{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:50:41Z","timestamp":1761511841058,"version":"3.28.0"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2000,9,1]],"date-time":"2000-09-01T00:00:00Z","timestamp":967766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The pharmacokinetics and hepatoprotective effects of 2-methylaminoethyl-4,4\u2032-dimethoxy-5,6,5\u2032,6\u2032-dimethylenedioxybiphenyl-2-carboxylic acid-2\u2032-carboxylate monohydrochloride (DDB-S) have been investigated in rats with CCl4-induced acute hepatic failure.<\/jats:p>\n               <jats:p>To study the pharmacokinetics of DDB-S, rats were divided into a control group and a CCl4-intoxicated group. DDB-S 50 mg kg\u22121 was administered by intravenous bolus injection to both groups of rats. In the CCl4-intoxicated rats the plasma concentrations of DDB-S were significantly higher, the area under the plasma concentration-time curve from time zero to time infinity was significantly greater (6.46 vs 3.34 mg min mL\u22121), and the total body (7.74 vs 15.0 mL min\u22121 kg\u22121), renal (2.55 vs 5.10 mL min\u22121 kg\u22121), nonrenal (5.07 vs 9.65 mL min\u22121 kg\u22121), and biliary (1.48 vs 2.69 mL min\u22121 kg\u22121) clearances were significantly slower compared with the control rats. This could be due to decreased hepatic cytochrome P450 activity and impaired kidney function induced by CCl4.<\/jats:p>\n               <jats:p>To study the hepatoprotective effects of DDB-S, rats were divided into three groups, control rats and CCl4-intoxicated rats with or without DDB-S pretreatment (50 mg kg\u22121, i.p.). The effects of DDB-S pretreatment on CCl4-induced liver injury were considerable; the serum levels of alanine transaminase, aspartate transaminase, and alkaline phosphatase were significantly lower by 54.3, 44.6 and 67.2%, respectively, compared with the CCl4-intoxicated-only group.<\/jats:p>\n               <jats:p>In an in-vitro study, rat hepatocytes were exposed to fresh medium containing 10 mM CCl4 and various concentrations of DDB-S (10 or 100 \u03bcg mL\u22121). The levels of alanine transaminase and aspartate transaminase in the medium were measured as an indicator of hepatocyte injury. DDB-S dose-dependently decreased the levels of alanine transaminase and aspartate transaminase compared with CCl4-intoxication only.<\/jats:p>\n               <jats:p>These results indicate that DDB-S has hepatoprotective activity.<\/jats:p>","DOI":"10.1211\/0022357001775029","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"1099-1103","source":"Crossref","is-referenced-by-count":4,"title":["Pharmacokinetics and Hepatoprotective Effects of 2-Methylaminoethyl-4,4\u2018-diiiethoxy-5,6,5\u2019,6\u2018-dimethylenedioxybiphenyl-2-carboxylic acid-2\u2019-carboxylate monohydrochloride in Rats with CCl4-induced Acute Hepatic Failure"],"prefix":"10.1093","volume":"52","author":[{"given":"S Y","family":"Oh","sequence":"first","affiliation":[{"name":"College of Pharmacy, Ewha Womans University , 11-1 Daehyun-Dong, Seodaemun-Gu, Seoul 120\u2013750,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Pusan National University , 30 Changjeon-Dong, Keumjeong-Gu, Pusan 609\u2013735,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y S","family":"Ku","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Ewha Womans University , 11-1 Daehyun-Dong, Seodaemun-Gu, Seoul 120\u2013750,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,9,1]]},"reference":[{"key":"2024103110055427600_cit1","article-title":"Isolated hepatocytes preparation, properties and applications","volume-title":"Laboratory Techniques in Biochemistry and Molecular Biology","author":"Berry","year":"1991"},{"key":"2024103110055427600_cit2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/BF01960740","article-title":"Pharmacokinetics in liver disease","volume":"9","author":"Breimer","year":"1987","journal-title":"Pharm. 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