{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:41:41Z","timestamp":1790649701353,"version":"4.1.0"},"reference-count":150,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2000,5,1]],"date-time":"2000-05-01T00:00:00Z","timestamp":957139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nimesulide, a non-steroidal anti-inflammatory drug (NSAID), is administered orally or rectally twice daily for a variety of inflammation and pain states. This is a unique NSAID, not only because of its chemical structure but also because of its specific affinity to inhibit cyclooxygenase-2 (COX-2), thus exerting milder effects on the gastrointestinal mucosa. Current data on selective COX-2 inhibitors suggest that they may have an efficacy similar to that of standard NSAIDs. Initial general clinical experience with selective COX-2 inhibitors appears to show that they are particularly promising in individuals at risk because of renal diseases, hypertension or congestive heart failure.<\/jats:p>\n               <jats:p>Various experimental models and clinical studies have demonstrated the anti-inflammatory efficacy of nimesulide. Nimesulide is superior, or at least comparable in efficacy, to other NSAIDs, but is better tolerated and has less potential for adverse reactions. Thus, selective COX-2 inhibitors should have anti-inflammatory effects devoid of side effects on the kidney and stomach. They may also demonstrate new important therapeutic benefits as anticancer agents as well as help prevention of premature labour and even retard the progression of Alzheimer's disease. No clinically significant drug interactions have been reported for nimesulide.<\/jats:p>\n               <jats:p>Not much has been reported about the pharmaceutical aspects of nimesulide. Its poor aqueous solubility poses bioavailability problems in-vivo. This could be overcome by the formation of inclusion complexes with \u03b2-cyclodextrin, as has been reported by various researchers. However, absence of any in-vivo data regarding the relative absorption of nimesulide from \u03b2-cyclodextrin complex compared with that from conventional formulations of the drug makes the use of such fast-releasing complexes rather questionable. Only a limited number of assay procedures (HPLC, spectrophotometric, spectrofluorimetric) for the determination of nimesulide and its metabolite in plasma\/urine samples or in dosage forms have been reported in the literature.<\/jats:p>\n               <jats:p>The purpose of this review is to provide a concise overview of the pharmacological and pharmaceutical profile of nimesulide. Various investigations carried out recently are reported, although older references to research performed on nimesulide have also been included, where appropriate.<\/jats:p>","DOI":"10.1211\/0022357001774255","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:05Z","timestamp":1033509845000},"page":"467-486","source":"Crossref","is-referenced-by-count":71,"title":["Review Nimesulide: Some Pharmaceutical and Pharmacological Aspects\u2014An Update"],"prefix":"10.1093","volume":"52","author":[{"given":"Anil K","family":"Singla","sequence":"first","affiliation":[{"name":"Pharmaceutics Division, University Institute of Pharmaceutical Sciences, Punjab University , Chandigarh 160 014,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Chawla","sequence":"additional","affiliation":[{"name":"Pharmaceutics Division, University Institute of Pharmaceutical Sciences, Punjab University , Chandigarh 160 014,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Singh","sequence":"additional","affiliation":[{"name":"Panacea Biotec Ltd , P.O. Lalru, Lalru, Punjab 140 501,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,5,1]]},"reference":[{"key":"2024103110052560200_cit1","first-page":"313","article-title":"Combined treatment of allergic rhinitis with terfenadine and nimesulide, a nonsteroidal anti-inflammatory drug","volume":"24","author":"Andri","year":"1992","journal-title":"Allerg. Immunol."},{"key":"2024103110052560200_cit2","first-page":"29","article-title":"Tolerability of nimesulide in aspirin-sensitive patients","volume":"72","author":"Andri","year":"1994","journal-title":"Ann. Allergy"},{"issue":"Suppl","key":"2024103110052560200_cit3","first-page":"1","article-title":"The treatment of ENT phlogosis: seaprose-S versus nimesulide","volume":"13","author":"Antonelli","year":"1993","journal-title":"Acta Otorhinolaryngol. Ital."},{"key":"2024103110052560200_cit4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S1081-1206(10)62818-9","article-title":"Aspirin and paracetamol tolerance in patients with nimesulide induced urticaria","volume":"81","author":"Asero","year":"1998","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"2024103110052560200_cit5","first-page":"217","article-title":"Action of a new non-steroidal anti-inflammatory drug, nimesulide, on activation of the complement system: an in-vitro study","volume":"10","author":"Auteri","year":"1988","journal-title":"Int. J. Tissue React."},{"key":"2024103110052560200_cit6","first-page":"267","article-title":"Clinical study on pharmacological interaction between nimesulide and warfarin","volume":"11","author":"Auteri","year":"1991","journal-title":"Int. J. Clin. Pharmacol. Res."},{"key":"2024103110052560200_cit7","first-page":"211","article-title":"Pharmacokinetics and pharmacodynamics of slow-release theophylline during treatment with nimesulide","volume":"11","author":"Auteri","year":"1991","journal-title":"Int. J. Clin. Pharmacol. Res."},{"key":"2024103110052560200_cit8","doi-asserted-by":"crossref","first-page":"PL 323","DOI":"10.1016\/S0024-3205(99)80011-3","article-title":"Nimesulide prevents lipopolysaccharide-induced elevation in plasma tumor necrosis factor-alpha in rats","volume":"63","author":"Azab","year":"1998","journal-title":"Life Sci."},{"key":"2024103110052560200_cit9","first-page":"385","article-title":"Nimesulide\/\u03b2-cyclodextrin inclusion compounds: characterization and dissolution studies","volume":"24","author":"Barbato","year":"1997","journal-title":"Proc. Int. Symp. Control. Rel. Bioact. Mater."