{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,17]],"date-time":"2025-10-17T14:17:18Z","timestamp":1760710638045,"version":"3.37.3"},"reference-count":62,"publisher":"The Endocrine Society","issue":"10","license":[{"start":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T00:00:00Z","timestamp":1623715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["ERC-2014-CoG-648916"],"award-info":[{"award-number":["ERC-2014-CoG-648916"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1117687"],"award-info":[{"award-number":["1117687"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016036","name":"Health~Holland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Context<\/jats:title><jats:p>Adult obesity is associated with chronic low-grade inflammation and may give rise to future chronic disease. However, it is unclear whether adiposity-related inflammation is already apparent in childhood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To study associations between child adiposity measures with circulating monocytes and naive and memory subsets in CD4, CD8, and \u03b3\u03b4 T cell lineages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten-year-old children (n = 890) from the Generation R Cohort underwent dual-energy x-ray absorptiometry and magnetic resonance imaging for body composition (body mass index [BMI], fat mass index [FMI], android-to-gynoid fat mass ratio, visceral fat index, liver fat fraction). Blood samples were taken for detailed immunophenotyping of leukocytes by 11-color flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several statistically significant associations were observed. A 1-SD increase in total FMI was associated with +8.4% (95% CI 2.0, 15.2) V\u03b42+V\u03b39+ and +7.4% (95% CI 2.4, 12.5) CD8+TEMRO cell numbers. A 1-SD increase in visceral fat index was associated with +10.7% (95% CI 3.3, 18.7) V\u03b42+V\u03b39+ and +8.3% (95% CI 2.6, 14.4) CD8+TEMRO cell numbers. Higher android-to-gynoid fat mass ratio was only associated with higher V\u03b42+V\u03b39+ T cells. Liver fat was associated with higher CD8+TEMRO cells but not with V\u03b42+V\u03b39+ T cells. Only liver fat was associated with lower Th17 cell numbers: a 1-SD increase was associated with \u22128.9% (95% CI \u221213.7, \u22123.7) Th17 cells. No associations for total CD8+, CD4+ T cells, or monocytes were observed. BMI was not associated with immune cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Higher V\u03b42+V\u03b39+ and CD8+TEMRO cell numbers in children with higher visceral fat index could reflect presence of adiposity-related inflammation in children with adiposity of a general population.<\/jats:p><\/jats:sec>","DOI":"10.1210\/clinem\/dgab433","type":"journal-article","created":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T13:15:27Z","timestamp":1623762927000},"page":"e3923-e3935","source":"Crossref","is-referenced-by-count":4,"title":["Childhood Adiposity Associated With Expanded Effector Memory CD8+ and V\u03b42+V\u03b39+ T Cells"],"prefix":"10.1210","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1984-564X","authenticated-orcid":false,"given":"Kirsten I M","family":"Looman","sequence":"first","affiliation":[{"name":"Generation R Study Group, Erasmus MC, University Medical Center, GD, Rotterdam,the Netherlands"},{"name":"Department of Pediatrics, Sophia Children\u2019s Hospital, Erasmus MC, University Medical Center, GD, Rotterdam, the Netherlands"}]},{"given":"Susana","family":"Santos","sequence":"additional","affiliation":[{"name":"Generation R Study Group, Erasmus MC, University Medical Center, GD, Rotterdam,the Netherlands"},{"name":"Department of Pediatrics, Sophia Children\u2019s Hospital, Erasmus MC, University Medical Center, GD, Rotterdam, the Netherlands"}]},{"given":"Henriette A","family":"Moll","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sophia Children\u2019s Hospital, Erasmus MC, University Medical Center, GD, Rotterdam, the Netherlands"}]},{"given":"Charlotte W E","family":"Leijten","sequence":"additional","affiliation":[{"name":"Generation R Study Group, Erasmus MC, University Medical Center, GD, Rotterdam,the Netherlands"},{"name":"Department of Pediatrics, Sophia Children\u2019s Hospital, Erasmus MC, University Medical Center, GD, Rotterdam, the Netherlands"}]},{"given":"Christina","family":"Grosserichter-Wagener","sequence":"additional","affiliation":[{"name":"Department of Immunology, Erasmus