{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T08:07:03Z","timestamp":1782547623094,"version":"3.54.5"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2000,11,1]],"date-time":"2000-11-01T00:00:00Z","timestamp":973036800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The first-pass effect of furosemide was investigated in rats. Furosemide intravenous solution (20 mgkg\u22121 Lasix), was administered via the jugular vein and the portal vein, orally, and instilled directly into the duodenum of rats. The first-pass effects of furosemide by lung, heart, and liver seemed to be negligible in rats. The absolute bioavailability of furosemide was 28.9 and 48.3% after oral and intraduodenal administration, respectively. Based on the gastrointestinal (GI) recovery study, 68.3 and 69.5% of furosemide were found to have disappeared mainly due to absorption and\/or metabolism from rat GI tract after oral and intraduodenal administration, respectively.<\/jats:p>\n               <jats:p>The results indicate that gastrointestinal and intestinal first-pass effects of furosemide were approximately 40% (68.3\u201328.9%) and 20% (69.5\u201348.3%) of the dose, respectively.<\/jats:p>","DOI":"10.1211\/0022357001777487","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:05Z","timestamp":1033509845000},"page":"1337-1343","source":"Crossref","is-referenced-by-count":16,"title":["Gastrointestinal First-pass Effect of Furosemide in Rats"],"prefix":"10.1093","volume":"52","author":[{"given":"Eun Jung","family":"Kim","sequence":"first","affiliation":[{"name":"College of Pharmacy, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kye Soo","family":"Han","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myung Gull","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Seoul National University , San 56-1, Shinlim-Dong, Kwanak-Gu, Seoul 151-742,","place":["Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,11,1]]},"reference":[{"key":"2024103110055660400_cit1","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1365-2125.1982.tb01984.x","article-title":"In vitro studies on the hydrolysis of furosemide in gastrointestinal juices","volume":"14","author":"Andreasen","year":"1982","journal-title":"Br. J. Clin. Pharmacol."},{"key":"2024103110055660400_cit2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF00613429","article-title":"On the fate of furosemide in man","volume":"9","author":"Beerman","year":"1975","journal-title":"Eur. J. Clin. Pharmacol."},{"key":"2024103110055660400_cit3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/ki.1982.149","article-title":"Absorption and disposition of furosemide in congestive heart failure","volume":"22","author":"Brater","year":"1982","journal-title":"Kidney Int."},{"key":"2024103110055660400_cit4","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF01062108","article-title":"Critical evaluation of potential error in pharmacokinetic studies using the linear trapezoidal rule method for the calculation of the area under the plasma level-time curve","volume":"6","author":"Chiou","year":"1978","journal-title":"J. Pharmacokinet. 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