},{"issue":"Suppl. 1","key":"2024103110052560200_cit10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.2165\/00003495-199300461-00056","article-title":"Double blind evaluation of nimesulide vs lysine-aspirin in the treatment of paediatric acute respiratory tract infections","volume":"46","author":"Barberi","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit11","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1177\/107155769800500603","article-title":"In-vivo administration of nimesulide, a selective PGHS-2 inhibitor, increases in-vitro myometrial sensitivity to prostaglandins while lowering sensitivity to oxytocin","volume":"5","author":"Beguma-Nibasheka","year":"1998","journal-title":"J. Soc. Gynecol. Investig."},{"issue":"Suppl. 1","key":"2024103110052560200_cit12","doi-asserted-by":"crossref","first-page":"64","DOI":"10.2165\/00003495-199300461-00013","article-title":"The pharmacokinetic profile of nimesulide in healthy volunteers","volume":"46","author":"Bernareggi","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit13","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2165\/00003088-199835040-00001","article-title":"Clinical pharmacokinetics of nimesulide","volume":"35","author":"Bernareggi","year":"1998","journal-title":"Clin. Pharmacokinet."},{"key":"2024103110052560200_cit14","first-page":"739","article-title":"Evaluation of a new pharmaceutical form of nimesulide for the treatment of influenza","volume":"11","author":"Bernasconi","year":"1985","journal-title":"Drugs Exp. Clin. Res."},{"key":"2024103110052560200_cit15","first-page":"1011","article-title":"Antianaphylactic and antihistaminic activity of the nonsteroidal anti-inflammatory compound nimesulide in guinea pig","volume":"40","author":"Berti","year":"1990","journal-title":"Arzneim. Forsch."},{"key":"2024103110052560200_cit16","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0922-4106(94)90067-1","article-title":"Nimesulide decreases superoxide production by inhibiting phosphodiesterase type IV","volume":"268","author":"Bevilacqua","year":"1994","journal-title":"Eur. J. Pharmacol."},{"key":"2024103110052560200_cit17","first-page":"23","article-title":"Nimesulide - a new nonsteroidal anti-inflammatory agent","volume":"24","author":"Biscarini","year":"1988","journal-title":"Drugs Today"},{"key":"2024103110052560200_cit18","first-page":"39","article-title":"Multicentre double-blind study to define the most favorable dose of nimesulide in terms of efficacy\/safety ratio in the treatment of osteoarthritis","volume":"14","author":"Bourgeois","year":"1994","journal-title":"Eur. J. Rheumatol. Inflamm."},{"key":"2024103110052560200_cit19","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1146\/annurev.med.47.1.401","article-title":"The role of anti-inflammatory drugs in the prevention and treatment of Alzheimer's disease","volume":"47","author":"Breitner","year":"1996","journal-title":"Annu. Rev. Med."},{"key":"2024103110052560200_cit20","first-page":"992","article-title":"Inhibition of neutrophil function in-vitro by nimesulide: preliminary evidence of an adenosine-mediated mechanism","volume":"43","author":"Capecchi","year":"1993","journal-title":"Arzneim. Forsch."},{"key":"2024103110052560200_cit21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/BF01974932","article-title":"Inhibition of neutrophil oxidative metabolism by nimesulide","volume":"21","author":"Capsoni","year":"1987","journal-title":"Agents Actions"},{"key":"2024103110052560200_cit22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/j.1365-2133.1996.tb07851.x","article-title":"Psoriasiform and sclerodermoid dermatitis of the fingers with apparent shortening of the nail plate: a distinct entity","volume":"134","author":"Caputo","year":"1996","journal-title":"Br. J. Dermatol."},{"key":"2024103110052560200_cit23","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0731-7085(98)00172-1","article-title":"Mass spectrometric characterization and HPLC determination of the main urinary metabolites of nimesulide in man","volume":"18","author":"Carini","year":"1998","journal-title":"J. Pharm. Biomed. Anal."},{"key":"2024103110052560200_cit24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.2165\/00003495-199549010-00005","article-title":"Nonsteroidal anti-inflammatory drugs in perisurgical pain management: mechanisms of action and rationale for optimum use","volume":"49","author":"Cashman","year":"1995","journal-title":"Drugs"},{"key":"2024103110052560200_cit25","first-page":"1375","article-title":"Nimesulide, a sulphonanilide nonsteroidal anti-inflammatory drug, inhibits mediator release from basophils and mast cells","volume":"267","author":"Casolaro","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2024103110052560200_cit26","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/0378-4347(88)80048-3","article-title":"Simultaneous determination of nimesulide and hydroxynimesulide in human plasma and urine by high performance liquid chromatography","volume":"425","author":"Castoldi","year":"1988","journal-title":"J. Chromatogr."},{"issue":"Suppl 2","key":"2024103110052560200_cit27","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1007\/BF03258312","article-title":"Action of nimesulide on rat gastric prostaglandins and renal functions","volume":"3","author":"Ceserani","year":"1991","journal-title":"Drug Invest."},{"key":"2024103110052560200_cit28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1677\/jme.0.0160107","article-title":"Developmental expression of the cyclooxygenase-1 and cyclooxygenase-2 genes in the peri-implantation mouse uterus and their differential regulation by the blastocyst and ovarian steroids","volume":"16","author":"Chakraborty","year":"1996","journal-title":"J. Mol. Endocrinol."