MC, University Medical Center, GD, Rotterdam,the Netherlands"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2830-6813","authenticated-orcid":false,"given":"Trudy","family":"Voortman","sequence":"additional","affiliation":[{"name":"Generation R Study Group, Erasmus MC, University Medical Center, GD, Rotterdam,the Netherlands"},{"name":"Department of Epidemiology, Erasmus MC, University Medical Center, GD, Rotterdam, the Netherlands"}]},{"given":"Vincent V W","family":"Jaddoe","sequence":"additional","affiliation":[{"name":"Generation R Study Group, Erasmus MC, University Medical Center, GD, Rotterdam,the Netherlands"},{"name":"Department of Pediatrics, Sophia Children\u2019s Hospital, Erasmus MC, University Medical Center, GD, Rotterdam, the Netherlands"}]},{"given":"Menno C","family":"van Zelm","sequence":"additional","affiliation":[{"name":"Department of Immunology and Pathology, Central Clinical School, Monash University and Alfred Hospital, Melbourne, Victoria, Australia"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-0918","authenticated-orcid":false,"given":"Jessica C","family":"Kiefte-de Jong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Sophia Children\u2019s Hospital, Erasmus MC, University Medical Center, GD, Rotterdam, the Netherlands"},{"name":"Department of Epidemiology, Erasmus MC, University Medical Center, GD, Rotterdam, the Netherlands"},{"name":"Department of Public Health and Primary Care\/LUMC Campus The Hague, Leiden University Medical Center, RC, Leiden,The Netherlands"}]}],"member":"80","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"2021110612093177500_CIT0001","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1016\/S0140-6736(17)32129-3","article-title":"Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128.9 million children, adolescents, and adults","volume":"390","author":"NCD Risk Factor Collaboration (NCD-RisC)","year":"2017","journal-title":"Lancet"},{"issue":"1","key":"2021110612093177500_CIT0002","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1542\/peds.2004-0220","article-title":"The relation of childhood BMI to adult adiposity: the Bogalusa Heart Study","volume":"115","author":"Freedman","year":"2005","journal-title":"Pediatrics."},{"issue":"5","key":"2021110612093177500_CIT0003","doi-asserted-by":"crossref","first-page":"1499S","DOI":"10.3945\/ajcn.2010.28701B","article-title":"Childhood obesity and adult morbidities","volume":"91","author":"Biro","year":"2010","journal-title":"Am J Clin Nutr."},{"issue":"13","key":"2021110612093177500_CIT0004","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1056\/NEJM199709253371301","article-title":"Predicting obesity in young adulthood from childhood and parental obesity","volume":"337","author":"Whitaker","year":"1997","journal-title":"N Engl J Med."},{"issue":"3","key":"2021110612093177500_CIT0005","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1164\/rccm.201905-0942OC","article-title":"General and organ fat assessed by magnetic resonance imaging and respiratory outcomes in childhood","volume":"201","author":"Mensink-Bout","year":"2020","journal-title":"Am J Respir Crit Care Med."},{"issue":"1","key":"2021110612093177500_CIT0006","doi-asserted-by":"crossref","first-page":"3755","DOI":"10.1038\/s41467-020-17307-0","article-title":"Mucosal-associated invariant T cells promote inflammation and intestinal dysbiosis leading to metabolic dysfunction during obesity","volume":"11","author":"Toubal","year":"2020","journal-title":"Nat Commun."},{"issue":"1","key":"2021110612093177500_CIT0007","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s12889-018-5172-8","article-title":"Obesity and risk of respiratory tract infections: results of an infection-diary based cohort study","volume":"18","author":"Maccioni","year":"2018","journal-title":"BMC Public Health."},{"key":"2021110612093177500_CIT0008","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2020.597600","article-title":"The impact of obesity and lifestyle on the immune system and susceptibility to infections such as COVID-19","volume":"7","author":"de Frel","year":"2020","journal-title":"Frontiers Nutrition"},{"issue":"9","key":"2021110612093177500_CIT0009","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1002\/term.2836","article-title":"CD8+ T cells are involved in early inflammation before macrophages in a rat adipose tissue engineering chamber model","volume":"13","author":"Yuan","year":"2019","journal-title":"J Tissue Eng Regen Med."