{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T22:49:25Z","timestamp":1768171765147,"version":"3.49.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We have investigated the inhibitory effect of salmosin on integrin-mediated human tumour cell proliferation. SK-Mel-2 human melanoma cell adhesion to denatured collagen or vitronectin was found to be significantly and statistically inhibited by salmosin in a dose-dependent manner (P &amp;lt; 0.05). Moreover, the binding of SK-Mel-2 cells to salmosin-coated plates was specifically disrupted by anti-integrin \u03b1v monoclonal antibody at 8\u03b1g mL\u22121, but not by anti-integrin monoclonal antibody. These findings indicated that salmosin inhibited the adhesion of SK-Mel-2 cells to denatured collagen by specifically blocking integrin \u03b1v. The proliferation of SK-Mel-2 cells on a denatured collagen-coated plate was statistically and significantly inhibited by salmosin induced apoptosis in a dose-dependent manner (P &amp;lt; 0.05). Anti-integrin \u03b1v monoclonal antibody, anti-integrin \u03b1v\u03b23 monoclonal antibody, and synthetic RGD peptide also suppressed SK-Mel-2 cell proliferation. Several lines of experimental evidence strongly suggested that the inhibition of SK-Mel-2 cell proliferation by salmosin was due to the induction of apoptosis via the blocking of integrin \u03b1v-mediated cell survival.<\/jats:p>","DOI":"10.1211\/0022357022160","type":"journal-article","created":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T23:48:55Z","timestamp":1070322535000},"page":"1577-1582","source":"Crossref","is-referenced-by-count":22,"title":["Inhibitory effect of salmosin, a Korean snake venomderived disintegrin, on the integrin \u03b1v-mediated proliferation of SK-Mel-2 human melanoma cells"],"prefix":"10.1093","volume":"55","author":[{"given":"Kwang-Hoe","family":"Chung","sequence":"first","affiliation":[{"name":"Cardiovascular Research Institute and BK21 Project for Medical Sciences, Yonsei University College of Medicine , Seoul 120\u2013752,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University , Yongin 449\u2013701,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu-yeon","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Oncology, Graduate School of East-West Medical Science, Kyunghee University , Yongin 449\u2013701,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young-Doug","family":"Sohn","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute and BK21 Project for Medical Sciences, Yonsei University College of Medicine , Seoul 120\u2013752,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo-Ik","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Natural Science, Biotechnology Research Institute, Chungbuk National University , Chungjoo 361\u2013763,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang-Hyun","family":"Baek","sequence":"additional","affiliation":[{"name":"Cell and Gene Therapy Research Institute, College of Medicine, Pochon CHA University, CHA General Hospital , Seoul 135\u2013081,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yangsoo","family":"Jang","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Institute and BK21 Project for Medical Sciences, Yonsei University College of Medicine , Seoul 120\u2013752,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doo-Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Science and Bioproducts Research Center, Yonsei University , Seoul 120\u2013749,","place":["Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-Cheol","family":"Kang","sequence":"additional","affiliation":[{"name":"Biotechnology Research Institute, Chungbuk National University , 48 San, Gashin-dong, Chungju 361\u2013763,","place":["South Korea"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,11,1]]},"reference":[{"key":"2024103109393363500_cit1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/S0955-0674(99)00045-9","article-title":"Cell adhesion molecules, signal transduction and cell growth","volume":"11","author":"Aplin","year":"1999","journal-title":"Curr. 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