},{"key":"2024103110052560200_cit29","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/0197-4580(96)00110-8","article-title":"Prostaglandin G\/H synthase 2 (cyclooxygenase-2) mRNA expression is decreased in Alzheimer's disease","volume":"17","author":"Chang","year":"1996","journal-title":"Neurobiol. Aging"},{"key":"2024103110052560200_cit30","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1002\/jps.2600661211","article-title":"Determination of an anti-inflammatory methanesulphonanilide in plasma by high speed liquid chromatography","volume":"66","author":"Chang","year":"1977","journal-title":"J. Pharm. Sci."},{"key":"2024103110052560200_cit31","first-page":"396","article-title":"A new spectrophotometric method for the determination of nimesulide","volume":"34","author":"Chowdary","year":"1997","journal-title":"Indian Drugs"},{"key":"2024103110052560200_cit32","first-page":"86","article-title":"New spectrophotometric methods for the determination of nimesulide","volume":"61","author":"Chowdary","year":"1999","journal-title":"Indian J. Pharm. Sci."},{"key":"2024103110052560200_cit33","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1056\/NEJM198403013100905","article-title":"Renal syndromes associated with non steroidal anti-inflammatory drugs","volume":"310","author":"Clive","year":"1984","journal-title":"N. Engl. J. Med."},{"key":"2024103110052560200_cit34","first-page":"1137","article-title":"Comparative effects of nabumetone, sulindac and ibuprofen on renal function","volume":"24","author":"Cook","year":"1997","journal-title":"J. Rheumatol."},{"issue":"Suppl. 1","key":"2024103110052560200_cit35","doi-asserted-by":"crossref","first-page":"174","DOI":"10.2165\/00003495-199300461-00042","article-title":"A comparison of nimesulide and ketoprofen in the prevention and treatment of painful postoperative inflammatory complications of ear, nose and throat surgery","volume":"46","author":"Coscarelli","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit36","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1001\/archinte.1992.00400180017003","article-title":"Effects of nonsteroidal anti-inflammatory drugs on endogenous gastrointestinal prostaglandins and therapeutic strategies for prevention and treatment of nonsteroidal anti-inflammatory drug induced damage","volume":"152","author":"Cryer","year":"1992","journal-title":"Arch. Intern. Med."},{"key":"2024103110052560200_cit37","first-page":"160","article-title":"Nimesulide in the treatment of hyperpyrexia in the aged: double blind comparison with paracetamol","volume":"43","author":"Cunietti","year":"1993","journal-title":"Arzneim. Forsch."},{"key":"2024103110052560200_cit38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000196015","article-title":"The anti-inflammatory drug nimesulide rescues alpha-1-proteinase inhibitor from oxidative inactivation by phagocytosing neutrophils","volume":"59","author":"Dallegri","year":"1992","journal-title":"Respiration"},{"key":"2024103110052560200_cit39","first-page":"419","article-title":"Effect of nonsteroidal anti-inflammatory drugs on the neutrophil promoted inactivation of alpha-1-proteinase inhibitor","volume":"19","author":"Dallegri","year":"1992","journal-title":"J. Rheumatol."},{"key":"2024103110052560200_cit40","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1159\/000196365","article-title":"The anti-inflammatory drug nimesulide inhibits neutrophil adherence to and migration across monolayers of cytokine-activated endothelial cells","volume":"61","author":"Dapino","year":"1994","journal-title":"Respiration"},{"key":"2024103110052560200_cit41","doi-asserted-by":"crossref","first-page":"431","DOI":"10.2165\/00003495-199448030-00008","article-title":"Nimesulide: an update of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy","volume":"48","author":"Davis","year":"1994","journal-title":"Drugs"},{"key":"2024103110052560200_cit42","first-page":"489","article-title":"Action of the 4-nitro-2-phenoxymethane sulfonanilide (nimesulide) on neutrophil chemotaxis and superoxide production","volume":"112","author":"De Mello","year":"1994","journal-title":"Rev. Paul. Med."},{"key":"2024103110052560200_cit43","first-page":"511","article-title":"Evaluation of the efficacy and tolerability of nimesulide in the treatment of mastodynia","volume":"44","author":"Dionigi","year":"1992","journal-title":"Minerva Ginecol."},{"key":"2024103110052560200_cit44","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/0016-5085(94)90246-1","article-title":"Upregulation of cyclooxygenase-2 gene expression in human colorectal adenomas and adenocarcinomas","volume":"104","author":"Eberhart","year":"1994","journal-title":"Gastroenterology"},{"key":"2024103110052560200_cit45","first-page":"1102","article-title":"Differential inhibition of superoxide, hydroxyl and peroxyl radicals by nimesulide and its main metabolite 4-hydroxy nimesulide","volume":"45","author":"Facino","year":"1995","journal-title":"Arzneim. Forsch."},{"key":"2024103110052560200_cit46","first-page":"157","article-title":"Hydroxynimesulide, the main metabolite of nimesulide, prevents hydroperoxide\/hemoglobin-induced hemolysis of rat erythrocytes","volume":"23","author":"Facino","year":"1997","journal-title":"Drugs Exp. Clin. Res."},{"key":"2024103110052560200_cit47","first-page":"30","article-title":"Spectrophotometric determination of nimesulide in tablets","volume":"76","author":"Fallavena","year":"1995","journal-title":"Rev. Bras. Farm."},{"key":"2024103110052560200_cit48","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5173(97)00221-4","article-title":"pKa determination of nimesulide in methanol-water mixtures by potentiometric titrations","volume":"158","author":"Fallavena","year":"1997","journal-title":"Int. J. Pharm."},{"key":"2024103110052560200_cit49","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1007\/s000110050221","article-title":"In-vitro and in-vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide - an overview","volume":"46","author":"Famaey","year":"1997","journal-title":"Inflamm. Res."},{"key":"2024103110052560200_cit50","doi-asserted-by":"crossref","first-page":"229","DOI":"10.3181\/00379727-201-43503A","article-title":"Eicosanoids and their functions in renal epithelia ion transport","volume":"201","author":"Frazier","year":"1992","journal-title":"Proc. Soc. Exp. Biol. Med."