{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T10:14:46Z","timestamp":1760782486970,"version":"3.28.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2003,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The effects of orally co-administered antibiotics on the pharmacokinetics of paeoniflorin (PF) and paeonimetabolin-I (PM-I), a bioactive metabolite derived from PF by intestinal bacteria, from the traditional Chinese formulation, Shaoyao-Gancao-tang (SGT), were investigated in rats to clarify the effect of administering SGT together with some synthetic drugs. Co-administration of the antibiotics amoxicillin and metronidazole (AMPC-MET) significantly increased the area under the plasma concentration versus time curve (AUC) of PF, whereas it markedly decreased that of PM-I, to 2.6% of the normal AUC by administration of a single dose, and less than 1% by a 3-day pretreatment. Similar effects were observed using the combination of ofloxacin with SGT. The PF-metabolizing activity of intestinal bacteria was reduced to 16% and 33% of normal levels by treatment with AMPC-MET and ofloxacin, respectively, which caused alterations of that degree in the extent of absorption of PF and PM-I, but did not affect their rate of absorption or elimination. The present study suggests that it may not be appropriate to use SGT simultaneously with antibiotics such as AMPC-MET or ofloxacin, and also reveals the important role of intestinal bacteria in the pharmacokinetics of the active components of this traditional Chinese formulation.<\/jats:p>","DOI":"10.1211\/002235702748","type":"journal-article","created":{"date-parts":[[2003,5,1]],"date-time":"2003-05-01T02:09:13Z","timestamp":1051754953000},"page":"313-321","source":"Crossref","is-referenced-by-count":21,"title":["Influence of co-administered antibiotics on the pharmacokinetic fate in rats of paeoniflorin and its active metabolite paeonimetabolin-I from Shaoyao-Gancao-tang"],"prefix":"10.1093","volume":"55","author":[{"given":"Ju-Xiu","family":"He","sequence":"first","affiliation":[{"name":"Institute of Natural Medicine, Toyama Medical and Pharmaceutical University , 2630 Sugitani, Toyama 930\u20130194,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruaki","family":"Akao","sequence":"additional","affiliation":[{"name":"Faculty of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University , 2630 Sugitani, Toyama 930\u20130194,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadato","family":"Tani","sequence":"additional","affiliation":[{"name":"Institute of Natural Medicine, Toyama Medical and Pharmaceutical University , 2630 Sugitani, Toyama 930\u20130194,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2003,3,1]]},"reference":[{"key":"2024103109393780600_cit1","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1248\/bpb.22.491","article-title":"Anticonvulsant activity of paeonimetabolin-I adducts obtained by incubation of paeoniflorin and thiol compounds with Lactobacillus brevis","volume":"22","author":"Abdel-Hafez","year":"1999","journal-title":"Biol. 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