{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:30:16Z","timestamp":1762918216780,"version":"3.41.2"},"reference-count":156,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Kalluri Laboratory","award":["NCI RO1 CA213233","NCI RO1 CA195733","NCI RO1 CA231465"],"award-info":[{"award-number":["NCI RO1 CA213233","NCI RO1 CA195733","NCI RO1 CA231465"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Extracellular vesicles (EVs) are key players of intercellular communication in the physiological and pathological setting. In cancer, EVs mediate complex signaling mechanisms between cancer cells and the tumor microenvironment (TME), and can influence tumor progression and the response to existing therapies. Importantly, EVs can be loaded with therapeutic agents and modified to display tumor-targeting molecules. In the field of nanomedicine, EVs have been engineered to serve as therapeutic delivery vehicles for several anticancer agents, including antibodies, chemotherapy, compounds, CRISPR\/Cas9 (clustered regularly interspaced short palindromic repeats\u2013associated endonuclease 9), and small interfering RNA (siRNA). Notably, the engineered EVs were shown to suppress malignant features of cancer cells, to elicit antitumor immunity, and to decrease tumor angiogenesis. Here, we review the EV-based therapies designed to target cancer cells and to educate components of the TME to drive antitumor responses. These studies illustrate the multifunctional applications of EVs in the development of anticancer therapies and their translational potential for cancer treatment.<\/jats:p>","DOI":"10.1210\/endocr\/bqaa250","type":"journal-article","created":{"date-parts":[[2021,1,13]],"date-time":"2021-01-13T19:49:14Z","timestamp":1610567354000},"source":"Crossref","is-referenced-by-count":25,"title":["Multifunctional Applications of Engineered Extracellular Vesicles in the Treatment of Cancer"],"prefix":"10.1210","volume":"162","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-1275","authenticated-orcid":false,"given":"Fernanda G","family":"Kugeratski","sequence":"first","affiliation":[{"name":"Department of Cancer Biology, Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}]},{"given":"Kathleen M","family":"McAndrews","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"}]},{"given":"Raghu","family":"Kalluri","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Metastasis Research Center, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA"},{"name":"Department of Bioengineering, Rice University, Houston, Texas, USA"},{"name":"Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA"}]}],"member":"80","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"issue":"6478","key":"2021121701474702100_CIT0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"1","key":"2021121701474702100_CIT0002","doi-asserted-by":"crossref","first-page":"32570","DOI":"10.3402\/jev.v5.32570","article-title":"High-resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources","volume":"5","author":"Haraszti","year":"2016","journal-title":"J Extracell Vesicles."},{"issue":"52","key":"2021121701474702100_CIT0003","doi-asserted-by":"crossref","first-page":"86999","DOI":"10.18632\/oncotarget.13569","article-title":"Proteomic profiling of NCI-60 extracellular vesicles uncovers common protein cargo and cancer type-specific biomarkers","volume":"7","author":"Hurwitz","year":"2016","journal-title":"Oncotarget."},{"issue":"1","key":"2021121701474702100_CIT0004","doi-asserted-by":"crossref","first-page":"1442985","DOI":"10.1080\/20013078.2018.1442985","article-title":"Glycosylation of extracellular vesicles: current knowledge, tools and clinical perspectives","volume":"7","author":"Williams","year":"2018","journal-title":"J Extracell Vesicles."},{"issue":"3","key":"2021121701474702100_CIT0005","doi-asserted-by":"crossref","first-page":"e0151339","DOI":"10.1371\/journal.pone.0151339","article-title":"Enabling metabolomics based biomarker discovery studies using molecular phenotyping of exosome-like vesicles","volume":"11","author":"Altadill","year":"2016","journal-title":"PloS One."},{"issue":"6","key":"2021121701474702100_CIT0006","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1038\/ncb1596","article-title":"Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells","volume":"9","author":"Valadi","year":"2007","journal-title":"Nat Cell Biol."},{"issue":"7","key":"2021121701474702100_CIT0007","doi-asserted-by":"crossref","first-page":"3869","DOI":"10.1074\/jbc.C113.532267","article-title":"Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer","volume":"289","author":"Kahlert","year":"2014","journal-title":"J Biol Chem."},{"issue":"3","key":"2021121701474702100_CIT0008","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s41556-018-0040-4","article-title":"Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation","volume":"20","author":"Zhang","year":"2018","journal-title":"Nat Cell Biol."},{"issue":"25","key":"2021121701474702100_CIT0009","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1182\/blood-2014-05-576116","article-title":"Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1","volume":"124","author":"Umezu","year":"2014","journal-title":"Blood."},{"issue":"3","key":"2021121701474702100_CIT0010","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41590-017-0043-5","article-title":"Tumor-derived exosomes antagonize innate antiviral immunity","volume":"19","author":"Gao","year":"2018","journal-title":"Nat Immunol."},{"issue":"1","key":"2021121701474702100_CIT0011","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1158\/1541-7786.MCR-16-0163","article-title":"Exosomal Annexin II promotes angiogenesis and breast cancer metastasis","volume":"15","author":"Maji","year":"2017","journal-title":"Mol Cancer Res."},{"issue":"9","key":"2021121701474702100_CIT0012","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1182\/blood-2008-02-142596","article-title":"Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells","volume":"113","author":"Klibi","year":"2009","journal-title":"Blood."},{"issue":"2","key":"2021121701474702100_CIT0013","first-page":"457","article-title":"Membrane-associated Hsp72 from tumor-derived exosomes mediates STAT3-dependent immunosuppressive function of mouse and human myeloid-derived suppressor cells","volume":"120","author":"Chalmin","year":"2010","journal-title":"J Clin Invest."