{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T07:25:37Z","timestamp":1777274737852,"version":"3.51.4"},"reference-count":80,"publisher":"The Endocrine Society","issue":"8","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Context<\/jats:title>\n                  <jats:p>Prolactin (PRL) is a highly versatile, multifunctional hormone synthesized and secreted by lactotroph cells of the anterior pituitary. Its metabolic role has been extensively studied even in normoprolactinemic populations. Recently, a wealth of observational data have outlined the potential prognostic value of PRL in various clinical settings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This systematic review aims to systematically evaluate and quantitatively synthesize the association between serum PRL levels and risk of mortality in adults without prolactinoma.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A systematic literature search was conducted up to June 10, 2023, to identify studies reporting the association of serum PRL levels with clinical outcomes of adults without prolactinoma. A random-effects meta-analysis was conducted to quantify the adjusted hazard ratios [(a)HRs] for all-cause and cardiovascular death (CVD) during follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-eight studies were deemed eligible reporting the outcomes of adults without prolactinoma, in whom serum PRL levels were measured for risk-stratification. Fourteen studies reported appropriate data for meta-analysis encompassing a total of 23 596 individuals. Each unit of PRL increase was independently associated with increased risk of all-cause (pooled aHR = 1.17 [1.08-1.27]; I2 = 48%) and CV mortality (pooled aHR = 1.54 [1.14-2.09]; I2 = 89%). Individuals belonging to the highest PRL category had significantly higher risk for all-cause (pooled aHR = 1.81 [1.43-2.30]; I2 = 65%) and CV (pooled aHR = 1.59 [1.04-2.42]; I2 = 82%) mortality compared to their lowest-PRL category counterparts. The association between PRL levels and in-hospital death did not reach statistical significance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>PRL levels seem to be an independent predictor for mortality. Further validation is warranted before its role as a risk-stratification tool can be delineated in clinical practice.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1210\/clinem\/dgae087","type":"journal-article","created":{"date-parts":[[2024,2,17]],"date-time":"2024-02-17T06:47:10Z","timestamp":1708152430000},"page":"e1652-e1664","source":"Crossref","is-referenced-by-count":15,"title":["Serum Prolactin Levels and Mortality in Adults Without Prolactinoma: A Meta-Analysis"],"prefix":"10.1210","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4981-8121","authenticated-orcid":false,"given":"Andreas S","family":"Papazoglou","sequence":"first","affiliation":[{"name":"Cardiology Department, Athens Naval Hospital , Athens 11521 , Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4111-3787","authenticated-orcid":false,"given":"Ana Rita","family":"Leite","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o , Alameda Hern\u00e2ni Monteiro, 4200-319, Porto , Portugal"},{"name":"Department of Surgery and Physiology, Faculty of Medicine of University of Porto, Unit of Cardiovascular Research and Development\u2014Unic@RISE , Alameda Hern\u00e2ni Monteiro, 4200-319, Porto , Portugal"}]},{"given":"Dimitrios V","family":"Moysidis","sequence":"additional","affiliation":[{"name":"424 General Military Hospital of Thessaloniki , Thessaloniki 56429 , Greece"}]},{"given":"Vasileios","family":"Anastasiou","sequence":"additional","affiliation":[{"name":"First Cardiology Department, AHEPA University Hospital of Thessaloniki , Thessaloniki 54636 , Greece"}]},{"given":"Stylianos","family":"Daios","sequence":"additional","affiliation":[{"name":"First Cardiology Department, AHEPA University Hospital of Thessaloniki , Thessaloniki 54636 , Greece"}]},{"given":"Marta","family":"Borges-Canha","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o , Alameda Hern\u00e2ni Monteiro, 4200-319, Porto , Portugal"},{"name":"Department of Surgery and Physiology, Faculty of Medicine of University of Porto, Unit of Cardiovascular Research and Development\u2014Unic@RISE , Alameda Hern\u00e2ni Monteiro, 4200-319, Porto , Portugal"}]},{"given":"Georgios","family":"Giannopoulos","sequence":"additional","affiliation":[{"name":"Second Cardiology Department, Ippokrateion University Hospital of Thessaloniki , Thessaloniki 54642 , Greece"}]},{"given":"Jo\u00e3o S\u00e9rgio","family":"Neves","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar Universit\u00e1rio de S\u00e3o Jo\u00e3o , Alameda Hern\u00e2ni Monteiro, 4200-319, Porto , Portugal"},{"name":"Department of Surgery and Physiology, Faculty of Medicine of University of Porto, Unit of Cardiovascular Research and Development\u2014Unic@RISE , Alameda Hern\u00e2ni Monteiro, 4200-319, Porto , Portugal"}]},{"given":"Antonios","family":"Ziakas","sequence":"additional","affiliation":[{"name":"First Cardiology Department, AHEPA University Hospital of Thessaloniki , Thessaloniki 54636 , Greece"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7491-6319","authenticated-orcid":false,"given":"George","family":"Giannakoulas","sequence":"additional","affiliation":[{"name":"First Cardiology Department, AHEPA University Hospital of Thessaloniki , Thessaloniki 54636 , Greece"}]}],"member":"80","published-online":{"date-parts":[[2024,2,15]]},"reference":[{"issue":"4","key":"2024071216411008800_dgae087-B1","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1152\/physrev.2000.80.4.1523","article-title":"Prolactin: structure, function, and regulation of secretion","volume":"80","author":"Freeman","year":"2000","journal-title":"Physiol 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