{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T02:58:59Z","timestamp":1785898739232,"version":"3.56.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The effect of erdosteine, a mucoactive drug, on hypochlorous acid (HOCl)-induced lung injury, and the lipopolysaccharide (LPS)-induced increase in tumour necrosis factor-\u03b1 (TNF-\u03b1) production and neutrophil recruitment into the airway, was investigated.<\/jats:p>\n               <jats:p>Male BALB\/c mice were orally administered erdosteine (3\u2013100 mg kg\u22121), ambroxol hydrochloride (ambroxol) (3\u201330 mg kg\u22121), S-carboxymethyl-L-cysteine (S-CMC) (100\u2013600 mg kg\u22121) or prednisolone (10 mg kg\u22121), 1h before intratracheal injection of HOC1 or LPS. In the HOCl-injected mice, erdosteine markedly suppressed increases in the ratios of lung wet weight to bodyweight and lung dry weight to bodyweight, whereas the other mucoactive drugs ambroxol and S-CMC had little effect. Erdosteine also inhibited the LPS-induced neutrophil influx, although it did not affect the increased level of TNF-\u03b1 in the bronchoalveolar lavage fluid.<\/jats:p>\n               <jats:p>The results suggest that attenuation of reactive oxygen species and neutrophil recruitment is involved in the clinical efficacy of erdosteine in the treatment of chronic bronchitis.<\/jats:p>","DOI":"10.1211\/0022357001777414","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:05Z","timestamp":1033509845000},"page":"1411-1416","source":"Crossref","is-referenced-by-count":25,"title":["Protective Effect of Erdosteine Against Hypochlorous Acid-induced Acute Lung Injury and Lipopolysaccharide-induced Neutrophilic Lung Inflammation in Mice"],"prefix":"10.1093","volume":"52","author":[{"given":"Ken-Ichi","family":"Hayashi","sequence":"first","affiliation":[{"name":"Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Hosoe","sequence":"additional","affiliation":[{"name":"Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Raise","sequence":"additional","affiliation":[{"name":"Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ohmori","sequence":"additional","affiliation":[{"name":"Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2024103110054276300_cit1","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.4049\/jimmunol.157.4.1630","article-title":"In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation","volume":"157","author":"Blackwell","year":"1996","journal-title":"J. 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