},{"issue":"1","key":"2021121701474702100_CIT0014","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/s41467-017-01433-3","article-title":"Pre-metastatic cancer exosomes induce immune surveillance by patrolling monocytes at the metastatic niche","volume":"8","author":"Plebanek","year":"2017","journal-title":"Nat Commun."},{"issue":"7718","key":"2021121701474702100_CIT0015","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41586-018-0392-8","article-title":"Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response","volume":"560","author":"Chen","year":"2018","journal-title":"Nature."},{"issue":"4","key":"2021121701474702100_CIT0016","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nrm.2017.125","article-title":"Shedding light on the cell biology of extracellular vesicles","volume":"19","author":"van Niel","year":"2018","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"1","key":"2021121701474702100_CIT0017","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41556-018-0250-9","article-title":"Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication","volume":"21","author":"Mathieu","year":"2019","journal-title":"Nat Cell Biol."},{"issue":"12","key":"2021121701474702100_CIT0018","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers11121979","article-title":"Engineered extracellular vesicles as a reliable tool in cancer nanomedicine","volume":"11","author":"Susa","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"1","key":"2021121701474702100_CIT0019","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12943-019-0963-9","article-title":"Mechanisms associated with biogenesis of exosomes in cancer","volume":"18","author":"McAndrews","year":"2019","journal-title":"Mol Cancer."},{"issue":"4","key":"2021121701474702100_CIT0020","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1080\/21541248.2016.1215283","article-title":"Biology and biogenesis of shed microvesicles","volume":"8","author":"Tricarico","year":"2017","journal-title":"Small GTPases."},{"issue":"1","key":"2021121701474702100_CIT0021","doi-asserted-by":"crossref","first-page":"1648167","DOI":"10.1080\/20013078.2019.1648167","article-title":"Extracellular vesicles or exosomes? On primacy, precision, and popularity influencing a choice of nomenclature","volume":"8","author":"Witwer","year":"2019","journal-title":"J Extracell Vesicles."},{"key":"2021121701474702100_CIT0022","doi-asserted-by":"crossref","first-page":"26913","DOI":"10.3402\/jev.v3.26913","article-title":"Minimal experimental requirements for definition of extracellular vesicles and their functions: a position statement from the International Society for Extracellular Vesicles","volume":"3","author":"L\u00f6tvall","year":"2014","journal-title":"J Extracell Vesicles."},{"issue":"1","key":"2021121701474702100_CIT0023","doi-asserted-by":"crossref","first-page":"1535750","DOI":"10.1080\/20013078.2018.1535750","article-title":"Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines","volume":"7","author":"Th\u00e9ry","year":"2018","journal-title":"J Extracell Vesicles."},{"issue":"7","key":"2021121701474702100_CIT0024","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.tibtech.2017.03.004","article-title":"Exosomes in cancer nanomedicine and immunotherapy: prospects and challenges","volume":"35","author":"Syn","year":"2017","journal-title":"Trends Biotechnol."},{"issue":"1","key":"2021121701474702100_CIT0025","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.nano.2015.09.011","article-title":"Designer exosomes as next-generation cancer immunotherapy","volume":"12","author":"Bell","year":"2016","journal-title":"Nanomedicine."},{"issue":"9","key":"2021121701474702100_CIT0026","doi-asserted-by":"crossref","first-page":"3625","DOI":"10.1021\/acs.molpharmaceut.8b00277","article-title":"Exosomes as a drug delivery system in cancer therapy: potential and challenges","volume":"15","author":"Kibria","year":"2018","journal-title":"Mol Pharm."},{"issue":"9","key":"2021121701474702100_CIT0027","doi-asserted-by":"crossref","first-page":"3100","DOI":"10.1111\/cas.14563","article-title":"Biology and therapeutic potential of mesenchymal stem cell-derived exosomes","volume":"111","author":"Xunian","year":"2020","journal-title":"Cancer Sci."},{"issue":"7659","key":"2021121701474702100_CIT0028","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1038\/nature22341","article-title":"Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer","volume":"546","author":"Kamerkar","year":"2017","journal-title":"Nature."},{"issue":"1","key":"2021121701474702100_CIT0029","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1479-5876-3-10","article-title":"Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of the first phase I clinical trial","volume":"3","author":"Escudier","year":"2005","journal-title":"J Transl Med."},{"issue":"1","key":"2021121701474702100_CIT0030","doi-asserted-by":"crossref","first-page":"1324730","DOI":"10.1080\/20013078.2017.1324730","article-title":"Comprehensive toxicity and immunogenicity studies reveal minimal effects in mice following sustained dosing of extracellular vesicles derived from HEK293T cells","volume":"6","author":"Zhu","year":"2017","journal-title":"J Extracell Vesicles."},{"issue":"8","key":"2021121701474702100_CIT0031","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/jci.insight.99263","article-title":"Generation and testing of clinical-grade exosomes for pancreatic cancer","volume":"3","author":"Mendt","year":"2018","journal-title":"JCI Insight"},{"key":"2021121701474702100_CIT0032","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/jev.v3.24641","article-title":"Routes and mechanisms of extracellular vesicle uptake","volume":"3","author":"Mulcahy","year":"2014","journal-title":"J Extracell Vesicles"},{"issue":"14","key":"2021121701474702100_CIT0033","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1158\/1078-0432.CCR-15-2170","article-title":"TNF-related apoptosis-inducing ligand (TRAIL)-armed exosomes deliver proapoptotic signals to tumor site","volume":"22","author":"Rivoltini","year":"2016","journal-title":"Clin Cancer Res."