},{"issue":"Suppl. 1","key":"2024103110052560200_cit51","doi-asserted-by":"crossref","first-page":"277","DOI":"10.2165\/00003495-199300461-00070","article-title":"Tolerability of nimesulide: epidemiological data","volume":"46","author":"Fusetti","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit52","first-page":"1071","article-title":"First dose and steady state pharmacokinetics of nimesulide and 4-hydroxy metabolite in healthy volunteers","volume":"46","author":"Gandini","year":"1991","journal-title":"Farmaco."},{"key":"2024103110052560200_cit53","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/(SICI)1099-0801(199803\/04)12:2<50::AID-BMC719>3.0.CO;2-B","article-title":"Determination of nimesulide and hydroxynimesulide in human plasma by high performance liquid chromatography","volume":"12","author":"Giachetti","year":"1998","journal-title":"Biomed. Chromatogr."},{"key":"2024103110052560200_cit54","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1677\/joe.0.1500497","article-title":"Localization of prostaglandin H synthase type 2 protein and mRNA in term human foetal membranes and decidua","volume":"150","author":"Gibb","year":"1996","journal-title":"J. Endocrinol."},{"key":"2024103110052560200_cit55","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/S0014-2999(98)00508-1","article-title":"Differential effects of inhibitors of cyclooxygenase (cyclooxygenase-1 and cyclooxygenase-2) in acute inflammation","volume":"355","author":"Gilroy","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"2024103110052560200_cit56","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1023\/A:1022350111213","article-title":"The effect of cyclooxygenase-2 inhibitors on cartilage erosion and bone loss in a model of Mycobacterium tuberculosis induced monoarticular arthritis in the rat","volume":"22","author":"Gilroy","year":"1998","journal-title":"Inflammation"},{"key":"2024103110052560200_cit57","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S1081-1206(10)63376-5","article-title":"Floctafenine: a valid alternative in patients with adverse reactions to nonsteroidal anti-inflammatory drugs","volume":"78","author":"Giuseppe","year":"1997","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"2024103110052560200_cit58","first-page":"759","article-title":"Anti-inflammatory activity of 4-nitro-2-phenoxymethanesulfonanilide (R 805)","volume":"34","author":"Grant","year":"1975","journal-title":"Fed. Proc."},{"key":"2024103110052560200_cit59","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1038\/sj.bjp.0701673","article-title":"Selective cyclooxygenase-2 inhibitors and their influence on the protective effect of a mild irritant in the rat stomach","volume":"123","author":"Gretzer","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"2024103110052560200_cit60","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1136\/gut.38.1.79","article-title":"Cyclooxygenase-1 and cyclooxygenase-2 gene expression in human colorectal adenocarcinomas and in azoxymethane induced colonic tumours in rats","volume":"38","author":"Gustafson-Svard","year":"1996","journal-title":"Gut"},{"key":"2024103110052560200_cit61","first-page":"599","article-title":"Inflammatory and immunological mechanisms in Alzheimer's disease","volume":"8","author":"Hampel","year":"1995","journal-title":"Drug News Prespect."},{"key":"2024103110052560200_cit62","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0090-6980(98)00033-1","article-title":"Differing profiles of prostaglandin formation inhibition between selective prostaglandin H synthase-2 inhibitors and conventional NSAIDs in inflammatory and non-inflammatory sites of the rat","volume":"55","author":"Harada","year":"1998","journal-title":"Prostaglandins Other Lipid Medial."},{"key":"2024103110052560200_cit63","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(98)12154-2","article-title":"COX-2 inhibitors","volume":"353","author":"Hawkey","year":"1999","journal-title":"Lancet"},{"key":"2024103110052560200_cit64","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1016\/S0024-3205(97)00739-X","article-title":"Effects of selective cyclooxygenase-2 inhibitors on alkaline secretory and mucosal ulcerogenic responses in rat duodenum","volume":"61","author":"Hirata","year":"1997","journal-title":"Life Sci."},{"key":"2024103110052560200_cit65","first-page":"293A","article-title":"SC 58635, a highly selective inhibitor of COX-2 is an effective analgesic in an acute post surgical pain model","volume":"44","author":"Hubbard","year":"1996","journal-title":"J. Invest. Med."},{"key":"2024103110052560200_cit66","doi-asserted-by":"crossref","first-page":"563","DOI":"10.2165\/00003495-199753040-00003","article-title":"Cyclooxygenase isoenzymes. How recent findings affect thinking about nonsteroidal anti-inflammatory drugs","volume":"53","author":"Jouzeau","year":"1997","journal-title":"Drugs"},{"key":"2024103110052560200_cit67","first-page":"572","article-title":"Crystal forms of nimesulide-a sulfonanilide (NSAID)","volume":"37B","author":"Kapoor","year":"1998","journal-title":"Indian J. Chem."},{"key":"2024103110052560200_cit68","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1053\/gast.1996.v111.pm8690211","article-title":"Characterization of prostaglandin G\/H synthase 1 and 2 in rat, dog, monkey and human gastrointestinal tracts","volume":"111","author":"Kargman","year":"1996","journal-title":"Gastroenterology"},{"key":"2024103110052560200_cit69","first-page":"409","article-title":"Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor against colon carcinogenesis","volume":"58","author":"Kawamori","year":"1998","journal-title":"Cancer Res."