{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:10:35Z","timestamp":1730434235077,"version":"3.28.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The functional effects of the amine agmatine, the putative endogenous ligand for \u03b12-adrenoceptors and imidazoline receptors, in rat vas deferens were investigated by using the epididymal and prostatic portions. Tissues were contracted by electrical stimulation or by exogenous drugs. In electrically stimulated portions, agmatine caused a dual effect on contractions. In the epididymal portion an inhibition on twitch contractions was observed, which was partially antagonised by idazoxan and yohimbine, indicating the involvement of at least a presynaptic \u03b12-adrenoceptor-mediated mechanism, without the interference of imidazoline receptors. In the prostatic portion, agmatine enhanced the amplitude of twitches. In contractions induced by exogenous drugs, agmatine potentiated, only in the prostatic segment, the effects of noradrenaline (norepinephrine) or ATP; it also enhanced the effect of low concentrations of KCl and blocked the maximum effect of the higher concentrations. Effects induced by agmatine on the exogenous ATP in the prostatic portion were blocked by cromakalim, suggesting a blocking action on the postsynaptic K+ channels, which explains, in part, the potentiation of the twitch amplitude. It was concluded that agmatine interferes with sympathetic neurotransmission, but the physiological relevance of this needs to be better understood because of the high doses employed to induce its effects.<\/jats:p>","DOI":"10.1211\/002235702720","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T02:09:13Z","timestamp":1051754953000},"page":"373-380","source":"Crossref","is-referenced-by-count":7,"title":["Dual effect of agmatine in the bisected rat vas deferens"],"prefix":"10.1093","volume":"55","author":[{"given":"Wilson C","family":"Santos","sequence":"first","affiliation":[{"name":"Departamento de Farm\u00e1cia e Administra\u00e7\u00e3o Farmac\u00eautica, UFF, Faculdade de Farm\u00e1cia , 24241\u2013000, Niter\u00f3i, RJ,","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soraya S","family":"Smaili","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, UNIFESP, Escola Paulista de Medicina , 04021\u2013023, S\u00e3o Paulo, SP,","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aron","family":"Jurkiewicz","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, UNIFESP, Escola Paulista de Medicina , 04021\u2013023, S\u00e3o Paulo, SP,","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Pi\u00e7arro","sequence":"additional","affiliation":[{"name":"Departamento de Fisiologia, UNIFESP, Escola Paulista de Medicina , 04021\u2013023, S\u00e3o Paulo, SP,","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00facia","family":"Garcez-do-Carmo","sequence":"additional","affiliation":[{"name":"Departamento de Farmacologia, UNIFESP, Escola Paulista de Medicina , 04021\u2013023, S\u00e3o Paulo, SP,","place":["Brasil"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2024103109392243300_cit1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/jphysiol.1977.sp012079","article-title":"An analysis of the anatomical basis for the mechanical response to motor nerve stimulation of the rat vas deferens","volume":"273","author":"Anton","year":"1977","journal-title":"J. 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