},{"issue":"11","key":"2021121701474702100_CIT0034","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/pros.23996","article-title":"Antitumor efficacy of interferon-\u03b3-modified exosomal vaccine in prostate cancer","volume":"80","author":"Shi","year":"2020","journal-title":"Prostate."},{"key":"2021121701474702100_CIT0035","doi-asserted-by":"crossref","first-page":"31053","DOI":"10.3402\/jev.v5.31053","article-title":"Display of GPI-anchored anti-EGFR nanobodies on extracellular vesicles promotes tumour cell targeting","volume":"5","author":"Kooijmans","year":"2016","journal-title":"J Extracell Vesicles."},{"issue":"2","key":"2021121701474702100_CIT0036","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.ymthe.2019.11.020","article-title":"Genetically engineered cell-derived nanoparticles for targeted breast cancer immunotherapy","volume":"28","author":"Shi","year":"2020","journal-title":"Mol Ther."},{"key":"2021121701474702100_CIT0037","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.jconrel.2019.08.037","article-title":"Exosome-like nanoplatform modified with targeting ligand improves anti-cancer and anti-inflammation effects of imperialine","volume":"311-312","author":"Lin","year":"2019","journal-title":"J Control Release."},{"key":"2021121701474702100_CIT0038","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1038\/ncomms2282","article-title":"Delivery of chemotherapeutic drugs in tumour cell-derived microparticles","volume":"3","author":"Tang","year":"2012","journal-title":"Nat Commun."},{"issue":"1","key":"2021121701474702100_CIT0039","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1038\/s41467-019-11718-4","article-title":"Tumor exosome-based nanoparticles are efficient drug carriers for chemotherapy","volume":"10","author":"Yong","year":"2019","journal-title":"Nat Commun."},{"key":"2021121701474702100_CIT0040","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.jconrel.2018.05.015","article-title":"Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment","volume":"283","author":"Garofalo","year":"2018","journal-title":"J Control Release."},{"issue":"10","key":"2021121701474702100_CIT0041","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/s41929-019-0333-4","article-title":"Cancer-derived exosomes loaded with ultrathin palladium nanosheets for targeted bioorthogonal catalysis","volume":"2","author":"Sancho-Albero","year":"2019","journal-title":"Nat Catal."},{"issue":"18","key":"2021121701474702100_CIT0042","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/adfm.201707360","article-title":"Designer exosomes for active targeted chemo-photothermal synergistic tumor therapy","volume":"28","author":"Wang","year":"2018","journal-title":"Adv Funct Mater"},{"key":"2021121701474702100_CIT0043","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.biomaterials.2019.01.024","article-title":"Extracellular vesicles based self-grown gold nanopopcorn for combinatorial chemo-photothermal therapy","volume":"197","author":"Zhang","year":"2019","journal-title":"Biomaterials."},{"issue":"1","key":"2021121701474702100_CIT0044","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1039\/C9NR05865F","article-title":"SPION decorated exosome delivery of TNF-\u03b1 to cancer cell membranes through magnetism","volume":"12","author":"Zhuang","year":"2020","journal-title":"Nanoscale."},{"issue":"9","key":"2021121701474702100_CIT0045","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat Rev Cancer."},{"issue":"5-6","key":"2021121701474702100_CIT0046","doi-asserted-by":"crossref","first-page":"e1700167","DOI":"10.1002\/pmic.201700167","article-title":"Cancer associated fibroblasts: the architects of stroma remodeling","volume":"18","author":"Santi","year":"2018","journal-title":"Proteomics."},{"issue":"27","key":"2021121701474702100_CIT0047","doi-asserted-by":"crossref","first-page":"3496","DOI":"10.1038\/onc.2013.304","article-title":"Vascular remodeling in cancer","volume":"33","author":"Farnsworth","year":"2014","journal-title":"Oncogene."},{"issue":"10","key":"2021121701474702100_CIT0048","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/nri.2016.80","article-title":"Regulatory circuits of T cell function in cancer","volume":"16","author":"Speiser","year":"2016","journal-title":"Nat Rev Immunol."},{"issue":"19","key":"2021121701474702100_CIT0049","doi-asserted-by":"crossref","first-page":"5597","DOI":"10.1158\/0008-5472.CAN-16-0431","article-title":"The emerging role of B cells in tumor immunity","volume":"76","author":"Tsou","year":"2016","journal-title":"Cancer Res."},{"issue":"1","key":"2021121701474702100_CIT0050","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nrc.2015.5","article-title":"NK cells and cancer: you can teach innate cells new tricks","volume":"16","author":"Morvan","year":"2016","journal-title":"Nat Rev Cancer."},{"issue":"2","key":"2021121701474702100_CIT0051","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/JLB.4RI0818-311R","article-title":"Monocyte heterogeneity and functions in cancer","volume":"106","author":"Olingy","year":"2019","journal-title":"J Leukoc Biol."},{"issue":"7","key":"2021121701474702100_CIT0052","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat Rev Clin Oncol."},{"key":"2021121701474702100_CIT0053","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.coi.2017.01.002","article-title":"Dendritic cells in cancer: the role revisited","volume":"45","author":"Veglia","year":"2017","journal-title":"Curr Opin Immunol."},{"issue":"7","key":"2021121701474702100_CIT0054","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrc.2016.52","article-title":"Neutrophils in cancer: neutral no more","volume":"16","author":"Coffelt","year":"2016","journal-title":"Nat Rev Cancer."},{"key":"2021121701474702100_CIT0055","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.coi.2018.03.009","article-title":"Plasticity of myeloid-derived suppressor cells in cancer","volume":"51","author":"Tcyganov","year":"2018","journal-title":"Curr Opin Immunol."},{"issue":"Pt 23","key":"2021121701474702100_CIT0056","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.1242\/jcs.116392","article-title":"The tumor microenvironment at a glance","volume":"125","author":"Balkwill","year":"2012","journal-title":"J Cell Sci."