{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T21:26:37Z","timestamp":1760131597640,"version":"3.28.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>To assess whether peripheral changes related to skin temperature rise were induced by ovarian hormone deficiency, we investigated the effects of anaesthesia on calcitonin gene-related peptide (CGRP)- or luteinizing hormone-releasing hormone (LH-RH)-induced elevation of skin temperature in female rats. CGRP was used as an inducer of peripherally-mediated elevation of skin temperature, whereas LH-RH was used as an inducer of centrally-mediated elevation of skin temperature. Intravenous (i.v.) but not intracerebroventricular injection of CGRP (10 \u03bcg kg\u22121) or intracerebroventricular but not intravenous injection of LH-RH (10 \u03bcg\/rat) elevated the skin temperature of unanaesthetized rats restrained in a Ballman's cage. The elevation with LH-RH was completely inhibited by urethane anaesthesia, whereas the elevation with CGRP was not. These results suggested that changes in skin temperature measured under anaesthesia reflected a peripherally rather than a centrally mediated mechanism. The CGRP (1.0\u201330 \u03bcg kg\u22121, i.v.)-induced elevation of skin temperature was potentiated in ovariectomized rats and inhibited by pretreatment with a CGRP receptor antagonist CGRP8\u201337 (1000 \u03bcg kg\u22121, i.v.), suggesting that the potentiation may participate in peripheral factors such as a postsynaptic hypersensitivity to CGRP following ovarian hormone deficiency. Thus, measurement of skin temperature in the anaesthetized rat was a useful procedure to seek the peripheral mechanism of potentiation of skin temperature induced by CGRP, thought to be closely related to menopausal hot flashes.<\/jats:p>","DOI":"10.1211\/0022357022142","type":"journal-article","created":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T23:48:55Z","timestamp":1070322535000},"page":"1547-1552","source":"Crossref","is-referenced-by-count":6,"title":["Significance of measured elevation of skin temperature induced by calcitonin gene-related peptide in anaesthetized rats"],"prefix":"10.1093","volume":"55","author":[{"given":"Masamichi","family":"Noguchi","sequence":"first","affiliation":[{"name":"Tsumura Research Institute Medical Evaluation Laboratory , 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300\u20131192,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasushi","family":"Ikarashi","sequence":"additional","affiliation":[{"name":"Tsumura Research Institute Medical Evaluation Laboratory , 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300\u20131192,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutoshi","family":"Yuzurihara","sequence":"additional","affiliation":[{"name":"Tsumura Research Institute Medical Evaluation Laboratory , 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300\u20131192,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Kase","sequence":"additional","affiliation":[{"name":"Tsumura Research Institute Medical Evaluation Laboratory , 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300\u20131192,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuichi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Tsumura Research Institute Medical Evaluation Laboratory , 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300\u20131192,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Aburada","sequence":"additional","affiliation":[{"name":"Tsumura Research Institute Medical Evaluation Laboratory , 3586 Yoshiwara, Ami-machi, Inashiki-gun, Ibaraki 300\u20131192,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,11,1]]},"reference":[{"key":"2024103109392690800_cit1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0140-6736(93)91911-5","article-title":"Menopausal flushes and calcitonin-gene related peptide","volume":"342","author":"Chen","year":"1993","journal-title":"Lancet"},{"key":"2024103109392690800_cit2","first-page":"123","article-title":"hCGRP8\u201337, a calcitonin gene-related peptide antagonist revealing calcitonin gene-related peptide receptor heterogeneity in brain and periphery","volume":"254","author":"Dennis","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"2024103109392690800_cit3","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/ajhb.1077","article-title":"Physiology of hot flashes","volume":"13","author":"Freedman","year":"2001","journal-title":"Am. J. Human Biol."},{"key":"2024103109392690800_cit4","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0006-8993(97)00060-7","article-title":"Effect of gonadotropin releasing hormone on thermoregulatory vasomotor activity in ovariectomized female rats","volume":"754","author":"Hosono","year":"1997","journal-title":"Brain Res."},{"key":"2024103109392690800_cit5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0378-5122(86)90009-5","article-title":"Regional skin temperature changes in a rat model for the menopausal hot flush","volume":"8","author":"Katovich","year":"1986","journal-title":"Maturitas"},{"key":"2024103109392690800_cit6","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0006-8993(89)90146-7","article-title":"Effects of acute central LH-RH administration of the skin temperature response in morphine dependent rats","volume":"494","author":"Katovich","year":"1989","journal-title":"Brain Res."