},{"key":"2024103110052560200_cit70","first-page":"519","article-title":"Fluorimetric determination of nimesulide with N-(1-naphthyl) ethylene diamine","volume":"35","author":"Lakshmi","year":"1998","journal-title":"Indian Drugs"},{"key":"2024103110052560200_cit71","first-page":"A194","article-title":"A pilot endoscopic study of the gastroduodenal effects of SC 58635, a novel COX-2 selective inhibitor","volume":"112","author":"Lanza","year":"1997","journal-title":"Gastroenterology"},{"key":"2024103110052560200_cit72","first-page":"A194","article-title":"Selective inhibition of cyclooxygenase-2 (COX-2) with MK 0966 (250 mg qd) is associated with less gastrointestinal damage than aspirin (ASA) 650 mg qid or ibuprofen (IBU) 800 mg tid","volume":"112","author":"Lanza","year":"1997","journal-title":"Gastroenterology"},{"key":"2024103110052560200_cit73","first-page":"249","article-title":"In-vivo selectivity of nonsteroidal anti-inflammatory drugs on COX1\u2013COX2 and gastrointestinal ulcers, in rats","volume":"28","author":"Laudanno","year":"1998","journal-title":"Acta Gastroenterol. Latinoam."},{"key":"2024103110052560200_cit74","first-page":"29","article-title":"Treatment of tendinitis and bursitis: a comparison of nimesulide and naproxen sodium in a double-blind parallel trial","volume":"14","author":"Lecomte","year":"1994","journal-title":"Eur. J. Rheumatol. Inflamm."},{"key":"2024103110052560200_cit75","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0092-8674(00)80402-X","article-title":"Multiple female reproductive failures in cyclooxygenase-2 deficient mice","volume":"91","author":"Lim","year":"1997","journal-title":"Cell"},{"key":"2024103110052560200_cit76","first-page":"25","article-title":"Specific COX-2 inhibitors in arthritis, oncology and beyond: which way is the science headed","volume":"26","author":"Lipsky","year":"1999","journal-title":"J. Rheumatol."},{"key":"2024103110052560200_cit77","doi-asserted-by":"crossref","first-page":"51S","DOI":"10.1016\/S0002-9343(99)00117-5","article-title":"The clinical potential of cyclooxygenase-2 specific inhibitors","volume":"106","author":"Lipsky","year":"1999","journal-title":"Am. J. Med."},{"key":"2024103110052560200_cit78","first-page":"99","article-title":"A simplified method for evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Therap."},{"key":"2024103110052560200_cit79","first-page":"5336","article-title":"Report on the Pharmacokinetics and relative bioavailability\/bioequivalence of three different nimesulide formulations in 18 healthy volunteers","author":"Lucker","year":"1991","journal-title":"Helsinn data on file"},{"key":"2024103110052560200_cit80","first-page":"556SE","volume-title":"Bioavailability after single administration to 18 subjects of the tablets or granules","author":"Lucker","year":"1992"},{"key":"2024103110052560200_cit81","first-page":"29","article-title":"Double blind randomised, multicentre clinical study evaluating the efficacy and tolerability of nimesulide in comparison with etodolac in patients suffering from osteoarthritis of the knee","volume":"14","author":"Lucker","year":"1994","journal-title":"Eur. J. Rheumatol. Inflamm."},{"issue":"Suppl 2","key":"2024103110052560200_cit82","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF03258309","article-title":"Nimesulide: an overview","volume":"3","author":"Magni","year":"1991","journal-title":"Drug Invest."},{"key":"2024103110052560200_cit83","first-page":"233","article-title":"Influence of R 805 on the contractility and reactivity of rat myometrium","volume":"238","author":"Malofiejew","year":"1979","journal-title":"Arch. Int. Pharmacodyn."},{"key":"2024103110052560200_cit84","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3949\/ccjm.66.5.285","article-title":"COX-2 selective NSAIDs: biology, promises and concerns","volume":"66","author":"Mandell","year":"1999","journal-title":"Clevel. Clinic J. Med."},{"key":"2024103110052560200_cit85","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s002280050479","article-title":"The effect of nimesulide versus placebo on hemostasis in healthy volunteers","volume":"54","author":"Marbet","year":"1998","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"2024103110052560200_cit86","first-page":"409","article-title":"Controlled clinical study of the efficacy and tolerability of methoxybutropate compared to nimesulide in gynecology","volume":"49","author":"Melis","year":"1997","journal-title":"Minerva Ginecol."},{"key":"2024103110052560200_cit87","first-page":"G601","article-title":"Protective effects of prostaglandins against gastric mucosal damage","volume":"245","author":"Miller","year":"1983","journal-title":"Am. J. Physiol."},{"key":"2024103110052560200_cit88","author":"Moore","year":"1974"},{"key":"2024103110052560200_cit89","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0092-8674(95)90125-6","article-title":"Prostaglandin synthase 2 gene description causes severe renal pathology in the mouse","volume":"83","author":"Morham","year":"1995","journal-title":"Cell"},{"key":"2024103110052560200_cit90","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0952-3278(96)90122-2","article-title":"Effects of nimesulide, a preferential cyclooxygenase-2 inhibitor, on carrageenan-induced pleurisy and stress induced gastric lesions in rats","volume":"55","author":"Nakatsugi","year":"1996","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"2024103110052560200_cit91","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0952-3278(96)90130-1","article-title":"Effects of nonsteroidal anti-inflammatory drugs on prostaglandin E2 production by cyclooxygenase-2 from endogenous and exogenous arachidonic acid in rat peritoneal macrophages stimulated with lipopolysaccharide","volume":"55","author":"Nakatsugi","year":"1996","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"2024103110052560200_cit92","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1349-7006.1997.tb00337.x","article-title":"Suppression of intestinal polyp development by nimesulide, a selective cyclooxygenase-2 inhibitor in min mice","volume":"88","author":"Nakatsugi","year":"1997","journal-title":"Jpn. J. Cancer Res."},{"key":"2024103110052560200_cit93","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1152\/physrev.1996.76.2.425","article-title":"Paracrine regulation of the renal microcirculation","volume":"76","author":"Navar","year":"1996","journal-title":"Physiol. Rev."