},{"issue":"3","key":"2021110612093177500_CIT0010","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1002\/oby.21003","article-title":"Adipose tissue as an immunological organ","volume":"23","author":"Grant","year":"2015","journal-title":"Obesity (Silver Spring)."},{"issue":"7121","key":"2021110612093177500_CIT0011","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature05485","article-title":"Inflammation and metabolic disorders","volume":"444","author":"Hotamisligil","year":"2006","journal-title":"Nature."},{"issue":"12","key":"2021110612093177500_CIT0012","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1161\/ATVBAHA.114.304636","article-title":"T-cell profile in adipose tissue is associated with insulin resistance and systemic inflammation in humans","volume":"34","author":"McLaughlin","year":"2014","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"10","key":"2021110612093177500_CIT0013","doi-asserted-by":"crossref","first-page":"2322","DOI":"10.1161\/ATVBAHA.111.230979","article-title":"CD14dimCD16+ and CD14+CD16+ monocytes in obesity and during weight loss: relationships with fat mass and subclinical atherosclerosis","volume":"31","author":"Poitou","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol."},{"issue":"10","key":"2021110612093177500_CIT0014","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1007\/s00125-012-2641-y","article-title":"Systemic inflammation in childhood obesity: circulating inflammatory mediators and activated CD14++ monocytes","volume":"55","author":"Schipper","year":"2012","journal-title":"Diabetologia."},{"issue":"2","key":"2021110612093177500_CIT0015","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/cei.12267","article-title":"Excess body mass is associated with T cell differentiation indicative of immune ageing in children","volume":"176","author":"Spielmann","year":"2014","journal-title":"Clin Exp Immunol."},{"issue":"12","key":"2021110612093177500_CIT0016","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1172\/JCI200319246","article-title":"Obesity is associated with macrophage accumulation in adipose tissue","volume":"112","author":"Weisberg","year":"2003","journal-title":"J Clin Invest."},{"issue":"8","key":"2021110612093177500_CIT0017","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.4049\/jimmunol.1402655","article-title":"Profiling of the three circulating monocyte subpopulations in human obesity","volume":"194","author":"Dev\u00eavre","year":"2015","journal-title":"J Immunol."},{"issue":"5","key":"2021110612093177500_CIT0018","doi-asserted-by":"crossref","first-page":"e16","DOI":"10.1182\/blood-2010-12-326355","article-title":"Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets","volume":"118","author":"Wong","year":"2011","journal-title":"Blood."},{"issue":"1","key":"2021110612093177500_CIT0019","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1172\/JCI88876","article-title":"Role of innate and adaptive immunity in obesity-associated metabolic disease","volume":"127","author":"McLaughlin","year":"2017","journal-title":"J Clin Invest."},{"key":"2021110612093177500_CIT0020","doi-asserted-by":"crossref","DOI":"10.3390\/jcm6070068","article-title":"Pathogenic role of IL-17-producing immune cells in obesity, and related inflammatory diseases","volume":"6","author":"Chehimi","year":"2017","journal-title":"J Clin Med"},{"issue":"1","key":"2021110612093177500_CIT0021","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1189\/jlb.3A0414-211RR","article-title":"\u03b3\u03b4 T cells promote inflammation and insulin resistance during high fat diet-induced obesity in mice","volume":"97","author":"Mehta","year":"2015","journal-title":"J Leukoc Biol."},{"issue":"3","key":"2021110612093177500_CIT0022","doi-asserted-by":"crossref","first-page":"e0120918","DOI":"10.1371\/journal.pone.0120918","article-title":"Obesity impairs \u03b3\u03b4 T cell homeostasis and antiviral function in humans","volume":"10","author":"Costanzo","year":"2015","journal-title":"Plos One."},{"key":"2021110612093177500_CIT0023","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3389\/fimmu.2018.00800","article-title":"Improving the efficiency of V\u03b39V\u03b42 T-cell immunotherapy in cancer","volume":"9","author":"Hoeres","year":"2018","journal-title":"Front Immunol."