{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T02:19:46Z","timestamp":1767665986122,"version":"3.28.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2002,3,1]],"date-time":"2002-03-01T00:00:00Z","timestamp":1014940800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The gastroprotective effect of the labdane diterpene solidagenone was assessed on gastric ulcer in rats. The effect of a single oral dose of the compound was evaluated at 50, 100 and 200 mg kg\u22121 in the following test systems: pylorus ligature (Shay), aspirin- and ethanol-induced gastric ulcers. In pylorus-ligated rats (Shay model), the ulcerative index decreased by 37% with solidagenone pre-treatment at the three assayed doses. The effect of a single oral dose of 50 mg kg\u22121 solidagenone was comparable with ranitidine at the same concentration and similar to higher doses of the compound. A significant effect (P&amp;lt; 0.001) at 100 and 200 mg kg\u22121 was observed in the aspirin-induced ulcer model. At both doses, reduction in the number of lesions was approximately 50% compared with controls. The effect was comparable with the reference compound ranitidine (50 mg kg\u22121). With the ethanol-induced gastric ulcers, the effect of solidagen one at 100 and 200 mg kg\u22121 was similar to a single oral dose of 20 mg kg\u22121 omeprazole with a 50% reduction of the mean number of lesions compared with controls. In acute toxicity tests on mice, intraperitoneal administration of solidagenone showed no toxicity at doses up to 600 mg kg\u22121. This is the first report on the gastroprotective activity of a labdane diterpene.<\/jats:p>","DOI":"10.1211\/0022357021778466","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T20:14:04Z","timestamp":1034367244000},"page":"399-404","source":"Crossref","is-referenced-by-count":20,"title":["Gastroprotective activity of solidagenone on experimentally-induced gastric lesions in rats"],"prefix":"10.1093","volume":"54","author":[{"given":"Jaime A","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda Vegetaly Biotecnolog\u00eda, Universidad de Talca , Casilla 747, Talca,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Bustamante","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de Recursos Naturales, Universidad de Talca , Casilla 747, Talca,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis","family":"Astudillo","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de Recursos Naturales, Universidad de Talca , Casilla 747, Talca,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Schmeda-Hirschmann","sequence":"additional","affiliation":[{"name":"Instituto de Qu\u00edmica de Recursos Naturales, Universidad de Talca , Casilla 747, Talca,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2002,3,1]]},"reference":[{"key":"2024103109384170000_cit1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/BF02233904","article-title":"The mechanism of gastric hyperacidity produced by pyloric ligation in the rat","volume":"111","author":"Brodie","year":"1966","journal-title":"Am. 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