},{"issue":"Suppl. 1","key":"2024103110052560200_cit94","doi-asserted-by":"crossref","first-page":"73","DOI":"10.2165\/00003495-199300461-00014","article-title":"Effect of age and disease on the pharmacokinetics of nimesulide","volume":"46","author":"Olive","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit95","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0092-8674(00)81988-1","article-title":"Suppression of intestinal polyposis in Apcdelta716 knockout mice by inhibition of cyclooxygenase-2 (COX-2)","volume":"87","author":"Oshima","year":"1996","journal-title":"Cell"},{"key":"2024103110052560200_cit96","first-page":"91","article-title":"Inhibition of the neutrophil oxidative response induced by the oral administration of nimesulide in normal volunteers","volume":"37","author":"Ottonello","year":"1992","journal-title":"J. Clin. Lab. Immunol."},{"key":"2024103110052560200_cit97","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/S0009-9236(98)90091-1","article-title":"Effects of nimesulide on constitutive and inducible prostanoid biosynthesis in human beings","volume":"63","author":"Panara","year":"1998","journal-title":"Clin. Pharmacol. Ther."},{"key":"2024103110052560200_cit98","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1111\/j.2042-7158.1997.tb06110.x","article-title":"High performance thin layer chromatography for the determination of nimesulide in human plasma, and its use in pharmacokinetic studies","volume":"49","author":"Pandya","year":"1997","journal-title":"J. Pharm. Pharmacol."},{"issue":"Suppl. 1","key":"2024103110052560200_cit99","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2165\/00003495-199300461-00041","article-title":"A controlled clinical study of the efficacy and tolerability of nimesulide versus naproxen in maxillofacial surgery","volume":"46","author":"Parabita","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit100","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0306-4522(98)00218-8","article-title":"Cyclooxygenase-2 expression is increased in frontal cortex of Alzheimer's disease brain","volume":"87","author":"Pasinetti","year":"1998","journal-title":"Neuroscience"},{"key":"2024103110052560200_cit101","doi-asserted-by":"crossref","first-page":"233","DOI":"10.7326\/0003-4819-112-3-233_2","article-title":"Nimesulide, thrombocytopenic pupura, and human immunodeficiency virus (HIV) infection","volume":"112","author":"Pasticci","year":"1990","journal-title":"Ann. Intern. Med."},{"key":"2024103110052560200_cit102","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1111\/j.1398-9995.1998.tb03995.x","article-title":"Atopy and intolerance of antimicrobial drugs increase the risk of reactions to acetaminophen and nimesulide in patients allergic to nonsteroidal anti-inflammatory drugs","volume":"53","author":"Pastorello","year":"1998","journal-title":"Allergy"},{"key":"2024103110052560200_cit103","first-page":"393","article-title":"Two NSAIDs, nimesulide and naproxen, can reduce the synthesis of urokinase and IL-6 while increasing PAI-1, in human OA synovial fibroblasts","volume":"15","author":"Pelletier","year":"1997","journal-title":"Clin. Exp. Rheumatol."},{"issue":"Suppl. 1","key":"2024103110052560200_cit104","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2165\/00003495-199300461-00015","article-title":"Drug interactions with nimesulide","volume":"46","author":"Perucca","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit105","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1021\/js960298k","article-title":"Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide; isolation and characterization of nimesulide-L-lysine-cyclodextrin complexes","volume":"86","author":"Piel","year":"1997","journal-title":"J. Pharm. Sci."},{"issue":"Suppl. 1","key":"2024103110052560200_cit106","doi-asserted-by":"crossref","first-page":"168","DOI":"10.2165\/00003495-199300461-00040","article-title":"A double blind comparison of nimesulide and ketoprofen in dental surgery","volume":"46","author":"Pierleoni","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit107","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2340\/00015555746869","article-title":"Hallopeau's acrodermatitis continua of the nail apparatus: a clinical and pathological study of 20 patients","volume":"74","author":"Piraccini","year":"1994","journal-title":"Acta Derm. Venerol."},{"key":"2024103110052560200_cit108","doi-asserted-by":"crossref","first-page":"549","DOI":"10.3109\/00016349509024388","article-title":"The effect of nimesulide and naproxen on the uterine and ovarian arterial blood flow velocity. A Doppler study","volume":"74","author":"Pirhonen","year":"1995","journal-title":"Acta Obstet. Gynecol. Scand."},{"key":"2024103110052560200_cit109","first-page":"197","article-title":"Post marketing survey of nimesulide in the short-term treatment of osteoarthritis","volume":"17","author":"Pochobradsky","year":"1991","journal-title":"Drugs Exp. Clin. Res."},{"key":"2024103110052560200_cit110","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S1081-1206(10)63083-9","article-title":"Long-term tolerability of nimesulide and acetaminophen in nonsteroidal anti-inflammatory drug intolerant patients","volume":"79","author":"Quaratino","year":"1997","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"2024103110052560200_cit111","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1358\/dot.1996.32.5.381680","article-title":"Nimesulide: a selective cyclooxygenase-2 inhibitor anti-inflammatory drug","volume":"32","author":"Rabasseda","year":"1996","journal-title":"Drugs Today"},{"key":"2024103110052560200_cit112","first-page":"4566","article-title":"Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis","volume":"56","author":"Reddy","year":"1996","journal-title":"Cancer Res."},{"key":"2024103110052560200_cit113","first-page":"172","article-title":"Spectrophotometric determination of nimesulide","volume":"60","author":"Reddy","year":"1998","journal-title":"Indian J. Pharm. Sci."