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This review summarises progress in the development of carbohydrate-based therapeutics that involve: inhibition of carbohydrate-lectin interactions; immunisation, using monoclonal antibodies for carbohydrate antigens; inhibition of enzymes that synthesise disease-associated carbohydrates; replacement of carbohydrate-processing enzymes; targeting of drugs to specific disease cells via carbohydrate-lectin interactions; carbohydrate based anti-thrombotic agents.<\/jats:p>","DOI":"10.1211\/0022357023619","type":"journal-article","created":{"date-parts":[[2004,6,28]],"date-time":"2004-06-28T22:02:27Z","timestamp":1088460147000},"page":"691-702","source":"Crossref","is-referenced-by-count":59,"title":["Carbohydrate-based therapeutics"],"prefix":"10.1093","volume":"56","author":[{"given":"Helen M I","family":"Osborn","sequence":"first","affiliation":[{"name":"School of Chemistry, University of Reading , Whiteknights, Reading RG6 6AD,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip G","family":"Evans","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Reading , Whiteknights, Reading RG6 6AD,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Gemmell","sequence":"additional","affiliation":[{"name":"Dyson Perrins Laboratory, University of Oxford , South Parks Road, Oxford, OX1 3QY,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadie D","family":"Osborne","sequence":"additional","affiliation":[{"name":"School of Chemistry, University of Southampton , Highfield, Southampton, SO17 1BJ,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,6,1]]},"reference":[{"key":"2024103109405201500_cit1","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0957-4166(00)00113-0","article-title":"Sugar-mimic glycosidase inhibitors: natural occurrence, biological activity and prospects for therapeutic application","volume":"11","author":"Asano","year":"2000","journal-title":"Tetrahedron. 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