{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:21:12Z","timestamp":1791163272572,"version":"4.1.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2002,4,1]],"date-time":"2002-04-01T00:00:00Z","timestamp":1017619200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The gastroprotective effect of the triterpene oleanolic acid (OA) was assessed on gastric ulceration in rats. The effect of a single oral dose of OA was evaluated at 50, 100 and 200 mg kg\u22121 in the following models: pylorus ligature (Shay), and aspirin- and ethanol-induced gastric ulcers. A single oral administration of OA at doses of 50, 100 and 200 mg kg\u22121 inhibited the appearance of gastric lesions induced by ethanol, aspirin and pylorus ligature. In the pylorus ligature and aspirin models, the effect of OA at the selected concentrations was comparable with that of ranitidine at 50 mg kg\u22121. In the ethanol-induced gastric lesion model, OA showed a dose-dependent activity, and at 100 and 200 mg kg\u22121 was as active as omeprazole at 20 mg kg\u22121. The effect of OA, its acetylated and methoxylated derivatives, oleanonic acid and its methyl ester were assessed on HCl\/ethanol-induced ulcers in mice at 200 mg kg\u22121. OA and its methoxylated (OAM) and acetylated (OAAM, OAA) derivatives proved to be active in this animal model. The semisynthetic derivatives OAM and OAAM had the greatest gastroprotective activity, but their effect was not significantly greater than OA. In an acute toxicity test on mice, intraperitoneal administration of OA showed no toxicity at doses up to 600 mg kg\u22121.<\/jats:p>","DOI":"10.1211\/0022357021778718","type":"journal-article","created":{"date-parts":[[2002,10,11]],"date-time":"2002-10-11T20:14:04Z","timestamp":1034367244000},"page":"583-588","source":"Crossref","is-referenced-by-count":35,"title":["Gastroprotective activity of oleanolic acid derivatives on experimentally induced gastric lesions in rats and mice"],"prefix":"10.1093","volume":"54","author":[{"given":"Luis","family":"Astudillo","sequence":"first","affiliation":[{"name":"Instituto de Quimica de Recursos Naturales, Universidad de Talca , Casilla 747, Talca,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime A","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Instituto de Biologfa Vegetal y Biotecnologfa, Universidad de Talca , Casilla 747, Talca,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Schmeda-Hirschmann","sequence":"additional","affiliation":[{"name":"Instituto de Quimica de Recursos Naturales, Universidad de Talca , Casilla 747, Talca,","place":["Chile"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,4,1]]},"reference":[{"key":"2024103109375756200_cit1","first-page":"86","volume-title":"Handbook of natural products data. Volume 1. Pentacyclic triterpenoids","author":"Ahmad","year":"1994"},{"key":"2024103109375756200_cit2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0378-8741(98)00049-X","article-title":"Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fractions of Turnera ulmifolia (Turneraceae)","volume":"61","author":"Antonio","year":"1998","journal-title":"J. Ethnopharmacol"},{"key":"2024103109375756200_cit3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/0039-128X(94)90091-4","article-title":"Licorice and enzymes other than 11 beta-hydroxysteroid dehydrogenase: an evolutionary perspective","volume":"59","author":"Baker","year":"1994","journal-title":"Steroids"},{"key":"2024103109375756200_cit4","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1021\/np990240w","article-title":"DNA polymerase beta inhibitors from Baeckea gunniana","volume":"62","author":"Deng","year":"1999","journal-title":"J. Nat. Prod"},{"key":"2024103109375756200_cit5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF01983482","article-title":"Gastric and duodenal anti-ulcer activity of sulpiride, a dopamine D2 receptor antagonist, in rats","volume":"42","author":"Desai","year":"1993","journal-title":"Agents Actions"},{"key":"2024103109375756200_cit6","first-page":"221","volume-title":"Statistics for toxicologists. principles and methods of toxicology","author":"Gad","year":"1994"},{"key":"2024103109375756200_cit7","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1078\/0944-7113-00017","article-title":"Gastroprotective effect of aparisthman, a diterpene isolated from Aparisthmium cordatum, on experimental gastric ulcer models in rats and mice","volume":"8","author":"Hiruma-Lima","year":"2001","journal-title":"Phytomedicine"},{"key":"2024103109375756200_cit8","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0378-4274(99)00004-1","article-title":"Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetra-chloride-induced hepatic injury","volume":"105","author":"Jeong","year":"1999","journal-title":"Toxicol. Lett"},{"key":"2024103109375756200_cit9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1055\/s-2006-960474","article-title":"Chitin synthase II inhibitory activity of ursolic acid, isolated from Crataegus pinnatifida","volume":"65","author":"Jeong","year":"1999","journal-title":"Planta Med"},{"key":"2024103109375756200_cit10","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1021\/np9800710","article-title":"Anti-AIDS agents. 