},{"key":"2024103110052560200_cit114","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/sj.bjp.0701076","article-title":"Biochemical and pharmacological profile of a tetra-substituted furanone as a highly selective COX-2 inhibitor","volume":"121","author":"Riendeau","year":"1997","journal-title":"Br. J. Pharmacol."},{"key":"2024103110052560200_cit115","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/0016-5085(79)90002-7","article-title":"Cytoprotection by prostaglandins in rats: prevention of gastric necrosis produced by alcohol, HCl, NaOH, hypertonic NaCl and thermal injury","volume":"77","author":"Robert","year":"1979","journal-title":"Gastroenterology"},{"key":"2024103110052560200_cit116","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/archinte.158.1.33","article-title":"Risk of hospitalisation for upper gastrointestinal tract bleeding associated with ketorolac, other nonsteroidal anti-inflammatory drugs, calcium antagonists and other antihypertensive drugs","volume":"158","author":"Rodriguez","year":"1998","journal-title":"Arch. Intern. Med."},{"key":"2024103110052560200_cit117","first-page":"196","article-title":"Nimesulide in the treatment of primary dysmenorrhea. Comparative clinical evaluation with mefenamic acid and fentiazac","volume":"57","author":"Rosales","year":"1989","journal-title":"Ginecol. Obstet. Mex."},{"key":"2024103110052560200_cit118","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1016\/0006-2952(82)90580-9","article-title":"Nonsteroidal anti-inflammatories-XII. Mode of action of anti-inflammatory methane sulfonanilides","volume":"31","author":"Rufer","year":"1982","journal-title":"Biochem. Pharmacol."},{"key":"2024103110052560200_cit119","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/jat\/21.3.197","article-title":"A unique metabolite of nimesulide","volume":"21","author":"Sarkar","year":"1997","journal-title":"J. Anal. Toxicol."},{"key":"2024103110052560200_cit120","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0140-6736(05)62229-5","article-title":"Use of a cyclooxygenase type 2 selective nonsteroidal anti-inflammatory agent to prevent preterm delivery","volume":"350","author":"Sawdy","year":"1997","journal-title":"Lancet"},{"key":"2024103110052560200_cit121","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/sj.bjp.0702211","article-title":"Effect of nimesulide and indomethacin on contractility and the Ca++ channel current in myometrial smooth muscle from pregnant women","volume":"125","author":"Sawdy","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"2024103110052560200_cit122","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/sj.bjp.0701672","article-title":"Effects of inhibition of prostaglandin endoperoxide synthase-2 in chronic gastrointestinal ulcers in rats","volume":"123","author":"Schmassmann","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"2024103110052560200_cit123","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s002280050510","article-title":"Analgesic efficacy and pharmacokinetics of topical nimesulide gel in healthy human volunteers: double blind comparison with piroxicam, diclofenac and placebo","volume":"54","author":"Sengupta","year":"1998","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"2024103110052560200_cit124","doi-asserted-by":"crossref","first-page":"94","DOI":"10.2165\/00002018-199614020-00004","article-title":"Nimesulide in the treatment of patients intolerant of aspirin and other NSAIDs","volume":"14","author":"Senna","year":"1996","journal-title":"Drug Safety"},{"key":"2024103110052560200_cit125","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0378-5173(98)00304-4","article-title":"Spectrophotometric determination of pKa of nimesulide","volume":"176","author":"Singh","year":"1999","journal-title":"Int. J. Pharm."},{"key":"2024103110052560200_cit126","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0090-6980(96)00005-6","article-title":"The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin 4","volume":"51","author":"Spaziani","year":"1996","journal-title":"Prostaglandins"},{"key":"2024103110052560200_cit127","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0168-8278(98)80188-8","article-title":"Nimesulide induced acute hepatitis: evidence from six cases","volume":"29","author":"Steenbergen","year":"1998","journal-title":"J. Hepatol."},{"issue":"Suppl. 1","key":"2024103110052560200_cit128","doi-asserted-by":"crossref","first-page":"257","DOI":"10.2165\/00003495-199300461-00066","article-title":"Renal effects of nimesulide in furosemide treated subjects","volume":"46","author":"Steinhauslin","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit129","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1212\/WNL.48.3.626","article-title":"Risk of Alzheimer's disease and duration of NSAID use","volume":"48","author":"Stewart","year":"1997","journal-title":"Neurology"},{"key":"2024103110052560200_cit130","first-page":"132","article-title":"4-Nitro-2-phenoxymethanesulfonanilide (R 805): a chemically novel anti-inflammatory agent","volume":"221","author":"Swingle","year":"1976","journal-title":"Arch. Int. Pharmacodyn."},{"key":"2024103110052560200_cit131","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1007\/BF01209649","article-title":"Suppression of azoxymethane induced aberrant crypt foci in rat colon by nimesulide, a selective inhibitor of cyclooxygenase-2","volume":"122","author":"Takahashi","year":"1996","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"2024103110052560200_cit132","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1007\/BF02252931","article-title":"Interaction between enoxicam, a new antimicrobial and nimesulide a new nonsteroidal anti-inflammatory agent in mice","volume":"45","author":"Taniguchi","year":"1996","journal-title":"Inflamm. Res."},{"key":"2024103110052560200_cit133","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0014-2999(97)00183-0","article-title":"Inhibition of brain cyclooxygenase-2 activity and the antipyretic action of nimesulide","volume":"330","author":"Taniguchi","year":"1997","journal-title":"Eur. J. Pharmacol."