},{"key":"2021110612093177500_CIT0024","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/j.jaci.2016.10.023","article-title":"Effects of nongenetic factors on immune cell dynamics in early childhood: the Generation R Study","volume":"139","author":"van den Heuvel","year":"2017","journal-title":"J Allergy Clin Immunol."},{"issue":"1","key":"2021110612093177500_CIT0025","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.1038\/s41467-018-04076-0","article-title":"The human V\u03b42+ T-cell compartment comprises distinct innate-like V\u03b39+ and adaptive V\u03b39- subsets","volume":"9","author":"Davey","year":"2018","journal-title":"Nat Commun."},{"key":"2021110612093177500_CIT0026","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1007\/s10654-016-0224-9","article-title":"The Generation R Study: design and cohort update 2017","volume":"31","author":"Kooijman","year":"2016","journal-title":"Eur J Epidemiol."},{"key":"2021110612093177500_CIT0027","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1136\/adc.82.2.107","article-title":"Body index measurements in 1996-7 compared with 1980","volume":"82","author":"Fredriks","year":"2000","journal-title":"Arch Dis Child"},{"issue":"4","key":"2021110612093177500_CIT0028","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1111\/j.2047-6310.2012.00064.x","article-title":"Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity","volume":"7","author":"Cole","year":"2012","journal-title":"Pediatr Obes."},{"issue":"7","key":"2021110612093177500_CIT0029","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1210\/jc.2013-4345","article-title":"Fetal and infant growth patterns associated with total and abdominal fat distribution in school-age children","volume":"99","author":"Gishti","year":"2014","journal-title":"J Clin Endocrinol Metab."},{"issue":"7","key":"2021110612093177500_CIT0030","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1007\/s00247-009-1247-0","article-title":"Pediatric body composition analysis with dual-energy x-ray absorptiometry","volume":"39","author":"Helba","year":"2009","journal-title":"Pediatr Radiol."},{"issue":"3","key":"2021110612093177500_CIT0031","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41366-018-0186-y","article-title":"Maternal body mass index, gestational weight gain, and childhood abdominal, pericardial, and liver fat assessed by magnetic resonance imaging","volume":"43","author":"Santos","year":"2019","journal-title":"Int J Obes (Lond)."},{"issue":"9","key":"2021110612093177500_CIT0032","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1038\/leu.2012.122","article-title":"EuroFlow standardization of flow cytometer instrument settings and immunophenotyping protocols","volume":"26","author":"Kalina","year":"2012","journal-title":"Leukemia."},{"issue":"1","key":"2021110612093177500_CIT0033","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1111\/all.14010","article-title":"Associations of Th2, Th17, Treg cells, and IgA+ memory B cells with atopic disease in children: The Generation R Study","volume":"75","author":"Looman","year":"2020","journal-title":"Allergy."},{"issue":"3","key":"2021110612093177500_CIT0034","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1084\/jem.20030235","article-title":"Differentiation of effector\/memory Vdelta2 T cells and migratory routes in lymph nodes or inflammatory sites","volume":"198","author":"Dieli","year":"2003","journal-title":"J Exp Med."},{"issue":"4","key":"2021110612093177500_CIT0035","doi-asserted-by":"crossref","first-page":"791","DOI":"10.3945\/jn.114.208280","article-title":"Vitamin D deficiency in school-age children is associated with sociodemographic and lifestyle factors","volume":"145","author":"Voortman","year":"2015","journal-title":"J Nutr."},{"issue":"3","key":"2021110612093177500_CIT0036","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s00394-018-1651-z","article-title":"Diet quality in childhood: the Generation R Study","volume":"58","author":"van der Velde","year":"2019","journal-title":"Eur J Nutr."},{"key":"2021110612093177500_CIT0037","doi-asserted-by":"crossref","DOI":"10.1111\/obr.13133","article-title":"Metabolic tissue-resident CD8(+) T cells: a key player in obesity-related diseases","author":"Wang","year":"2021","journal-title":"Obes Rev."},{"issue":"8","key":"2021110612093177500_CIT0038","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1038\/nm.1964","article-title":"CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity","volume":"15","author":"Nishimura","year":"2009","journal-title":"Nat Med."