{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T04:35:57Z","timestamp":1773290157346,"version":"3.50.1"},"reference-count":48,"publisher":"The Endocrine Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,9,1]]},"abstract":"<jats:p>Excess mineralocorticoid signaling is deleterious for cardiovascular functions, as demonstrated by the beneficial effects of mineralocorticoid receptor (MR) antagonism on morbidity and mortality in patients with heart failure. However, the understanding of signaling pathways after MR activation in the heart remains limited. We performed transcriptomic analyses in the heart of double-transgenic mice with conditional, cardiomyocyte-specific, overexpression of the MR (MRcardio mice) or the glucocorticoid receptor (GR; GRcardio mice). Some of the genes induced in MRcardio mice were selected for comparative evaluation (real time PCR) in vivo in the heart of mice and ex vivo in the MR-expressing cardiomyocyte H9C2 cell line after aldosterone or corticosterone treatment. We demonstrate that chronic MR overexpression in the heart results in a limited number of induced (n = 24) and repressed (n = 22) genes compared with their control littermates. These genes are specifically modulated by MR because there is limited overlap (three induced, four repressed) with the genes that are regulated in the heart of GRcardio mice (compared with control mice: 70 induced, 73 repressed). Interestingly, some MR-induced genes that are up-regulated in vivo in mice are also induced by 24-h aldosterone treatment in H9C2 cells, such as plasminogen activator inhibitor 1 and Serpina-3 (\u03b11-antichymotrypsin). The signaling pathways that are affected by long-term activation of MR may be of particular interest to design novel therapeutic targets in cardiac diseases.<\/jats:p>","DOI":"10.1210\/en.2010-0237","type":"journal-article","created":{"date-parts":[[2010,7,1]],"date-time":"2010-07-01T01:10:24Z","timestamp":1277946624000},"page":"4467-4476","source":"Crossref","is-referenced-by-count":53,"title":["Molecular Signature of Mineralocorticoid Receptor Signaling in Cardiomyocytes: From Cultured Cells to Mouse Heart"],"prefix":"10.1210","volume":"151","author":[{"given":"Celine","family":"Latouche","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 Mixte de Recherche 872 Team 1 (C.L., Y.S.-M., P.C.C., N.F., F.J.), Centre de Recherches des Cordeliers, Universite\u0301 Pierre et Marie Curie, 75006 Paris, France"}]},{"given":"Yannis","family":"Sainte-Marie","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 Mixte de Recherche 872 Team 1 (C.L., Y.S.-M., P.C.C., N.F., F.J.), Centre de Recherches des Cordeliers, Universite\u0301 Pierre et Marie Curie, 75006 Paris, France"}]},{"given":"Marja","family":"Steenman","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale, Unite\u0301 Mixte de Recherche 915 (M.S.), Institut du Thorax, Universite\u0301 de Nantes, 44000 Nantes, France"}]},{"given":"Paulo","family":"Castro Chaves","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 Mixte de Recherche 872 Team 1 (C.L., Y.S.-M., P.C.C., N.F., F.J.), Centre de Recherches des Cordeliers, Universite\u0301 Pierre et Marie Curie, 75006 Paris, France"}]},{"given":"Aniko","family":"Naray-Fejes-Toth","sequence":"first","affiliation":[{"name":"Department of Physiology (A.N.-F.-T., G.F.-T.), Dartmouth Medical School, Lebanon, New Hampshire 03756"}]},{"given":"Geza","family":"Fejes-Toth","sequence":"first","affiliation":[{"name":"Department of Physiology (A.N.-F.-T., G.F.-T.), Dartmouth Medical School, Lebanon, New Hampshire 03756"}]},{"given":"Nicolette","family":"Farman","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 Mixte de Recherche 872 Team 1 (C.L., Y.S.-M., P.C.C., N.F., F.J.), Centre de Recherches des Cordeliers, Universite\u0301 Pierre et Marie Curie, 75006 Paris, France"}]},{"given":"Frederic","family":"Jaisser","sequence":"first","affiliation":[{"name":"Institut National de la Sante\u0301 et de la Recherche Me\u0301dicale Unite\u0301 Mixte de Recherche 872 Team 1 (C.L., Y.S.-M., P.C.C., N.F., F.J.), Centre de Recherches des Cordeliers, Universite\u0301 Pierre et Marie Curie, 75006 Paris, France"}]}],"member":"80","published-online":{"date-parts":[[2010,6,30]]},"reference":[{"key":"2020071612462653100_R1","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/S1043-2760(00)00270-8","article-title":"Aldosterone and the heart.","volume":"11","author":"Young","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"2020071612462653100_R2","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1056\/NEJM199909023411001","article-title":"The effect of spironolactone on morbidity and mortality in patients with severe heart failure. 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