},{"issue":"1","key":"2021121701474702100_CIT0057","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12964-020-0530-4","article-title":"Tumor microenvironment complexity and therapeutic implications at a glance","volume":"18","author":"Baghban","year":"2020","journal-title":"Cell Commun Signal."},{"issue":"1","key":"2021121701474702100_CIT0058","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41392-020-0207-x","article-title":"Therapeutic siRNA: state of the art","volume":"5","author":"Hu","year":"2020","journal-title":"Signal Transduct Target Ther."},{"issue":"2","key":"2021121701474702100_CIT0059","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1172\/JCI59227","article-title":"Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice","volume":"122","author":"Collins","year":"2012","journal-title":"J Clin Invest."},{"issue":"9","key":"2021121701474702100_CIT0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1101\/cshperspect.a031435","article-title":"KRAS: the critical driver and therapeutic target for pancreatic cancer","volume":"8","author":"Waters","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2021121701474702100_CIT0061","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s41544-019-0034-9","article-title":"Tumor-specific delivery of KRAS siRNA with iRGD-exosomes efficiently inhibits tumor growth","volume":"1","author":"Yu Zhou","year":"2019","journal-title":"ExRNA"},{"issue":"1","key":"2021121701474702100_CIT0062","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41565-017-0012-z","article-title":"Nanoparticle orientation to control RNA loading and ligand display on extracellular vesicles for cancer regression","volume":"13","author":"Pi","year":"2018","journal-title":"Nat Nanotechnol."},{"key":"2021121701474702100_CIT0063","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2019.12.005","article-title":"Exosome-mediated siRNA delivery to suppress postoperative breast cancer metastasis","volume":"318","author":"Zhao","year":"2020","journal-title":"J Control Release."},{"key":"2021121701474702100_CIT0064","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.2147\/IJN.S231214","article-title":"Exosome-delivered c-Met siRNA could reverse chemoresistance to cisplatin in gastric cancer","volume":"15","author":"Zhang","year":"2020","journal-title":"Int J Nanomedicine."},{"key":"2021121701474702100_CIT0065","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1478-811X-11-88","article-title":"Exosomes are natural carriers of exogenous siRNA to human cells in vitro","volume":"11","author":"Shtam","year":"2013","journal-title":"Cell Commun Signal."},{"key":"2021121701474702100_CIT0066","doi-asserted-by":"crossref","first-page":"241.e1","DOI":"10.1016\/j.urology.2016.01.028","article-title":"PLK-1 silencing in bladder cancer by siRNA delivered with exosomes","volume":"91","author":"Greco","year":"2016","journal-title":"Urology."},{"issue":"1","key":"2021121701474702100_CIT0067","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s12010-018-2813-4","article-title":"Engineered exosomes for targeted transfer of siRNA to HER2 positive breast cancer cells","volume":"187","author":"Limoni","year":"2019","journal-title":"Appl Biochem Biotechnol."},{"issue":"1","key":"2021121701474702100_CIT0068","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41580-018-0059-1","article-title":"Regulation of microRNA biogenesis and its crosstalk with other cellular pathways","volume":"20","author":"Treiber","year":"2019","journal-title":"Nat Rev Mol Cell Biol."},{"issue":"1","key":"2021121701474702100_CIT0069","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/mt.2012.180","article-title":"Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast cancer cells","volume":"21","author":"Ohno","year":"2013","journal-title":"Mol Ther."},{"key":"2021121701474702100_CIT0070","doi-asserted-by":"crossref","first-page":"e126","DOI":"10.1038\/mtna.2013.60","article-title":"Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity","volume":"2","author":"Munoz","year":"2013","journal-title":"Mol Ther Nucleic Acids."},{"issue":"3","key":"2021121701474702100_CIT0071","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.ymthe.2018.01.001","article-title":"Exosomes serve as nanoparticles to deliver anti-miR-214 to reverse chemoresistance to cisplatin in gastric cancer","volume":"26","author":"Wang","year":"2018","journal-title":"Mol Ther."},{"issue":"1","key":"2021121701474702100_CIT0072","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1038\/s41467-018-04791-8","article-title":"Efficient RNA drug delivery using red blood cell extracellular vesicles","volume":"9","author":"Usman","year":"2018","journal-title":"Nat Commun."},{"key":"2021121701474702100_CIT0073","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1146\/annurev-biochem-060815-014607","article-title":"CRISPR\/Cas9 in genome editing and beyond","volume":"85","author":"Wang","year":"2016","journal-title":"Annu Rev Biochem."},{"key":"2021121701474702100_CIT0074","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.jconrel.2017.09.013","article-title":"Cancer-derived exosomes as a delivery platform of CRISPR\/Cas9 confer cancer cell tropism-dependent targeting","volume":"266","author":"Kim","year":"2017","journal-title":"J Control Release."},{"issue":"5","key":"2021121701474702100_CIT0075","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.7150\/thno.17092","article-title":"Interleukin 3- receptor targeted exosomes inhibit in vitro and in vivo chronic myelogenous leukemia cell growth","volume":"7","author":"Bellavia","year":"2017","journal-title":"Theranostics."},{"key":"2021121701474702100_CIT0076","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3389\/fphar.2018.00245","article-title":"Editorial: adverse effects of cancer chemotherapy: anything new to improve tolerance and reduce sequelae?","volume":"9","author":"Nurgali","year":"2018","journal-title":"Front Pharmacol."},{"issue":"25","key":"2021121701474702100_CIT0077","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.2174\/092986709788803312","article-title":"Doxorubicin: the good, the bad and the ugly effect","volume":"16","author":"Carvalho","year":"2009","journal-title":"Curr Med Chem."