{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T04:10:47Z","timestamp":1730434247235,"version":"3.28.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The modulatory effect of the methanolic extract of Morus indica on 12-O-tetradecanoyl-phorbol-13-acetate (TPA) induced oxidative stress and 7,12-dimethylbenz(a)anthracene induced and croton oil (0.5% per mouse\/0.2 mL acetone, v\/v) promoted skin tumourigenesis in Swiss albino mice was studied. The efficacy of the M. indica extract was also evaluated in-vitro by studying the inhibition of the activity and level of aryl hydrocarbon hydroxylase, cytochrome P450, DNA sugar damage in calf thymus DNA and Fe++\/ascorbate-induced lipid peroxidation in microsomes of mice. Significant increases in the activity of antioxidant enzymes (P &amp;lt; 0.001) and a concomitant decrease (P &amp;lt; 0.001) in the cutaneous malondialdehyde level were observed at three doses of plant extract (2.5, 5.0 and 7.5 mg kg\u22121). Application of M. indica 1 h before each application of croton oil showed inhibitory effects on tumour promotion in terms of a reduction in the number of tumours\/mouse and percentage of mice with tumours. It was also accompanied by an extension of the tumour latency period. TPA, which resulted in a rapid and transient stimulation of mouse epidermal ornithine decarboxylase activity (P &amp;lt; 0.001), was inhibited dose dependently by pre-treatment with M. indica extract (P &amp;lt; 0.001). The results suggest that M. indica extract may be useful as a therapeutic agent for cancer control as it blocks or suppresses events associated with chemical carcinogenesis.<\/jats:p>","DOI":"10.1211\/0022357044373","type":"journal-article","created":{"date-parts":[[2004,9,28]],"date-time":"2004-09-28T22:38:46Z","timestamp":1096411126000},"page":"1291-1298","source":"Crossref","is-referenced-by-count":3,"title":["Modulatory effect of <i>Morus indica<\/i> against two-stage skin carcinogenesis in Swiss albino mice: possible mechanism by inhibiting aryl hydrocarbon hydroxylase"],"prefix":"10.1093","volume":"56","author":[{"given":"Lakshmi","family":"Prasad","sequence":"first","affiliation":[{"name":"Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University) , Hamdard Nagar, New Delhi 110062,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tajdar H","family":"Khan","sequence":"additional","affiliation":[{"name":"Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University) , Hamdard Nagar, New Delhi 110062,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anuradha","family":"Sehrawat","sequence":"additional","affiliation":[{"name":"Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University) , Hamdard Nagar, New Delhi 110062,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarwat","family":"Sultana","sequence":"additional","affiliation":[{"name":"Section of Chemoprevention and Nutrition Toxicology, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University) , Hamdard Nagar, New Delhi 110062,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,10,1]]},"reference":[{"key":"2024103109412342500_cit1","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0378-8741(98)00049-X","article-title":"Oral anti-inflammatory and anti-ulcerogenic activities of a hydroalcoholic extract and partitioned fraction of Turnera ulmifora (Turneraceae)","volume":"61","author":"Antonio","year":"1998","journal-title":"J. Ethnopharmacol."},{"key":"2024103109412342500_cit2","doi-asserted-by":"crossref","first-page":"20 509","DOI":"10.1016\/S0021-9258(19)47091-9","article-title":"Damage to the bases in DNA induced by hydrogen peroxide and ferric ion on chelates","volume":"264","author":"Aruoma","year":"1989","journal-title":"J. Biol. Chem."},{"key":"2024103109412342500_cit3","doi-asserted-by":"crossref","first-page":"5216","DOI":"10.1073\/pnas.77.9.5216","article-title":"Increase of NADPH: quinone reductase activity by dietary antioxidant. Possible role in protection against carcinogenesis and toxicity","volume":"77","author":"Benson","year":"1980","journal-title":"Proc. Natl Acad. Sci."},{"key":"2024103109412342500_cit4","first-page":"5575","article-title":"Glutathione reductase level in rat brain","volume":"250","author":"Carlberg","year":"1975","journal-title":"J. Biol. Chem."},{"key":"2024103109412342500_cit5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1126\/science.2981433","article-title":"Prooxidant states and tumor promotion","volume":"227","author":"Cerutti","year":"1985","journal-title":"Science"},{"key":"2024103109412342500_cit6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1152\/physrev.1979.59.3.527","article-title":"Hydrogen peroxide metabolism in mammalian organs","volume":"59","author":"Chance","year":"1979","journal-title":"Physiol. 