{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:26:46Z","timestamp":1791559606315,"version":"4.3.4"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2000,12,1]],"date-time":"2000-12-01T00:00:00Z","timestamp":975628800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2000,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Dimethylglycine is an anti-stress nutrient with antioxidant properties. Recently, studies have implicated the generation of oxygen-derived free radicals and lipid peroxidation as one of the mechanisms in the pathogenesis of gastric ulcer. Hence, we evaluated the antiulcer activity of dimethylglycine in various rat models of ulcer and also investigated the probable antioxidant mechanism of the anti-ulcer effect.<\/jats:p>\n               <jats:p>The results suggest that the gastroprotective effect of dimethylglycine could be mediated by its free radical scavenging activity and cytoprotection of gastric mucosa.<\/jats:p>\n               <jats:p>Dimethylglycine at a dose of 25 and 35 mg kg\u22121 significantly reduced ulcer number, ulcer size and ulcer index in pyloric-ligation-, ibuprofen- and stress-induced ulcers. The 35 mg kg\u22121 dose was more effective than 25 mg kg\u22121 and was comparable to famotidine. Dimethylglycine did not produce any significant change in acid secretion, unlike famotidine. There was a significant increase in plasma and tissue malondialdehyde levels in pyloric-ligated rats but these levels fell following dimethylglycine treatment. Also, there was a significant reduction in glutathione levels after dimethylglycine treatment.<\/jats:p>","DOI":"10.1211\/0022357001777568","type":"journal-article","created":{"date-parts":[[2002,10,1]],"date-time":"2002-10-01T22:04:05Z","timestamp":1033509845000},"page":"1519-1522","source":"Crossref","is-referenced-by-count":40,"title":["Effect of Dimethylglycine on Gastric Ulcers in Rats"],"prefix":"10.1093","volume":"52","author":[{"given":"K","family":"Hariganesh","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Kasturba Medical College , Manipal \u2014 576119, Karnataka,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Prathiba","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Kasturba Medical College , Manipal \u2014 576119, Karnataka,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2000,12,1]]},"reference":[{"key":"2024103110051805100_cit1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/1043-6618(94)80046-4","article-title":"Effect of verapamil and hydralazine on stress and chemically-induced gastric ulcers in rats","volume":"29","author":"Al-Bekairi","year":"1994","journal-title":"Pharmacol. Res."},{"key":"2024103110051805100_cit2","first-page":"55","article-title":"Role of reactive oxygen species in mercaptomethylimidazole-induced gastric acid secretion and stress-induced gastric ulceration","volume":"76","author":"Bandyopadhyay","year":"1999","journal-title":"Curr. Sci."},{"key":"2024103110051805100_cit3","first-page":"882","article-title":"Improved method for the determination of blood glutathione","volume":"61","author":"Beutler","year":"1963","journal-title":"J. Lab. Clin. Med."},{"key":"2024103110051805100_cit4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1136\/gut.35.2.179","article-title":"Helicobacter pylori stimulates antral mucosal reactive oxygen metabolite production in vivo","volume":"35","author":"Davies","year":"1994","journal-title":"Gut"},{"key":"2024103110051805100_cit5","first-page":"3","article-title":"Pathogenesis of peptic ulcer disease and current trends in therapy","volume":"41","author":"Desai","year":"1997","journal-title":"Ind. J. Physiol. Pharmacol."},{"key":"2024103110051805100_cit6","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1093\/oxfordjournals.bmb.a072626","article-title":"Measuring free radical reaction in vivo","volume":"49","author":"Holley","year":"1993","journal-title":"Br. Med. Bull."},{"key":"2024103110051805100_cit7","first-page":"S82","article-title":"Effect of oxygen radical scavengers on the quality of gastric ulcer healing in rats","volume":"21","author":"Naito","year":"1995","journal-title":"J. Clin. Gastroenterol."},{"key":"2024103110051805100_cit8","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by the thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"2024103110051805100_cit9","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/0278-6915(94)90155-4","article-title":"Role of lipid peroxidation in calcium-induced impairment of the gastric mucosal barrier","volume":"32","author":"Oner","year":"1994","journal-title":"Food. Chem. Toxicol."},{"key":"2024103110051805100_cit10","first-page":"45","article-title":"Dimethylglycine (DMG) update: new studies confirm DMG improves health","volume":"2","author":"Passwater","year":"1987","journal-title":"Let's Live"},{"key":"2024103110051805100_cit11","first-page":"64","article-title":"Zinc complexes of NSAIDs abolish gastric ulceration propensity of parent drugs","volume":"28","author":"Rao","year":"1990","journal-title":"Indian Drugs"},{"key":"2024103110051805100_cit12","first-page":"G296","article-title":"Role of glutathione in gastric mucosal cytoprotection","volume":"247","author":"Robert","year":"1984","journal-title":"Am. J. Physiol."},{"key":"2024103110051805100_cit13","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0009-8981(78)90081-5","article-title":"Serum lipid peroxidation in cerebrovascular disorders determined by a new calorimetric method","volume":"90","author":"Satoh","year":"1978","journal-title":"Clinica Chimica Acta."},{"key":"2024103110051805100_cit14","first-page":"43","article-title":"A simple method for the uniform production of gastric ulceration in the rat","volume":"5","author":"Shay","year":"1945","journal-title":"Gastroenterology"},{"key":"2024103110051805100_cit15","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1126\/science.7280691","article-title":"Sulfhydryl compounds may mediate gastric cytoprotection","volume":"214","author":"Szabo","year":"1981","journal-title":"Science"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357001777568","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/52\/12\/1519\/60263306\/0022357001777568.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/52\/12\/1519\/60263306\/0022357001777568.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:43:28Z","timestamp":1730371408000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/52\/12\/1519\/6157599"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,12,1]]},"references-count":15,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2000,12,1]]},"published-print":{"date-parts":[[2000,12,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357001777568","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2000,12]]},"published":{"date-parts":[[2000,12,1]]}}}