},{"key":"2024103109392690800_cit7","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/335164a0","article-title":"Calcitonin gene-related peptide acts as novel vasodilator neurotransmitter in mesenteric resistance vessels of the rats","volume":"335","author":"Kawasaki","year":"1988","journal-title":"Nature"},{"key":"2024103109392690800_cit8","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1677\/joe.0.1460431","article-title":"Basal tail skin temperature elevation and augmented response to calcitonin gene-related peptide in ovariectomized rats","volume":"146","author":"Kobayashi","year":"1995","journal-title":"J. Endocrinol."},{"key":"2024103109392690800_cit9","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1139\/y87-208","article-title":"Thermoregulatory physiology of menopausal hot flashes: a review","volume":"65","author":"Kronenberg","year":"1987","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2024103109392690800_cit10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0531-5565(94)90012-4","article-title":"Hot flashes: phenomenology, quality of life, and search for treatment options","volume":"29","author":"Kronenberg","year":"1994","journal-title":"Exp. Gerontol."},{"key":"2024103109392690800_cit11","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0163-7258(93)90060-Q","article-title":"Postmenopausal hot flashes and their management","volume":"57","author":"Lomax","year":"1993","journal-title":"Pharmacol. Ther."},{"key":"2024103109392690800_cit12","first-page":"208","article-title":"Thermoregulatory effects of luteinizing hormone releasing hormone in the rats","volume-title":"Thermoregulatory mechanisms and their therapeutic implications. 4th Int. Symp. on the Pharmacology of Thermoregulation","author":"Lomax","year":"1980"},{"key":"2024103109392690800_cit13","first-page":"307","article-title":"General anesthetics","volume-title":"The pharmacological basis of therapeutics.","author":"Marshall","year":"1995","edition":"9th edn"},{"key":"2024103109392690800_cit14","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0378-5122(98)00045-0","article-title":"The effect of estrogens and antiestrogens in a rat model for hot flush","volume":"30","author":"Merchenthaler","year":"1998","journal-title":"Maturitas"},{"key":"2024103109392690800_cit15","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1677\/joe.0.1750177","article-title":"Up-regulation of calcitonin gene-related peptide receptors underlying elevation of skin temperature in ovariectomized rats","volume":"175","author":"Noguchi","year":"2002","journal-title":"J. Endocrinol."},{"key":"2024103109392690800_cit16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0143-4179(02)00090-2","article-title":"Effects of the vasoactive neuropeptides calcitonin gene-related peptide, substance P and vasoactive intestinal polypeptide on the skin temperature in ovariectomized rats","volume":"36","author":"Noguchi","year":"2002","journal-title":"Neuropeptides"},{"key":"2024103109392690800_cit17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1677\/joe.0.1760359","article-title":"Effects of the Japanese herbal medicine Keishi-bukuryo-gan and 17\u03b2-estradiol on calcitonin gene-related peptide-induced elevation of skin temperature in ovariectomized rats","volume":"176","author":"Noguchi","year":"2003","journal-title":"J. Endocrinol."},{"key":"2024103109392690800_cit18","volume-title":"The rat brain in stereotaxic coordinates.","author":"Paxinos","year":"1986","edition":"2nd edn"},{"key":"2024103109392690800_cit19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1139\/y65-025","article-title":"The tail of the rat in temperature regulation and acclimatization","volume":"43","author":"Rand","year":"1965","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"2024103109392690800_cit20","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/ob.1996.v175.a74287","article-title":"Changes of plasma calcitonin gene-related peptide levels in postmenopausal women","volume":"175","author":"Valentini","year":"1996","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2024103109392690800_cit21","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0091-3057(96)00071-8","article-title":"Effect of restraint on drug-induced changes in skin and core temperature in biotelemetered rats","volume":"55","author":"Wright","year":"1996","journal-title":"Pharmacol. Biochem. Behav."}],"container-title":["Journal of Pharmacy and Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1211%2F0022357022142","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/55\/11\/1547\/60259616\/0022357022142.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpp\/article-pdf\/55\/11\/1547\/60259616\/0022357022142.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T10:10:40Z","timestamp":1730369440000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpp\/article\/55\/11\/1547\/6148261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11,1]]},"references-count":21,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2003,11,1]]},"published-print":{"date-parts":[[2003,11,1]]}},"URL":"https:\/\/doi.org\/10.1211\/0022357022142","relation":{},"ISSN":["0022-3573","2042-7158"],"issn-type":[{"type":"print","value":"0022-3573"},{"type":"electronic","value":"2042-7158"}],"subject":[],"published-other":{"date-parts":[[2003,11]]},"published":{"date-parts":[[2003,11,1]]}}}