{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T04:51:18Z","timestamp":1783831878775,"version":"3.55.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2002,12,1]],"date-time":"2002-12-01T00:00:00Z","timestamp":1038700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2002,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We examined the effect of a kappa agonist, U-50488H, upon the bladder motility of anaesthetized rats. The frequency of distension-induced rhythmic bladder contractions was reduced by the intravenous (10 mg kg\u22121) or intrathecal (10\u2013100 \u03bcg) administration of U-50488H. The effect of intravenous U-50488H was inhibited by pre-treatment with nor-binaltorphimine (10 mg kg\u22121, s.c.). The inhibition of bladder contractions by intrathecal U-50488H (30 \u03bcg) was eliminated with the concomitant use of nor-binaltorphimine (10 mg kg\u22121, s.c.), and diminished by reserpine (4 mg kg\u22121, i.p.), yohimbine (10 \u03bcg, i.t.) or methysergide (20 \u03bcg, i.t.). The amplitude of bladder contractions induced by an electrical stimulation of the pontine micturition centre was not inhibited by intrathecal U-50488H (30 and 100 \u03bcg). These results suggested that a kappa agonist could inhibit micturition reflex as well as other opioids, and at least part of the inhibition was due to the diminishment of bladder sensation based on the activation of the descending monoaminergic systems through the spinal kappa-opioid receptors.<\/jats:p>","DOI":"10.1211\/002235702397","type":"journal-article","created":{"date-parts":[[2003,1,24]],"date-time":"2003-01-24T03:38:08Z","timestamp":1043379488000},"page":"1645-1650","source":"Crossref","is-referenced-by-count":7,"title":["Inhibition of urinary bladder motility by a spinal action of U-50488H in rats"],"prefix":"10.1093","volume":"54","author":[{"given":"Akinobu","family":"Gotoh","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine , 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650\u20130017,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Goto","sequence":"additional","affiliation":[{"name":"Kampo & Pharmacognosy Laboratories, Tsumura & Co. , 3586 Yoshiwara, Ami-machi, Ibaraki 300\u20131192,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Sengoku","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine , 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650\u20130017,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiro","family":"Shirakawa","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine , 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650\u20130017,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinobu","family":"Akao","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine , 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650\u20130017,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Fujisawa","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine , 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650\u20130017,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Okada","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine , 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650\u20130017,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichi","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine , 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650\u20130017,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Kampo & Pharmacognosy Laboratories, Tsumura & Co. , 3586 Yoshiwara, Ami-machi, Ibaraki 300\u20131192,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sadao","family":"Kamidono","sequence":"additional","affiliation":[{"name":"Division of Urology, Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine , 7\u20135\u20132 Kusunoki-cho, Chuo-ku, Kobe, Hyogo 650\u20130017,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2002,12,1]]},"reference":[{"key":"2024103109380514400_cit1","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/S0090-4295(97)00086-1","article-title":"Modulation of feline bladder and distal urethral responses to dorsal sacral root stimulation by intrathecal administration of a kappa1-opioid agonist","volume":"49","author":"Abdelmagid","year":"1997","journal-title":"Urology"},{"key":"2024103109380514400_cit2","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF01250516","article-title":"Possible regulatory role of dynorphin A in the urinary bladder","volume":"90","author":"Berggren","year":"1992","journal-title":"J. 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