},{"key":"2021110612093177500_CIT0039","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.3389\/fimmu.2019.01587","article-title":"Tissue immune cells fuel obesity-associated inflammation in adipose tissue and beyond","volume":"10","author":"Liu","year":"2019","journal-title":"Front Immunol."},{"issue":"6754","key":"2021110612093177500_CIT0040","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/44385","article-title":"Two subsets of memory T lymphocytes with distinct homing potentials and effector functions","volume":"401","author":"Sallusto","year":"1999","journal-title":"Nature."},{"issue":"8","key":"2021110612093177500_CIT0041","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1038\/icb.2011.110","article-title":"The adaptive immune system as a fundamental regulator of adipose tissue inflammation and insulin resistance","volume":"90","author":"Winer","year":"2012","journal-title":"Immunol Cell Biol."},{"issue":"8","key":"2021110612093177500_CIT0042","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1038\/nm0809-846","article-title":"T-ing up inflammation in fat","volume":"15","author":"Lumeng","year":"2009","journal-title":"Nat Med."},{"issue":"11","key":"2021110612093177500_CIT0043","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1038\/s41366-019-0351-y","article-title":"Effects of bariatric surgery on telomere length and T-cell aging","volume":"43","author":"Jongbloed","year":"2019","journal-title":"Int J Obes (Lond)."},{"issue":"2","key":"2021110612093177500_CIT0044","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/s41574-019-0286-3","article-title":"The role of macrophages in obesity-associated islet inflammation and \u03b2-cell abnormalities","volume":"16","author":"Ying","year":"2020","journal-title":"Nat Rev Endocrinol."},{"issue":"12","key":"2021110612093177500_CIT0045","doi-asserted-by":"crossref","first-page":"e0168610","DOI":"10.1371\/journal.pone.0168610","article-title":"Chronic low-grade inflammation in childhood obesity is associated with decreased IL-10 expression by monocyte subsets","volume":"11","author":"Mattos","year":"2016","journal-title":"Plos One."},{"issue":"5","key":"2021110612093177500_CIT0046","doi-asserted-by":"crossref","first-page":"e1180","DOI":"10.1542\/peds.2011-2477","article-title":"Obese Mexican American children have elevated MCP-1, TNF-\u03b1, monocyte concentration, and dyslipidemia","volume":"129","author":"Breslin","year":"2012","journal-title":"Pediatrics."},{"key":"2021110612093177500_CIT0047","doi-asserted-by":"crossref","first-page":"e200031","DOI":"10.20900\/immunometab20200031","article-title":"Innate-like T cells in the context of metabolic disease and novel therapeutic targets","volume":"2","author":"van der Woude","year":"2020","journal-title":"Immunometabolism"},{"issue":"1","key":"2021110612093177500_CIT0048","doi-asserted-by":"crossref","first-page":"5509","DOI":"10.1038\/s41598-017-05849-1","article-title":"Ageing and latent CMV infection impact on maturation, differentiation and exhaustion profiles of T-cell receptor gammadelta T-cells","volume":"7","author":"Kallemeijn","year":"2017","journal-title":"Sci Rep."},{"key":"2021110612093177500_CIT0049","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.591110","article-title":"The obesity paradox in lung cancer: associations with body size versus body shape","volume":"10","author":"Ardesch","year":"2020","journal-title":"Frontiers Oncol."},{"issue":"2","key":"2021110612093177500_CIT0050","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.pcad.2018.06.004","article-title":"Overview of epidemiology and contribution of obesity and body fat distribution to cardiovascular disease: an update","volume":"61","author":"Pich\u00e9","year":"2018","journal-title":"Prog Cardiovasc Dis."},{"key":"2021110612093177500_CIT0051","doi-asserted-by":"crossref","first-page":"368","DOI":"10.3389\/fendo.2019.00368","article-title":"Brown and beige adipose tissue and aging","volume":"10","author":"Zoico","year":"2019","journal-title":"Front Endocrinol (Lausanne)."},{"key":"2021110612093177500_CIT0052","doi-asserted-by":"crossref","first-page":"846578","DOI":"10.1155\/2014\/846578","article-title":"Importance of android\/gynoid fat ratio in predicting metabolic and cardiovascular disease risk in normal weight as well as overweight and obese children","volume":"2014","author":"Samsell","year":"2014","journal-title":"J Obes."