{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:11:30Z","timestamp":1730434290068,"version":"3.28.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have assessed the tocolytic activity of formoterol, a novel long-acting and potent \u03b22-adrenoceptor agonist, through its production of cyclic adenosine monophosphate, in comparison with ritodrine, a \u03b22-adrenoceptor agonist used clinically to counter premature delivery.<\/jats:p>\n               <jats:p>Formoterol and ritodrine inhibited the amplitude and frequency of rat uterine contraction, with IC50 values of 3.8 times 10\u221210 and 4.7 times 10\u22127 M, respectively. Intravenous administration of formoterol or ritodrine caused inhibition of uterine motility and increased heart rate in a dose-dependent manner. Inhibition of uterine motility by oral administration of formoterol (0.3 and 1 mg kg\u22121) continued for at least 60 min, whereas that with ritodrine (100 mg kg\u22121) persisted for 15 min with rapid recovery thereafter in pregnant rats. The \u03b2-adrenoceptor binding of [125I]iodopindolol to the myometrium of pregnant rats was competitive with formoterol and ritodrine, with Ki values of 0.04 and 6.10 nM, respectively. Formoterol (10\u22126 \u2014 10\u22124 M) and ritodrine (10\u22126 \u2014 10\u22124 M) increased the level of cyclic adenosine monophosphate in lymphocytes in a dose-dependent manner.<\/jats:p>\n               <jats:p>The results suggested that formoterol caused relaxation of uterine motility through production of cyclic adenosine monophosphate. Thus, formoterol may be useful as a treatment to counter premature delivery.<\/jats:p>","DOI":"10.1211\/0022357001777423","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:05Z","timestamp":1033509845000},"page":"1417-1423","source":"Crossref","is-referenced-by-count":4,"title":["Tocolytic Effects of a Long-acting \u03b22-Adrenoceptor Agonist, Formoterol, in Rats"],"prefix":"10.1093","volume":"52","author":[{"given":"Norihiro","family":"Shinkai","sequence":"first","affiliation":[{"name":"Research Department, Saitama Daiichi Pharmaceutical Co., Ltd , 8-1, Minamisakae-cho, Kasukabe, Saitama 344-0057,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Takayama","sequence":"additional","affiliation":[{"name":"Research Department, Saitama Daiichi Pharmaceutical Co., Ltd , 8-1, Minamisakae-cho, Kasukabe, Saitama 344-0057,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2024103110053656000_cit1","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0002-9378(80)90777-2","article-title":"Oral ritodrine maintenance in the treatment of preterm labor","volume":"137","author":"Creasy","year":"1980","journal-title":"Am. 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