{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T02:40:29Z","timestamp":1768272029119,"version":"3.49.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A decoction of Mikania cordata (Compositae) is commonly used for the treatment of gastric ulcer in the Rajbari district of Bangladesh. We have evaluated the anti-ulcerogenic effect of the alkaloidal fraction from the whole plant of M. cordata on diclofenac sodium-induced gastrointestinal lesion in rats.<\/jats:p>\n               <jats:p>Long Evan's rats were divided into five groups. The control group was kept undisturbed. The vehicle group received vehicle after a 48-h fast. The diclofenac group received diclofenac sodium suspension (80mgkg\u22121) after a 48-h fast. The diclofenac-ranitidine group (anti-ulcer drug used as a standard) received 35 mgkg\u22121 ranitidine hydrochloride suspension 1 h after diclofenac sodium administration, after a 48-h fast. The diclofenac-extract group received alkaloidal fraction (50 mgkg\u22121) 1 h after diclofenac administration, after a 48-h fast. The biochemical, morphological and histological changes were studied.<\/jats:p>\n               <jats:p>The data showed that the pH values of the stomach and duodenum were increased significantly (P &amp;lt; 0.001) in the alkaloidal-administered group compared with the control group (3.09 \u00b1 0.0429 vs 2.07 \u00b1 0.0339 and 6.79 \u00b1 0.1162 vs 6.19 \u00b1 0.1273, respectively). There were significant changes (P &amp;lt; 0.001) detected in the morphological study. The ulcer index of the stomach (0.268 \u00b1 0.0346) and of the duodenum (0.050 \u00b1 0.0129) in the alkaloidal-administered group were significantly lower than the diclofenac-only administered group (0.691 \u00b1 0.0184 and 0.093 \u00b1 0.0138, respectively). According to the grading of tissue damage in the histological study, there were less or no lesions on the gastrointestinal mucosa of the alkaloidal-administered group compared with the diclofenac-only group (0 vs 5, respectively). When the results of the alkaloid extract group where compared with the ranitidine hydrochloride group a similar or more potent effect was observed with the alkaloidal extract group.<\/jats:p>\n               <jats:p>The results of this study revealed that the bioactive principles of M. cordata have anti-ulcerogenic effects. The results validate the traditional use of this plant for the treatment of gastric ulcer in Bangladesh.<\/jats:p>","DOI":"10.1211\/0022357001774930","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"1157-1162","source":"Crossref","is-referenced-by-count":12,"title":["The Anti-ulcerogenic Effect of an Alkaloidal Fraction from <i>Mikania cordata<\/i> on Diclofenac Sodium-induced Gastrointestinal Lesions in Rats"],"prefix":"10.1093","volume":"52","author":[{"given":"M Ashik","family":"Mosaddik","sequence":"first","affiliation":[{"name":"Department of Pharmacy, University of Rajshahi , Rajshahi 6205,","place":["Bangladesh"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khandker M Faisal","family":"Alam","sequence":"additional","affiliation":[{"name":"IMO, Rajshahi Medical College Hospital , Rajshahi 6000,","place":["Bangladesh"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2024103110055333500_cit1","first-page":"697","article-title":"Isolation and purification of a new flavone from Mikania cordata","volume":"45","author":"Ahmed","year":"1990","journal-title":"Pharmazie"},{"key":"2024103110055333500_cit2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/030006059101900311","article-title":"Study on the mechanism of activities of ranitidine HCl on an animal model","volume":"19","author":"Al-Ghamdi","year":"1991","journal-title":"J. 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