{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T10:54:09Z","timestamp":1758970449806,"version":"3.28.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2001,11,1]],"date-time":"2001-11-01T00:00:00Z","timestamp":1004572800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2001,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The 2-aryl-3-indoleacetamides FGIN-1\u201327 and FGIN-1\u201343 have already been characterized in-vitro as potent and specific ligands for the mitochondrial DBI receptor. This affinity was associated with psychotropic properties in several rodent behavioural tasks (in particular anxiolytic action) via enhancement of GABA transmission through neurosteroid production. The synthesis of new 3-aryl-3-pyrrol-1-ylpropanamides 1a-i, analogues of FGIN-1\u201327 and FGIN-1\u201343, is described in four steps starting from the corresponding arylaldehydes. Preliminary evaluation of these compounds in behavioural studies (spontaneous locomotor activity and anxiolytic activity) in mice was also undertaken.<\/jats:p>","DOI":"10.1211\/0022357011777945","type":"journal-article","created":{"date-parts":[[2003,7,18]],"date-time":"2003-07-18T23:43:52Z","timestamp":1058571832000},"page":"1561-1568","source":"Crossref","is-referenced-by-count":6,"title":["Synthesis and preliminary behavioural evaluation in mice of new 3-aryl-3-pyrrol-1-ylpropanamides, analogues of FGIN-1\u201327 and FGIN-1\u201343"],"prefix":"10.1093","volume":"53","author":[{"given":"J","family":"Guillon","sequence":"first","affiliation":[{"name":"EA 2962-Pharmacochimie, UFR des Sciences Pharmaceutiques, Universit\u00e9 Victor Segalen Bordeaux 2 , 146 Rue L\u00e9o Saignat, 33076 Bordeaux cedex,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Boulouard","sequence":"additional","affiliation":[{"name":"Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie, Laboratoire de Pharmacochimie, UFR des Sciences Pharmaceutiques , 1 Rue Vaub\u00e9nard, 14032 Caen cedex,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Lelong","sequence":"additional","affiliation":[{"name":"Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie, Laboratoire de Pharmacochimie, UFR des Sciences Pharmaceutiques , 1 Rue Vaub\u00e9nard, 14032 Caen cedex,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Dallemagne","sequence":"additional","affiliation":[{"name":"Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie, Laboratoire de Pharmacochimie, UFR des Sciences Pharmaceutiques , 1 Rue Vaub\u00e9nard, 14032 Caen cedex,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Rault","sequence":"additional","affiliation":[{"name":"Centre d'Etudes et de Recherche sur le M\u00e9dicament de Normandie, Laboratoire de Pharmacochimie, UFR des Sciences Pharmaceutiques , 1 Rue Vaub\u00e9nard, 14032 Caen cedex,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Jarry","sequence":"additional","affiliation":[{"name":"EA 2962-Pharmacochimie, UFR des Sciences Pharmaceutiques, Universit\u00e9 Victor Segalen Bordeaux 2 , 146 Rue L\u00e9o Saignat, 33076 Bordeaux cedex,","place":["France"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2001,11,1]]},"reference":[{"key":"2024103110060842000_cit1","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1248\/cpb.42.1605","article-title":"Synthesis and cytotoxic activity against L1210 leukemia of new aminocyclopenta[c]thiophenones","volume":"42","author":"Alsaidi","year":"1994","journal-title":"Chem. 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