30. Anti-HIV activity of oleanolic acid, pomolic acid, and structurally related triterpenoids","volume":"61","author":"Kashiwada","year":"1998","journal-title":"J. Nat. Prod"},{"key":"2024103109375756200_cit11","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1055\/s-2000-8585","article-title":"Cytotoxic triterpenes from stem bark of Physocarpus intermedius","volume":"66","author":"Kim","year":"2000","journal-title":"Planta Med"},{"key":"2024103109375756200_cit12","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1248\/cpb.47.290","article-title":"Hepatoprotective and hepatotoxic actions of oleanolic acid-type triterpenoidal glucuronides on rat primary hepatocyte cultures","volume":"47","author":"Kinjo","year":"1999","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"2024103109375756200_cit13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0944-7113(99)80038-5","article-title":"Inhibitory effect of some triterpenes from cacti on 32Pi-incorporation into phospholipids of HeLa cells promoted by 12-O-tetradecanoylphorbol-13-acetate","volume":"6","author":"Kinoshita","year":"1999","journal-title":"Phytomedicine"},{"key":"2024103109375756200_cit14","first-page":"179","article-title":"Effect of oleanolic acid-cyclodextrin inclusion compounds on dental caries by in vitro experiment and rat-caries model","volume":"97","author":"Kozai","year":"1999","journal-title":"Microbios"},{"key":"2024103109375756200_cit15","first-page":"201","article-title":"Anti-ulcer drugs of plant origin","volume-title":"Progress in medicinal chemistry","author":"Lewis","year":"1991"},{"key":"2024103109375756200_cit16","first-page":"99","article-title":"A simplified method of evaluating dose-effect experiments","volume":"96","author":"Litchfield","year":"1949","journal-title":"J. Pharmacol. Exp. Ther"},{"key":"2024103109375756200_cit17","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0378-8741(95)90032-2","article-title":"Pharmacology of oleanolic acid and ursolic acid","volume":"49","author":"Liu","year":"1995","journal-title":"J. Ethnopharmacol"},{"key":"2024103109375756200_cit18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1021\/np9902441","article-title":"Inhibitory effects on HIV-1 protease of constituents from the wood of Xanthoceras sorbifolia","volume":"63","author":"Ma","year":"2000","journal-title":"J. Nat. Prod."},{"key":"2024103109375756200_cit19","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0024-3205(98)00426-3","article-title":"Protective effects of oleanolic acid oligoglycosides on ethanol- or indomethacin-induced gastric mucosal lesions in rats","volume":"63","author":"Matsuda","year":"1998","journal-title":"Life Sci"},{"key":"2024103109375756200_cit20","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0021-5198(19)39795-1","article-title":"Effects of the new anti-ulcer agent KB-5492 on experimental gastric mucosal lesions and gastric mucosal defensive factors, as compared to those of teprenone and cimetidine","volume":"57","author":"Morimoto","year":"1991","journal-title":"Jpn. J. Pharmacol"},{"key":"2024103109375756200_cit21","first-page":"213","volume-title":"Guide to the care and use of experimental animals","author":"Olfert","year":"1993"},{"key":"2024103109375756200_cit22","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1016\/S0031-9422(00)89738-1","article-title":"Sesquiterpenes from Fabiana imbricata","volume":"36","author":"Schmeda-Hirschmann","year":"1994","journal-title":"Phytochemistry"},{"key":"2024103109375756200_cit23","first-page":"43","article-title":"A simple method for the uniform production of gastric ulceration in the rat","volume":"5","author":"Shay","year":"1945","journal-title":"Gastroenterology"},{"key":"2024103109375756200_cit24","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.2042-7158.1992.tb03646.x","article-title":"Anti-inflammatory activity of oleanolic acid in rats and mice","volume":"44","author":"Singh","year":"1992","journal-title":"J. Pharm. Pharmacol"},{"key":"2024103109375756200_cit25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1055\/s-2006-957388","article-title":"***Antiulcerogenic activity of trans-dehydrocrotonin from Croton cajucara","volume":"64","author":"Souza Brito","year":"1998","journal-title":"Planta Med."},{"key":"2024103109375756200_cit26","first-page":"25","article-title":"Pharmacological methods in phytotherapy research","author":"Williamson","year":"1996"},{"key":"2024103109375756200_cit27","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0378-8741(96)01502-4","article-title":"Effects of Cistus laurifolius L. flowers on gastric and duodenal lesions","volume":"55","author":"Yesilada","year":"1997","journal-title":"J. Ethnopharmacol"}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357021778718","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/54\/4\/583\/60258778\/0022357021778718.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/54\/4\/583\/60258778\/0022357021778718.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:03:36Z","timestamp":1730369016000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/54\/4\/583\/6150148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,4,1]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2002,4,1]]},"published-print":{"date-parts":[[2002,4,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357021778718","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"value":"0022-3573","type":"print"},{"value":"2042-7158","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2002,4]]},"published":{"date-parts":[[2002,4,1]]}}}