{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T11:41:25Z","timestamp":1771501285715,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study was carried out to investigate the protective effects of the hot-water extract from Artemisia iwayomogi (Compositae) on carbon tetrachloride-induced liver fibrosis in rats.<\/jats:p>\n               <jats:p>Liver injury was induced by oral administration of carbon tetrachloride (1 mL kg\u22121) twice a week during 4 weeks of A. iwayomogi treatment. Extracts from A. iwayomogi were prepared and administered to rats orally (2 g kg\u22121 as A. iwayomogi for 4 weeks) as follows: group 1, hot-water extract; group 2, ethanol-soluble part of hot-water extract; group 3, ethanol-insoluble part of hot-water extract; and group 4, methanol extract.<\/jats:p>\n               <jats:p>In rats treated with the ethanol-soluble part of the hot-water extract, liver hydroxyproline content was reduced to 74% that of carbon tetrachloride control rats (P &amp;lt; 0.05). Protein expression of alpha smooth muscle cell like actin was also decreased in rats treated with the ethanol-soluble part of the hot-water extract, which indicates inhibition of hepatic stellate cell activation. Liver malondialdehyde levels were significantly lowered in rats treated with the ethanol-soluble part of hot-water extract (P &amp;lt; 0.05). Serum cholesterol levels in rats treated with hot-water extract, ethanol-soluble or -insoluble parts of hot-water extract or methanol extract were significantly reduced when compared with those of carbon tetrachloride control rats (P &amp;lt; 0.05).<\/jats:p>\n               <jats:p>The ethanol-soluble part of the hot-water extract from A. iwayomogi inhibited fibrosis and lipid peroxidation in rats with liver fibrosis induced by carbon tetrachloride. Both hot-water extract (either ethanol-soluble or -insoluble) and methanol extract of A. iwayomogi also lowered serum cholesterol levels in fibrotic rats.<\/jats:p>","DOI":"10.1211\/0022357001774561","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"875-881","source":"Crossref","is-referenced-by-count":37,"title":["The Ethanol-soluble Part of a Hot-water Extract from <i>Artemisia iwayomogi<\/i> Inhibits Liver Fibrosis Induced by Carbon Tetrachloride in Rats"],"prefix":"10.1093","volume":"52","author":[{"given":"Eun-Jeon","family":"Park","sequence":"first","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Xing","family":"Nan","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Young","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee-Chul","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hwan","family":"Choi","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"So Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo Hye","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sun Jin","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Chul","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Hwan","family":"Sohn","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Medical Resources Research Center, Wonkwang University , Iksan, Cheonbuk 570\u2013749,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"2024103110054214900_cit1","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1136\/jcp.31.5.395","article-title":"The morphology of cirrhosis","volume":"31","author":"Anthony","year":"1978","journal-title":"J. Clin. Pathol."},{"key":"2024103110054214900_cit2","first-page":"352","article-title":"Antimutagenic principle of Artemisia iwayomogi Kit. and its action mechanism","volume":"24","author":"Bae","year":"1992","journal-title":"J. Kor. Cancer Assoc."},{"issue":"Suppl. 3","key":"2024103110054214900_cit3","doi-asserted-by":"crossref","first-page":"S26","DOI":"10.1016\/0168-8278(91)90005-V","article-title":"Beneficial effects of inhibitors of prolyl 4-hydroxylase in CCl4-induced fibrosis of the livers in rats","volume":"13","author":"Bickel","year":"1991","journal-title":"J. Hepatol."},{"key":"2024103110054214900_cit4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"112","author":"Jamall","year":"1981","journal-title":"Anal. Biochem."},{"key":"2024103110054214900_cit5","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1007\/BF02974002","article-title":"Chlorogenic acid, an antioxidant principle from the aerial parts of Artemisia iwayomogi that acts on 1,1-diphenyl-2-picrylhydrazyl radical","volume":"20","author":"Kim","year":"1997","journal-title":"Arch. Pharm. Res."},{"key":"2024103110054214900_cit6","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/BF02974179","article-title":"Antitumor and immuno-modulating activities of the polysaccharide fractions from Artemisia selengenesis and Artemisia iwayomogi","volume":"17","author":"Koo","year":"1994","journal-title":"Arch. Pharm. Res."},{"key":"2024103110054214900_cit7","first-page":"194","article-title":"Hepatoprotective effects of extracts from Artemisia iwayomogi","volume":"5","author":"Lee","year":"1997","journal-title":"J. Appl. Pharmacol."},{"key":"2024103110054214900_cit8","first-page":"119","article-title":"A study on the hepatoprotective effect of PS-1 form Artemisia iwayomogi","volume":"6","author":"Lee","year":"1998","journal-title":"J. Appl. Pharmacol."},{"key":"2024103110054214900_cit9","first-page":"1","article-title":"Structural organization of the liver","volume-title":"Hepatotoxicology","author":"Miyai","year":"1991"},{"key":"2024103110054214900_cit10","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1248\/bpb.20.417","article-title":"Antifibrotic effects of a polysaccharide extracted from Ganoderma lucidum, glycyrrhizin, and pentoxifylline in rats with cirrhosis induced by biliary obstruction","volume":"20","author":"Park","year":"1997","journal-title":"Biol. Pharm. Bull."},{"key":"2024103110054214900_cit11","first-page":"839","article-title":"Detection and evaluation of chemically induced liver injury","volume-title":"Principles and Methods of Toxicology","author":"Plaa","year":"1994","edition":"3rd"},{"key":"2024103110054214900_cit12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1515\/znc-1995-5-604","article-title":"Flavonoid aglycones from the leaf surfaces of some Artemisia sp. (Compositae-Anthemideae)","volume":"50c","author":"Valant-Vetschera","year":"1995","journal-title":"Z. Naturforsch."},{"key":"2024103110054214900_cit13","first-page":"524","article-title":"Artemisia iwayomogi","volume-title":"Coloured Medicinal Plants of Korea","author":"Yook","year":"1989"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357001774561","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/52\/7\/875\/60263830\/0022357001774561.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/52\/7\/875\/60263830\/0022357001774561.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:45:19Z","timestamp":1730371519000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/52\/7\/875\/6157594"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,7,1]]},"references-count":13,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2000,7,1]]},"published-print":{"date-parts":[[2000,7,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357001774561","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,7]]},"published":{"date-parts":[[2000,7,1]]}}}