{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T17:18:58Z","timestamp":1767892738220,"version":"3.49.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cancer patients experience a high incidence of fungal infections due to their immuno-suppressed condition. This work has investigated the interaction of an anti-neoplastic agent, adriamycin (doxorubicin), with the yeast Candida albicans and examined whether this drug altered the susceptibility of the yeast to amphotericin B \u2013 an anti-fungal agent used for the treatment of systemic fungal infections in cancer patients. Exposure to adriamycin for 24 h increased the growth of C. albicans and increased the tolerance to amphotericin B by a small, but statistically significant, extent. Growth in adriamycin-supplemented medium suppressed the respiration rate of C. albicans, which resulted in a decrease in the ergosterol content of the fungal cell membrane. The tolerance to amphotericin B was lost after exposure to adriamycin for 48 h, which coincided with a restoration in the respiration rate and the ergosterol content of the fungal cell membrane. This work demonstrated that short-term exposure (24 h) to adriamycin increased the tolerance of C. albicans for amphotericin B, which may be mediated by a decrease in the ergosterol content as a result of an adriamycin-induced disruption of oxidative phosphorylation.<\/jats:p>","DOI":"10.1211\/0022357022359","type":"journal-article","created":{"date-parts":[[2004,1,13]],"date-time":"2004-01-13T22:33:58Z","timestamp":1074033238000},"page":"1629-1633","source":"Crossref","is-referenced-by-count":10,"title":["Exposure of the yeast <i>Candida albicans<\/i> to the anti-neoplastic agent adriamycin increases the tolerance to amphotericin B"],"prefix":"10.1093","volume":"55","author":[{"given":"Joseph","family":"O'Keeffe","sequence":"first","affiliation":[{"name":"Medical Mycology Unit, National Institute for Cellular Biotechnology, Department of Biology, National University of Ireland , Maynooth, Co. Kildare,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean","family":"Doyle","sequence":"additional","affiliation":[{"name":"Medical Mycology Unit, National Institute for Cellular Biotechnology, Department of Biology, National University of Ireland , Maynooth, Co. Kildare,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Kavanagh","sequence":"additional","affiliation":[{"name":"Medical Mycology Unit, National Institute for Cellular Biotechnology, Department of Biology, National University of Ireland , Maynooth, Co. Kildare,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,12,1]]},"reference":[{"key":"2024103109394760500_cit1","first-page":"122","article-title":"Amphotericin B: an update","volume":"53","author":"Abu-Salah","year":"1996","journal-title":"Br. J. Biomed. 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