noisy-le-grand)"}],"container-title":["Molecular Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/mend\/article-pdf\/16\/3\/497\/10716012\/mend0497.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T11:59:52Z","timestamp":1746100792000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mend\/article\/16\/3\/497\/2741557"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,3,1]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2002,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/mend.16.3.0794","relation":{},"ISSN":["0888-8809","1944-9917"],"issn-type":[{"value":"0888-8809","type":"print"},{"value":"1944-9917","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,3,1]]}}}