{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:17:32Z","timestamp":1768979852820,"version":"3.49.0"},"reference-count":38,"publisher":"The Endocrine Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,11,1]]},"DOI":"10.1210\/jc.2005-2559","type":"journal-article","created":{"date-parts":[[2006,8,23]],"date-time":"2006-08-23T03:44:04Z","timestamp":1156304644000},"page":"4628-4634","source":"Crossref","is-referenced-by-count":171,"title":["Circulating Soluble Receptor for Advanced Glycation End Products Is Inversely Associated with Glycemic Control and S100A12 Protein"],"prefix":"10.1210","volume":"91","author":[{"given":"Giuseppina","family":"Basta","sequence":"first","affiliation":[{"name":"Consiglio Nazionale delle Richerche Institute of Clinical Physiology (G.B., A.M.S., G.L., S.D.T., E.B., E.F., A.G.) 56124 Pisa, Italy"}]},{"given":"Anna Maria","family":"Sironi","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Richerche Institute of Clinical Physiology (G.B., A.M.S., G.L., S.D.T., E.B., E.F., A.G.) 56124 Pisa, Italy"}]},{"given":"Guido","family":"Lazzerini","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Richerche Institute of Clinical Physiology (G.B., A.M.S., G.L., S.D.T., E.B., E.F., A.G.) 56124 Pisa, Italy"}]},{"given":"Serena","family":"Del Turco","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Richerche Institute of Clinical Physiology (G.B., A.M.S., G.L., S.D.T., E.B., E.F., A.G.) 56124 Pisa, Italy"}]},{"given":"Emma","family":"Buzzigoli","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Richerche Institute of Clinical Physiology (G.B., A.M.S., G.L., S.D.T., E.B., E.F., A.G.) 56124 Pisa, Italy"}]},{"given":"Arturo","family":"Casolaro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.C., A.N., E.F.), University of Pisa School of Medicine, 56124 Pisa, Italy"}]},{"given":"Andrea","family":"Natali","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (A.C., A.N., E.F.), University of Pisa School of Medicine, 56124 Pisa, Italy"}]},{"given":"Ele","family":"Ferrannini","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Richerche Institute of Clinical Physiology (G.B., A.M.S., G.L., S.D.T., E.B., E.F., A.G.) 56124 Pisa, Italy"},{"name":"Department of Internal Medicine (A.C., A.N., E.F.), University of Pisa School of Medicine, 56124 Pisa, Italy"}]},{"given":"Amalia","family":"Gastaldelli","sequence":"additional","affiliation":[{"name":"Consiglio Nazionale delle Richerche Institute of Clinical Physiology (G.B., A.M.S., G.L., S.D.T., E.B., E.F., A.G.) 56124 Pisa, Italy"}]}],"member":"80","reference":[{"key":"key\n\t\t\t\t2019041114141184800_R1","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.2337\/diacare.22.9.1543","article-title":"Serum levels of advanced glycation end products are increased in patients with type 2 diabetes and coronary heart disease","volume":"22","author":"Kilhovd","year":"1999","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041114141184800_R2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/BF03345377","article-title":"Advanced glycosylation end products in skin, serum, saliva and urine and its association with complications of patients with type 2 diabetes mellitus","volume":"28","author":"Garay-Sevilla","year":"2005","journal-title":"J Endocrinol Invest"},{"key":"key\n\t\t\t\t2019041114141184800_R3","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.cardiores.2004.05.001","article-title":"Advanced glycation end products and vascular inflammation: implications for accelerated atherosclerosis in diabetes","volume":"63","author":"Basta","year":"2004","journal-title":"Cardiovasc Res"},{"key":"key\n\t\t\t\t2019041114141184800_R4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1254\/jphs.CPJ04005X","article-title":"Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury","volume":"97","author":"Yonekura","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"key\n\t\t\t\t2019041114141184800_R5","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0092-8674(00)80801-6","article-title":"RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100\/calgranulin polypeptides","volume":"97","author":"Hofmann","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t2019041114141184800_R6","doi-asserted-by":"crossref","first-page":"2792","DOI":"10.2337\/diabetes.50.12.2792","article-title":"Diabetes-associated sustained activation of the transcription factor nuclear factor-\u03baB","volume":"50","author":"Bierhaus","year":"2001","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041114141184800_R7","doi-asserted-by":"crossref","first-page":"28929","DOI":"10.1016\/S0021-9258(19)61996-4","article-title":"Primary structure and binding properties of calgranulin C, a novel S100-like calcium-binding protein from pig granulocytes","volume":"269","author":"Dell\u2019Angelica","year":"1994","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041114141184800_R8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1042\/bj20021371","article-title":"Novel splice variants of the receptor for advanced glycation end-products expressed in human vascular endothelial cells and pericytes, and their putative roles