},{"issue":"2","key":"2021121701474702100_CIT0078","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/j.2042-7158.2012.01567.x","article-title":"Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems","volume":"65","author":"Tacar","year":"2013","journal-title":"J Pharm Pharmacol."},{"issue":"7","key":"2021121701474702100_CIT0079","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/j.nano.2018.05.020","article-title":"A33 antibody-functionalized exosomes for targeted delivery of doxorubicin against colorectal cancer","volume":"14","author":"Li","year":"2018","journal-title":"Nanomedicine."},{"issue":"7","key":"2021121701474702100_CIT0080","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1016\/j.biomaterials.2013.11.083","article-title":"A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy","volume":"35","author":"Tian","year":"2014","journal-title":"Biomaterials."},{"issue":"19","key":"2021121701474702100_CIT0081","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.2217\/nnm.15.118","article-title":"Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin","volume":"10","author":"Toffoli","year":"2015","journal-title":"Nanomedicine (Lond)."},{"issue":"18","key":"2021121701474702100_CIT0082","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.2217\/nnm-2016-0154","article-title":"Exosomes increase the therapeutic index of doxorubicin in breast and ovarian cancer mouse models","volume":"11","author":"Hadla","year":"2016","journal-title":"Nanomedicine (Lond)."},{"issue":"19","key":"2021121701474702100_CIT0083","doi-asserted-by":"crossref","first-page":"10854","DOI":"10.1039\/D0NR00523A","article-title":"Engineering macrophage-derived exosomes for targeted chemotherapy of triple-negative breast cancer","volume":"12","author":"Li","year":"2020","journal-title":"Nanoscale."},{"issue":"8","key":"2021121701474702100_CIT0084","doi-asserted-by":"crossref","first-page":"3474","DOI":"10.7150\/thno.39434","article-title":"Tumor cell-derived exosomes home to their cells of origin and can be used as Trojan horses to deliver cancer drugs","volume":"10","author":"Qiao","year":"2020","journal-title":"Theranostics."},{"key":"2021121701474702100_CIT0085","first-page":"293","article-title":"Cancer chemotherapy: targeting folic acid synthesis","volume":"2","author":"Hagner","year":"2010","journal-title":"Cancer Manag Res."},{"issue":"15","key":"2021121701474702100_CIT0086","doi-asserted-by":"crossref","first-page":"12341","DOI":"10.1021\/acsami.7b18135","article-title":"Methotrexate-loaded extracellular vesicles functionalized with therapeutic and targeted peptides for the treatment of glioblastoma multiforme","volume":"10","author":"Ye","year":"2018","journal-title":"ACS Appl Mater Interfaces."},{"issue":"18","key":"2021121701474702100_CIT0087","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1091\/mbc.e14-04-0916","article-title":"How Taxol\/paclitaxel kills cancer cells","volume":"25","author":"Weaver","year":"2014","journal-title":"Mol Biol Cell."},{"issue":"Pt B","key":"2021121701474702100_CIT0088","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.jconrel.2015.09.031","article-title":"Microvesicle- and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells","volume":"220","author":"Saari","year":"2015","journal-title":"J Control Release."},{"issue":"3","key":"2021121701474702100_CIT0089","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.nano.2015.10.012","article-title":"Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells","volume":"12","author":"Kim","year":"2016","journal-title":"Nanomedicine."},{"issue":"1","key":"2021121701474702100_CIT0090","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.nano.2017.09.011","article-title":"Engineering macrophage-derived exosomes for targeted paclitaxel delivery to pulmonary metastases: in vitro and in vivo evaluations","volume":"14","author":"Kim","year":"2018","journal-title":"Nanomedicine."},{"issue":"6","key":"2021121701474702100_CIT0091","doi-asserted-by":"crossref","first-page":"1801899","DOI":"10.1002\/advs.201801899","article-title":"Embryonic stem cells-derived exosomes endowed with targeting properties as chemotherapeutics delivery vehicles for glioblastoma therapy","volume":"6","author":"Zhu","year":"2019","journal-title":"Adv Sci (Weinh)."},{"issue":"1","key":"2021121701474702100_CIT0092","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1517\/14796694.1.1.7","article-title":"Role of gemcitabine in cancer therapy","volume":"1","author":"Toschi","year":"2005","journal-title":"Future Oncol."},{"key":"2021121701474702100_CIT0093","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.actbio.2019.10.022","article-title":"Gemcitabine loaded autologous exosomes for effective and safe chemotherapy of pancreatic cancer","volume":"101","author":"Li","year":"2020","journal-title":"Acta Biomater."},{"issue":"10","key":"2021121701474702100_CIT0094","doi-asserted-by":"crossref","first-page":"3173","DOI":"10.1111\/cas.14181","article-title":"Targeted exosome-encapsulated erastin induced ferroptosis in triple negative breast cancer cells","volume":"110","author":"Yu","year":"2019","journal-title":"Cancer Sci."},{"key":"2021121701474702100_CIT0095","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.ejphar.2014.07.025","article-title":"Cisplatin in cancer therapy: molecular mechanisms of action","volume":"740","author":"Dasari","year":"2014","journal-title":"Eur J Pharmacol."},{"issue":"7","key":"2021121701474702100_CIT0096","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1080\/03639045.2020.1776320","article-title":"The effects of umbilical cord-derived macrophage exosomes loaded with cisplatin on the growth and drug resistance of ovarian cancer cells","volume":"46","author":"Zhang","year":"2020","journal-title":"Drug Dev Ind Pharm."},{"issue":"2","key":"2021121701474702100_CIT0097","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/s41556-018-0256-3","article-title":"Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models","volume":"21","author":"Keklikoglou","year":"2019","journal-title":"Nat Cell Biol."},{"issue":"3","key":"2021121701474702100_CIT0098","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.immuni.2019.01.010","article-title":"Specific decrease in B-cell-derived extracellular vesicles enhances post-chemotherapeutic CD8+ T cell responses","volume":"50","author":"Zhang","year":"2019","journal-title":"Immunity."