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Rev. Biochem. Mol. Biol."},{"key":"2024103109412342500_cit11","first-page":"4875","article-title":"Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons. GHA Clowes Memorial Lecture","volume":"42","author":"Conney","year":"1982","journal-title":"Cancer Res."},{"key":"2024103109412342500_cit12","doi-asserted-by":"crossref","first-page":"526","DOI":"10.7326\/0003-4819-107-4-526","article-title":"Oxygen radicals and human disease","volume":"197","author":"Cross","year":"1987","journal-title":"Ann. Intern. Med."},{"key":"2024103109412342500_cit13","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0378-8741(97)00129-3","article-title":"Antimicrobial activity of aerial parts of Drossera pelitata Smith on oral bacteria","volume":"60","author":"Didry","year":"1998","journal-title":"J. Ethnopharmacol."},{"key":"2024103109412342500_cit14","first-page":"4137","article-title":"Superoxide dismutase, glutathione peroxidase and catalase in red blood cells from patients with malignant diseases","volume":"44","author":"Gonzalis","year":"1984","journal-title":"Cancer Res."},{"key":"2024103109412342500_cit15","first-page":"1569","article-title":"Depression of the hepatic cytochrome P450 monooxygenase system by treatment of mice with the anti-neoplastic agent, 5-azacytidine","volume":"45","author":"Gooderham","year":"1985","journal-title":"Cancer Res."},{"key":"2024103109412342500_cit16","doi-asserted-by":"crossref","first-page":"7130","DOI":"10.1016\/S0021-9258(19)42083-8","article-title":"GST: the first enzymatic step in mercapturic acid formation","volume":"249","author":"Habig","year":"1974","journal-title":"J. Biol. 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Med."},{"key":"2024103109412342500_cit21","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"2024103109412342500_cit22","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1021\/jf011178n","article-title":"Polyphenolic antioxidants from the fruits of Chrysophyllum cainito L. (star apple)","volume":"5","author":"Luo","year":"2002","journal-title":"J. Agric. Food Chem."},{"key":"2024103109412342500_cit23","first-page":"V","article-title":"Chemical carcinogenesis: mechanism and approaches to its control","volume":"47","author":"Miller","year":"1971","journal-title":"J. Natl Cancer Inst."},{"key":"2024103109412342500_cit24","first-page":"5086","article-title":"Differential distribution of glutathione and glutathione related enzymes in rabbit kidney","volume":"44","author":"Mohandas","year":"1984","journal-title":"Cancer Res."},{"key":"2024103109412342500_cit25","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.lfs.2003.06.036","article-title":"Inhibitory effect of quercetin on carrageenan-induced inflammation in rats","volume":"74","author":"Morikawa","year":"2003","journal-title":"Life Sci."},{"key":"2024103109412342500_cit26","doi-asserted-by":"crossref","first-page":"6242","DOI":"10.1016\/S0021-9258(18)94484-4","article-title":"Substrate inducible microsomal aryl hydrocarbon hydrolase in mammalian cell culture: assay and properties of induced enzyme","volume":"243","author":"Nebert","year":"1968","journal-title":"J. Biol. Chem."},{"key":"2024103109412342500_cit27","first-page":"1662","article-title":"Induction of the polyamine biosynthesis enzymes in mouse epidermis by tumor promoting agents","volume":"35","author":"O'Brien","year":"1975","journal-title":"Cancer Res."},{"key":"2024103109412342500_cit28","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/S0021-9258(20)82244-3","article-title":"The carbon monoxide binding pigment of liver microsome","volume":"239","author":"Omura","year":"1964","journal-title":"J. Biol. Chem."},{"key":"2024103109412342500_cit29","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1271\/bbb.65.1402","article-title":"Mulberry moracins: scavengers of UV stress-generated free radicals","volume":"65","author":"Sharma","year":"2001","journal-title":"Biosci. Biotechnol. Biochem."},{"key":"2024103109412342500_cit30","first-page":"945","article-title":"Perspectives in cancer chemoprevention","volume":"105","author":"Stoner","year":"1977","journal-title":"Environ. Health Perspect."},{"key":"2024103109412342500_cit31","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0378-8741(94)01214-K","article-title":"Crude extracts of hepatoprotective plants Solnum nigrum and Cichorium intybus inhibit free radical mediated DNA damage","volume":"45","author":"Sultana","year":"1997","journal-title":"J. Ethnopharmacol."},{"key":"2024103109412342500_cit32","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/0891-5849(90)90156-D","article-title":"Free radicals, antioxidant enzymes and carcinogenesis","volume":"8","author":"Sun","year":"1990","journal-title":"Free Radic. Biol. 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