{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T03:07:19Z","timestamp":1761620839002,"version":"3.28.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2000,7,1]],"date-time":"2000-07-01T00:00:00Z","timestamp":962409600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We examined the possible modulation by chitosan of the antitumour effects and side effects of cisplatin (cis-diaminedichloroplatinum, CDDP). The study showed that CDDP had potent antitumour activity when administered orally as well as intraperitoneally. We also compared the antitumour activity and side effects of orally administered CDDP plus orally administered chitosan versus intraperitoneally administered CDDP plus orally administered chitosan in sarcoma 180-bearing mice.<\/jats:p>\n               <jats:p>When CDDP (1.25 mg kg\u22121 \u00d7 2 day\u22121) was intraperitoneally administered to sarcoma 180-bearing mice, myelotoxicity (the reduction of leucocyte and platelet numbers), nephrotoxicity (the increase of blood nitrogen urea level), immunotoxicity (the reduction of spleen and thymus weight) and a reduction in body weight resulted. These intraperitoneally administered CDDP-induced side effects were not prevented by oral administration of chitosan (150 mg kg\u22121 \u00d7 2 day\u22121 and 750 mg kg\u22121 \u00d7 2 day\u22121) for 14 consecutive days. On the other hand, the side effects such as the reductions of body and spleen weights induced by orally administered CDDP (1.25 mg kg\u22121 \u00d7 2 day\u22121) were prevented by the oral administration of chitosan (150 mg kg\u22121 \u00d7 2 day\u22121 and 750 mg kg\u22121 \u00d7 2 day\u22121).<\/jats:p>\n               <jats:p>From these results, we conclude that the orally administered chitosan plus CDDP might be useful for the prevention of body weight reduction and immunotoxicity (the reduction of spleen weight) induced by the orally administered CDDP without diminishing antitumour activity.<\/jats:p>","DOI":"10.1211\/0022357001774570","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"883-890","source":"Crossref","is-referenced-by-count":11,"title":["Antitumour Activity and Side Effects of Combined Treatment with Chitosan and Cisplatin in Sarcoma 180-Bearing Mice"],"prefix":"10.1093","volume":"52","author":[{"given":"Yoshiyuki","family":"Kimura","sequence":"first","affiliation":[{"name":"Second Department of Medical Biochemistry, School of Medicine, Ehime University , Shigenobu-cho, Onsen-gun, Ehime 791-0295,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Onoyama","sequence":"additional","affiliation":[{"name":"Second Department of Medical Biochemistry, School of Medicine, Ehime University , Shigenobu-cho, Onsen-gun, Ehime 791-0295,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiki","family":"Sera","sequence":"additional","affiliation":[{"name":"Second Department of Medical Biochemistry, School of Medicine, Ehime University , Shigenobu-cho, Onsen-gun, Ehime 791-0295,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromichi","family":"Okuda","sequence":"additional","affiliation":[{"name":"Second Department of Medical Biochemistry, School of Medicine, Ehime University , Shigenobu-cho, Onsen-gun, Ehime 791-0295,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,7,1]]},"reference":[{"key":"2024103110053552900_cit1","first-page":"771","article-title":"Clinical evaluation of irinotecan combined with cisplatin by divided administration in patients with untreated primary non-small cell lung cancer","volume":"36","author":"Asano","year":"1998","journal-title":"Nippon Kokyuki Gakkai Zasshi"},{"key":"2024103110053552900_cit2","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000190321","article-title":"Effect of L-histidinol on cisplatin nephrotoxicity in the rat","volume":"77","author":"Bardary","year":"1997","journal-title":"Nephron"},{"key":"2024103110053552900_cit3","first-page":"1197","article-title":"Clinical evaluation of azasetron hydrochloride: a new selective 5-HT3 receptor antagonist-antiemetic profile and plasma concentration in transcatheter arterial chemoembolization using CDDP for unresectable hepatocellular carcinoma","volume":"25","author":"Beppu","year":"1998","journal-title":"Jpn. 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