},{"issue":"1","key":"2021121701474702100_CIT0099","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s12951-019-0526-7","article-title":"Functional exosome-mediated co-delivery of doxorubicin and hydrophobically modified microRNA 159 for triple-negative breast cancer therapy","volume":"17","author":"Gong","year":"2019","journal-title":"J Nanobiotechnology."},{"issue":"1","key":"2021121701474702100_CIT0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12951-019-0563-2","article-title":"Engineered exosomes for targeted co-delivery of miR-21 inhibitor and chemotherapeutics to reverse drug resistance in colon cancer","volume":"18","author":"Liang","year":"2020","journal-title":"J Nanobiotechnology."},{"issue":"17","key":"2021121701474702100_CIT0101","doi-asserted-by":"crossref","first-page":"7889","DOI":"10.7150\/thno.45028","article-title":"Engineering blood exosomes for tumor-targeting efficient gene\/chemo combination therapy","volume":"10","author":"Zhan","year":"2020","journal-title":"Theranostics."},{"issue":"6","key":"2021121701474702100_CIT0102","doi-asserted-by":"crossref","first-page":"5100","DOI":"10.1021\/acsami.6b14633","article-title":"Folate-engineered microvesicles for enhanced target and synergistic therapy toward breast cancer","volume":"9","author":"Zhu","year":"2017","journal-title":"ACS Appl Mater Interfaces."},{"issue":"12","key":"2021121701474702100_CIT0103","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nrc948","article-title":"Oncolytic viruses","volume":"2","author":"Chiocca","year":"2002","journal-title":"Nat Rev Cancer."},{"key":"2021121701474702100_CIT0104","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.jconrel.2018.12.022","article-title":"Extracellular vesicles enhance the targeted delivery of immunogenic oncolytic adenovirus and paclitaxel in immunocompetent mice","volume":"294","author":"Garofalo","year":"2019","journal-title":"J Control Release."},{"issue":"6","key":"2021121701474702100_CIT0105","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s40495-016-0073-y","article-title":"Enzyme\/prodrug systems for cancer gene therapy","volume":"2","author":"Malekshah","year":"2016","journal-title":"Curr Pharmacol Rep."},{"issue":"5","key":"2021121701474702100_CIT0106","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1158\/1535-7163.MCT-17-0827","article-title":"Anti-HER2 scFv-directed extracellular vesicle-mediated mRNA-based gene delivery inhibits growth of HER2-positive human breast tumor xenografts by prodrug activation","volume":"17","author":"Wang","year":"2018","journal-title":"Mol Cancer Ther."},{"issue":"12","key":"2021121701474702100_CIT0107","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1158\/1535-7163.MCT-19-0299","article-title":"Microvesicle-mediated delivery of minicircle DNA results in effective gene-directed enzyme prodrug cancer therapy","volume":"18","author":"Kanada","year":"2019","journal-title":"Mol Cancer Ther."},{"key":"2021121701474702100_CIT0108","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.ijpharm.2019.06.028","article-title":"Development of a nanoamorphous exosomal delivery system as an effective biological platform for improved encapsulation of hydrophobic drugs","volume":"566","author":"Tran","year":"2019","journal-title":"Int J Pharm."},{"key":"2021121701474702100_CIT0109","doi-asserted-by":"crossref","first-page":"118786","DOI":"10.1016\/j.ijpharm.2019.118786","article-title":"Aspirin-loaded nanoexosomes as cancer therapeutics","volume":"572","author":"Tran","year":"2019","journal-title":"Int J Pharm."},{"issue":"1","key":"2021121701474702100_CIT0110","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.yexmp.2016.05.013","article-title":"Exosomal formulation enhances therapeutic response of celastrol against lung cancer","volume":"101","author":"Aqil","year":"2016","journal-title":"Exp Mol Pathol."},{"issue":"6","key":"2021121701474702100_CIT0111","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1208\/s12248-017-0154-9","article-title":"Exosomes for the enhanced tissue bioavailability and efficacy of curcumin","volume":"19","author":"Aqil","year":"2017","journal-title":"AAPS J."},{"key":"2021121701474702100_CIT0112","doi-asserted-by":"crossref","first-page":"9","DOI":"10.5772\/63437","article-title":"ZnO nanoparticles: a promising anticancer agent","volume":"3","author":"Bisht","year":"2016","journal-title":"Nanobiomedicine (Rij)."},{"issue":"21","key":"2021121701474702100_CIT0113","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.2217\/nnm-2019-0231","article-title":"ZnO nanocrystals shuttled by extracellular vesicles as effective Trojan nano-horses against cancer cells","volume":"14","author":"Dumontel","year":"2019","journal-title":"Nanomedicine (Lond)."},{"key":"2021121701474702100_CIT0114","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3402\/jev.v3.23244","article-title":"Enhancement of Gemcitabine sensitivity in pancreatic adenocarcinoma by novel exosome-mediated delivery of the Survivin-T34A mutant","volume":"3","author":"Aspe","year":"2014","journal-title":"J Extracell Vesicles"},{"issue":"10","key":"2021121701474702100_CIT0115","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/nrc2465","article-title":"The TRAIL apoptotic pathway in cancer onset, progression and therapy","volume":"8","author":"Johnstone","year":"2008","journal-title":"Nat Rev Cancer."},{"issue":"1","key":"2021121701474702100_CIT0116","doi-asserted-by":"crossref","first-page":"1265291","DOI":"10.1080\/20013078.2017.1265291","article-title":"TRAIL delivery by MSC-derived extracellular vesicles is an effective anticancer therapy","volume":"6","author":"Yuan","year":"2017","journal-title":"J Extracell Vesicles."},{"key":"2021121701474702100_CIT0117","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.3389\/fonc.2020.01453","article-title":"The antitumor effect of gene-engineered exosomes in the treatment of brain metastasis of breast cancer","volume":"10","author":"Liu","year":"2020","journal-title":"Front Oncol."