{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T18:03:37Z","timestamp":1790273017760,"version":"4.1.0"},"reference-count":46,"publisher":"The Endocrine Society","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Australian Diabetes Society Skip-Martin Early Career","id":[{"id":"https:\/\/ror.org\/009mmq515","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Australian National Health and Medical Research Council","award":["APP1194510"],"award-info":[{"award-number":["APP1194510"]}],"id":[{"id":"https:\/\/ror.org\/011kf5r70","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001030","name":"National Heart Foundation of Australia","doi-asserted-by":"publisher","award":["APP107158"],"award-info":[{"award-number":["APP107158"]}],"id":[{"id":"10.13039\/501100001030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This prospective cohort study aimed to quantify dose\u2013response associations between intensity-specific incidental physical activity (IPA) and the incidence of type 2 diabetes (T2D) in a large cohort of UK adults. A secondary aim was to estimate the T2D-specific equivalence of 1 minute of vigorous-intensity IPA relative to moderate- and light-intensity IPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Participants were adults from the UK Biobank accelerometry sub-study who self-reported as nonexercisers. Individuals were excluded if they had T2D at baseline, were using insulin therapy, or received a T2D diagnosis within 12 months of follow-up. T2D status was primarily derived from primary care records. Device-measured IPA was categorized into light (LIPA; 1.5 to &amp;lt;3 METs), moderate (MIPA; 3 to &amp;lt;6 METs), and vigorous (VIPA; \u22656 METs) intensities. Additional analyses examined the T2D-specific equivalence of 1 minute of VIPA to MIPA and LIPA. The reference group comprised participants accumulating neither MIPA nor VIPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The primary analysis included 22 857 nonexercisers (mean age 62.1 \u00b1 7.7 years, 42.8% male). Over a 7.8-year follow-up period, 721 (3.2%) participants developed T2D. MIPA and VIPA, but not LIPA, exhibited near-linear inverse associations with T2D risk. Median VIPA (4.75\u2005minutes\/day) was associated with a hazard ratio (HR) 0.62 [95% confidence interval (CI) 0.53-0.73], and median MIPA (23.70\u2005minutes\/day) showed a HR of 0.67 (95% CI: 0.52-0.86). One minute of VIPA\/day was associated with an equivalent T2D risk reduction of 5.9\u2005minutes MIPA\/day and 46.6\u2005minutes LIPA\/day.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MIPA and VIPA were associated with lower T2D risk in a dose-dependent manner. Although median LIPA was linked to reduced risk, it did not demonstrate a consistent dose\u2013response relationship.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1210\/clinem\/dgag316","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T11:58:59Z","timestamp":1790164739000},"source":"Crossref","is-referenced-by-count":0,"title":["The dose-response association between wearables-quantified incidental physical activity and type 2 diabetes: a prospective cohort study"],"prefix":"10.1210","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0195-7029","authenticated-orcid":false,"given":"Angelo","family":"Sabag","sequence":"first","affiliation":[{"name":"Sydney School of Health Sciences, Faculty of Medicine and Health, The University of Sydney , Sydney, NSW 2006 ,","place":["Australia"]},{"name":"Charles Perkins Centre, The University of Sydney , Sydney, NSW 2006 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