},{"issue":"Suppl. 1","key":"2024103110052560200_cit134","doi-asserted-by":"crossref","first-page":"275","DOI":"10.2165\/00003495-199300461-00069","article-title":"Nimesulide, new clinical opportunities","volume":"46","author":"Tognella","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit135","first-page":"1110","article-title":"Inhibition of the production of platelet activating factor and leukotriene B4 in activated neutrophils by nimesulide due to an elevation of intracellular cyclic adenosine monophosphate","volume":"45","author":"Tool","year":"1995","journal-title":"Arzneim. Forsch."},{"issue":"Suppl.","key":"2024103110052560200_cit136","first-page":"141s","article-title":"The effect of salmeterol and of nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils","volume":"22","author":"Tool","year":"1996","journal-title":"Eur. Respir. J."},{"issue":"Suppl. 1","key":"2024103110052560200_cit137","doi-asserted-by":"crossref","first-page":"215","DOI":"10.2165\/00003495-199300461-00055","article-title":"Clinical and pharmacokinetic study of nimesulide in children","volume":"46","author":"Ugazio","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit138","first-page":"1096","article-title":"Effect of nimesulide action time dependence on selectivity towards prostaglandin G\/H synthase\/cyclooxygenase activity","volume":"45","author":"Vago","year":"1995","journal-title":"Arzneim. Forsch."},{"key":"2024103110052560200_cit139","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-94-010-9029-2_1","article-title":"Overview: mechanism of action of anti-inflammatory drugs","volume-title":"Improved Nonsteroidal Anti-inflammatory Drugs","author":"Vane","year":"1996"},{"key":"2024103110052560200_cit140","doi-asserted-by":"crossref","first-page":"S78","DOI":"10.1007\/s000110050284","article-title":"Anti-inflammatory drugs and their mechanism of action","volume":"47","author":"Vane","year":"1998","journal-title":"Inflamm. Res."},{"key":"2024103110052560200_cit141","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1081\/DDC-100102206","article-title":"Inclusion complexation of nimesulide with \u03b2-cyclodextrins","volume":"25","author":"Vavia","year":"1999","journal-title":"Drug Dev. Ind. Pharm."},{"key":"2024103110052560200_cit142","first-page":"631","article-title":"Prostaglandins, NSAIDs and cytoprotection","volume":"21","author":"Wallace","year":"1992","journal-title":"Gastrointest. Pharmacol."},{"key":"2024103110052560200_cit143","first-page":"S28","article-title":"Selective inhibitors of cyclooxygenase-2: are they really effective, selective and GI safe","volume":"27","author":"Wallace","year":"1998","journal-title":"Gastrointest. Pharmacol."},{"key":"2024103110052560200_cit144","doi-asserted-by":"crossref","first-page":"732","DOI":"10.2165\/00003495-198836060-00004","article-title":"Nimesulide, a preliminary review of its pharmacological properties and therapeutic efficacy in inflammation states","volume":"36","author":"Ward","year":"1988","journal-title":"Drugs"},{"issue":"Suppl. 1","key":"2024103110052560200_cit145","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00003495-199300461-00067","article-title":"Renal and general tolerability of repeated doses of nimesulide in normal subjects","volume":"46","author":"Warrington","year":"1993","journal-title":"Drugs"},{"key":"2024103110052560200_cit146","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0014-2999(76)90057-1","article-title":"Relationship between the prevention of rat gastric erosions and the inhibition of acid secretion by prostaglandins","volume":"40","author":"Whittle","year":"1976","journal-title":"Eur. J. Pharmacol."},{"key":"2024103110052560200_cit147","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1742-1241.1998.tb11598.x","article-title":"Comparative efficacy and safety of the nonsteroidal anti-inflammatory drugs nimesulide and diclofenac in patients with acute subdeltoid bursitis and bicipital tendinitis","volume":"52","author":"Wober","year":"1998","journal-title":"Int. J. Clin. Pract."},{"key":"2024103110052560200_cit148","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1210\/endo.139.7.6109","article-title":"Inhibition of prostaglandin production by nimesulide is accompanied by changes in expression of the cassette of uterine labor-related genes in pregnant sheep","volume":"139","author":"Wu","year":"1998","journal-title":"Endocrinology"},{"key":"2024103110052560200_cit149","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1073\/pnas.94.10.5296","article-title":"Amyloid-\u03b2 peptide receptor for advanced glycation endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: a proinflammatory pathway in Alzheimer disease","volume":"94","author":"Yan","year":"1997","journal-title":"Proc. Natl Acad. Sci."},{"key":"2024103110052560200_cit150","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/BF02259611","article-title":"Human whole blood assays for inhibition of prostaglandin G\/H synthases-1 and \u22122 using A 23187 and lipopolysaccharide stimulation of thromboxane B2 production","volume":"45","author":"Young","year":"1996","journal-title":"Inflamm. Res."}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357001774255","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/52\/5\/467\/60263467\/0022357001774255.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/52\/5\/467\/60263467\/0022357001774255.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:44:23Z","timestamp":1730371463000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/52\/5\/467\/6157532"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,5,1]]},"references-count":150,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2000,5,1]]},"published-print":{"date-parts":[[2000,5,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357001774255","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,5]]},"published":{"date-parts":[[2000,5,1]]}}}