in diabetes-induced vascular injury","volume":"370","author":"Yonekura","year":"2003","journal-title":"Biochem J"},{"key":"key\n\t\t\t\t2019041114141184800_R9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1172\/JCI118397","article-title":"Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy. Soluble receptor for advanced glycation end products blocks hyperpermeability in diabetic rats","volume":"97","author":"Wautier","year":"1996","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041114141184800_R10","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/2012","article-title":"Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts","volume":"4","author":"Park","year":"1998","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t2019041114141184800_R11","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1161\/01.CIR.0000039325.03698.36","article-title":"RAGE blockade stabilizes established atherosclerosis in diabetic apolipoprotein E-null mice","volume":"106","author":"Bucciarelli","year":"2002","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041114141184800_R12","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1172\/JCI200317115","article-title":"Central role of RAGE-dependent neointimal expansion in arterial restenosis","volume":"111","author":"Sakaguchi","year":"2003","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t2019041114141184800_R13","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1161\/01.ATV.0000160342.20342.00","article-title":"Plasma levels of soluble receptor for advanced glycation end products and coronary artery disease in nondiabetic men","volume":"25","author":"Falcone","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2019041114141184800_R14","doi-asserted-by":"crossref","first-page":"R817","DOI":"10.1186\/ar1749","article-title":"Decreased levels of soluble receptor for advanced glycation end products in patients with rheumatoid arthritis indicating deficient inflammatory control","volume":"7","author":"Pullerits","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"key\n\t\t\t\t2019041114141184800_R15","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1097\/01.hjh.0000177535.45785.64","article-title":"Decreased plasma levels of soluble receptor for advanced glycation end-products in patients with essential hypertension","volume":"23","author":"Geroldi","year":"2005","journal-title":"J Hypertens"},{"key":"key\n\t\t\t\t2019041114141184800_R16","doi-asserted-by":"crossref","first-page":"2716","DOI":"10.2337\/diacare.28.11.2716","article-title":"Decreased endogenous secretory advanced glycation end product receptor in type 1 diabetic patients: its possible association with diabetic vascular complications","volume":"28","author":"Katakami","year":"2005","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041114141184800_R17","doi-asserted-by":"crossref","first-page":"2587","DOI":"10.1161\/01.ATV.0000190660.32863.cd","article-title":"Plasma level of endogenous secretory RAGE is associated with components of the metabolic syndrome and atherosclerosis","volume":"25","author":"Koyama","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2019041114141184800_R18","doi-asserted-by":"crossref","first-page":"2090","DOI":"10.1007\/s00125-005-1891-3","article-title":"Visceral fat and \u03b2 cell function in non-diabetic humans","volume":"48","author":"Gastaldelli","year":"2005","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041114141184800_R19","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1093\/eurheartj\/ehi113","article-title":"Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vessels","volume":"26","author":"Natali","year":"2005","journal-title":"Eur Heart J"},{"key":"key\n\t\t\t\t2019041114141184800_R20","article-title":"Circulating levels of N\u03b5-carboxymethyllisine (CML) are increased in systemic sclerosis","author":"Kaloudi","journal-title":"Rheumatology"},{"key":"key\n\t\t\t\t2019041114141184800_R21","doi-asserted-by":"crossref","first-page":"24212","DOI":"10.1074\/jbc.M009477200","article-title":"The dimerization interface of the metastasis-associated protein S100A4 (Mts1): in vivo and in vitro studies","volume":"276","author":"Tarabykina","year":"2001","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t2019041114141184800_R22","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1107\/S0907444903004700","article-title":"Structure of the human S100A12-copper complex: implications for host-parasite defence","volume":"59","author":"Moroz","year":"2003","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"key\n\t\t\t\t2019041114141184800_R23","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"Wilson","year":"1998","journal-title":"Circulation"},{"key":"key\n\t\t\t\t2019041114141184800_R24","doi-asserted-by":"crossref","first-page":"166","DOI":"10.2337\/diabetes.53.1.166","article-title":"Long-term renal effects of a neutralizing RAGE antibody in obese type 2 diabetic mice","volume":"53","author":"Flyvbjerg","year":"2004","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t2019041114141184800_R25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.atherosclerosis.2005.06.013","article-title":"RAGE