},{"issue":"1","key":"2021110612093177500_CIT0053","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/hep.31018","article-title":"Liver Fat and Cardiometabolic Risk Factors Among School-Age Children","volume":"72","author":"Geurtsen","year":"2020","journal-title":"Hepatology."},{"issue":"1","key":"2021110612093177500_CIT0054","doi-asserted-by":"crossref","first-page":"e000824","DOI":"10.1136\/bmjdrc-2019-000824","article-title":"Abdominal visceral and subcutaneous adipose tissues in association with cardiometabolic risk in children and adolescents: the China Child and Adolescent Cardiovascular Health (CCACH) study","volume":"7","author":"Yan","year":"2019","journal-title":"BMJ Open Diabetes Res Care."},{"issue":"41","key":"2021110612093177500_CIT0055","doi-asserted-by":"crossref","first-page":"9096","DOI":"10.3748\/wjg.v22.i41.9096","article-title":"Th17 involvement in nonalcoholic fatty liver disease progression to non-alcoholic steatohepatitis","volume":"22","author":"Chackelevicius","year":"2016","journal-title":"World J Gastroenterol."},{"issue":"1","key":"2021110612093177500_CIT0056","doi-asserted-by":"crossref","first-page":"97","DOI":"10.4049\/jimmunol.1501175","article-title":"Progression from nonalcoholic fatty liver to nonalcoholic steatohepatitis is marked by a higher frequency of Th17 cells in the liver and an increased Th17\/resting regulatory T cell ratio in peripheral blood and in the liver","volume":"196","author":"Rau","year":"2016","journal-title":"J Immunol."},{"key":"2021110612093177500_CIT0057","doi-asserted-by":"crossref","first-page":"82","DOI":"10.3389\/fimmu.2019.00082","article-title":"The differential roles of T cells in non-alcoholic fatty liver disease and obesity","volume":"10","author":"Van Herck","year":"2019","journal-title":"Front Immunol."},{"issue":"11","key":"2021110612093177500_CIT0058","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1161\/CIRCRESAHA.115.306885","article-title":"Obesity-induced changes in adipose tissue microenvironment and their impact on cardiovascular disease","volume":"118","author":"Fuster","year":"2016","journal-title":"Circ Res."},{"issue":"1","key":"2021110612093177500_CIT0059","doi-asserted-by":"crossref","first-page":"12284","DOI":"10.1038\/s41598-019-48678-0","article-title":"Linkage of CD8+ T cell exhaustion with high-fat diet-induced tumourigenesis","volume":"9","author":"Kado","year":"2019","journal-title":"Sci Rep."},{"issue":"8","key":"2021110612093177500_CIT0060","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.21037\/qims.2020.04.06","article-title":"Imaging of body composition in children","volume":"10","author":"Simoni","year":"2020","journal-title":"Quant Imaging Med Surg."},{"issue":"9","key":"2021110612093177500_CIT0061","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1038\/ni1240","article-title":"Chemokine receptor CCR7 guides T cell exit from peripheral tissues and entry into afferent lymphatics","volume":"6","author":"Bromley","year":"2005","journal-title":"Nat Immunol."},{"issue":"5","key":"2021110612093177500_CIT0062","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1182\/blood-2003-02-0420","article-title":"Ex vivo characterization of human CD8+ T subsets with distinct replicative history and partial effector functions","volume":"102","author":"Rufer","year":"2003","journal-title":"Blood."}],"container-title":["The Journal of Clinical Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/advance-article-pdf\/doi\/10.1210\/clinem\/dgab433\/39845055\/dgab433.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/10\/e3923\/41098254\/dgab433.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcem\/article-pdf\/106\/10\/e3923\/41098254\/dgab433.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,31]],"date-time":"2022-12-31T05:41:05Z","timestamp":1672465265000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/106\/10\/e3923\/6299303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,15]]},"references-count":62,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2021,6,15]]},"published-print":{"date-parts":[[2021,9,27]]}},"URL":"https:\/\/doi.org\/10.1210\/clinem\/dgab433","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"type":"print","value":"0021-972X"},{"type":"electronic","value":"1945-7197"}],"subject":[],"published-other":{"date-parts":[[2021,10,1]]},"published":{"date-parts":[[2021,6,15]]}}}