{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T14:51:07Z","timestamp":1791211867549,"version":"4.1.0"},"reference-count":20,"publisher":"The Endocrine Society","issue":"3","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013317","name":"Lipedema Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["DK56341"],"award-info":[{"award-number":["DK56341"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017553","name":"Nutrition Obesity Research Center","doi-asserted-by":"publisher","award":["DK20579"],"award-info":[{"award-number":["DK20579"]}],"id":[{"id":"10.13039\/100017553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007878","name":"Diabetes Research Center","doi-asserted-by":"publisher","award":["UL1TR002345"],"award-info":[{"award-number":["UL1TR002345"]}],"id":[{"id":"10.13039\/100007878","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinical and Translational Science Award"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,23]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Lipedema is a lipodystrophic disease characterized primarily by a disproportionate increase in lower body subcutaneous fat. Although moderate weight loss decreases lower body fat mass in women with obesity and lipedema, it is possible that this decrease is due to a reduction in normal subcutaneous fat, rather than lipedema-affected fat. We evaluated the effect of moderate (11%) diet-induced weight loss on body fat mass and distribution, assessed by dual-energy X-ray absorptiometry and magnetic resonance imaging, in a 56-year-old woman with lipedema who was normal weight (body mass index: 23.9\u2005kg\/m2) at baseline. Approximately 85% of the decrease in body weight comprised body fat. The relative reduction in upper body fat (abdominal subcutaneous, arm and trunk fat) was similar to the relative reduction in lower body (total leg fat and thigh subcutaneous fat). Accordingly, weight loss did not change the proportion of total body fat comprising leg fat (44.8% and 45.1% before and after weight loss, respectively) or arm fat (9.1% and 9.6% before and after weight loss, respectively). These data suggest weight loss decreases lipedema-affected adipose tissue and demonstrate the therapeutic effect of weight loss on body composition in women with lipedema even if they are normal weight.<\/jats:p>","DOI":"10.1210\/jcemcr\/luag018","type":"journal-article","created":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T12:43:08Z","timestamp":1772109788000},"source":"Crossref","is-referenced-by-count":0,"title":["Moderate weight loss decreases lipedema-affected body fat mass in a woman who is lean with lipedema"],"prefix":"10.1210","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-2053-4396","authenticated-orcid":false,"given":"Giuseppe","family":"De Girolamo","sequence":"first","affiliation":[{"name":"Center for Human Nutrition, Washington University School of Medicine , St. Louis, MO 63110 ,","place":["USA"]},{"name":"Department of Medical and Surgical Sciences, University of Foggia , Foggia 71122 ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0063-046X","authenticated-orcid":false,"given":"Gordon I","family":"Smith","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Washington University School of Medicine , St. Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard I","family":"Stein","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Washington University School of Medicine , St. Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"Wright","sequence":"additional","affiliation":[{"name":"Laser, Lipo and Vein Center , St. Louis, MO 63368 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7127-1156","authenticated-orcid":false,"given":"Samuel","family":"Klein","sequence":"additional","affiliation":[{"name":"Center for Human Nutrition, Washington University School of Medicine , St. Louis, MO 63110 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"80","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"issue":"9","key":"2026022706552476600_luag018-B1","doi-asserted-by":"crossref","first-page":"e1043","DOI":"10.1097\/GOX.0000000000001043","article-title":"Lipedema: a relatively common disease with extremely common misconceptions","volume":"4","author":"Buck","year":"2016","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"10","key":"2026022706552476600_luag018-B2","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/oby.22597","article-title":"Lipedema: a call to 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A review of the literature","volume":"161","author":"Langendoen","year":"2009","journal-title":"Br J Dermatol"},{"issue":"4","key":"2026022706552476600_luag018-B13","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1002\/ajmg.a.33313","article-title":"Lipedema: an inherited condition","volume":"152A","author":"Child","year":"2010","journal-title":"Am J Med Genet A"},{"issue":"5","key":"2026022706552476600_luag018-B14","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.7326\/0003-4819-34-5-1243","article-title":"Lipedema of the legs; a syndrome characterized by fat legs and edema","volume":"34","author":"Wold","year":"1951","journal-title":"Ann Intern Med"},{"key":"2026022706552476600_luag018-B15","author":"GE HealthCare"},{"issue":"2","key":"2026022706552476600_luag018-B16","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1093\/ajcn\/51.2.241","article-title":"A new predictive equation for resting energy expenditure in healthy individuals","volume":"51","author":"Mifflin","year":"1990","journal-title":"Am J Clin Nutr"},{"issue":"25","key":"2026022706552476600_luag018-B17","doi-asserted-by":"crossref","first-page":"2549","DOI":"10.1056\/NEJMoa033179","article-title":"Absence of an effect of liposuction on insulin action and risk factors for coronary heart disease","volume":"350","author":"Klein","year":"2004","journal-title":"N Engl J Med"},{"issue":"6","key":"2026022706552476600_luag018-B18","doi-asserted-by":"crossref","first-page":"E1333","DOI":"10.1152\/ajpendo.2001.281.6.E1333","article-title":"Gender differences in lipid and glucose kinetics during short-term fasting","volume":"281","author":"Mittendorfer","year":"2001","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"5","key":"2026022706552476600_luag018-B19","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1053\/j.gastro.2008.01.075","article-title":"Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects","volume":"134","author":"Korenblat","year":"2008","journal-title":"Gastroenterology"},{"issue":"4","key":"2026022706552476600_luag018-B20","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.cmet.2024.03.002","article-title":"Cardiometabolic characteristics of people with metabolically healthy and unhealthy obesity","volume":"36","author":"Petersen","year":"2024","journal-title":"Cell Metab"}],"container-title":["JCEM Case Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/3\/luag018\/67154190\/luag018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jcemcr\/article-pdf\/4\/3\/luag018\/67154190\/luag018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T11:55:29Z","timestamp":1772193329000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jcemcr\/article\/doi\/10.1210\/jcemcr\/luag018\/8501025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,23]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,2,23]]}},"URL":"https:\/\/doi.org\/10.1210\/jcemcr\/luag018","relation":{},"ISSN":["2755-1520"],"issn-type":[{"value":"2755-1520","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,2,23]]},"article-number":"luag018"}}