modulates vascular inflammation and atherosclerosis in a murine model of type 2 diabetes","volume":"185","author":"Wendt","year":"2006","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041114141184800_R26","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1161\/01.ATV.0000164804.05324.8b","article-title":"Soluble levels of receptor for advanced glycation endproducts (sRAGE) and coronary artery disease: the next C-reactive protein?","volume":"25","author":"Hudson","year":"2005","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"key\n\t\t\t\t2019041114141184800_R27","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s00125-001-0726-0","article-title":"Beyond postprandial hyperglycaemia: metabolic factors associated with cardiovascular disease","volume":"45","author":"Heine","year":"2002","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t2019041114141184800_R28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/s11906-005-0081-5","article-title":"Advanced-glycation end products in insulin-resistant states","volume":"7","author":"Soldatos","year":"2005","journal-title":"Curr Hypertens Rep"},{"key":"key\n\t\t\t\t2019041114141184800_R29","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0021-9150(99)00059-3","article-title":"Postprandial plasma glucose is an independent risk factor for increased carotid intima-media thickness in non-diabetic individuals","volume":"144","author":"Hanefeld","year":"1999","journal-title":"Atherosclerosis"},{"key":"key\n\t\t\t\t2019041114141184800_R30","doi-asserted-by":"crossref","first-page":"333","DOI":"10.2337\/diacare.22.2.333","article-title":"Increased intimal-medial thickness in newly detected type 2 diabetes: risk factors","volume":"22","author":"Temelkova-Kurktschiev","year":"1999","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t2019041114141184800_R31","doi-asserted-by":"crossref","first-page":"2363","DOI":"10.1681\/ASN.2005010062","article-title":"Modulation of soluble receptor for advanced glycation end products by angiotensin-converting enzyme-1 inhibition in diabetic nephropathy","volume":"16","author":"Forbes","year":"2005","journal-title":"J Am Soc Nephrol"},{"key":"key\n\t\t\t\t2019041114141184800_R32","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/S0022-3565(24)35053-0","article-title":"The human and rat recombinant receptors for advanced glycation end products have a high degree of homology but different pharmacokinetic properties in rats","volume":"290","author":"Renard","year":"1999","journal-title":"J Pharmacol Exp Ther"},{"key":"key\n\t\t\t\t2019041114141184800_R33","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1007\/BF03402128","article-title":"Detection of noncarboxymethyllysine and carboxymethyllysine advanced glycation end products (AGE) in serum of diabetic patients","volume":"5","author":"Takeuchi","year":"1999","journal-title":"Mol Med"},{"key":"key\n\t\t\t\t2019041114141184800_R34","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/S0140-6736(03)12986-8","article-title":"S100A12 (EN-RAGE) in monitoring Kawasaki disease","volume":"361","author":"Foell","year":"2003","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019041114141184800_R35","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1093\/rheumatology\/keg385","article-title":"Expression of the pro-inflammatory protein S100A12 (EN-RAGE) in rheumatoid and psoriatic arthritis","volume":"42","author":"Foell","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"key\n\t\t\t\t2019041114141184800_R36","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/gut.52.6.847","article-title":"Neutrophil derived human S100A12 (EN-RAGE) is strongly expressed during chronic active inflammatory bowel disease","volume":"52","author":"Foell","year":"2003","journal-title":"Gut"},{"key":"key\n\t\t\t\t2019041114141184800_R37","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1210\/jc.2003-032223","article-title":"Increased plasma S100A12 (EN-RAGE) levels in patients with type 2 diabetes","volume":"89","author":"Kosaki","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019041114141184800_R38","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.atherosclerosis.2003.08.021","article-title":"The regulation of EN-RAGE (S100A12) gene expression in human THP-1 macrophages","volume":"171","author":"Hasegawa","year":"2003","journal-title":"Atherosclerosis"}],"container-title":["The Journal of Clinical Endocrinology & Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jcem\/article-pdf\/91\/11\/4628\/9064754\/jcem4628.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,10]],"date-time":"2025-01-10T14:44:33Z","timestamp":1736520273000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcem\/article\/91\/11\/4628\/2656826"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,1]]},"references-count":38,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2006,11,1]]}},"URL":"https:\/\/doi.org\/10.1210\/jc.2005-2559","relation":{},"ISSN":["0021-972X","1945-7197"],"issn-type":[{"value":"0021-972X","type":"print"},{"value":"1945-7197","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,1]]}}}