{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:20:44Z","timestamp":1788826844601,"version":"build-2803163510"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Eleven lignans (1\u201311) were isolated from the CH2Cl2 fraction of the bark of Machilus thunbergii Sieb, et Zucc. (Lauraceae). These were identified as (-)-acuminatin (1), (-)-isoguaiacin (2), meso-dihydroguaiaretic acid (3), (+)-galbacin (4), (-)-sesamin (5), (+)-galbelgin (6), machilin A (7), machilin G (8), licarin A (9), and nectandrin A (10) and B (11).<\/jats:p>\n               <jats:p>Primary cultures of rat hepatocytes were co-incubated for 90 min with the hepatotoxin CCl4 and each of the 11 lignans (50 \u03bcM). Hepatoprotective activity was determined by measuring the level of glutamic pyruvic transaminase released into the medium from the primary cultures of rat hepatocytes. (-)-Acuminatin, (-)-isoguaiacin and meso-dihy-droguaiaretic acid all significantly reduced the level of glutamic pyruvic transaminase released. Further investigation revealed that these three compounds significantly preserved the levels and the activities of glutathione, superoxide dismutase, glutathione peroxidase and catalase. (-)-Acuminatin, (-)-isoguaiacin and meso-dihydroguaiaretic acid also ameliorated lipid peroxidation as demonstrated by a reduction of malondialdehyde production.<\/jats:p>\n               <jats:p>These results suggest that (-)-acuminatin, (-)-isoguaiacin and meso-dihydroguaiaretic acid exert diverse hepatoprotective activities, perhaps by serving as potent antioxidants.<\/jats:p>","DOI":"10.1211\/0022357001774949","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"1163-1169","source":"Crossref","is-referenced-by-count":50,"title":["Antioxidant Lignans from <i>Machilus thunbergii<\/i> Protect CCl4-injured Primary Cultures of Rat Hepatocytes"],"prefix":"10.1093","volume":"52","author":[{"given":"Young Uck","family":"Yu","sequence":"first","affiliation":[{"name":"College of Pharmacy, Seoul National University , Seoul, 151\u2013742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"So Young","family":"Kang","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , Seoul, 151\u2013742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hae Young","family":"Park","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , Seoul, 151\u2013742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Hyun","family":"Sung","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , Seoul, 151\u2013742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , Seoul, 151\u2013742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Yeou","family":"Kim","sequence":"additional","affiliation":[{"name":"Graduate School of East-West Oriental Medicine, Kyunghee University , Hoeki-dong Dongdae Moon-Ku, Seoul, 130\u2013701,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Choong","family":"Kim","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , Seoul, 151\u2013742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2024103110054186800_cit1","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/S0031-9422(00)82370-5","article-title":"Lignans, neolignans and norneolignans from Krameria cystisoides","volume":"26","author":"Achenbach","year":"1987","journal-title":"Phytochemistry"},{"key":"2024103110054186800_cit2","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0040-4020(77)80444-4","article-title":"Novel hydroxy lignans from the heartwood of Gmelina arborea","volume":"33","author":"Ajaneyulu","year":"1977","journal-title":"Tetrahedron"},{"key":"2024103110054186800_cit3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(19)50881-X","article-title":"A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase","volume":"195","author":"Beers","year":"1952","journal-title":"J. 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