},{"issue":"2","key":"2021121701474702100_CIT0118","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.coi.2012.01.010","article-title":"The CD47-SIRP\u03b1 pathway in cancer immune evasion and potential therapeutic implications","volume":"24","author":"Chao","year":"2012","journal-title":"Curr Opin Immunol."},{"key":"2021121701474702100_CIT0119","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.biomaterials.2017.01.004","article-title":"Exosome-SIRP\u03b1, a CD47 blockade increases cancer cell phagocytosis","volume":"121","author":"Koh","year":"2017","journal-title":"Biomaterials."},{"issue":"5","key":"2021121701474702100_CIT0120","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"Hallmarks of cancer: the next generation","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell."},{"issue":"4","key":"2021121701474702100_CIT0121","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1172\/JCI81136","article-title":"Exosomes and tumor-mediated immune suppression","volume":"126","author":"Whiteside","year":"2016","journal-title":"J Clin Invest."},{"key":"2021121701474702100_CIT0122","article-title":"Exosomes as mediators of immune regulation and immunotherapy in cancer","author":"Kugeratski","year":"2020","journal-title":"FEBS J"},{"issue":"5256","key":"2021121701474702100_CIT0123","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1126\/science.271.5256.1734","article-title":"Enhancement of antitumor immunity by CTLA-4 blockade","volume":"271","author":"Leach","year":"1996","journal-title":"Science."},{"issue":"2","key":"2021121701474702100_CIT0124","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/intimm\/dxh194","article-title":"PD-1 blockade inhibits hematogenous spread of poorly immunogenic tumor cells by enhanced recruitment of effector T cells","volume":"17","author":"Iwai","year":"2005","journal-title":"Int Immunol."},{"issue":"6382","key":"2021121701474702100_CIT0125","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1126\/science.aar4060","article-title":"Cancer immunotherapy using checkpoint blockade","volume":"359","author":"Ribas","year":"2018","journal-title":"Science."},{"issue":"50","key":"2021121701474702100_CIT0126","doi-asserted-by":"crossref","first-page":"9361","DOI":"10.1016\/j.vaccine.2011.09.133","article-title":"Increasing vaccine potency through exosome antigen targeting","volume":"29","author":"Hartman","year":"2011","journal-title":"Vaccine."},{"issue":"11","key":"2021121701474702100_CIT0127","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1111\/j.1582-4934.2009.00851.x","article-title":"Membrane-bound HSP70-engineered myeloma cell-derived exosomes stimulate more efficient CD8+ CTL- and NK-mediated antitumour immunity than exosomes released from heat-shocked tumour cells expressing cytoplasmic HSP70","volume":"14","author":"Xie","year":"2010","journal-title":"J Cell Mol Med."},{"issue":"5","key":"2021121701474702100_CIT0128","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/nm0598-594","article-title":"Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes","volume":"4","author":"Zitvogel","year":"1998","journal-title":"Nat Med."},{"issue":"1","key":"2021121701474702100_CIT0129","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1479-5876-3-9","article-title":"A phase I study of dexosome immunotherapy in patients with advanced non\u2013small cell lung cancer","volume":"3","author":"Morse","year":"2005","journal-title":"J Transl Med."},{"issue":"4","key":"2021121701474702100_CIT0130","doi-asserted-by":"crossref","first-page":"e1071008","DOI":"10.1080\/2162402X.2015.1071008","article-title":"Dendritic cell-derived exosomes as maintenance immunotherapy after first line chemotherapy in NSCLC","volume":"5","author":"Besse","year":"2016","journal-title":"Oncoimmunology."},{"issue":"4","key":"2021121701474702100_CIT0131","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1172\/JCI81137","article-title":"Dendritic cell-derived exosomes for cancer therapy","volume":"126","author":"Pitt","year":"2016","journal-title":"J Clin Invest."},{"issue":"3","key":"2021121701474702100_CIT0132","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.4049\/jimmunol.1400703","article-title":"Dendritic cell-derived exosomes as immunotherapies in the fight against cancer","volume":"193","author":"Pitt","year":"2014","journal-title":"J Immunol."},{"issue":"10","key":"2021121701474702100_CIT0133","doi-asserted-by":"crossref","first-page":"221","DOI":"10.21037\/atm.2017.02.23","article-title":"Dendritic cell-derived exosomes for cancer immunotherapy: hope and challenges","volume":"5","author":"Tian","year":"2017","journal-title":"Ann Transl Med."},{"issue":"1","key":"2021121701474702100_CIT0134","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2009.00782.x","article-title":"Molecular mechanism and function of CD40\/CD40L engagement in the immune system","volume":"229","author":"Elgueta","year":"2009","journal-title":"Immunol Rev."},{"issue":"1","key":"2021121701474702100_CIT0135","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3892\/mmr.2013.1759","article-title":"More efficient induction of antitumor T cell immunity by exosomes from CD40L gene-modified lung tumor cells","volume":"9","author":"Wang","year":"2014","journal-title":"Mol Med Rep."},{"issue":"1","key":"2021121701474702100_CIT0136","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1038\/s41467-020-15569-2","article-title":"Alarmin-painted exosomes elicit persistent antitumor immunity in large established tumors in mice","volume":"11","author":"Zuo","year":"2020","journal-title":"Nat Commun."},{"issue":"11","key":"2021121701474702100_CIT0137","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS-STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat Rev Genet."},{"issue":"4","key":"2021121701474702100_CIT0138","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.4049\/jimmunol.1601694","article-title":"DNA-containing exosomes derived from cancer cells treated with topotecan activate a STING-dependent pathway and reinforce antitumor immunity","volume":"198","author":"Kitai","year":"2017","journal-title":"J Immunol."},{"issue":"1","key":"2021121701474702100_CIT0139","doi-asserted-by":"crossref","first-page":"2658","DOI":"10.1038\/s41467-018-05077-9","article-title":"Priming of dendritic cells by DNA-containing extracellular vesicles from activated T cells through antigen-driven contacts","volume":"9","author":"Torralba","year":"2018","journal-title":"Nat Commun."},{"issue":"8","key":"2021121701474702100_CIT0140","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1158\/2326-6066.CIR-17-0581","article-title":"Exosomes shuttle TREX1-sensitive IFN-stimulatory dsDNA from irradiated cancer cells to DCs","volume":"6","author":"Diamond","year":"2018","journal-title":"Cancer Immunol Res."},{"issue":"48","key":"2021121701474702100_CIT0141","doi-asserted-by":"crossref","first-page":"16413","DOI":"10.1021\/jacs.8b10047","article-title":"Reprogramming exosomes as nanoscale controllers of cellular immunity","volume":"140","author":"Cheng","year":"2018","journal-title":"J Am Chem Soc."},{"issue":"5","key":"2021121701474702100_CIT0142","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s13402-020-00535-3","article-title":"Enhanced immunogenicity of leukemia-derived exosomes via transfection with lentiviral vectors encoding costimulatory molecules","volume":"43","author":"Hu","year":"2020","journal-title":"Cell Oncol (Dordr)"},{"issue":"1","key":"2021121701474702100_CIT0143","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3892\/ijo.2015.2993","article-title":"Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: a novel vaccine for renal cell carcinoma","volume":"36","author":"Zhang","year":"2010","journal-title":"Int J Oncol."},{"key":"2021121701474702100_CIT0144","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.2147\/IJN.S196975","article-title":"Decoy exosomes as a novel biologic reagent to antagonize inflammation","volume":"14","author":"Duong","year":"2019","journal-title":"Int J Nanomedicine."},{"issue":"6801","key":"2021121701474702100_CIT0145","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature."},{"issue":"7347","key":"2021121701474702100_CIT0146","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nature10144","article-title":"Molecular mechanisms and clinical applications of angiogenesis","volume":"473","author":"Carmeliet","year":"2011","journal-title":"Nature."},{"issue":"8","key":"2021121701474702100_CIT0147","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrc.2017.51","article-title":"Microenvironmental regulation of tumour angiogenesis","volume":"17","author":"De Palma","year":"2017","journal-title":"Nat Rev Cancer."},{"issue":"567","key":"2021121701474702100_CIT0148","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1126\/scisignal.aan8247","article-title":"Hypoxic cancer-associated fibroblasts increase NCBP2-AS2\/HIAR to promote endothelial sprouting through enhanced VEGF signaling","volume":"12","author":"Kugeratski","year":"2019","journal-title":"Sci Signal"},{"key":"2021121701474702100_CIT0149","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.biopha.2018.03.148","article-title":"Tumor-derived extracellular vesicles in angiogenesis","volume":"102","author":"Song","year":"2018","journal-title":"Biomed Pharmacother."},{"issue":"6","key":"2021121701474702100_CIT0150","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/nrd3455","article-title":"Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases","volume":"10","author":"Carmeliet","year":"2011","journal-title":"Nat Rev Drug Discov."},{"issue":"2","key":"2021121701474702100_CIT0151","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1208\/s12248-016-0015-y","article-title":"Delivery of small interfering RNA to inhibit vascular endothelial growth factor in zebrafish using natural brain endothelia cell-secreted exosome nanovesicles for the treatment of brain cancer","volume":"19","author":"Yang","year":"2017","journal-title":"AAPS J."},{"issue":"3","key":"2021121701474702100_CIT0152","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1111\/cas.13488","article-title":"Exosomes serve as nanoparticles to suppress tumor growth and angiogenesis in gastric cancer by delivering hepatocyte growth factor siRNA","volume":"109","author":"Zhang","year":"2018","journal-title":"Cancer Sci."},{"issue":"10","key":"2021121701474702100_CIT0153","doi-asserted-by":"crossref","first-page":"1962","DOI":"10.1111\/1759-7714.13175","article-title":"Soluble fms-like tyrosine kinase-1-enriched exosomes suppress the growth of small cell lung cancer by inhibiting endothelial cell migration","volume":"10","author":"Hao","year":"2019","journal-title":"Thorac Cancer."},{"issue":"22","key":"2021121701474702100_CIT0154","doi-asserted-by":"crossref","first-page":"10705","DOI":"10.1073\/pnas.90.22.10705","article-title":"Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor","volume":"90","author":"Kendall","year":"1993","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"7","key":"2021121701474702100_CIT0155","first-page":"2019","article-title":"Soluble FLT-1 expression suppresses carcinomatous ascites in nude mice bearing ovarian cancer","volume":"62","author":"Hasumi","year":"2002","journal-title":"Cancer Res."},{"issue":"8","key":"2021121701474702100_CIT0156","first-page":"2169","article-title":"Suppression of tumor angiogenesis and growth by gene transfer of a soluble form of vascular endothelial growth factor receptor into a remote organ","volume":"60","author":"Takayama","year":"2000","journal-title":"Cancer Res."}],"container-title":["Endocrinology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/endo\/advance-article-pdf\/doi\/10.1210\/endocr\/bqaa250\/35506472\/bqaa250.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/162\/3\/bqaa250\/41793239\/bqaa250.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/endo\/article-pdf\/162\/3\/bqaa250\/41793239\/bqaa250.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:51:34Z","timestamp":1639705894000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/endo\/article\/doi\/10.1210\/endocr\/bqaa250\/6067593"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,7]]},"references-count":156,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3,1]]}},"URL":"https:\/\/doi.org\/10.1210\/endocr\/bqaa250","relation":{},"ISSN":["0013-7227","1945-7170"],"issn-type":[{"type":"print","value":"0013-7227"},{"type":"electronic","value":"1945-7170"}],"subject":[],"published-other":{"date-parts":[[2021,3]]},"published":{"date-parts":[[2021,1,7]]},"article-number":"bqaa250"}}